Error catastrophe and antiviral strategy
Open accessAbstract
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Selection in quasi-species systems acts on the entire quasi-species, not on individual mutants.
“Selection in these systems thus does not act on the level of individual mutants, but rather on the entire quasi-species [8–10].”
From Towards open-ended evolution in self-replicating molecular systems (2017) · cites this paper as [10]
The paper describes the whole mutant distribution as behaving ‘quasi’ as a single species, supporting the quasispecies-level part of the claim. But in its discussion of the error threshold, it says natural selection rates each mutant’s contribution to quasispecies reproduction and that selectivity differs among mutant classes. The claim’s exclusion of selection at the mutant level is therefore not supported. Page numbers are unavailable in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIncreasing the mutation rate to precipitate an error catastrophe appears to be a practical anti-retroviral strategy.
“Indeed, increasing the mutation rate to precipitate an error catastrophe appears to be a practical anti-retroviral strategy (14–16).”
From The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA (2011) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Selforganization of matter and the evolution of biological macromolecules
Eigen, M. (1971) · Die Naturwissenschaften · doi:10.1007/bf00623322 · Cited by 3,788 · see citing works
Self-citationThe Hypercycle: A principle of natural self-organization
Eigen, M., & Schuster, P. M. (1979) · Cited by 1,906 · see citing works
Self-citationA principle of natural self-organization: Part A: Emergence of the hypercycle
Eigen, M., & Schuster, P. (1977) · Naturwissenschaften · doi:10.1007/bf00450633 · Cited by 1,752 · see citing works
Self-citationEigen, M., & Schuster, P. (1979) · doi:10.1007/978-3-642-67247-7 · Cited by 949 · see citing works
Self-citationRNA virus error catastrophe: Direct molecular test by using ribavirin
Crotty, S., Cameron, C. E., & Andino, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111085598 · Cited by 844 · see citing works
The Hypercycle: A principle of natural self-organization Part B: The abstract hypercycle
Eigen, M., & Schuster, P. (1978) · Naturwissenschaften · doi:10.1007/bf00420631 · Cited by 702 · see citing works
Self-citationHamming, R. W. (1980) · Cited by 693 · see citing works
Eigen, M., McCaskill, J., & Schuster, P. (1988) · The Journal of Physical Chemistry · doi:10.1021/j100335a010 · Cited by 670 · see citing works
Self-citationOrigin and Evolution of Viruses
Holland, J. J., & Domingo, E. (1998) · Virus Genes · doi:10.1023/a:1007989407305 · Cited by 524 · see citing works
Lethal mutagenesis of HIV with mutagenic nucleoside analogs
Loeb, L. A., Essigmann, J. M., Kazazi, F., Zhang, J., Rose, K. D., & Mullins, J. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1492 · Cited by 357 · see citing works
Stationary mutant distributions and evolutionary optimization
Schuster, P., & Swetina, J. (1988) · Bulletin of Mathematical Biology · doi:10.1016/s0092-8240(88)80059-4 · Cited by 202 · see citing works
Viruses at the Edge of Adaptation
Domingo, E. (2000) · Virology · doi:10.1006/viro.2000.0320 · Cited by 174 · see citing works
Tarazona, P. (1992) · Physical Review A · doi:10.1103/physreva.45.6038 · Cited by 169 · see citing works
Grande-Pérez, A., Sierra, S., Castro, M. G., Domingo, E., & Lowenstein, P. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182426999 · Cited by 143 · see citing works
Eigen, M., Biebricher, C. Κ., Gebinoga, M., & Gardiner, W. C. (1991) · Biochemistry · doi:10.1021/bi00110a001 · Cited by 120 · see citing works
Self-citationPhysical Approaches to Biological Evolution
Volkenstein, M. V. (1994) · Springer eBooks · doi:10.1007/978-3-642-78788-1 · Cited by 80 · see citing works
Perspective - Lethal Mutagenesis of HIV by Mutagenic Ribonucleoside Analogs
Loeb, L. A., & Mullins, J. I. (2000) · AIDS Research and Human Retroviruses · doi:10.1089/088922200309539 · Cited by 70 · see citing works
How old is the immunodeficiency virus?
