Cited by 1,163Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorAutism Spectrum Disorder Research

The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.

Schizophrenia as a Disorder of Neurodevelopment

Lewis, David A., Levitt, Pat·2002·Annual Review of Neuroscience

DOI 10.1146/annurev.neuro.25.112701.142754

Open this paper in CoChat — free account

Abstract

▪ Abstract A combination of genetic susceptibility and environmental perturbations appear to be necessary for the expression of schizophrenia. In addition, the pathogenesis of the disease is hypothesized to be neurodevelopmental in nature based on reports of an excess of adverse events during the pre- and perinatal periods, the presence of cognitive and behavioral signs during childhood and adolescence, and the lack of evidence of a neurodegenerative process in most individuals with schizophrenia. Recent studies of neurodevelopmental mechanisms strongly suggest that no single gene or factor is responsible for driving a highly complex biological process. Together, these findings suggest that combinatorial genetic and environmental factors, which disturb a normal developmental course early in life, result in molecular and histogenic responses that cumulatively lead to different developmental trajectories and the clinical phenotype recognized as schizophrenia.

Integrity signals

Registry

Crossref · 10.1146/annurev.neuro.25.112701.142754

Cites

118 of 118 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,311
Synaptic density in human frontal cortex —Developmental changes and effects of aging
Peter R., H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90349-4 · Cited by 2,645
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
Kuida, K., Zheng, T. S., Na, S., Kuan, C.-Y., Yang, D., Karasuyama, H., RAKIC, P. T., & Flavell, R. A. (1996) · Nature · doi:10.1038/384368a0 · Cited by 1,881
Searching for genetic determinants in the new millennium
Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839
Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?
Feinberg, I. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90038-3 · Cited by 1,395
Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies
Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,389
Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort
JONES, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90569-x · Cited by 1,353

Show all 118 references

Research works printed but not linked: 3

Lane A, Larkin C, Waddington JL, O'Callaghan E. 1996.Dysmorphic features and schizophrenia.InThe Neurodevelopmental Basis of Schizophrenia, ed. JL Waddington, PF Buckley, pp. 79–94. Georgetown, TX: Landes
Risch N, 1984, Am. J. Hum. Genet., 36, 1039
Takei N, 1998, Int. Med. J., 5, 13

