Cited by 984Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsMultiple Sclerosis Research Studies

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MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

González-Scarano, F., Baltuch, Gordon·1999·Annual Review of Neuroscience

DOI 10.1146/annurev.neuro.22.1.219

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Abstract

▪ Abstract Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediating cellular degeneration as well as protecting the CNS. In entities like human immunodeficiency virus (HIV) infection of the nervous system, microglia are also critical to viral persistence. In this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: HIV, multiple sclerosis, and Alzheimer's disease.

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Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
Ho, D. D., Neumann, A. U., Perelson, A. S., Chen, W., Leonard, J. M., & Markowitz, M. H. (1995) · Nature · doi:10.1038/373123a0 · Cited by 4,261
HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
Feng, Y. Y., Broder, C. C., Kennedy, P. E., & Berger, E. A. (1996) · Science · doi:10.1126/science.272.5263.872 · Cited by 4,169
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
Dragic, T., Litwin, V., Allaway, G. P., Martin, S. R., Huang, Y., Nagashima, K. A., Cayanan, C. S., Maddon, P. J., Koup, R. A., Moore, J. P., et al. (1996) · Nature · doi:10.1038/381667a0 · Cited by 3,173
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,531
A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors
Doranz, B. J., Rucker, J. B., Yi, Y., Smyth, R. J., Samson, M., Peiper, S. C., Parmentier, M., Collman, R. G., & Doms, R. W. (1996) · Cell · doi:10.1016/s0092-8674(00)81314-8 · Cited by 1,833
Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
McGeer, P. L., Schulzer, M., & McGeer, E. G. (1996) · Neurology · doi:10.1212/wnl.47.2.425 · Cited by 1,367
Activation of microglial cells by β-amyloid protein and interferon-γ
Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314
Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients.
Wiley, C. A., Schrier, R. D., Nelson, J. A., Lampert, P. W., & Oldstone, M. B. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.18.7089 · Cited by 1,242
Cytotoxicity of microglia
Banati, R. B., Gehrmann, J., Schubert, P., & Kreutzberg, G. W. (1993) · Glia · doi:10.1002/glia.440070117 · Cited by 1,032

Show all 129 references

Research works printed but not linked: 14

del Rio Hortega P. 1932.Microglia.InCytology and Cellular Pathology of the Nervous System, ed. W Penfield, pp. 482–534. New York: Hoeber
10.1101/SQB.1996.061.01.057 · DOI
Hickey WF, Williams KC. 1998.Mononuclear phagocyte heterogeneity and the blood brain barrier: a model for HIV-1 neuropathogenesis.InThe Neurology of AIDS, ed. HE Gendelman, SA Lipton, L Epstein, S Swindells, pp. 61–72. New York: Chapman & Hall
Iqbal K, Grundke-Iqbal I. 1994.Neurofibrillary tangles.InNeurodegenerative Diseases, ed. DB Calne, pp. 71–81. Philadelphia: Saunders
Lane JH, 1997, J. Neurovirol., 6, 423
Lavi E, 1997, Am. J. Pathol., 151, 1035
Masliah E, 1992, Lab. Invest., 66, 285
McArthur JC, Selnes OA, Glass JD, Hoover DR, Bacellar H. 1994. InHIV,AIDS and the Brain, ed. RW Price, SW Perry, pp. 251–72. New York: Raven
Nuovo GJ, 1994, Am. J. Pathol., 144, 659
Prineas JW. 1996.Pathology of multiple sclerosis.InHandbook of Multiple Sclerosis, ed. SE Cook, pp. 223–55. Monticello, NY: Dekker
Rottman JB, 1997, Am. J. Pathol., 151, 1341
Waksman BH. 1959.Evidence favouring delayed sensitization as a mechanism underlying EAE.InAllergic Encephalitis, ed. M Kies, EC Alvord, pp. 419–43. Springfield, IL: Thomas
Westmoreland SV, 1998, Am. J. Pathol., 152, 659
Wisniewski T, 1994, Am. J. Pathol., 145, 1030