Eigen, M., & Nieselt-Struwe, K. (1990) · AIDS · doi:10.1097/00002030-199001001-00014 · Cited by 46 · see citing works
Self-citationThe Immune System in Vertical HIV Infection: The Immune Response and Disease Progression
Paul, M. E. (1997) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1997.13.1 · Cited by 24 · see citing works
The fifth Paul Ehrlich lecture virus strains as models of molecular evolution
Eigen, M. (1993) · Medicinal Research Reviews · doi:10.1002/med.2610130402 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 16
- [1]Eigen M. (1971) Naturwissenschaften 58, 465-523. [DOI] [PubMed] [Google Scholar]
- [2]Crotty S., Cameron, C. E. & Audino, R. (2001) Proc. Natl. Acad. Sci. USA 98, 6895-6900. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [3]Loeb L. A., Essigman, J. M., Kazazi, F., Zhang, J., Rose, K. D. & Mullins, J. I. (1999) Proc. Natl. Acad. Sci. USA 96, 1492-1497. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [4]Loeb L. A. & Mullins, J. I. (2000) AIDS Res. Hum. Retroviruses 13, 1-3. [DOI] [PubMed] [Google Scholar]
- [5]Domingo E. (2000) Virology 270, 251-253. [DOI] [PubMed] [Google Scholar]
- [6]Holland J. J. & Domingo, E. (1998) Virus Genes 16, 13-21. [DOI] [PubMed] [Google Scholar]
- [7]Eigen M. (1993) Med. Res. Rev. 4, 385-398. [DOI] [PubMed] [Google Scholar]
- [8]Grande-Pérez A., Sierra, S., Castro, M. G., Domingo, E. & Lowenstein, P. R. (2002) Proc. Natl. Acad. Sci. USA 99, 12938-12943. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [9]Kimura M. & Ohta, T., (1971) Population Genetics (Princeton Univ. Press, Princeton, NJ).
- [11]Eigen M., McCaskill, J. & Schuster, P. (1988) J. Phys. Chem. 92, 6881-6891. [Google Scholar]
- [12]Eigen M., McCaskill, J. & Schuster, P. (1989) Adv. Chem. Phys. 75, 149-263. [Google Scholar]
- [13]Schuster P. & Swetina, J. (1988) Bull. Math. Biol. 50, 635-650. [DOI] [PubMed] [Google Scholar]
- [14]Tarazona P. (1992) Phys. Rev. A 45, 6038-6050. [DOI] [PubMed] [Google Scholar]
- [15]Eigen M. & Nieselt-Struwe, K. (1990) AIDS 4,(Suppl. 1), 585-593. [PubMed] [Google Scholar]
- [16]Eigen M., Biebricher, C. K., Gebinoga, M. & Gardiner, W. C. (1991) Biochemistry 30, 11005-11018. [DOI] [PubMed] [Google Scholar]
- [17]Gebinoga M., (1991) Ph.D. thesis (Technical University of Braunschweig, Braunschweig, Germany).
Cited by
Sorted by citations
Domingo, E., Sheldon, J., & Perales, C. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05023-11 · Cited by 1,009 · see citing works
Quasispecies Theory and the Behavior of RNA Viruses
Lauring, A. S., & Andino, R. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001005 · Cited by 840 · see citing works
de Miranda, J. R., & Genersch, E. (2009) · Journal of Invertebrate Pathology · doi:10.1016/j.jip.2009.06.012 · Cited by 555 · see citing works
Colloquium : Criticality and dynamical scaling in living systems
Muñoz, M. A. (2018) · Reviews of Modern Physics · doi:10.1103/revmodphys.90.031001 · Cited by 546 · see citing works
Cancer as a robust system: implications for anticancer therapy
Kitano, H. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1300 · Cited by 456 · see citing works
Dynamics of HIV-1 recombination in its natural target cells
Levy, D. N., Aldrovandi, G. M., Kutsch, O., & Shaw, G. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306764101 · Cited by 437 · see citing works
Cancer chromosomal instability: therapeutic and diagnostic challenges
McGranahan, N., Burrell, R. A., Endesfelder, D., Novelli, M. R., & Swanton, C. (2012) · EMBO Reports · doi:10.1038/embor.2012.61 · Cited by 377 · see citing works
The role of mutational robustness in RNA virus evolution
Lauring, A. S., Frydman, J., & Andino, R. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3003 · Cited by 354 · see citing works
Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer
Birkbak, N. J., Eklund, A. C., Li, Q., McClelland, S. E., Endesfelder, D., Tan, P. B. O., Tan, I. B., Richardson, A. L., Szállási, Z., & Swanton, C. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3667 · Cited by 339 · see citing works
