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Cited by 400Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

The DOI matches its Crossref record, with a small difference in title or year; 55 of the 55 references it cites were found in a registry or an index.

CIRCADIAN RHYTHMS: Basic Neurobiology and Clinical Applications

Moore MD, Robert Y.·1997·Annual Review of Medicine
DOI 10.1146/annurev.med.48.1.253
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Abstract

▪ Abstract Circadian rhythms are major features of adaptation to our environment. In mammals, circadian rhythms are generated and regulated by a circadian timing system. This system consists of entrainment pathways, pacemakers, and pacemaker output to effector systems that are under circadian control. The primary entrainment pathway is the retinohypothalamic tract, which terminates in the circadian pacemakers, the suprachiasmatic nuclei of the hypothalamus. The output of the suprachiasmatic nuclei is principally to the hypothalamus, the midline thalamus, and the basal forebrain. This provides a temporal organization to the sleep-wake cycle, to many physiological and endocrine functions, and to psychomotor performance functions. Disorders of circadian timing primarily affect entrainment and pacemaker functions. The pineal hormone, melatonin, appears to be a promising agent for therapy of some circadian timing disorders.

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Show all 55 references

Research works printed but not linked: 11

  1. Minors DS, 1992, Neurosci. Lett., 13, 36
  2. Van Cauter E, 1993, J. Biol. Rhythms, 8, S99
  3. Moore RY, 1978, J. Neural. Trans., 13, 47
  4. Speh JC, 1995, Soc. Neurosci., 21, 179
  5. Watts AG. 1991. The efferent projections of the suprachiasmatic nucleus: anatomical insights into the control of circadian rhythms. InThe Suprachiasmatic Nucleus—The Mind's Clock, ed. DC Klein, RY Moore, ST Reppert, pp. 77–106. New York:Oxford
  6. Graeber RC. 1994. Jet lag and sleep disruption. InPrinciples and Practice of Sleep Medicine, ed. MH Kryger, T Roth, WC Dement, pp. 463–70. New York: Saunders
  7. Monk TH. 1994. Shift work. InPrinciples and Practice of Sleep Medicine, ed. MH Kryger, T Roth, WC Dement, pp. 471–76. New York: Saunders
  8. Wagner DR. 1990. Circadian rhythm sleep disorders. InHandbook of Sleep Disorders, ed. M Thorpy, pp. 493–52. New York: Dekker
  9. Roehrs T, Roth T. 1994. Chronic insomnias associated with circadian rhythm disorders. InPrinciples and Practice of Sleep Medicine, ed. MH Kryger, T Roth, WC Dement, pp. 447–81. New York: Saunders
  10. Prinz PN, 1984, J. G erontol., 39, 30
  11. Wirz-Justice A. 1995. Biological rhythms in mood disorders. InPsychopharmacology: The Fourth Generation of Progress, ed. FE Bloom, DJ Kupfer, pp. 999–1017. New York: Raven

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Metadata

Authors
Moore MD, R. Y.
Affiliations
Departments of Psychiatry, Neurology, and Neuroscience, Center for Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15621
Venue
Annual Review of Medicine
Publisher
Annual Reviews
Published
1997-02
Volume
48
Issue
1
Pages
253-266
ISSN
  • 0066-4219 (ISSN-L)
  • 1545-326X
DOI
10.1146/annurev.med.48.1.253
OpenAlex
W2027654356
Cited by
400
References
55
Citations by year
2026: 3 · 2025: 10 · 2024: 12 · 2023: 8 · 2022: 6 · 2021: 16 · 2020: 12 · 2019: 10 · 2018: 20 · 2017: 16 · 2016: 15 · 2015: 8 · 2014: 10 · 2013: 13 · 2012: 19
FWCI
1.79
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
circadian rhythm, circadian system, suprachiasmatic nucleus, retinohypothalamic tract, circadian pacemaker, sleep-wake cycle, melatonin, circadian rhythm disorders, chronobiology, hormonal regulation, psychomotor performance
MeSH terms
Animals, Brain, Brain Mapping, Circadian Rhythm, Humans, Hypothalamus, Neural Pathways, Retina, Sleep Stages, Suprachiasmatic Nucleus, Thalamus, Wakefulness, Prosencephalon

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