Cited by 142Genetics, Aging, and Longevity in Model OrganismsGenetic Associations and EpidemiologyGenetics and Physical Performance

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Genetics of Longevity and Aging

Vijg, Jan, Suh, Yousin·2005·Annual Review of Medicine

DOI 10.1146/annurev.med.56.082103.104617

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Abstract

Longevity, i.e., the property of being long-lived, has its natural limitation in the aging process. Longevity has a strong genetic component, as has become apparent from studies with a variety of organisms, from yeast to humans. Genetic screening efforts with invertebrates have unraveled multiple genetic pathways that suggest longevity is promoted through the manipulation of metabolism and the resistance to oxidative stress. To some extent, these same mechanisms appear to act in mammals also, despite considerable divergence during evolution. Thus far, evidence from population-based studies with humans suggests the importance of genes involved in cardiovascular disease as important determinants of longevity. The challenge is to test if the candidate longevity genes that have emerged from studies with model organisms exhibit genetic variation for life span in human populations. Future investigations are likely to involve large-scale case-control studies, in which large numbers of genes, corresponding to entire gene functional modules, will be assessed for all possible sequence variation and associated with detailed phenotypic information on each individual over extended periods of time. This should eventually unravel the genetic factors that contribute to each particular aging phenotype.

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Authors: Vijg, J., & Suh, Y.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
ORCID: Vijg, Jan
Suh, Yousin
Venue: Annual Review of Medicine
Publisher: Annual Reviews
Published: 2005-02-01
Volume: 56
Issue: 1
Pages: 193-212
ISSN: 0066-4219 (ISSN-L)
1545-326X
DOI: 10.1146/annurev.med.56.082103.104617
OpenAlex: W2148208805
Cited by: 142
References: 94
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 14 · 2015: 6 · 2014: 4 · 2013: 13 · 2012: 10
FWCI: 0.92
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG 17242, AG23292, R01AG020438, R01AG024391, R03AG023292, AG 20438, P01AG017242)
National Institute of Environmental Health Sciences (ES 11044, U01ES011044)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
Keywords: longevity, aging, longevity genes, oxidative stress resistance, metabolism, cardiovascular disease genes, model organisms, case-control study, aging phenotypes
MeSH terms: Aging, Animals, Cardiovascular Diseases, Biological Evolution, Humans, Insulin, Longevity, Phenotype, Genetic Variation, Signal Transduction, Case-Control Studies, Oxidative Stress

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