Sorted by citations

Items 401–500 of 998

Exploring intermediate phenotypes with EEG: Working memory dysfunction in schizophrenia
Haenschel, C., & Linden, D. E. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.045 · Cited by 54
Gsx1 expression defines neurons required for prepulse inhibition
Bergeron, S. A., Carrier, N., Li, G. H., Ahn, S., & Burgess, H. A. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.106 · Cited by 46
Early maternal deprivation induces changes on the expression of 2-AG biosynthesis and degradation enzymes in neonatal rat hippocampus
Suárez, J., Rivera, P., Llorente, R., Romero‐Zerbo, S., Bermúdez‐Silva, F. J., de Fonseca, F. R., & Viveros, M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.06.042 · Cited by 48
An entropy-based approach for testing genetic epistasis underlying complex diseases
Kang, G., Yue, W., Zhang, J., Cui, Y., Zuo, Y., & Zhang, D. (2007) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2007.10.001 · Cited by 48
Prenatal administration of lipopolysaccharide induces sex-dependent changes in glutamic acid decarboxylase and parvalbumin in the adult rat brain
Basta‐Kaim, A., Fijał, K., Ślusarczyk, J., Trojan, E., Głombik, K., Budziszewska, B., Leśkiewicz, M., Regulska, M., Kubera, M., Lasoń, W., et al. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.013 · Cited by 48
Postnatal Phencyclidine (PCP) as a Neurodevelopmental Animal Model of Schizophrenia Pathophysiology and Symptomatology: A Review
Grayson, B., Barnes, S. A., Markou, A., Piercy, C., Podda, G., & Neill, J. C. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_403 · Cited by 51
Increased expression of receptor phosphotyrosine phosphatase-β/ζ is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes
Takahashi, N., Sakurai, T., Bozdagi-Gunal, O., Dorr, N. P., Moy, J., Krug, L., Gama-Sosa, M. A., Elder, G. A., Koch, R. J., Walker, R. H., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.8 · Cited by 49
Neuropathology of schizophrenia
Harrison, P. J. (2005) · Psychiatry · doi:10.1383/psyt.2005.4.10.18 · Cited by 47
Disrupted‐in‐Schizophrenia‐1 (DISC1)
Sawamura, N., & Sawa, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1377.018 · Cited by 48
Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits
Wells, A. C., & Lotfipour, S. (2023) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2023.11628 · Cited by 50
“…typically involve exposure of the neonate, either during gestation or the perinatal period, to adverse environmental insults such as maternal stress, hypoxia, malnutrition, or post-weaning social isolation that alter the brain development and cause behavioral de ﬁ cits into adulthood [100 – 102].”
Background
Development and Application of Brain Region–Specific Organoids for Investigating Psychiatric Disorders
Zhang, Z., Wang, X., Park, S. S., Song, H., & Ming, G. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.12.015 · Cited by 49
Differential Repression by Freud-1/CC2D1A at a Polymorphic Site in the Dopamine-D2 Receptor Gene
Rogaeva, A., Ou, X., Jafar‐Nejad, H., Lemonde, S., & Albert, P. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610038200 · Cited by 45
Work and Unemployment as Stressors
Lennon, M. C., & Limonic, L. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511984945.015 · Cited by 46
Association of NPAS3 exonic variation with schizophrenia
MacIntyre, G., Alford, T., Xiong, L., Rouleau, G. A., Tibbo, P. G., & Cox, D. W. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.04.002 · Cited by 48
Reduced intra-amygdala activity to positively valenced faces in adolescent schizophrenia offspring
Barbour, T. A., Murphy, E. R., Pruitt, P. J., Eickhoff, S. B., Keshavan, M. S., Rajan, U., Zajac‐Benitez, C., & Diwadkar, V. A. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.07.023 · Cited by 50
Early postnatal development of sensory gating
Kisley, M. A., Polk, S. D., Ross, R. G., Levisohn, P. M., & Freedman, R. (2003) · Neuroreport · doi:10.1097/00001756-200304150-00007 · Cited by 46
The Interleukin 3 Gene (IL3) Contributes to Human Brain Volume Variation by Regulating Proliferation and Survival of Neural Progenitors
Luo, X., Li, M., Huang, L., Nho, K. T., Deng, M., Chen, Q., Weinberger, D. R., Vásquez, A. A., Rijpkema, M., Mattay, V. S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050375 · Cited by 46