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Muessel, M. J., Klein, R. M., Wilson, A. M., & Berman, N. E. J. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00158-4 · Cited by 63
Pain in experimental autoimmune encephalitis: a comparative study between different mouse models
Lu, J., Kurejová, M., Wirotanseng, L. N., Linker, R. A., Kuner, R., & Tappe‐Theodor, A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-233 · Cited by 63
Rosuvastatin enhances anti-inflammatory and inhibits pro-inflammatory functions in cultured microglial cells
Kata, D., Földesi, I., Fehér, L. Z., Hackler, L., Puskás, L. G., & Gulya, K. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.053 · Cited by 64
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Yan, E. B., Unthank, J. K., Castillo-Meléndez, M., Miller, S., Langford, S. J., & Walker, D. W. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00617.2004 · Cited by 63
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Yoon, H.-M., Jang, K.-J., Han, M. S., Jeong, J.-W., Kim, G., Lee, J., & Choi, Y. H. (2013) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2013.895 · Cited by 62
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Passos, G. F., Figueiredo, C. P., Prediger, R. D., Pandolfo, P., Duarte, F. S., Medeiros, R., & Calixto, J. Β. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081113 · Cited by 65
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Girolamo, F., Coppola, C., & Ribatti, D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.017 · Cited by 61
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Hamilton, J. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0103037 · Cited by 59
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Fox, H. S., Weed, M. R., Huitrón‐Reséndiz, S., Baig, J., Horn, T. F. W., Dailey, P. J., Bischofberger, N., & Henriksen, S. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9102 · Cited by 60
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Jeong, G., Li, B., Lee, D., Kim, K. H., Lee, I. K., Lee, K. R., & Kim, Y. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.09.013 · Cited by 60
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Wu, Y.-P., McMahon, E., Matsuda, J., Suzuki, K., Matsushima, G. K., & Suzuki, K. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.11.1062 · Cited by 59
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Zhang, L., Zhang, Z., Fu, Y., Yang, P., Qin, Z., Chen, Y., & Xu, Y. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.08.013 · Cited by 58
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Silva, A. R., Pinheiro, A. M., de Souza, C. S., Freitas, S. R., Vasconcellos, V., Freire, S. M., Velozo, E. S., Tardy, M., El-Bachá, R. D. S., Costa, M. F. D., et al. (2007) · Cell Biology and Toxicology · doi:10.1007/s10565-007-9017-y · Cited by 57
Growth factors and cytokines/chemokines as surrogate biomarkers in cerebrospinal fluid and blood for diagnosing Alzheimer’s disease and mild cognitive impairment
Olson, L., & Humpel, C. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.011 · Cited by 57
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Authors: González-Scarano, F., & Baltuch, G.
Affiliations: Departments of 1Neurology and Microbiology; and 2Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6146;
University of Pennsylvania (US)
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 1999-03
Volume: 22
Issue: 1
Pages: 219-240
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev.neuro.22.1.219
OpenAlex: W2146901670
Cited by: 984
References: 129
Citations by year: 2026: 2 · 2025: 5 · 2024: 12 · 2023: 20 · 2022: 18 · 2021: 25 · 2020: 15 · 2019: 25 · 2018: 37 · 2017: 37 · 2016: 23 · 2015: 40 · 2014: 32 · 2013: 38 · 2012: 51
FWCI: 4.95
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (NS35743, NS 27405, R01NS035743)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: microglia, neuroinflammation, neurodegeneration, multiple sclerosis, Alzheimer's disease, central nervous system immunity, viral persistence, neuroprotection
MeSH terms: Alzheimer Disease, Animals, Central Nervous System Diseases, Humans, Inflammation, Multiple Sclerosis, Nerve Degeneration, HIV Infections, Microglia

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MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

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