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Pharmacogenomics and Individualized Drug Therapy
Abstract
Pharmacogenetics deals with inherited differences in the response to drugs. The best-recognized examples are genetic polymorphisms of drug-metabolizing enzymes, which affect about 30% of all drugs. Loss of function of thiopurine S-methyltransferase (TPMT) results in severe and life-threatening hematopoietic toxicity if patients receive standard doses of mercaptopurine and azathioprine. Gene duplication of cytochrome P4502D6 (CYP2D6), which metabolizes many antidepressants, has been identified as a mechanism of poor response in the treatment of depression. There is also a growing list of genetic polymorphisms in drug targets that have been shown to influence drug response. A major limitation that has heretofore moderated the use of pharmacogenetic testing in the clinical setting is the lack of prospective clinical trials demonstrating that such testing can improve the benefit/risk ratio of drug therapy.
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Metadata
- Authors
- Eichelbaum, M., Ingelman-Sundberg, M., & Evans, W. E.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2006-02-01
- Volume
- 57
- Issue
- 1
- Pages
- 119-137
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2131131247
- Cited by
- 720
- References
- 0
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- closed
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