Interleukin-1, inflammasomes, autoinflammation and the skin

Contassot, Emmanuel; Beer, Hans-Dietmar; French, Lars E.

doi:10.4414/smw.2012.13590

Cited by 130Inflammasome and immune disordersImmune Response and InflammationAutoimmune and Inflammatory Disorders Research

Interleukin-1, inflammasomes, autoinflammation and the skin

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Contassot, Emmanuel, Beer, Hans-Dietmar, French, Lars E.·2012·Swiss Medical Weekly

DOI 10.4414/smw.2012.13590

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Abstract

Interleukin 1, one of the first cytokines discovered in the 1980s, and a potent mediator of fever, pain and inflammation, is at present experiencing a revival in biology and medicine. Whereas the mechanism of activation and secretion of interleukin 1β, which critically regulates the function of this molecule, has remained mysterious for some 30 years following its discovery, the identification of a new cytoplasmic complex of proteins regulating IL-1β activation and secretion has carried our understanding of the role of IL1 in biology and disease one big step further. The inflammasomes, recently identified innate immune complexes that sense intracellular danger- (e.g. uric acid, ATP, cytoplasmic DNA) or pathogen-associated molecular patterns (e.g. muramyl dipeptide, flagellin, anthrax lethal toxin), are now known to be responsible for triggering inflammation in response to several molecular patterns, including, for example, uric acid, a danger-associated molecular pattern and trigger of gout. Dysregulation of inflammasome function is however also the cause of a family of genetic autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS) characterised by recurrent episodes of fever, urticarial-like skin lesions, systemic inflammation and arthritis. In mouse models recapitulating mutations observed in CAPS, neutrophilic inflammation of the skin is a cardinal feature, in a manner similar to several autoinflammatory diseases with skin involvement such as PAPA (pyoderma gangrenosum, acne and pyogenic arthritis) and Schnitzler's syndrome, in which IL-1β very probably plays a pathogenic role. In this article the role of the inflammasome in IL-1 biology, autoinflammation and disease is reviewed, together with new avenues for the therapy of these diseases.

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Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis
Thyssen, J. P., & Kežić, S. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.06.014 · Cited by 398 · see citing works
Steroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works
Pyoderma Gangrenosum: An Update on Pathophysiology, Diagnosis and Treatment
Alavi, A., French, L. E., Davis, M. D. P., Brassard, A., & Kirsner, R. S. (2017) · American Journal of Clinical Dermatology · doi:10.1007/s40257-017-0251-7 · Cited by 320 · see citing works
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Pathophysiology of pyoderma gangrenosum (PG): An updated review
Braswell, S. F., Kostopoulos, T. C., & Ortega‐Loayza, A. G. (2015) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.06.021 · Cited by 269 · see citing works
Targeting the Redox Balance in Inflammatory Skin Conditions
Wagener, F. A. D. T. G., Carels, C. E. L., & Lundvig, D. M. S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14059126 · Cited by 219 · see citing works
Antioxidants in dermatology
Addor, F. A. S. (2017) · Anais Brasileiros de Dermatologia · doi:10.1590/abd1806-4841.20175697 · Cited by 189 · see citing works
Understanding innate immunity and inflammation in acne: implications for management
Dréno, B., Gollnick, H. P. M., Kang, S., Thiboutot, D. M., Bettoli, V., Torres, V., Leyden, J., & the Global Alliance to Improve Outcomes in Acne (2015) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13190 · Cited by 181 · see citing works
