Psychological Stress-Induced Modulation of Interleukin 2 Receptor Gene Expression and Interleukin 2 Production in Peripheral Blood Leukocytes

Glaser, Ronald

doi:10.1001/archpsyc.1990.01810200015002

Cited by 163Stress Responses and CortisolTryptophan and brain disordersCancer, Stress, Anesthesia, and Immune Response

Psychological Stress-Induced Modulation of Interleukin 2 Receptor Gene Expression and Interleukin 2 Production in Peripheral Blood Leukocytes

Glaser, Ronald·1990·Archives of General Psychiatry

DOI 10.1001/archpsyc.1990.01810200015002

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Abstract

We explored the expression of the interleukin 2 receptor (IL-2R) and the synthesis of IL-2R messenger RNA by peripheral blood leukocytes obtained from medical students experiencing examination stress in three independent studies. The peripheral blood leukocytes obtained at low-stress baseline periods had significantly higher percentages of IL-2R-positive cells when compared with cells obtained from the same individuals during examinations. In addition, IL2-R messenger RNA in peripheral blood leukocytes decreased significantly during examination periods in a subset of 13 subjects. In one study, we found an increase in the accumulation of interleukin 2 in cultures of cells showing down regulation of IL-2R expression and IL-2R messenger RNA levels. While there are ample data demonstrating stress-associated decrements in the immune response in humans and animals, these data provide the first evidence that this interaction may be observed at the level of gene expression. The data suggest one mechanism whereby the central nervous system modulates the immune response during psychological stress.

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From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [107]
Medical students under examination stress exhibit reduced IL-2R-positive cells and IL-2R messenger RNA in blood leukocytes, suggesting a compromised immune function.
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From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [107]

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Authors: Glaser, R.
Affiliations: The Ohio State University (US)
Corresponding author: Glaser, Ronald
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 1990-08-01
Volume: 47
Issue: 8
Pages: 707
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.1990.01810200015002
OpenAlex: W2146218160
Cited by: 163
References: 47
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
FWCI: 4.97
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01mh040787-07)
National Institute of Mental Health (MH18831, T32MH018831, MH 40787, MH-44660, P01MH044660)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
Keywords: psychological stress, interleukin-2 receptor, interleukin-2, gene expression, mRNA, peripheral blood leukocytes, exam stress, medical students
MeSH terms: Adult, Cells, Cultured, Female, Humans, Interleukin-2, Leukocytes, Lymphocyte Activation, Male, RNA, Messenger, Stress, Psychological, Receptors, Interleukin-2, Down-Regulation, Gene Expression

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Psychological Stress-Induced Modulation of Interleukin 2 Receptor Gene Expression and Interleukin 2 Production in Peripheral Blood Leukocytes

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