Dysfunction and Dysconnection in Cortical–Striatal Networks during Sustained Attention: Genetic Risk for Schizophrenia or Bipolar Disorder and its Impact on Brain Network Function
Diwadkar, V. A., Bakshi, N. K., Gupta, G., Pruitt, P. J., White, R. T., & Eickhoff, S. B. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00050 · Cited by 46
Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population
Zhang, Y., Yu, X., Yuan, Y., Ling, Y., Ruan, Y., Si, T., Lu, T., Wu, S., Gong, X., Zhu, Z., et al. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30076 · Cited by 46
Altered Transfer of Momentary Mental States (ATOMS) as the Basic Unit of Psychosis Liability in Interaction with Environment and Emotions
Wigman, J. T. W., Collip, D., Wichers, M., Delespaul, P., Derom, C. A., Thiery, E. W., Vollebergh, W., Lataster, T., Jacobs, N., Myin‐Germeys, I., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054653 · Cited by 45
Infragranular gene expression disturbances in the prefrontal cortex in schizophrenia: Signature of altered neural development?
Arion, D., Horváth, S., Lewis, D. A., & Mirnics, K. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.013 · Cited by 44
Self-citation
Nogo and Nogo receptor: Relevance to schizophrenia?
Willi, R., & Schwab, M. E. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.01.011 · Cited by 44
Transcriptional and Post-Transcriptional Mechanisms of the Development of Neocortical Lamination
Popovitchenko, T., & Rašin, M. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00102 · Cited by 45
Studying and modulating schizophrenia-associated dysfunctions of oligodendrocytes with patient-specific cell systems
Raabe, F. J., Galinski, S., Papiol, S., Falkai, P., Schmitt, A., & Rossner, M. J. (2018) · Schizophrenia · doi:10.1038/s41537-018-0066-4 · Cited by 48
Programming effects of antenatal dexamethasone in the developing mesolimbic pathways
Leão, P., Sousa, J. C., de Oliveira, M. A. R., Silva, R., Almeida, O. F. X., & Sousa, N. (2006) · Synapse · doi:10.1002/syn.20341 · Cited by 45
Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response
de Souza, R. P., Romano‐Silva, M. A., Lieberman, J. A., Meltzer, H. Y., MacNeil, L. T., Culotti, J. G., Kennedy, J. L., & Wong, A. H. C. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.01.002 · Cited by 45
Region-specific alteration of GABAergic markers in the brain of heterozygous reeler mice
Nullmeier, S., Panther, P., Dobrowolny, H., Frotscher, M., Zhao, S., Schwegler, H., & Wolf, R. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07563.x · Cited by 43
Long Non-Coding RNA Expression during Aging in the Human Subependymal Zone
Barry, G., Guennewig, B., Fung, S. J., Kaczorowski, D. C., & Weickert, C. S. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00045 · Cited by 43
Development of Hyperactivity and Anxiety Responses in Dopamine Transporter-Deficient Mice
Carpenter, A. C., Saborido, T. P., & Stanwood, G. D. (2012) · Developmental Neuroscience · doi:10.1159/000336824 · Cited by 46
Dimensions of Premorbid Functioning in Schizophrenia: A Review of Neuromotor, Cognitive, Social, and Behavioral Domains
Schenkel, L. S., & Silverstein, S. M. (2004) · Genetic Social and General Psychology Monographs · doi:10.3200/mono.130.3.241-272 · Cited by 53
DISC1 as a therapeutic target for mental illnesses
Hikida, T., Gamo, N. J., & Sawa, A. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.719879 · Cited by 42
COUP-TFII Expressing Interneurons in Human Fetal Forebrain
Reinchisi, G., Ijichi, K., Glidden, N. C., Jakovčevski, I., & Zečević, N. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr359 · Cited by 45
Biomarkers for Psychiatric Disorders
Turck, C. W. (2009) · Springer eBooks · doi:10.1007/978-0-387-79251-4 · Cited by 42
The future of psychotherapy for mentally ill children and adolescents
March, J. S. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.02034.x · Cited by 43
Antipsychotic Drugs Activate the C. elegans Akt Pathway via the DAF-2 Insulin/IGF-1 Receptor
Weeks, K. R., Dwyer, D. S., & Aamodt, E. J. (2010) · ACS Chemical Neuroscience · doi:10.1021/cn100010p · Cited by 42
Tau accumulation in the nucleus accumbens in tangle-predominant dementia
Kawakami, I., Hasegawa, M., Arai, T., Ikeda, K., Oshima, K., Niizato, K., Aoki, N., Omi, K., Higashi, S., Hosokawa, M., et al. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-40 · Cited by 41