Leukocyte Inclusion within a Platelet Rich Plasma-Derived Fibrin Scaffold Stimulates a More Pro-Inflammatory Environment and Alters Fibrin Properties
Anitua, E., Zalduendo, M., Troya, M., Padilla, S., & Orive, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121713 · Cited by 153 · see citing works
Inflammation and Epidural-Related Maternal Fever: Proposed Mechanisms
Sultan, P., David, A. L., Fernando, R., & Ackland, G. L. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001195 · Cited by 127 · see citing works
A critical role for interleukin-1β in the progression of autoimmune diseases
Zhao, R., Zhou, H., & Su, S. B. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.08.012 · Cited by 123 · see citing works
Role of the inflammasome in chronic obstructive pulmonary disease (COPD)
Colarusso, C., Terlizzi, M., Molino, A., Pinto, A., & Sorrentino, R. (2017) · Oncotarget · doi:10.18632/oncotarget.17850 · Cited by 89 · see citing works
Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells
Jang, Y., Lee, A. Y., Jeong, S., Park, K.-H., Paik, M.-K., Cho, N.-J., Kim, J., & Cho, M. (2015) · Toxicology · doi:10.1016/j.tox.2015.09.006 · Cited by 88 · see citing works
The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF)
Hori, J. I., Zamboni, D. S., Carrão, D. B., Goldman, G. H., & Berretta, A. A. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/418508 · Cited by 81 · see citing works
Deep Tissue Injury in Development of Pressure Ulcers: A Decrease of Inflammasome Activation and Changes in Human Skin Morphology in Response to Aging and Mechanical Load
Stojadinovic, O., Minkiewicz, J., Sawaya, A., Bourne, J. W., Torzilli, P., de Rivero Vaccari, J. P., Dietrich, W. D., Keane, R. W., & Tomic-Canic, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069223 · Cited by 77 · see citing works
Skin-Resident T Cells Sense Ultraviolet Radiation–Induced Injury and Contribute to DNA Repair
MacLeod, A. S., Rudolph, R., Corriden, R., Ye, I., Garijo, O., & Havran, W. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303297 · Cited by 77 · see citing works
Canakinumab for the treatment of chronic obstructive pulmonary disease
Rogliani, P., Calzetta, L., Ora, J., & Matera, M. G. (2015) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2015.01.005 · Cited by 76 · see citing works
Control of the Physical and Antimicrobial Skin Barrier by an IL-31–IL-1 Signaling Network
Hänel, K. H., Pfaff, C. M., Cornelissen, C. G., Amann, P. M., Marquardt, Y., Czaja, K., Kim, A. L., Lüscher, B., & Baron, J. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1402943 · Cited by 76 · see citing works
Curcumin and cancer stem cells: curcumin has asymmetrical effects on cancer and normal stem cells.
Sordillo, P. P., & Helson, L. (2015) · PubMed · Cited by 75 · see citing works
The Role of Interleukin-1 in Inflammatory and Malignant Human Skin Diseases and the Rationale for Targeting Interleukin-1 Alpha
Bou-Dargham, M. J., Khamis, Z. I., Cognetta, A. B., & Sang, Q. A. (2016) · Medicinal Research Reviews · doi:10.1002/med.21406 · Cited by 75 · see citing works
Epidural-related maternal fever: incidence, pathophysiology, outcomes, and management
Patel, S. D., Ciechanowicz, S., Blumenfeld, Y. J., & Sultan, P. (2023) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.06.026 · Cited by 75 · see citing works
A review of skin immune processes in acne
Jin, Z., Song, Y., & He, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1324930 · Cited by 77 · see citing works
Inflammasomes and dermatology
de Sá, D. C., & Neto, C. F. (2016) · Anais Brasileiros de Dermatologia · doi:10.1590/abd1806-4841.20165577 · Cited by 67 · see citing works
Inflammatory Cytokines and Antipsychotic-Induced Weight Gain: Review and Clinical Implications
Fonseka, T. M., Müller, D. J., & Kennedy, S. H. (2016) · Complex Psychiatry · doi:10.1159/000441521 · Cited by 64 · see citing works
Is acute myeloid leukemia a liquid tumor?