Domingo, E., & Perales, C. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008271 · Cited by 330 · see citing works
Applying evolutionary biology to address global challenges
Carroll, S. P., Jørgensen, P. S., Kinnison, M. T., Bergstrom, C. T., Denison, R. F., Gluckman, P. D., Smith, T. B., Strauss, S. Y., & Tabashnik, B. E. (2014) · Science · doi:10.1126/science.1245993 · Cited by 317 · see citing works
Viruses as Quasispecies: Biological Implications
Domingo, E., Martín, V., Perales, C., Grande-Pérez, A., García-Arriaza, J., & Arias, A. (2006) · Current Topics in Microbiology and Immunology · doi:10.1007/3-540-26397-7_3 · Cited by 290 · see citing works
Ogando, N. S., Zevenhoven-Dobbe, J. C., van der Meer, Y., Bredenbeek, P. J., Posthuma, C. C., & Snijder, E. J. (2020) · Journal of Virology · doi:10.1128/jvi.01246-20 · Cited by 276 · see citing works
Diversity in times of adversity: probabilistic strategies in microbial survival games
Wolf, D. M., Vazirani, V. V., & Arkin, A. P. (2005) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2004.11.020 · Cited by 270 · see citing works
Mutation Load: The Fitness of Individuals in Populations Where Deleterious Alleles Are Abundant
Agrawal, A. F., & Whitlock, M. C. (2012) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-110411-160257 · Cited by 253 · see citing works
Antiviral drug resistance as an adaptive process
Irwin, K. K., Renzette, N., Kowalik, T. F., & Jensen, J. D. (2016) · Virus Evolution · doi:10.1093/ve/vew014 · Cited by 237 · see citing works
Genomic Instability in Cancer: Teetering on the Limit of Tolerance
Andor, N., Maley, C. C., & Ji, H. P. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1553 · Cited by 235 · see citing works
Metabolism and antiviral activity of ribavirin
Parker, W. B. (2004) · Virus Research · doi:10.1016/j.virusres.2004.11.006 · Cited by 229 · see citing works
Viral error catastrophe by mutagenic nucleosides
Anderson, J. P., Daifuku, R., & Loeb, L. A. (2004) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123649 · Cited by 221 · see citing works
Biebricher, C. K., & Eigen, M. (2005) · Virus Research · doi:10.1016/j.virusres.2004.11.002 · Cited by 196 · see citing works
Self-citationParamyxovirus mRNA editing, the ‘rule of six’ and error catastrophe: a hypothesis
Kolakofsky, D., Roux, L., Garcin, D., & Ruigrok, R. W. H. (2005) · Journal of General Virology · doi:10.1099/vir.0.80986-0 · Cited by 188 · see citing works
Suppression of viral infectivity through lethal defection
Grande-Pérez, A., Lázaro, E., Lowenstein, P. R., Domingo, E., & Manrubia, S. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408871102 · Cited by 184 · see citing works
Systems protobiology: origin of life in lipid catalytic networks
Lancet, D., Zidovetzki, R., & Markovitch, O. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2018.0159 · Cited by 182 · see citing works
Biebricher, C. Κ., & Eigen, M. (2006) · Springer eBooks · doi:10.1007/3-540-26397-7_1 · Cited by 174 · see citing works
Self-citationAiraksinen, A., Pariente, N., Menéndez‐Arias, L., & Domingo, E. (2003) · Virology · doi:10.1016/s0042-6822(03)00144-2 · Cited by 156 · see citing works
Ogando, N. S., Ferrón, F., Decroly, É., Canard, B., Posthuma, C. C., & Snijder, E. J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01813 · Cited by 155 · see citing works
Vignuzzi, M., Stone, J. K., & Andino, R. (2004) · Virus Research · doi:10.1016/j.virusres.2004.11.007 · Cited by 151 · see citing works
Favipiravir elicits antiviral mutagenesis during virus replication in vivo
Arias, A., Thorne, L., & Goodfellow, I. (2014) · eLife · doi:10.7554/elife.03679 · Cited by 150 · see citing works
Pacing a small cage: mutation and RNA viruses
Belshaw, R. D., Gardner, A., Rambaut, A., & Pybus, O. G. (2008) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2007.11.010 · Cited by 150 · see citing works
Sierra, M., Airaksinen, A., González-López, C., Agudo, R., Arias, A., & Domingo, E. (2006) · Journal of Virology · doi:10.1128/jvi.01606-06 · Cited by 144 · see citing works