Abnormalities of localized connectivity in schizophrenia patients and their unaffected relatives: a meta-analysis of resting-state functional magnetic resonance imaging studies
Xiao, B., Wang, S., Liu, J., Meng, T., He, Y., & Luo, X. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s126678 · Cited by 41
Sensorimotor gating deficits in “two-hit” models of schizophrenia risk factors
Khan, A., & Powell, S. B. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.10.009 · Cited by 47
Enhanced local processing of dynamic visual information in autism: Evidence from speed discrimination
Chen, Y., Norton, D. J., McBain, R. K., Gold, J., Frazier, J. A., & Coyle, J. T. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.01.007 · Cited by 45
Morphological Abnormalities in Nitric-Oxide-Synthase-Positive Striatal Interneurons of Schizophrenic Patients
Lauer, M., Johannes, S., Fritzen, S., Senitz, D., Riederer, P. F., & Reif, A. (2005) · Neuropsychobiology · doi:10.1159/000087555 · Cited by 42
Differential gene expression in migrating cortical interneurons during mouse forebrain development
Faux, C. H., Rakić, S., Andrews, W. D., Yanagawa, Y., Obata, K., & Parnavelas, J. G. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22271 · Cited by 41
Neural oscillations during non‐rapid eye movement sleep as biomarkers of circuit dysfunction in schizophrenia
Gardner, R. J., Kersanté, F., Jones, M. W., & Bartsch, U. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12533 · Cited by 42
The GSK3B gene confers risk for both major depressive disorder and schizophrenia in the Han Chinese population
Chen, J., Wang, M., Khan, R. A. W., He, K., Wang, Q., Li, Z., Shen, J., Song, Z., Li, W., Wen, Z., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.040 · Cited by 41
Inferring the Dysconnection Syndrome in Schizophrenia: Interpretational Considerations on Methods for the Network Analyses of fMRI Data
Silverstein, B. H., Bressler, S. L., & Diwadkar, V. A. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00132 · Cited by 42
Is there a role for the nuclear receptor PPARγ in neuropsychiatric diseases?
García‐Bueno, B., Perez‐Nievas, B. G., & Leza, J. C. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000970 · Cited by 41
Structural brain abnormalities in early onset first-episode psychosis
Pagsberg, A. K., Baaré, W. F. C., Christensen, A. M. R., Fagerlund, B., Hansen, M.-B., LaBianca, J., Krabbe, K. S., Aarkrog, T., Paulson, O. B., & Hemmingsen, R. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0573-8 · Cited by 41
Association study of an SNP combination pattern in the dopaminergic pathway in paranoid schizophrenia: a novel strategy for complex disorders
Xu, Q., Jia, Y.-B., Zhang, B., Zou, K., Tao, Y.-B., Wang, Y.-P., Qiang, B.-Q., Wu, G.-Y., Shen, Y., Ji, H.-K., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001472 · Cited by 41
Variable prenatal stress results in impairments of sustained attention and inhibitory response control in a 5-choice serial reaction time task in rats
Wilson, C. A., Schade, R., & Terry, A. V. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.040 · Cited by 40
Attention network test (ANT) reveals gender-specific alterations of executive function in schizophrenia
Urbanek, C., Neuhaus, A. H., Opgen‐Rhein, C., Strathmann, S., Wieseke, N., Schaub, R., Hahn, E. W., & Dettling, M. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.04.006 · Cited by 40
Inefficiently increased anterior cingulate modulation of cortical systems during working memory in young offspring of schizophrenia patients
Bakshi, N. K., Pruitt, P. J., Radwan, J., Keshavan, M. S., Rajan, U., Zajac‐Benitez, C., & Diwadkar, V. A. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.01.002 · Cited by 41
Annual Research Review: Impact of advances in genetics in understanding developmental psychopathology
Addington, A. M., & Rapoport, J. L. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02478.x · Cited by 41
Cerebral Cortical Circuitry Formation Requires Functional Glycine Receptors
Morelli, G., Ávila, A., Ravanidis, S., Aourz, N., Neve, R. L., Smolders, I. J., Harvey, R. J., Rigo, J., Nguyen, L., & Brône, B. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw025 · Cited by 38
Neurobiology of Schizophrenia Onset
Woo, T.-U. W. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_243 · Cited by 46
Ontogenetic Expression of Dopamine-Related Transcription Factors and Tyrosine Hydroxylase in Prenatally Stressed Rats
