The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Genetics of Longevity and Aging
Abstract
Longevity, i.e., the property of being long-lived, has its natural limitation in the aging process. Longevity has a strong genetic component, as has become apparent from studies with a variety of organisms, from yeast to humans. Genetic screening efforts with invertebrates have unraveled multiple genetic pathways that suggest longevity is promoted through the manipulation of metabolism and the resistance to oxidative stress. To some extent, these same mechanisms appear to act in mammals also, despite considerable divergence during evolution. Thus far, evidence from population-based studies with humans suggests the importance of genes involved in cardiovascular disease as important determinants of longevity. The challenge is to test if the candidate longevity genes that have emerged from studies with model organisms exhibit genetic variation for life span in human populations. Future investigations are likely to involve large-scale case-control studies, in which large numbers of genes, corresponding to entire gene functional modules, will be assessed for all possible sequence variation and associated with detailed phenotypic information on each individual over extended periods of time. This should eventually unravel the genetic factors that contribute to each particular aging phenotype.
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“Genes that regulate lifespan in animal models6–9 and human studies10–14 as well as multiple experimental paradigms, such as caloric restriction, heterochronic parabiosis and partial epigenetic reprogramming, have demonstrated that it is possible to manipulate ageing biology to ‘rejuvenate’ physiological functioning in complex model organisms15–28.”
From Measuring biological age using omics data (2022) · cites this paper as [6]
Citations
Cites
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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239
Broken Limits to Life Expectancy
Oeppen, J., & Vaupel, J. W. (2002) · Science · doi:10.1126/science.1069675 · Cited by 2,819
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
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Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081
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AN UNSOLVED PROBLEM OF BIOLOGY
(1953) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1953.tb84985.x · Cited by 1,806
Cited by
Sorted by citations
Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
Ralser, M., Wamelink, M. M. C., Kowald, A., Gerisch, B., Heeren, G., Struys, E. A., Klipp, E., Jakobs, C., Breitenbach, M., Lehrach, H. R., et al. (2007) · Journal of Biology · doi:10.1186/jbiol61 · Cited by 627
Measuring biological age using omics data
Rutledge, J., Oh, H., & Wyss-Coray, T. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00511-7 · Cited by 570
The redox stress hypothesis of aging
Sohal, R. S., & Orr, W. C. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.445 · Cited by 473
Two faces of p53: aging and tumor suppression
Rodier, F., Campisi, J., & Bhaumik, D. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm744 · Cited by 413
Vijg, J., & Suh, Y. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183715 · Cited by 399
Self-citation
Metadata
- Authors
- Vijg, J., & Suh, Y.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- ORCID
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2005-02-01
- Volume
- 56
- Issue
- 1
- Pages
- 193-212
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2148208805
- Cited by
- 142
- References
- 94
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 14 · 2015: 6 · 2014: 4 · 2013: 13 · 2012: 10
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG 17242, AG23292, R01AG020438, R01AG024391, R03AG023292, AG 20438, P01AG017242)
- National Institute of Environmental Health Sciences (ES 11044, U01ES011044)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- longevity, aging, longevity genes, oxidative stress resistance, metabolism, cardiovascular disease genes, model organisms, case-control study, aging phenotypes
- MeSH terms
- Aging, Animals, Cardiovascular Diseases, Biological Evolution, Humans, Insulin, Longevity, Phenotype, Genetic Variation, Signal Transduction, Case-Control Studies, Oxidative Stress
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