A planarian nidovirus expands the limits of RNA genome size
Saberi, A., Gulyaeva, A. A., Brubacher, J. L., Newmark, P. A., & Gorbalenya, A. E. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007314 · Cited by 138 · see citing works
Cell entry and export of nucleoside analogues
Pastor‐Anglada, M., Cano‐Soldado, P., Molina‐Arcas, M., Lostao, M. P., Larráyoz, I. M., Martínez‐Picado, J., & Casado, F. J. (2004) · Virus Research · doi:10.1016/j.virusres.2004.11.005 · Cited by 136 · see citing works
Sequential structures provide insights into the fidelity of RNA replication
Ferrer‐Orta, C., Arias, A., Pérez-Luque, R., Escarmı́s, C., Domingo, E., & Verdaguer, N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700518104 · Cited by 134 · see citing works
Dixit, N. M., & Perelson, A. S. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5455-y · Cited by 124 · see citing works
Dynamics of Viral RNA Synthesis during Measles Virus Infection
Plumet, S., Duprex, W. P., & Gerlier, D. (2005) · Journal of Virology · doi:10.1128/jvi.79.11.6900-6908.2005 · Cited by 122 · see citing works
Quasispecies and its impact on viral hepatitis
Domingo, E., & Gomez, J. (2007) · Virus Research · doi:10.1016/j.virusres.2007.02.001 · Cited by 119 · see citing works
Gillick, K., Pollpeter, D., Phalora, P. K., Kim, E., Wolinsky, S. M., & Malim, M. H. (2012) · Journal of Virology · doi:10.1128/jvi.02587-12 · Cited by 108 · see citing works
Insights into Arbovirus Evolution and Adaptation from Experimental Studies
Ciota, A. T., & Kramer, L. D. (2010) · Viruses · doi:10.3390/v2122594 · Cited by 107 · see citing works
Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines
dos Santos, W. G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111272 · Cited by 106 · see citing works
Mutagenesis versus Inhibition in the Efficiency of Extinction of Foot-and-Mouth Disease Virus
Pariente, N., Airaksinen, A., & Domingo, E. (2003) · Journal of Virology · doi:10.1128/jvi.77.12.7131-7138.2003 · Cited by 106 · see citing works
Quasispecies dynamics and RNA virus extinction
Domingo, E., Escarmı́s, C., Lázaro, E., & Manrubia, S. C. (2004) · Virus Research · doi:10.1016/j.virusres.2004.11.003 · Cited by 106 · see citing works
Preextinction Viral RNA Can Interfere with Infectivity
González-López, C., Arias, A., Pariente, N., Gómez‐Mariano, G., & Domingo, E. (2004) · Journal of Virology · doi:10.1128/jvi.78.7.3319-3324.2004 · Cited by 99 · see citing works
High mutation rates, bottlenecks, and robustness of RNA viral quasispecies
Manrubia, S. C., Escarmı́s, C., Domingo, E., & Lázaro, E. (2005) · Gene · doi:10.1016/j.gene.2004.12.033 · Cited by 98 · see citing works
Amoutzias, G. D., Nikolaidis, M., Tryfonopoulou, E., Chlichlia, K., Markoulatos, P., & Oliver, S. G. (2022) · Viruses · doi:10.3390/v14010078 · Cited by 97 · see citing works
5-Azacytidine Can Induce Lethal Mutagenesis in Human Immunodeficiency Virus Type 1
Dapp, M. J., Clouser, C. L., Patterson, S., & Mansky, L. M. (2009) · Journal of Virology · doi:10.1128/jvi.01406-09 · Cited by 96 · see citing works
Agudo, R., Ferrer‐Orta, C., Arias, A., de la Higuera, I., Perales, C., Pérez-Luque, R., Verdaguer, N., & Domingo, E. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001072 · Cited by 95 · see citing works
Complete genetic linkage can subvert natural selection
Gerrish, P. J., Colato, A., Perelson, A. S., & Sniegowski, P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607280104 · Cited by 92 · see citing works
Efficiency of carcinogenesis with and without a mutator mutation
Beckman, R. A., & Loeb, L. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606271103 · Cited by 91 · see citing works
The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA
Leu, K., Obermayer, B., Rajamani, S., Gerland, U., & Chen, I. A. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr525 · Cited by 85 · see citing works