Ohanian, M. N., Faderl, S., Ravandi, F., Pemmaraju, N., Garcia‐Manero, G., Cortes, J. E., & Estrov, Z. E. (2013) · International Journal of Cancer · doi:10.1002/ijc.28012 · Cited by 64 · see citing works
PASS Syndrome: An IL-1-Driven Autoinflammatory Disease
Leuenberger, M., Berner, J., Lucca, J. D., Fischer, L., Kaparos, N., Conrad, C., Hohl, D., So, A. K.-L., & Gilliet, M. F. (2016) · Dermatology · doi:10.1159/000443648 · Cited by 60 · see citing works
miR-192 targeting IL-1RI regulates the immune response in miiuy croaker after pathogen infection in vitro and in vivo
Chu, Q., & Xu, T. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.05.007 · Cited by 58 · see citing works
Role of Interleukin 1 in Atopic Dermatitis
Abramovits, W., Bejarano, J. J. R., & Valdecantos, W. C. (2013) · Dermatologic Clinics · doi:10.1016/j.det.2013.04.008 · Cited by 57 · see citing works
Development, standardization and testing of a bacterial wound infection model based on ex vivo human skin
Schaudinn, C., Dittmann, C., Jurisch, J., Laue, M. M., Günday-Türeli, N., Blume‐Peytavi, U., Vogt, A., & Rancan, F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186946 · Cited by 56 · see citing works
Evaluating the effect of ozone in UV induced skin damage
Ferrara, F., Pambianchi, E., Woodby, B. L., Messano, N., Therrien, J., Pecorelli, A., Canella, R., & Valacchi, G. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.11.023 · Cited by 51 · see citing works
Encapsulation of cinnamon essential oil in whey protein enhances the protective effect against single or combined sub-chronic toxicity of fumonisin B1 and/or aflatoxin B1 in rats
Abdel-Wahhab, M. A., El‐Nekeety, A. A., Hassan, N. S., Gibriel, A. A., & Abdel-Wahhab, K. G. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-2921-2 · Cited by 50 · see citing works
Natural compounds with dual antimicrobial and anti-inflammatory effects
Sychrová, A., Koláriková, I., Žemlička, M., & Šmejkal, K. (2020) · Phytochemistry Reviews · doi:10.1007/s11101-020-09694-5 · Cited by 49 · see citing works
A myriad of roles of dendritic cells in atherosclerosis
Zhao, Y., Zhang, J., Zhang, W., & Xu, Y. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13634 · Cited by 49 · see citing works
Grape seed proanthocyanidin inhibits monocrotaline-induced pulmonary arterial hypertension via attenuating inflammation: in vivo and in vitro studies
Chen, F., Wang, H., Zhao, J., Yan, J., Meng, H., Zhan, H., Chen, L., & Yuan, L. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.01.013 · Cited by 48 · see citing works
Role of ROS and HMGB1 in Contact Allergen–Induced IL-18 Production in Human Keratinocytes
Galbiati, V., Papale, A., Galli, C. L., Marinovich, M., & Corsini, E. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.203 · Cited by 47 · see citing works
Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation
Zwicker, S., Hattinger, E., Bureik, D., Batycka-Baran, A., Schmidt, A., Gerber, P. A., Rothenfußer, S., Gilliet, M. F., Ruzicka, T., & Wolf, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175153 · Cited by 44 · see citing works
Hair curvature: a natural dialectic and review
Nissimov, J., & Chaudhuri, A. B. D. (2014) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12081 · Cited by 40 · see citing works
The Pathogenetic Effect of Natural and Bacterial Toxins on Atopic Dermatitis
Park, K. D., Pak, S., & Pak, S. C. (2016) · Toxins · doi:10.3390/toxins9010003 · Cited by 40 · see citing works
A randomized, double‐blind, placebo‐controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris
Chan, H. P., Chan, G. P., Santos, J. S., Dee, K., & Co, J. K. (2017) · International Journal of Dermatology · doi:10.1111/ijd.13607 · Cited by 40 · see citing works
The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation
Fenini, G., Grossi, S., Gehrke, S., Beer, H., Satoh, T. K., Contassot, E., & French, L. E. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.10.037 · Cited by 39 · see citing works
Self-citation
Plasma rich in growth factors (PRGF) and leukocyte-platelet rich fibrin (L-PRF): comparative release of growth factors and biological effect on osteoblasts
Baca-Gonzalez, L., Zamora, R. S., Rancán, L., Fernández-Tresguerres, F. G., Tresguerres, I. F., López‐Pintor, R. M., López-Quiles, J., Leco, I., & Torres, J. (2022) · International Journal of Implant Dentistry · doi:10.1186/s40729-022-00440-4 · Cited by 38 · see citing works
Evaluation of Effects of Topical Estradiol Benzoate Application on Cutaneous Wound Healing in Ovariectomized Female Mice
Mukai, K., Urai, T., Asano, K., Nakajima, Y., & Nakatani, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163560 · Cited by 37 · see citing works
Inhibition of TNF-α and IL-1 by compounds from selected plants for rheumatoid arthritis therapy: In vivo and in silico studies
Xu, S., Peng, H., Wang, N., & Meng, Z. (2018) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v17i2.12 · Cited by 36 · see citing works
Pyoderma gangrenosum: pathogenetic oriented treatment approaches
Wollina, U., & Tchernev, G. (2014) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-014-0285-x · Cited by 35 · see citing works
Inflammasome Activation in Pollution-Induced Skin Conditions
Ferrara, F., Prieux, R., Woodby, B. L., & Valacchi, G. (2020) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000007617 · Cited by 35 · see citing works
Skin symptoms as diagnostic clue for autoinflammatory diseases
Moreira, A., Torres, B., Peruzzo, J., Mota, A., Eyerich, K., Ring, J., & Unidade de Saúde Familiar Vale de Sorraia, P. (2017) · Anais Brasileiros de Dermatologia · doi:10.1590/abd1806-4841.20175208 · Cited by 34 · see citing works
Case Report: PsAPSASH syndrome: an alternative phenotype of syndromic hidradenitis suppurativa treated with the IL-17A inhibitor secukinumab
Nikolakis, G. D., Kreibich, K., Vaiopoulos, G., Kaleta, K., Talas, J. M., Becker, M., & Zouboulis, C. C. (2021) · F1000Research · doi:10.12688/f1000research.52100.1 · Cited by 30 · see citing works
Novel pharmacological approaches for the treatment of acne vulgaris
de Sousa, I. C. V. D. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.923401 · Cited by 30 · see citing works
Adalimumab mitigates ovarian ischemia–reperfusion injury in rats by regulating oxidative stress, apoptosis and resolution of inflammation
Beyazıt, F., Büyük, B., Türkön, H., Elmas, S., & Uzun, M. (2018) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.13846 · Cited by 28 · see citing works
Analysis of Potential Genes and Pathways Involved in the Pathogenesis of Acne by Bioinformatics
Chen, B., Zheng, Y., & Liang, Y. (2019) · BioMed Research International · doi:10.1155/2019/3739086 · Cited by 27 · see citing works
Novel Insights into the Regulatory Architecture of CD4+ T Cells in Rheumatoid Arthritis
Aterido, A., Palacio, C., Marsal, S., Avila-Pedretti, G., & Julià, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100690 · Cited by 25 · see citing works
Alveolar blood clots and platelet-rich fibrin induce in vitro fibroblast proliferation and migration
Bucur, M. B., Constantin, C., Neagu, M. T., Zurac, S., Dincă, O. M., Vlădan, C., Cioplea, M. D., Popp, C. G., Nichita, L., & Ionescu, E. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.7063 · Cited by 25 · see citing works
