Cited by 1,163Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorAutism Spectrum Disorder Research

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Schizophrenia as a Disorder of Neurodevelopment

Lewis, David A., Levitt, Pat·2002·Annual Review of Neuroscience

DOI 10.1146/annurev.neuro.25.112701.142754

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Abstract

▪ Abstract A combination of genetic susceptibility and environmental perturbations appear to be necessary for the expression of schizophrenia. In addition, the pathogenesis of the disease is hypothesized to be neurodevelopmental in nature based on reports of an excess of adverse events during the pre- and perinatal periods, the presence of cognitive and behavioral signs during childhood and adolescence, and the lack of evidence of a neurodegenerative process in most individuals with schizophrenia. Recent studies of neurodevelopmental mechanisms strongly suggest that no single gene or factor is responsible for driving a highly complex biological process. Together, these findings suggest that combinatorial genetic and environmental factors, which disturb a normal developmental course early in life, result in molecular and histogenic responses that cumulatively lead to different developmental trajectories and the clinical phenotype recognized as schizophrenia.

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Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,311
Synaptic density in human frontal cortex —Developmental changes and effects of aging
Peter R., H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90349-4 · Cited by 2,645
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
Kuida, K., Zheng, T. S., Na, S., Kuan, C.-Y., Yang, D., Karasuyama, H., RAKIC, P. T., & Flavell, R. A. (1996) · Nature · doi:10.1038/384368a0 · Cited by 1,881
Searching for genetic determinants in the new millennium
Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839
Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?
Feinberg, I. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90038-3 · Cited by 1,395
Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies
Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,389
Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort
JONES, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90569-x · Cited by 1,353

Show all 118 references

Research works printed but not linked: 3

Lane A, Larkin C, Waddington JL, O'Callaghan E. 1996.Dysmorphic features and schizophrenia.InThe Neurodevelopmental Basis of Schizophrenia, ed. JL Waddington, PF Buckley, pp. 79–94. Georgetown, TX: Landes
Risch N, 1984, Am. J. Hum. Genet., 36, 1039
Takei N, 1998, Int. Med. J., 5, 13

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Seitz, J., Yogesh Rathi, A., Lyall, A. E., Pasternak, O., del Re, E. C., Niznikiewicz, M. A., Nestor, P. G., Seidman, L. J., Petryshen, T. L., Mesholam‐Gately, R. I., et al. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9666-7 · Cited by 24
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Xie, S., Liu, B., Wang, J., Zhou, Y., Cui, Y. J., Song, M., Chen, Y., Li, P., Lü, L., Lv, L., et al. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.12.024 · Cited by 23
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Wei, T., Guo, Z., Wang, Z., Li, C., Zhu, W., Zheng, Y., Yin, Y., Mi, Y., Xia, X., Hou, H., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220010 · Cited by 24
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Association and expression study of synapsin III and schizophrenia
Chen, Q., Che, R., Wang, X., O’Neill, F. A., Walsh, D., Tang, W., Shi, Y., He, L., Kendler, K. S., & Chen, X. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.09.032 · Cited by 23
Postnatal functional inactivation of the entorhinal cortex or ventral subiculum has different consequences for latent inhibition‐related striatal dopaminergic responses in adult rats
Meyer, F., Peterschmitt, Y., & Louilot, A. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06755.x · Cited by 24
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Elsworth, J. D., Groman, S. M., Jentsch, J. D., Léránth, C., Redmond, D. E., Kim, J. D., Diano, S., & Roth, R. H. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu048 · Cited by 23
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Do, K. Q., Bovet, P., Cabungcal, J.-H., Conus, P., Gysin, R., Lavoie, S., Steullet, P., & Cuénod, M. (2009) · Springer eBooks · doi:10.1007/978-0-387-30410-6_8 · Cited by 22
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Brown, E. C., Taş, C., & Brüne, M. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.183 · Cited by 23
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Yun, Y., Phillips, L., Cotton, S., Yung, A. R., Francey, S. M., Yuen, H. P., & McGorry, P. D. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2005.01604.x · Cited by 23
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Vogt, J., Glumm, R., Schlüter, L., Schmitz, D., Rost, B. R., Streu, N., Rister, B., Bharathi, B. S., Gagiannis, D., Hildebrandt, H., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0868-2 · Cited by 22
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Zugno, A. I., Miranda, I. M., Budni, J., Volpato, A. M., Luca, R. D. D., Deroza, P. F., de Oliveira, M. B., Heylmann, A. S., Silveira, F. D. R., Wessler, P. G., et al. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.059 · Cited by 23
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DeRosa, B. A., Belle, K. C., Thomas, B. J., Cukier, H. N., Pericak‐Vance, M. A., Vance, J. M., & Dykxhoorn, D. M. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.08.007 · Cited by 26
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Yasuda, K., Hayashi, Y., Yoshida, T., Kashiwagi, M., Nakagawa, N., Michikawa, T., Tanaka, M., Ando, R., Huang, A. J. Y., Hosoya, T., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.19 · Cited by 22
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Inducible and conditional transgenic mouse models of schizophrenia
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Authors: Lewis, D. A., & Levitt, P.
Affiliations: University of Pittsburgh (US)
ORCID: Lewis, David A.
Levitt, Pat
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2002-03
Volume: 25
Issue: 1
Pages: 409-432
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev.neuro.25.112701.142754
OpenAlex: W2112572641
Cited by: 1,163
References: 118
Citations by year: 2026: 17 · 2025: 16 · 2024: 23 · 2023: 17 · 2022: 36 · 2021: 25 · 2020: 36 · 2019: 31 · 2018: 42 · 2017: 77 · 2016: 50 · 2015: 60 · 2014: 60 · 2013: 57 · 2012: 82
FWCI: 7.83
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 45156, P50MH045156)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords: schizophrenia, brain development, genetic susceptibility, environmental risk factors, perinatal adversity, developmental trajectories, neurodegeneration, clinical phenotype
MeSH terms: Adolescent, Animals, Brain, Child, Developmental Disabilities, Child, Preschool, Female, Humans, Male, Models, Neurological, Nervous System Malformations, Pregnancy, Prenatal Exposure Delayed Effects, Schizophrenia, Gene Expression Regulation, Developmental, Genetic Predisposition to Disease

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Schizophrenia as a Disorder of Neurodevelopment

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