Error catastrophe and antiviral strategy
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Selection in quasi-species systems acts on the entire quasi-species, not on individual mutants.
“Selection in these systems thus does not act on the level of individual mutants, but rather on the entire quasi-species [8–10].”
From Towards open-ended evolution in self-replicating molecular systems (2017) · cites this paper as [10]
The paper describes the whole mutant distribution as behaving ‘quasi’ as a single species, supporting the quasispecies-level part of the claim. But in its discussion of the error threshold, it says natural selection rates each mutant’s contribution to quasispecies reproduction and that selectivity differs among mutant classes. The claim’s exclusion of selection at the mutant level is therefore not supported. Page numbers are unavailable in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIncreasing the mutation rate to precipitate an error catastrophe appears to be a practical anti-retroviral strategy.
“Indeed, increasing the mutation rate to precipitate an error catastrophe appears to be a practical anti-retroviral strategy (14–16).”
From The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA (2011) · cites this paper as [16]
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Domingo, E. (2007) · Wiley eBooks · doi:10.1002/9780470015902.a0000436.pub2 · Cited by 54 · see citing works
The impact of quasispecies dynamics on the use of therapeutics
Perales, C., Iranzo, J., Manrubia, S. C., & Domingo, E. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.08.010 · Cited by 50 · see citing works
Fitness Trade-Offs Determine the Role of the Molecular Chaperonin GroEL in Buffering Mutations
Sabater‐Muñoz, B., Prats-Escriche, M., Montagud‐Martínez, R., López‐Cerdán, A., Toft, C., Aguilar-Rodríguez, J., Wagner, A., & Fares, M. A. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv144 · Cited by 49 · see citing works
Li, D., Fedeles, B. I., Singh, V., Peng, C. S., Silvestre, K. J., Simi, A. K., Simpson, J. H., Tokmakoff, A., & Essigmann, J. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405635111 · Cited by 47 · see citing works
Foot-and-Mouth Disease Virus Evolution: Exploring Pathways Towards Virus Extinction
Domingo, E., Pariente, N., Airaksinen, A., González-López, C., Sierra, S., Herrera, M., Grande-Pérez, A., Lowenstein, P. R., Manrubia, S. C., Lázaro, E., et al. (2005) · Current topics in microbiology and immunology · doi:10.1007/3-540-27109-0_7 · Cited by 47 · see citing works
Exploring the Fitness Landscape of an RNA Virus by Using a Universal Barcode Microarray
Lauring, A. S., & Andino, R. (2011) · Journal of Virology · doi:10.1128/jvi.02217-10 · Cited by 46 · see citing works
The Increasing Impact of Lethal Mutagenesis of Viruses
Perales, C., Gallego, I., de Ávila, A. I., Soria, M. E., Gregori, J., Quer, J., & Domingo, E. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0457 · Cited by 45 · see citing works
Invariant aphthovirus consensus nucleotide sequence in the transition to error catastrophe
González-López, C., Gómez‐Mariano, G., Escarmı́s, C., & Domingo, E. (2005) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2005.05.001 · Cited by 45 · see citing works
Bifurcations and phase transitions in spatially extended two-member hypercycles
Josep Sardanyés, A., & Solé, R. V. (2006) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2006.07.014 · Cited by 44 · see citing works
The Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting Strategies
Prindle, M. J., Fox, E., & Loeb, L. A. (2010) · Current Drug Targets · doi:10.2174/1389450111007011296 · Cited by 43 · see citing works
Adapting Clinical Paradigms to the Challenges of Cancer Clonal Evolution
Murugaesu, N., Chew, S. K., & Swanton, C. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.02.026 · Cited by 42 · see citing works
RNA Virus Fidelity Mutants: A Useful Tool for Evolutionary Biology or a Complex Challenge?
Kautz, T. F., & Forrester, N. L. (2018) · Viruses · doi:10.3390/v10110600 · Cited by 42 · see citing works
Tàpia, N., Fernández, G., Parera, M., Gómez‐Mariano, G., Clotet, B., Quiñones‐Mateu, M. E., Domingo, E., & Martı́nez, M. Á. (2005) · Virology · doi:10.1016/j.virol.2005.05.008 · Cited by 42 · see citing works
Agudo, R., Arias, A., Pariente, N., Perales, C., Escarmı́s, C., Jorge, A., Marina, A., & Domingo, E. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.07.033 · Cited by 42 · see citing works
Arias, A., Agudo, R., Ferrer‐Orta, C., Pérez-Luque, R., Airaksinen, A., Brocchi, E., Domingo, E., Verdaguer, N., & Escarmı́s, C. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.09.022 · Cited by 42 · see citing works
Arenavirus Quasispecies and Their Biological Implications
Grande-Pérez, A., Martı́n, V., Moreno, H., & de la Torre, J. C. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_468 · Cited by 41 · see citing works
Epistemic, Evolutionary, and Physical Conditions for Biological Information
Pattee, H. H. (2012) · Biosemiotics · doi:10.1007/s12304-012-9150-8 · Cited by 40 · see citing works
Structure–Activity Relationships and Design of Viral Mutagens and Application to Lethal Mutagenesis
Bonnac, L. F., Mansky, L. M., & Patterson, S. E. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400653j · Cited by 39 · see citing works
Experimental evolution of UV resistance in a phage
Tom, E. F., Molineux, I. J., Paff, M. L., & Bull, J. J. (2018) · PeerJ · doi:10.7717/peerj.5190 · Cited by 39 · see citing works
Fidelity of Ribonucleotide Incorporation by the SARS-CoV-2 Replication Complex
Yin, X., Popa, H., Stapon, A., Bouda, E., & García–Díaz, M. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.167973 · Cited by 39 · see citing works
Domingo, E., Escarmı́s, C., Menéndez‐Arias, L., Perales, C., Herrera, M., Novella, I. S., & Holland, J. J. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374153-0.00004-7 · Cited by 39 · see citing works
Transitions in Understanding of RNA Viruses: A Historical Perspective
Holland, J. J. (2006) · Springer eBooks · doi:10.1007/3-540-26397-7_14 · Cited by 39 · see citing works
- Authors
- Eigen, M.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Eigen, Manfred
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-10-07
- Volume
- 99
- Issue
- 21
- Pages
- 13374-13376
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC129678
- OpenAlex
- W1981105411
- Cited by
- 339
- References
- 19
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 10 · 2019: 15 · 2018: 12 · 2017: 11 · 2016: 12 · 2015: 20 · 2014: 19 · 2013: 14 · 2012: 25
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mathematical and Theoretical Epidemiology and Ecology Models
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- error catastrophe, antiviral strategies, viral replication, error threshold, viral quasispecies
- MeSH terms
- Antiviral Agents, DNA Replication, Models, Biological, Mutation, Virus Replication, Viruses, Virus Physiological Phenomena
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