The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Actin Cytoskeleton in T Cell Activation
Abstract
T cell cytoarchitecture differs dramatically depending on whether the cell is circulating within the bloodstream, migrating through tissues, or interacting with antigen-presenting cells. The transition between these states requires important signaling-dependent changes in actin cytoskeletal dynamics. Recently, analysis of actin-regulatory proteins associated with T cell activation has provided new insights into how T cells control actin dynamics in response to external stimuli and how actin facilitates downstream signaling events and effector functions. Among the actin-regulatory proteins that have been identified are nucleation-promoting factors such as WASp, WAVE2, and HS1; severing proteins such as cofilin; motor proteins such as myosin II; and linker proteins such as ezrin and moesin. We review the current literature on how signaling pathways leading from diverse cell surface receptors regulate the coordinated activity of these and other actin-regulatory proteins and how these proteins control T cell function.
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Cites
ERM proteins and merlin: integrators at the cell cortex
Bretscher, A., Edwards, K., & Fehon, R. G. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm882 · Cited by 1,306
Activation of Arp2/3 complex-mediated actin polymerization by cortactin
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TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
Štefanová, I., Hemmer, B., Vergelli, M., Martin, R., Biddison, W. E., & Germain, R. N. (2003) · Nature Immunology · doi:10.1038/ni895 · Cited by 465
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration
Fukui, Y., Hashimoto, O., Sanui, T., Oono, T., Koga, H., Abe, M., Inayoshi, A., Noda, M., Oike, M., Shirai, T., et al. (2001) · Nature · doi:10.1038/35090591 · Cited by 449
Polycomb Group Protein Ezh2 Controls Actin Polymerization and Cell Signaling
Su, I.-H., Dobenecker, M.-W., Dickinson, E., Oser, M., Basavaraj, A., Marqueron, R., Viale, A., Reinberg, D., Wülfing, C., & Tarakhovsky, A. (2005) · Cell · doi:10.1016/j.cell.2005.02.029 · Cited by 365
Nolz, J. C., Gomez, T. S., Zhu, P., Li, S., Medeiros, R. B., Shimizu, Y., Burkhardt, J. K., Freedman, B. D., & Billadeau, D. D. (2006) · Current Biology · doi:10.1016/j.cub.2005.11.036 · Cited by 237
Self-citationLeng, Y., Zhang, J., Badour, K., Arpaia, E., Freeman, S., Cheung, P., Siu, M., & Siminovitch, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409120102 · Cited by 210
Cited by
Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144
Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction
Huang, X., Yang, N., Fiore, V. F., Barker, T. H., Sun, Y., Morris, S. W., Ding, Q., Thannickal, V. J., & Zhou, Y. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0050oc · Cited by 530
Ezrin, Radixin and Moesin: key regulators of membrane–cortex interactions and signaling
Neisch, A. L., & Fehon, R. G. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.04.011 · Cited by 271
Comrie, W. A., Babich, A., & Burkhardt, J. K. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201406121 · Cited by 175
Self-citationEmerging topics in Reelin function
Förster, E., Bock, H. H., Herz, J., Chai, X., Frotscher, M., & Zhao, S. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07222.x · Cited by 130
Metadata
- Authors
- Burkhardt, J. K., Carrizosa, E., & Shaffer, M. H.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2008-04-01
- Volume
- 26
- Issue
- 1
- Pages
- 233-259
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2169289665
- Cited by
- 313
- References
- 7
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Burkhardt, J. K., Carrizosa, E., & Shaffer, M. H. (2008). The Actin Cytoskeleton in T Cell Activation. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.26.021607.090347
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