Hofmann, W. P., Polta, A., Herrmann, E. M., Mihm, U., Kronenberger, B., Sonntag, T., Lohmann, V., Schönberger, B., Zeuzem, S., & Sarrazin, C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.12.005 · Cited by 83 · see citing works
Optimization of DNA polymerase mutation rates during bacterial evolution
Loh, E., Salk, J. J., & Loeb, L. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912451107 · Cited by 81 · see citing works
Quasispecies as a matter of fact: Viruses and beyond
Ojosnegros, S., Perales, C., Más, A., & Domingo, E. (2011) · Virus Research · doi:10.1016/j.virusres.2011.09.018 · Cited by 80 · see citing works
Pillai, S. K., Wong, J. K., & Barbour, J. D. (2008) · Retrovirology · doi:10.1186/1742-4690-5-26 · Cited by 77 · see citing works
Caporale, L. H. (2003) · Annual Review of Microbiology · doi:10.1146/annurev.micro.57.030502.090855 · Cited by 77 · see citing works
Mutation of HIV-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside KP1461
Mullins, J. I., Heath, L., Hughes, J. P., Kicha, J., Styrchak, S. M., Wong, K. G., Rao, U., Hansen, A. R., Harris, K. S., Laurent, J.-P., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015135 · Cited by 76 · see citing works
Tumor progression: Chance and necessity in Darwinian and Lamarckian somatic (mutationless) evolution
Huang, S. (2012) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2012.05.001 · Cited by 76 · see citing works
Population Bottlenecks in Quasispecies Dynamics
Escarmı́s, C., Lázaro, E., & Manrubia, S. C. (2006) · Springer eBooks · doi:10.1007/3-540-26397-7_5 · Cited by 74 · see citing works
Lethal Mutagenesis: Targeting the Mutator Phenotype in Cancer
Fox, E., & Loeb, L. A. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.10.005 · Cited by 74 · see citing works
Risk factors for the evolutionary emergence of pathogens
Alexander, H. K., & Day, T. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0123 · Cited by 74 · see citing works
Towards open-ended evolution in self-replicating molecular systems
Duim, H., & Otto, S. (2017) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.13.118 · Cited by 72 · see citing works
Historical Perspective on the Discovery of the Quasispecies Concept
Domingo, E., García‐Crespo, C., & Perales, C. (2021) · Annual Review of Virology · doi:10.1146/annurev-virology-091919-105900 · Cited by 71 · see citing works
Extinction of Hepatitis C Virus by Ribavirin in Hepatoma Cells Involves Lethal Mutagenesis
Ortega‐Prieto, A. M., Sheldon, J., Grande-Pérez, A., Tejero, H., Gregori, J., Quer, J., Esteban, J. I., Domingo, E., & Perales, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071039 · Cited by 71 · see citing works
Potential Benefits of Sequential Inhibitor-Mutagen Treatments of RNA Virus Infections
Perales, C., Agudo, R., Tejero, H., Manrubia, S. C., & Domingo, E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000658 · Cited by 71 · see citing works
Quasispecies and the development of new antiviral strategies
Domingo, E. (2003) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8012-1_4 · Cited by 70 · see citing works
Domingo, E., & Perales, C. (2018) · European Biophysics Journal · doi:10.1007/s00249-018-1282-6 · Cited by 68 · see citing works
Quasispecies theory for multiple-peak fitness landscapes
Saakian, D. B., Muñoz, E., Hu, C., & Deem, M. W. (2006) · Physical Review E · doi:10.1103/physreve.73.041913 · Cited by 68 · see citing works
Examining The Theory of Error Catastrophe
Summers, J. W., & Litwin, S. (2005) · Journal of Virology · doi:10.1128/jvi.80.1.20-26.2006 · Cited by 68 · see citing works
Grande-Pérez, A., Gómez‐Mariano, G., Lowenstein, P. R., & Domingo, E. (2005) · Journal of Virology · doi:10.1128/jvi.79.16.10451-10459.2005 · Cited by 66 · see citing works
Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes
Fernández‐Sanlés, A., Ríos‐Marco, P., Romero‐López, C., & Berzal‐Herranz, A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00546 · Cited by 66 · see citing works
Therapeutically Targeting Rna Viruses Via Lethal Mutagenesis
Graci, J. D., & Cameron, C. E. (2008) · Future Virology · doi:10.2217/17460794.3.6.553 · Cited by 65 · see citing works
