The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
ROLE OF ENDOTHELIUM IN THROMBOSIS AND HEMOSTASIS
Abstract
▪ Abstract Vascular endothelium is strategically located at the interface between tissue and blood. It is pivotal for protecting against vascular injury and maintaining blood fluidity. Normal endothelium releases prostacyclin and nitric oxide, potent inhibitors of platelet and monocyte activation and vasodilators. Their syntheses are governed by isoforms of enzymes. Normal endothelial surface expresses ecto-adenosine diphosphatase, which degrades adenosine diphosphate and inhibits platelet aggregation; thrombomodulin, which serves as a binding site for thrombin to activate protein C; and heparin-like molecules, which serve as a cofactor for antithrombin III. Normal endothelium secretes tissue plasminogen activator, which activates the fibrinolysis system. Endothelium produces and secretes von Willebrand factor, which mediates platelet adhesion and shear-stress-induced aggregation. Injury to endothelium is accompanied by loss of protective molecules and expression of adhesive molecules, procoagulant activities, and mitogenic factors, leading to development of thrombosis, smooth muscle cell migration, and proliferation and atherosclerosis.
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Cites
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Cited by
Moll, G., Ankrum, J. A., Kamhieh-Milz, J., Bieback, K., Ringdén, O., Volk, H.-D., Geissler, S., & Reinke, P. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.12.006 · Cited by 440
Vascular dysfunction in diabetes mellitus
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Obesity and hypertension: two epidemics or one?
Davy, K. P., & Hall, J. E. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00707.2003 · Cited by 280
Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium
Jain, A., van der Meer, A. D., Papa, A.-L., Barrile, R., Lai, A., Schlechter, B. L., Otieno, M. A., Louden, C. S., Hamilton, G. A., Michelson, A. D., et al. (2016) · Biomedical Microdevices · doi:10.1007/s10544-016-0095-6 · Cited by 148
Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells
Silva, G., Jeney, V., Chora, Â., Larsen, R., Balla, J., & Soares, M. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.045344 · Cited by 137
Metadata
- Authors
- Wu, M. D., & Thiagarajan, M. D.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1996-02
- Volume
- 47
- Issue
- 1
- Pages
- 315-331
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2126254515
- Cited by
- 384
- References
- 31
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: ROLE OF ENDOTHELIUM IN THROMBOSIS AND HEMOSTASIS. https://app.cochat.ai/papers/10.1146/annurev.med.47.1.315
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- Wu, M. D., & Thiagarajan, M. D. (1996). ROLE OF ENDOTHELIUM IN THROMBOSIS AND HEMOSTASIS. Annual Review of Medicine. https://doi.org/10.1146/annurev.med.47.1.315
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