Katunar, M. R., Saez, T. M. M., Brusco, A., & Antonelli, M. C. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9132-z · Cited by 39
Increased d-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study
Habl, G., Zink, M., Petroianu, G. A., Bauer, M., Schneider-Axmann, T., von Wilmsdorff, M., Falkai, P., Henn, F. A., & Schmitt, A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0312-z · Cited by 39
Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilitiesPreprint
Mallard, T. T., Linnér, R. K., Grotzinger, A. D., Sanchez‐Roige, S., Seidlitz, J., Okbay, A., de Vlaming, R., Meddens, S. F. W., Palmer, A. A., Davis, L. K., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/603134 · Cited by 37
Diminished cerebral inhibition in neonates associated with risk factors for schizophrenia: parental psychosis, maternal depression, and nicotine use
Hunter, S. K., Kisley, M. A., McCarthy, L., Freedman, R., & Ross, R. G. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq036 · Cited by 38
A Prospective Longitudinal Investigation of Cortical Thickness and Gyrification in Schizophrenia
Nelson, E. A., Kraguljac, N. V., White, D. M., Jindal, R. D., Shin, A. L., & Lahti, A. C. (2020) · The Canadian Journal of Psychiatry · doi:10.1177/0706743720904598 · Cited by 38
A Handbook for the Study of Mental Health
(2017) · Cambridge University Press eBooks · doi:10.1017/9781316471289 · Cited by 43
Visual scan paths in first-episode schizophrenia and cannabis-induced psychosis
Benson, P. J., Leonards, U., Lothian, R., Clair, D. M. S., & Merlo, M. C. G. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0727 · Cited by 38
Association between myelin basic protein expression and left entorhinal cortex pre-alpha cell layer disorganization in schizophrenia
Parlapani, E., Schmitt, A., Erdmann, A., Bernstein, H., Breunig, B., Gruber, O., Petroianu, G. A., von Wilmsdorff, M., Schneider-Axmann, T., Honer, W. G., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.007 · Cited by 38
Early motor development is abnormal in complexin 1 knockout mice
Glynn, D., Sizemore, R. J., & Morton, A. J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.10.011 · Cited by 39
Reduced cerebrospinal fluid and plasma nerve growth factor in drug-naïve psychotic patients
Kale, A. A., Joshi, S., Pillai, A., Naphade, N. M., Raju, M., Nasrallah, H. A., & Mahadik, S. P. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.07.022 · Cited by 38
An Overview of Sociological Perspectives on the Definitions, Causes, and Responses to Mental Health and Illness
Horwitz, A. V. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511984945.004 · Cited by 40
Gestational Methylazoxymethanol Exposure Leads to NMDAR Dysfunction in Hippocampus During Early Development and Lasting Deficits in Learning
Snyder, M. A., Adelman, A. E., & Gao, W. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.180 · Cited by 40
Cannabinoids and Vanilloids in Schizophrenia: Neurophysiological Evidence and Directions for Basic Research
Ruggiero, R. N., Rossignoli, M. T., Ross, J. B. D., Hallak, J. E. C., Leite, J. P., & Bueno-Júnior, L. S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00399 · Cited by 39
Morphometry and gyrification in bipolar disorder and schizophrenia: A comparative MRI study
Madeira, N. G. G. F., Duarte, J. V., Martins, R., Costa, G. N., Macedo, A., & Castelo-Branco, M. S. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102220 · Cited by 37
Neurodevelopmental involvement in schizophrenia: the olfactory epithelium as an alternative model for research
Cascella, N. G., Takaki, M., Lin, S. Y., & Sawa, A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04628.x · Cited by 37
Support for NRG1 as a Susceptibility Factor for Schizophrenia in a Northern Swedish Isolated Population
Alaerts, M., Ceulemans, S., Forero, D. A., Moens, L., Zutter, S. D., Heyrman, L., Lenaerts, A., Norrback, K., Rijk, P. D., Nilsson, L., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.82 · Cited by 37
The Adolescent Brain: Implications for the Understanding, Pathophysiology, and Treatment of Schizophrenia
Uhlhaas, P. J. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr025 · Cited by 39
Long-term effect of prenatal exposure to malnutrition on risk of schizophrenia in adulthood: Evidence from the Chinese famine of 1959–1961
He, P., Chen, G., Guo, C., Wen, X., Song, X., & Zheng, X. (2018) · European Psychiatry · doi:10.1016/j.eurpsy.2018.01.003 · Cited by 36