Smith, R. A., Loeb, L. A., & Preston, B. D. (2005) · Virus Research · doi:10.1016/j.virusres.2004.11.011 · Cited by 62 · see citing works
Pathways to extinction: beyond the error threshold
Manrubia, S. C., Domingo, E., & Lázaro, E. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0076 · Cited by 62 · see citing works
Okada, A., & Iwatani, Y. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02027 · Cited by 59 · see citing works
Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity
Hassine, I. H., M’hadheb-Gharbi, M. B., & Menéndez‐Arias, L. (2022) · Viruses · doi:10.3390/v14040841 · Cited by 57 · see citing works
Phase transitions in unstable cancer cell populations
Solé, R. V. (2003) · The European Physical Journal B · doi:10.1140/epjb/e2003-00262-8 · Cited by 57 · see citing works
Action of mutagenic agents and antiviral inhibitors on foot-and-mouth disease virus
Pariente, N., Sierra, S., & Airaksinen, A. (2004) · Virus Research · doi:10.1016/j.virusres.2004.11.008 · Cited by 57 · see citing works
Briones, C., Domingo, E., & Molina-Parı́s, C. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00661-2 · Cited by 55 · see citing works
Coxsackieviruses and Quasispecies Theory: Evolution of Enteroviruses
Domingo, E., Martı́n, V., Perales, C., & Escarmı́s, C. (2008) · Springer eBooks · doi:10.1007/978-3-540-75546-3_1 · Cited by 54 · see citing works
Domingo, E. (2007) · Wiley eBooks · doi:10.1002/9780470015902.a0000436.pub2 · Cited by 54 · see citing works
The impact of quasispecies dynamics on the use of therapeutics
Perales, C., Iranzo, J., Manrubia, S. C., & Domingo, E. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.08.010 · Cited by 50 · see citing works
Fitness Trade-Offs Determine the Role of the Molecular Chaperonin GroEL in Buffering Mutations
Sabater‐Muñoz, B., Prats-Escriche, M., Montagud‐Martínez, R., López‐Cerdán, A., Toft, C., Aguilar-Rodríguez, J., Wagner, A., & Fares, M. A. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv144 · Cited by 50 · see citing works
Li, D., Fedeles, B. I., Singh, V., Peng, C. S., Silvestre, K. J., Simi, A. K., Simpson, J. H., Tokmakoff, A., & Essigmann, J. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405635111 · Cited by 47 · see citing works
Foot-and-Mouth Disease Virus Evolution: Exploring Pathways Towards Virus Extinction
Domingo, E., Pariente, N., Airaksinen, A., González-López, C., Sierra, S., Herrera, M., Grande-Pérez, A., Lowenstein, P. R., Manrubia, S. C., Lázaro, E., et al. (2005) · Current topics in microbiology and immunology · doi:10.1007/3-540-27109-0_7 · Cited by 47 · see citing works
Exploring the Fitness Landscape of an RNA Virus by Using a Universal Barcode Microarray
Lauring, A. S., & Andino, R. (2011) · Journal of Virology · doi:10.1128/jvi.02217-10 · Cited by 46 · see citing works
The Increasing Impact of Lethal Mutagenesis of Viruses
Perales, C., Gallego, I., de Ávila, A. I., Soria, M. E., Gregori, J., Quer, J., & Domingo, E. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0457 · Cited by 45 · see citing works
Invariant aphthovirus consensus nucleotide sequence in the transition to error catastrophe
González-López, C., Gómez‐Mariano, G., Escarmı́s, C., & Domingo, E. (2005) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2005.05.001 · Cited by 45 · see citing works
Bifurcations and phase transitions in spatially extended two-member hypercycles
Josep Sardanyés, A., & Solé, R. V. (2006) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2006.07.014 · Cited by 44 · see citing works
The Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting Strategies
Prindle, M. J., Fox, E., & Loeb, L. A. (2010) · Current Drug Targets · doi:10.2174/1389450111007011296 · Cited by 43 · see citing works
Adapting Clinical Paradigms to the Challenges of Cancer Clonal Evolution
Murugaesu, N., Chew, S. K., & Swanton, C. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.02.026 · Cited by 42 · see citing works
RNA Virus Fidelity Mutants: A Useful Tool for Evolutionary Biology or a Complex Challenge?
