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Cited by 280Blood Pressure and Hypertension StudiesRenin-Angiotensin System StudiesCardiovascular Disease and Adiposity

Obesity and hypertension: two epidemics or one?

Davy, Kevin P., Hall, John E.·2004·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.00707.2003
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Abstract

The association between obesity and hypertension is well documented, although the exact nature of this relation remains unclear. Sympathetic nervous and renin-angiotensin-aldosterone system activation appear to play an important role in the sodium and water retention, rightward shift in the pressure-natriuresis, and blood pressure elevation observed in obese individuals. Visceral obesity and the ectopic deposition of adipose tissue may be important in the activation of these systems and in the target organ damage that ensues. Weight loss is critical in the effective management of obesity hypertension and the accompanying target organ damage, although recidivism rates are high. However, prevention of weight gain should be the major priority for combating hypertension and its consequences in the future. The present review will provide an overview of our understanding of the etiology, pathophysiology, and treatment of obesity hypertension. Our focus is on the state of knowledge in humans. The potential role of abdominal obesity is considered throughout our review. We refer to relevant animal literature for supportive evidence and where little or no data in humans are available.

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Crossref · 10.1152/ajpregu.00707.2003

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  • Part of the variability in sympathetic nerve activity and blood pressure among individuals with obesity may relate to differences in visceral adipose tissue, which seems to be more closely correlated with increased sympathetic nerve activity and hypertension than overall adiposity.

    “Part of this variability may relate to differences in VAT, which seems to be more closely correlated with increased SNA and hypertension than does overall adiposity156.”

    From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [156]

  • Angiotensin is thought to cause sympathoexcitation, so there may be additive effects of renin-angiotensin and sympathetic activation with respect to blood pressure elevation and cardiac remodeling in obesity.

    “Angiotensin is thought to cause sympathoexcitation, so there may be additive effects of renin-angiotensin and sympathetic activation with respect to blood pressure elevation and cardiac remodeling in obesity (67).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [67]

  • Increased activity of the renin-angiotensin system has been implicated in human obesity hypertension.

    “Furthermore, increased activity of this system has been implicated in human obesity hypertension (67, 96).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [67]

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Authors
Davy, K. P., & Hall, J. E.
Affiliations
Virginia Tech (US)
ORCID
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2004-05
Volume
286
Issue
5
Pages
R803-R813
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.00707.2003
OpenAlex
W2094878829
Cited by
280
References
172
Citations by year
2026: 2 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 11 · 2018: 6 · 2017: 13 · 2016: 14 · 2015: 9 · 2014: 12 · 2013: 20 · 2012: 22
FWCI
11.67
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (K02HL067227, R01HL062283, P01HL051971)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
obesity, hypertension, abdominal obesity, visceral obesity, sympathetic nervous system, renin-angiotensin-aldosterone system, sodium and water retention, pressure natriuresis, target organ damage, weight loss, weight gain prevention, pathophysiology
MeSH terms
Animals, Disease Outbreaks, Humans, Hypertension, Obesity

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