New and emerging drugs for the treatment of acne vulgaris in adolescents
de Sousa, I. C. V. D. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1584182 · Cited by 25 · see citing works
Grass carp TGF-β1 impairs IL-1β signaling in the inflammatory responses: Evidence for the potential of TGF-β1 to antagonize inflammation in fish
Wang, X., Yang, X. P., Wen, C., Gao, Y., Qin, L., Zhang, S., Zhang, A., YANG, K. Y., & Zhou, H. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.01.018 · Cited by 24 · see citing works
Concerned topics of epidural labor analgesia: labor elongation and maternal pyrexia: a systematic review
Li, C.-J., Xia, F., Xu, S., & Shen, X. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000646 · Cited by 24 · see citing works
Mitigating neuroinflammation in Parkinson's disease: Exploring the role of proinflammatory cytokines and the potential of phytochemicals as natural therapeutics
Sharma, P. K., Kishore, A., De, I., Negi, S., Kumar, G., Bhardwaj, S., & Singh, M. P. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105604 · Cited by 24 · see citing works
Cutaneous lesions caused by mechanical injury
Dréno, B., Bettoli, V., Pérez, M., Bouloc, A., & Ochsendorf, F. R. (2015) · European Journal of Dermatology · doi:10.1684/ejd.2014.2502 · Cited by 23 · see citing works
The role of type I interferons (IFNs) in the regulation of chicken macrophage inflammatory response to bacterial challenge
Garrido, D., Alber, A., Kut, E., Chanteloup, N., Lion, A., Trotereau, A., Dupont, J., Tedin, K., Kaspers, B., Vervelde, L., et al. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.04.025 · Cited by 23 · see citing works
METTL3-mediated m6A methylation regulates ovarian cancer progression by recruiting myeloid-derived suppressor cells
Wang, J., Ling, D., Shi, L., Li, H., Peng, M., Wen, H., Liu, T., Liang, R., Lin, Y., Wei, L., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01149-6 · Cited by 22 · see citing works
Lesional Inflammatory Profile in Hidradenitis Suppurativa Is Not Solely Driven by IL-1
Vossen, A. R. J. V., van Straalen, K. R., Florencia, E. F., & Prens, E. P. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.01.023 · Cited by 21 · see citing works
Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study
Ferrara, F., Yan, X., Pecorelli, A., Guiotto, A., Colella, S., Pasqui, A., Lynch, S., Ivarsson, J., Anderias, S., Choudhary, H., et al. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16321 · Cited by 22 · see citing works
Electrospun biomaterials for dermal regeneration
Kalaf, E. A. G., Hixon, K. R., Kadakia, P. U., Dunn, A. J., & Sell, S. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-101022-8.00005-3 · Cited by 21 · see citing works
Fat Grafts Augmented With Vitamin E Improve Volume Retention and Radiation-Induced Fibrosis
Abbas, D. B., Lavin, C. V., Fahy, E. J., Griffin, M., Guardino, N. J., Nazerali, R. S., Nguyen, D. H., Momeni, A., Longaker, M. T., & Wan, D. C. (2022) · Aesthetic Surgery Journal · doi:10.1093/asj/sjac066 · Cited by 20 · see citing works
Pseudomonas aeruginosa-induced IL-1β production is inhibited by Sophora flavescens via the NF-κB/inflammasome pathways
Lee, J.-H., Shin, H., Kim, Y., Paek, S., Jin, S., & Ha, U. (2014) · The Journal of Microbiology · doi:10.1007/s12275-014-4512-3 · Cited by 20 · see citing works
Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica
Ахметовна, Б. А., Khaiboullina, S. F., Martynova, E. V., Алексеевич, А. В., Lombardi, V. C., & Rizvanov, A. A. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.14.88 · Cited by 20 · see citing works