Kautz, T. F., & Forrester, N. L. (2018) · Viruses · doi:10.3390/v10110600 · Cited by 42 · see citing works
Tàpia, N., Fernández, G., Parera, M., Gómez‐Mariano, G., Clotet, B., Quiñones‐Mateu, M. E., Domingo, E., & Martı́nez, M. Á. (2005) · Virology · doi:10.1016/j.virol.2005.05.008 · Cited by 42 · see citing works
Agudo, R., Arias, A., Pariente, N., Perales, C., Escarmı́s, C., Jorge, A., Marina, A., & Domingo, E. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.07.033 · Cited by 42 · see citing works
Arias, A., Agudo, R., Ferrer‐Orta, C., Pérez-Luque, R., Airaksinen, A., Brocchi, E., Domingo, E., Verdaguer, N., & Escarmı́s, C. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.09.022 · Cited by 42 · see citing works
Arenavirus Quasispecies and Their Biological Implications
Grande-Pérez, A., Martı́n, V., Moreno, H., & de la Torre, J. C. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_468 · Cited by 43 · see citing works
Epistemic, Evolutionary, and Physical Conditions for Biological Information
Pattee, H. H. (2012) · Biosemiotics · doi:10.1007/s12304-012-9150-8 · Cited by 40 · see citing works
Structure–Activity Relationships and Design of Viral Mutagens and Application to Lethal Mutagenesis
Bonnac, L. F., Mansky, L. M., & Patterson, S. E. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400653j · Cited by 39 · see citing works
Experimental evolution of UV resistance in a phage
Tom, E. F., Molineux, I. J., Paff, M. L., & Bull, J. J. (2018) · PeerJ · doi:10.7717/peerj.5190 · Cited by 39 · see citing works
Fidelity of Ribonucleotide Incorporation by the SARS-CoV-2 Replication Complex
Yin, X., Popa, H., Stapon, A., Bouda, E., & García–Díaz, M. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.167973 · Cited by 40 · see citing works
Domingo, E., Escarmı́s, C., Menéndez‐Arias, L., Perales, C., Herrera, M., Novella, I. S., & Holland, J. J. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374153-0.00004-7 · Cited by 39 · see citing works
Transitions in Understanding of RNA Viruses: A Historical Perspective
Holland, J. J. (2006) · Springer eBooks · doi:10.1007/3-540-26397-7_14 · Cited by 39 · see citing works
- Authors
- Eigen, M.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Eigen, Manfred
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-10-07
- Volume
- 99
- Issue
- 21
- Pages
- 13374-13376
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC129678
- OpenAlex
- W1981105411
- Cited by
- 339
- References
- 19
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 10 · 2019: 15 · 2018: 12 · 2017: 11 · 2016: 12 · 2015: 20 · 2014: 19 · 2013: 14 · 2012: 25
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mathematical and Theoretical Epidemiology and Ecology Models
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- error catastrophe, antiviral strategies, viral replication, error threshold, viral quasispecies
- MeSH terms
- Antiviral Agents, DNA Replication, Models, Biological, Mutation, Virus Replication, Viruses, Virus Physiological Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
