Cited by 3,466Immune Response and InflammationInflammasome and immune disordersCytokine Signaling Pathways and Interactions

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Immunological and Inflammatory Functions of the Interleukin-1 Family

Dinarello, Charles A.·2009·Annual Review of Immunology

DOI 10.1146/annurev.immunol.021908.132612

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Abstract

More than any other cytokine family, the interleukin (IL)-1 family is closely linked to the innate immune response. This linkage became evident upon the discovery that the cytoplasmic domain of the IL-1 receptor type I is highly homologous to the cytoplasmic domains of all Toll-like receptors (TLRs). Thus, fundamental inflammatory responses such as the induction of cyclooxygenase type 2, increased expression of adhesion molecules, or synthesis of nitric oxide are indistinguishable responses of both IL-1 and TLR ligands. Both families nonspecifically affect antigen recognition and lymphocyte function. IL-1beta is the most studied member of the IL-1 family because of its role in mediating autoinflammatory diseases. Although the TLR and IL-1 families evolved to assist in host defense against infection, unlike the TLR family, the IL-1 family also includes members that suppress inflammation, both specifically within the IL-1 family but also nonspecifically for TLR ligands and the innate immune response.

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Authors: Dinarello, C. A.
Affiliations: University of Colorado Anschutz (US)
Corresponding author: Dinarello, Charles A.
ORCID: Dinarello, Charles A.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2009-04-01
Volume: 27
Issue: 1
Pages: 519-550
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.immunol.021908.132612
OpenAlex: W2165275387
Cited by: 3,466
References: 170
Citations by year: 2026: 95 · 2025: 169 · 2024: 195 · 2023: 185 · 2022: 209 · 2021: 183 · 2020: 199 · 2019: 202 · 2018: 231 · 2017: 219 · 2016: 198 · 2015: 223 · 2014: 244 · 2013: 227 · 2012: 206
FWCI: 17.82
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI‑15614)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: interleukin-1 family, innate immunity, inflammation, Toll-like receptors, IL-1 receptor type I, IL-1β, autoinflammatory disease, adhesion molecules, nitric oxide, antigen recognition, lymphocyte function, anti-inflammatory cytokines
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, B-Lymphocytes, Carrier Proteins, T-Lymphocytes, Helper-Inducer, Humans, Immunity, Innate, Inflammation, Interleukin-1, Signal Transduction, Receptors, Interleukin-1, Receptors, Purinergic P2, Caspase 1, Toll-Like Receptors, Receptors, Purinergic P2X7

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Immunological and Inflammatory Functions of the Interleukin-1 Family

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