Resin Monomers Act as Adjuvants in Ni-induced Allergic Dermatitis in vivo
Bando, K., Takahashi, H., Kinbara, M., Tanaka, Y., Kuroishi, T., Sasaki, K., Takano‐Yamamoto, T., Sugawara, S., & Endo, Y. (2014) · Journal of Dental Research · doi:10.1177/0022034514552674 · Cited by 19 · see citing works
A Closer Look at Dexamethasone and the SARS-CoV-2-Induced Cytokine Storm: In Silico Insights of the First Life-Saving COVID-19 Drug
Morgan, P. M., Arnold, S. J., Hsiao, N., & Shu, C. (2021) · Antibiotics · doi:10.3390/antibiotics10121507 · Cited by 16 · see citing works
Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis
Wang, H., Dang, T., Feng, J., Wu, W., He, L., & Yang, J. (2023) · Epigenetics · doi:10.1080/15592294.2023.2199373 · Cited by 16 · see citing works
Molecular finds of pressure ulcer: A bioinformatics approach in pressure ulcer
Santos, E. M., Farias, L. C., Santos, S. H. S., de Paula, A. M. B., Silva, C. S. D. O. E., & Guimarães, A. L. S. (2017) · Journal of Tissue Viability · doi:10.1016/j.jtv.2017.01.002 · Cited by 15 · see citing works
Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk
Zhou, Y., Wu, J., Wang, W., & Sun, M. (2018) · Genes and Immunity · doi:10.1038/s41435-018-0019-y · Cited by 14 · see citing works
An analytical enrichment‐based review of structural genetic studies on keratoconus
Panahi, Y., Azimi, A., Naderi, M., Jadidi, K., & Sahebkar, A. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27764 · Cited by 14 · see citing works
Soluble Factors and Receptors Involved in Skin Innate Immunity—What Do We Know So Far?
Scurtu, L. G., & Simionescu, O. (2021) · Biomedicines · doi:10.3390/biomedicines9121795 · Cited by 13 · see citing works
Inflammatory mediators related to arthrogenic temporomandibular dysfunctions
Poluha, R. L., & Grossmann, E. (2018) · Brazilian Journal Of Pain · doi:10.5935/2595-0118.20180013 · Cited by 15 · see citing works
Monoclonal Antibodies in the Management of Inflammation in Wound Healing: An Updated Literature Review
Margiotta, F. M., Michelucci, A., Fidanzi, C., Granieri, G., Salvia, G., Bevilacqua, M., Janowska, A., Dini, V., & Romanelli, M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144089 · Cited by 13 · see citing works
Pyoderma gangraenosum und Sweet-Syndrom
Meier-Schiesser, B., Maul, J., & French, L. E. (2016) · Der Hautarzt · doi:10.1007/s00105-016-3888-x · Cited by 11 · see citing works
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The Role of Recombinant Secretory Leukocyte Protease Inhibitor to CD163, FGF-2, IL-1 and IL-6 Expression in Skin Wound Healing
Munadziroh, E., Putri, G. A., Ristiana, V., Agustantina, T. H., Nirwana, I., Razak, F. B. A., & Surboyo, M. D. C. (2022) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s358897 · Cited by 10 · see citing works
Safety, tolerability and pharmacokinetics and pharmacodynamics of HL2351, a novel hybrid fc‐fused interleukin‐1 receptor antagonist, in healthy subjects: A first‐in‐human study
Oh, J., Huh, K. Y., Cho, Y., Cha, J., Kim, S., Yoon, S. H., Park, S. S., Yoon, H., Lee, J., & Lee, H. (2019) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14161 · Cited by 10 · see citing works
The Bowel-Associated Arthritis–Dermatosis Syndrome (BADAS): A Systematic Review
Aromolo, I. F., Simeoli, D., Maronese, C., Altomare, A., Noviello, D., Caprioli, F., & Marzano, A. (2023) · Metabolites · doi:10.3390/metabo13070790 · Cited by 7 · see citing works
Tumour Necrosis Factor-Α, Interleukin-1 and Interleukin-6 Serum Levels and Its Correlation with Pain Severity in Chronic Tension-Type Headache Patients: Analysing Effect of Dexketoprofen Administration