Dysregulated Maturation of the Functional Connectome in Antipsychotic-Naïve, First-Episode Patients With Adolescent-Onset Schizophrenia
Li, M., Becker, B., Zheng, J., Zhang, Y., Chen, H., Liao, W., Duan, X., Liu, H., Zhao, J., & Chen, H. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby063 · Cited by 37
Insights on current and novel antipsychotic mechanisms from the MAM model of schizophrenia
Sonnenschein, S. F., & Grace, A. A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.05.009 · Cited by 37
ACC Glu/GABA ratio is decreased in euthymic bipolar disorder I patients: possible in vivo neurometabolite explanation for mood stabilization
Scotti-Muzzi, E., Chile, T., Moreno, R. A., Pastorello, B., Leite, C. D. C., Henning, A., Otaduy, M. C. G., Vallada, H., & Soeiro‐de‐Souza, M. G. (2020) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-020-01096-0 · Cited by 36
Role of neurotransmitters in schizophrenia: a comprehensive study
Bansal, V., & Chatterjee, I. (2021) · Kuwait Journal of Science · doi:10.48129/kjs.v48i2.9264 · Cited by 38
Integrated pathophysiology of schizophrenia, major depression, and bipolar disorder as monoamine axon disorder
Nakamura, S. (2022) · Frontiers in Bioscience-Scholar · doi:10.31083/j.fbs1401004 · Cited by 36
Epigenetics and Transcriptomics to Detect Adverse Drug Effects in Model Systems of Human Development
Balmer, N. V., & Leist, M. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12203 · Cited by 35
A Sensitive Period for GABAergic Interneurons in the Dentate Gyrus in Modulating Sensorimotor Gating
Guo, N., Yoshizaki, K., Kimura, R., Suto, F., Yanagawa, Y., & Osumi, N. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0032-12.2013 · Cited by 36
N-Methyl D-Aspartate Receptor Antagonist Kynurenic Acid Affects Human Cortical Development
Bagasrawala, I., Zečević, N., & Radonjić, N. V. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00435 · Cited by 39
Gene Expression in Patient-Derived Neural Progenitors Implicates WNT5A Signaling in the Etiology of Schizophrenia
Evgrafov, O. V., Armoskus, C., Wrobel, B., Spitsyna, V. N., Souaiaia, T., Herstein, J. S., Walker, C., Nguyen, J. D. K., Camarena, A., Weitz, J., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.01.005 · Cited by 34
Association of VSNL1 with schizophrenia, frontal cortical function, and biological significance for its gene product as a modulator of cAMP levels and neuronal morphology
Braunewell, K. H., Dwary, A. D., Richter, F., Trappe, K., Zhao, C., Giegling, I., Schönrath, K., & Rujescu, D. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.20 · Cited by 36
Structural and Diffusion Tensor Imaging of the Fornix in Childhood- and Adolescent-Onset Schizophrenia
Kendi, M., Kendi, A. T. K., Lehéricy, S., Ducros, M. G., Lim, K. O., Uǧurbil, K., Schulz, S. C., & White, T. J. H. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318172ef36 · Cited by 35
DISC1–kendrin interaction is involved in centrosomal microtubule network formation
Shimizu, S., Matsuzaki, S., Hattori, T., Kumamoto, N., Miyoshi, K., Katayama, T., & Tohyama, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.100 · Cited by 35
The neural correlates of performance in adolescents at risk for schizophrenia: Inefficiently increased cortico-striatal responses measured with fMRI
Diwadkar, V. A., Pruitt, P. J., Zhang, A., Radwan, J., Keshavan, M. S., Murphy, E. R., Rajan, U., & Zajac‐Benitez, C. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.016 · Cited by 35
Cognitive behavioural therapy versus supportive therapy for persistent positive symptoms in psychotic disorders: The POSITIVE Study, a multicenter, prospective, single-blind, randomised controlled clinical trial
Klingberg, S., Wittorf, A., Meisner, C., Wölwer, W., Wiedemann, G., Herrlich, J., Bechdolf, A., Müller, B. W., Sartory, G., Wagner, M., et al. (2010) · Trials · doi:10.1186/1745-6215-11-123 · Cited by 34
The prefrontal cortex as a target for atypical antipsychotics in schizophrenia, lessons of neurodevelopmental animal models
Tendilla‐Beltrán, H., Sanchez-Islas, N. D. C., Marina-Ramos, M., Leza, J. C., & Flores, G. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101967 · Cited by 36
Revisiting visual dysfunctions in schizophrenia from the retina to the cortical cells: A manifestation of defective neurodevelopment