Rambe, A. S., Sjahrir, H., & Machfoed, M. H. (2017) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2017.024 · Cited by 8 · see citing works
Interleukin 1-β, interleukin-1 receptor antagonist and vitamin D levels in children with atopic dermatitis
Machura, E., Szczepańska, M., Mazur, B., Ziora, K. T., & Kasperska−Zając, A. (2018) · Central European Journal of Immunology · doi:10.5114/ceji.2018.77388 · Cited by 8 · see citing works
Autoinflammatory Disorders, Pain, and Neural Regulation of Inflammation
Chen, M. C., & Meckfessel, M. (2013) · Dermatologic Clinics · doi:10.1016/j.det.2013.04.002 · Cited by 8 · see citing works
Splenic irradiation combined with tumor irradiation promotes T cell infiltration in the tumor microenvironment and helps in tumor control
Chen, H., Xie, H., Liu, X., Li, L., Bai, Y., & Gao, J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.01.071 · Cited by 8 · see citing works
INTERLEUKIN-1β LEVELS IN THE HUMAN GINGIVAL SULCUS: RATES AND FACTORS AFFECTING ITS LEVELS IN HEALTHY SUBJECTS
Al-dossary, O. A. I., Al-Kholani, A. I. M., AL-Haddad, K. A., Al-Najhi, M. M. A., Al-Shamahy, H. A., Al-adhami, I. A. A., & Aldhorae, K. (2022) · Universal Journal of Pharmaceutical Research · doi:10.22270/ujpr.v7i5.838 · Cited by 7 · see citing works
Migraine and neuroinflammation: correlation of adipokines and cytokines with clinical features
Ulutaş, C., Bayır, B. R. H., Çetinkaya, Y., Güler, E. M., Ağırcan, D., & Özkan, B. N. (2025) · BMC Neurology · doi:10.1186/s12883-025-04319-w · Cited by 8 · see citing works
A pilot study on serum lactoferrin in patients with mild versus severe acne in correlation with disease duration
Sharara, M. A., Diab, H. M., & Reda, A. E. R. (2019) · Journal of the Egyptian Womenʼs Dermatologic Society · doi:10.4103/jewd.jewd_35_19 · Cited by 7 · see citing works
Gallbladder Interleukins in Children with Calculous Cholecystitis
Deņisova, A., Pilmane, M., Eņģelis, A., & Pētersons, A. (2021) · Pediatric Reports · doi:10.3390/pediatric13030054 · Cited by 7 · see citing works
Interleukin-1α activation and localization in lipopolysaccharide-stimulated human monocytes and macrophages
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Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromescei_4535 382..390 OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diab
Ozkurede, V. U., & Franchi, L. (2011)

Authors: Contassot, E., Beer, H.-D., & French, L. E.
Affiliations: University Hospital Zurich (CH)
ORCID: Contassot, Emmanuel
Beer, Hans-Dietmar
French, Lars E.
Venue: Swiss Medical Weekly
Publisher: SMW Supporting Association
Published: 2012-05-20
Volume: 142
Issue: 2122
Pages: w13590
ISSN: 0036-7672 (ISSN-L)
1424-3997
DOI: 10.4414/smw.2012.13590
OpenAlex: W2094787046
Cited by: 130
References: 79
Citations by year: 2025: 4 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 12 · 2017: 14 · 2016: 14 · 2015: 13 · 2014: 14 · 2013: 12
FWCI: 1.14
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0 (unspecified)
Locations: Swiss Medical Weekly (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords: IL-1β, inflammasome, autoinflammatory disease, cryopyrin-associated periodic syndromes, PAPA syndrome, Schnitzler's syndrome, uric acid, IL-1β secretion, innate immunity, gout
MeSH terms: Animals, Autoimmune Diseases, Humans, Inflammation, Interleukin-1, Skin, Mice, Cryopyrin-Associated Periodic Syndromes, Inflammasomes

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Interleukin-1, inflammasomes, autoinflammation and the skin

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