Gagné, A.-M., Hébert, M., & Maziade, M. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.04.007 · Cited by 35
Abnormal neurological signs, visual contrast sensitivity, and the deficit syndrome of schizophrenia
Cimmer, C., Szendi, I., Csifcsák, G., Szekeres, G., Kovács, Z. A., Somogyi, I., Benedek, G., Janka, Z., & Kéri, S. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.021 · Cited by 34
Postnatal exposure to MK801 induces selective changes in GAD67 or parvalbumin
Turner, C. P., DeBenedetto, D., Ware, E., Stowe, R. C., Lee, A. J., Swanson, J. M., Walburg, C., Lambert, A., Lyle, M. A., Desai, P., et al. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-2059-z · Cited by 33
Stereological brain volume changes in post-weaned socially isolated rats
Fabricius, K., Helboe, L., Steiniger‐Brach, B., Fink‐Jensen, A., & Pakkenberg, B. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.040 · Cited by 34
Topical Review: Neuronal Migration in Cortical Development
Kanatani, S., Tabata, H., & Nakajima, K. (2005) · Journal of Child Neurology · doi:10.1177/08830738050200040201 · Cited by 34
Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration
Elsworth, J. D., Groman, S. M., Jentsch, J. D., Valles, R., Shahid, M., Wong, E. H. F., Marston, H. M., & Roth, R. H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.026 · Cited by 33
Challenges and opportunities for the development of new antipsychotic drugs
Forray, C., & Buller, R. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.05.009 · Cited by 34
Event-related potential correlates of paranormal ideation and unusual experiences
Sumich, A. L., Kumari, V., GORDON, E., Tunstall, N., & Brammer, M. J. (2008) · Cortex · doi:10.1016/j.cortex.2007.10.012 · Cited by 33
Microvessel length density, total length, and length per neuron in five subcortical regions in schizophrenia
Kreczmański, P., Heinsen, H., Mantua, V., Woltersdorf, F., Masson, T., Ulfig, N., Schmidt‐Kastner, R., Korr, H., Steinbusch, H. W. M., Hof, P. R., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0482-7 · Cited by 33
The Clinical-Basic Interface in Defining Pathogenesis in Disorders of Neurodevelopmental Origin
Thompson, B. L., & Levitt, P. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.037 · Cited by 33
Self-citation
Sensory Deprivation and Brain Plasticity
Ptito, M., Kupers, R. C., Lomber, S. G., & Pietrini, P. (2012) · Neural Plasticity · doi:10.1155/2012/810370 · Cited by 36
The Adenosine Neuromodulation System in Schizophrenia
Rial, D., Lara, D. R., & Cunha, R. A. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801022-8.00016-7 · Cited by 35
Prenatal restraint stress decreases the expression of alpha-7 nicotinic receptor in the brain of adult rat offspring
Baier, C. J., Pallarés, M. E., Adrover, E., Monteleone, M., Brocco, M., Barrantes, F., & Antonelli, M. (2015) · Stress · doi:10.3109/10253890.2015.1022148 · Cited by 32
GABA Transporter-1 Deficiency Confers Schizophrenia-Like Behavioral Phenotypes
Yu, Z., Fang, Q., Xiao, X., Wang, Y., Cai, Y.-Q., Cao, H., Hu, G., Chen, Z., Fei, J., Gong, N., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069883 · Cited by 34

Authors: Lewis, D. A., & Levitt, P.
Affiliations: University of Pittsburgh (US)
ORCID: Lewis, David A.
Levitt, Pat
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2002-03
Volume: 25
Issue: 1
Pages: 409-432
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev.neuro.25.112701.142754
OpenAlex: W2112572641
Cited by: 1,163
References: 118
Citations by year: 2026: 17 · 2025: 16 · 2024: 23 · 2023: 17 · 2022: 36 · 2021: 25 · 2020: 36 · 2019: 31 · 2018: 42 · 2017: 77 · 2016: 50 · 2015: 60 · 2014: 60 · 2013: 57 · 2012: 82
FWCI: 7.83
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 45156, P50MH045156)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords: schizophrenia, brain development, genetic susceptibility, environmental risk factors, perinatal adversity, developmental trajectories, neurodegeneration, clinical phenotype
MeSH terms: Adolescent, Animals, Brain, Child, Developmental Disabilities, Child, Preschool, Female, Humans, Male, Models, Neurological, Nervous System Malformations, Pregnancy, Prenatal Exposure Delayed Effects, Schizophrenia, Gene Expression Regulation, Developmental, Genetic Predisposition to Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Schizophrenia as a Disorder of Neurodevelopment

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks