Cited by 1,163Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorAutism Spectrum Disorder Research

The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.

Schizophrenia as a Disorder of Neurodevelopment

Lewis, David A., Levitt, Pat·2002·Annual Review of Neuroscience

DOI 10.1146/annurev.neuro.25.112701.142754

Open this paper in CoChat — free account

Abstract

▪ Abstract A combination of genetic susceptibility and environmental perturbations appear to be necessary for the expression of schizophrenia. In addition, the pathogenesis of the disease is hypothesized to be neurodevelopmental in nature based on reports of an excess of adverse events during the pre- and perinatal periods, the presence of cognitive and behavioral signs during childhood and adolescence, and the lack of evidence of a neurodegenerative process in most individuals with schizophrenia. Recent studies of neurodevelopmental mechanisms strongly suggest that no single gene or factor is responsible for driving a highly complex biological process. Together, these findings suggest that combinatorial genetic and environmental factors, which disturb a normal developmental course early in life, result in molecular and histogenic responses that cumulatively lead to different developmental trajectories and the clinical phenotype recognized as schizophrenia.

Integrity signals

Registry

Crossref · 10.1146/annurev.neuro.25.112701.142754

Cites

118 of 118 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,311
Synaptic density in human frontal cortex —Developmental changes and effects of aging
Peter R., H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90349-4 · Cited by 2,645
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
Kuida, K., Zheng, T. S., Na, S., Kuan, C.-Y., Yang, D., Karasuyama, H., RAKIC, P. T., & Flavell, R. A. (1996) · Nature · doi:10.1038/384368a0 · Cited by 1,881
Searching for genetic determinants in the new millennium
Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839
Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?
Feinberg, I. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90038-3 · Cited by 1,395
Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies
Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,389
Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort
JONES, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90569-x · Cited by 1,353

Show all 118 references

Research works printed but not linked: 3

Lane A, Larkin C, Waddington JL, O'Callaghan E. 1996.Dysmorphic features and schizophrenia.InThe Neurodevelopmental Basis of Schizophrenia, ed. JL Waddington, PF Buckley, pp. 79–94. Georgetown, TX: Landes
Risch N, 1984, Am. J. Hum. Genet., 36, 1039
Takei N, 1998, Int. Med. J., 5, 13

Sorted by citations

Items 301–400 of 998

Disrupted-in-Schizophrenia 1–mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling
Chen, S.-Y., Huang, P.-H., & Cheng, H.-J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018128108 · Cited by 73
Schizophrenia as a Disorder of Neuroplasticity
McCullumsmith, R. E., Clinton, S. M., & Meador‐Woodruff, J. H. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)59002-5 · Cited by 73
The 22q11 deletion: DiGeorge and velocardiofacial syndromes and the role of TBX1
Papangeli, I., & Scambler, P. J. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.75 · Cited by 73
Maternal complement C1q and increased odds for psychosis in adult offspring
Severance, E. G., Gressitt, K. L., Buka, S. L., Cannon, T. D., & Yolken, R. H. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.053 · Cited by 74
Age-dependent regulation of synaptic connections by dopamine D2 receptors
Jia, J., Zhao, J. W., Hu, Z., Lindberg, D. M., & Li, Z. (2013) · Nature Neuroscience · doi:10.1038/nn.3542 · Cited by 72
Aberrant maturation and connectivity of prefrontal cortex in schizophrenia—contribution of NMDA receptor development and hypofunction
Gao, W., Yang, S.-S., Mack, N. R., & Chamberlin, L. A. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01196-w · Cited by 74
Disrupted-in-Schizophrenia 1 (DISC1) Is Necessary for the Correct Migration of Cortical Interneurons
Steinecke, A., Gampe, C., Valkova, C., Kaether, C., & Bolz, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5036-11.2012 · Cited by 69
Spatio-temporal luminance contrast sensitivity and visual backward masking in schizophrenia
Slaghuis, W. L. (2004) · Experimental Brain Research · doi:10.1007/s00221-003-1771-3 · Cited by 71
Stereological studies of capillary length density in the frontal cortex of schizophrenics
Kreczmański, P., Schmidt‐Kastner, R., Heinsen, H., Steinbusch, H. W. M., Hof, P. R., & Schmitz, C. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1003-y · Cited by 71
Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity
Hildebrandt, H., Mühlenhoff, M., Oltmann‐Norden, I., Röckle, I., Burkhardt, H., Weinhold, B., & Gerardy‐Schahn, R. (2009) · Brain · doi:10.1093/brain/awp117 · Cited by 70
Alterations in resting-state gamma activity in patients with schizophrenia: a high-density EEG study
Baradits, M., Kakuszi, B., Bálint, S., Fullajtár, M., Mód, L., Bitter, I., & Czobor, P. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-018-0889-z · Cited by 77
Marital Status and Mental Health
Williams, K., Frech, A., & Carlson, D. L. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511984945.020 · Cited by 70
Gestational Restraint Stress and the Developing Dopaminergic System: An Overview
Baier, C. J., Katunar, M. R., Adrover, E., Pallarés, M. E., & Antonelli, M. C. (2012) · Neurotoxicity Research · doi:10.1007/s12640-011-9305-4 · Cited by 68
Research Review: Do motor deficits during development represent an endophenotype for schizophrenia? A meta‐analysis
Burton, B. K., Hjorthøj, C. R., Jepsen, J. R. M., Thorup, A. A. E., Nordentoft, M., & Plessen, K. J. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12479 · Cited by 68
Hospital Admission With Infection During Childhood and Risk for Psychotic Illness--A Population-based Cohort Study
Blomstrom, A., Karlsson, H., Svensson, A. C., Frisell, T., Lee, B. K., Dal, H., Magnusson, C., & Dalman, C. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt195 · Cited by 68
Regulation of Spine Formation by ErbB4 in PV-Positive Interneurons
Yin, D., Sun, X.-D., Bean, J. C., Lin, T. W., Sathyamurthy, A., Xiong, W., Gao, T.-M., Chen, Y., & Mei, L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2090-13.2013 · Cited by 70
Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice
Klug, M., Hill, R., Choy, K. H. C., Kyrios, M., Hannan, A. J., & van den Buuse, M. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.015 · Cited by 66
Neurocognitive impairments in individuals at ultra-high risk for psychosis: Who will really convert?
Bang, M., Kim, K. R., Song, Y. Y., Baek, S. Y., Lee, E. M., & An, S. K. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867414561527 · Cited by 67
Disordered corticolimbic interactions during affective processing in children and adolescents at risk for schizophrenia revealed by functional magnetic resonance imaging and dynamic causal modeling
Diwadkar, V. A. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1349 · Cited by 66
The Neuroimmunology of Schizophrenia
Annya, M., Smyth, Stephen, M., & Lawrie, S. M. (2013) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2013.11.3.107 · Cited by 68
Dysconnection Topography in Schizophrenia Revealed with State-Space Analysis of EEG
Jalili, M., Lavoie, S., Deppen, P., Meuli, R. A., Kim, Q., Cuénod, M., Hasler, M., Feo, O. D., & Knyazeva, M. G. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001059 · Cited by 66
Neurodevelopmental Animal Models of Schizophrenia: Role in Novel Drug Discovery and Development
Wilson, C., & Terry, A. V. (2010) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.4.2.4 · Cited by 70
DNA Damage in Major Psychiatric Diseases
Raza, M. U., Tufan, T., Wang, Y., Hill, C. P., & Zhu, M. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9621-9 · Cited by 70
Neonatal Head Ultrasound Abnormalities in Preterm Infants and Adolescent Psychiatric Disorders
Whitaker, A. H., Feldman, J. F., Lorenz, J. M., McNicholas, F., Fisher, P. W., Shen, S., Pinto‐Martin, J. A., Shaffer, D., & Paneth, N. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.62 · Cited by 67
A computational neuroscience approach to schizophrenia and its onset
Rolls, E. T., & Deco, G. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.001 · Cited by 67
The “addicted” spine
Spiga, S., Mulas, G., Piras, F., & Diana, M. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00110 · Cited by 63
Boundaries of Schizoaffective Disorder
Kotov, R., Leong, S. H., Mojtabai, R., Erlanger, A. C. E., Fochtmann, L. J., Constantino, E. A., Carlson, G. A., & Bromet, E. J. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.2350 · Cited by 64
Variation in the major histocompatibility complex [MHC] gene family in schizophrenia: Associations and functional implications
Debnath, M., Cannon, D. M., & Venkatasubramanian, G. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.009 · Cited by 67
Cortical and subcortical changes in typically developing preadolescent children
Muftuler, L. T., Davis, E. P., Buß, C., Head, K., Hasso, A. N., & Sandman, C. A. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.018 · Cited by 66
Neuregulin-1 Regulates Cell Adhesion via an ErbB2/Phosphoinositide-3 Kinase/Akt-Dependent Pathway: Potential Implications for Schizophrenia and Cancer
Kanakry, C. G., Li, Z., Nakai, Y., Sei, Y., & Weinberger, D. R. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001369 · Cited by 63
Targeting synapses and myelin in the prevention of schizophrenia
Woo, T., & Crowell, A. L. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.07.022 · Cited by 62
Association between white matter fiber integrity and subclinical psychotic symptoms in schizophrenia patients and unaffected relatives
Knöchel, C., O’Dwyer, L., Alves, G. S., Reinke, B., Magerkurth, J., Rotarska-Jagiela, A., Prvulovic, D., Hampel, H. J., Linden, D. E. J., & Oertel‐Knöchel, V. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.001 · Cited by 65
Sleep abnormalities in schizophrenia may suggest impaired trans-thalamic cortico-cortical communication: towards a dynamic model of the illness
Vukadinovic, Z. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07822.x · Cited by 63
Childhood negative experiences and subclinical psychosis in adolescence: a longitudinal general population study
Loore, E. D., Drukker, M., Günther, N., FERON, F. J. M., Deboutte, D., Sabbe, B., Mengelers, R., van Os, J., & Myin‐Germeys, I. (2007) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2007.00027.x · Cited by 64
Growth-associated protein 43 (GAP-43) and synaptophysin alterations in the dentate gyrus of patients with schizophrenia
Chambers, J. S., Thomas, D., Saland, L. C., Neve, R. L., & Perrone‐Bizzozero, N. I. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.013 · Cited by 62
Signal Transduction and Genes-to-Behaviors Pathways in Psychiatric Diseases
Manji, H. K., Gottesman, I. I., & Gould, T. D. (2003) · Science Signaling · doi:10.1126/stke.2003.207.pe49 · Cited by 64
Signal integration through blending, bolstering and bifurcating of intracellular information
Pawson, C. T., & Scott, J. D. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1843 · Cited by 62
Epigenetic signaling in schizophrenia
Ibi, D., & González‐Maeso, J. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.06.003 · Cited by 62
Phasic Dopamine Neuron Activity Elicits Unique Mesofrontal Plasticity in Adolescence
Mastwal, S. S., Ye, Y., Ren, M., Jimenez, D. V., Martinowich, K., Gerfen, C. R., & Wang, K. H. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1114-14.2014 · Cited by 61
Chronic administration of the neurotrophic agent cerebrolysin ameliorates the behavioral and morphological changes induced by neonatal ventral hippocampus lesion in a rat model of schizophrenia
Vázquez‐Roque, R. A., Ramos, B., Tecuatl, C., Juárez, I., Adame, A., de la Cruz, F., Zamudio, S., Mena, R., Rockenstein, E. M., Masliah, E., et al. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22753 · Cited by 63
Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development
Tomita, K., Kubo, K., Ishii, K., & Nakajima, K. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr194 · Cited by 61
Neuropsychological evidence for abnormal neurodevelopment associated with early-onset psychoses
Bombín, I., Mayoral, M., Castro‐Fornieles, J., González-Pinto, A. M., de la Serna, E., Rapado‐Castro, M., Barbeito, S., Parellada, M., Baeza, I., Graell, M., et al. (2012) · Psychological Medicine · doi:10.1017/s0033291712001535 · Cited by 63
Well-Being across the Life Course
Mirowsky, J., & Ross, C. E. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511984945.023 · Cited by 60
Morphometricity as a measure of the neuroanatomical signature of a trait
Sabuncu, M. R., Ge, T., Holmes, A. J., Smoller, J. W., Buckner, R. L., Fischl, B. R., Initiative, T. A. D. N., Weiner, M. W., Aisen, P., Weiner, M. W., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604378113 · Cited by 58
The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders
Zhang, K., Wang, Y., Fan, T., Zeng, C., & Sun, Z. S. (2020) · Protein & Cell · doi:10.1007/s13238-020-00812-9 · Cited by 60
Neural ECM in addiction, schizophrenia, and mood disorder
Lubbers, B. R., Smit, A. B., Spijker, S., & van den Oever, M. C. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63486-3.00012-8 · Cited by 62
Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site
Brandon, N. J., Schurov, I., Camargo, L. M., Handford, E. J., Duran-Jimenez, B., Hunt, P., Millar, J. K., Porteous, D. J., Shearman, M. S., & Whiting, P. J. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.11.003 · Cited by 60
The distribution and morphology of prefrontal cortex pyramidal neurons identified using anti-neurofilament antibodies SMI32, N200 and FNP7. Normative data and a comparison in subjects with schizophrenia, bipolar disorder or major depression
Law, A. J., & Harrison, P. J. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00075-x · Cited by 60
Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period
Canetta, S. E., Holt, E. S., Benoit, L. J., Teboul, E., Sahyoun, G. M., Ogden, R. T., Harris, A. Z., & Kellendonk, C. (2022) · eLife · doi:10.7554/elife.80324 · Cited by 59
Iron deficiency with or without anemia impairs prepulse inhibition of the startle reflex
Pisansky, M. T., Wickham, R. J., Su, J., Fretham, S. J. B., Yuan, L., Sun, M., Gewirtz, J. C., & Georgieff, M. (2013) · Hippocampus · doi:10.1002/hipo.22151 · Cited by 59
Molecular cloning and characterization of human RAI1, a gene associated with schizophrenia
Toulouse, A., Rochefort, D. L., Roussel, J., Joober, R., & Rouleau, G. A. (2003) · Genomics · doi:10.1016/s0888-7543(03)00101-0 · Cited by 59
Animal Models of Deficient Sensorimotor Gating in Schizophrenia: Are They Still Relevant?
Swerdlow, N. R., & Light, G. A. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5012 · Cited by 63
Biomarkers for Prediction of Schizophrenia: Insights From Resting-State EEG Microstates
Luo, Y., Tian, Q., Wang, C., Zhang, K., Wang, C., & Zhang, J. (2020) · IEEE Access · doi:10.1109/access.2020.3037658 · Cited by 59
The brain‐specific protein MLC1 implicated in megalencephalic leukoencephalopathy with subcortical cysts is expressed in glial cells in the murine brain
Schmitt, A. G., Gofferje, V., Weber, M. M., Meyer, J., Mößner, R., & Lesch, K. (2003) · Glia · doi:10.1002/glia.10304 · Cited by 58
Genetic Deletion of Lsamp Causes Exaggerated Behavioral Activation in Novel Environments
Catania, E. H., Pimenta, A. F., & Levitt, P. R. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.11.022 · Cited by 63
Self-citation
Stem Cells on the Brain: Modeling Neurodevelopmental and Neurodegenerative Diseases Using Human Induced Pluripotent Stem Cells
Srikanth, P., & Young‐Pearse, T. L. (2014) · Journal of Neurogenetics · doi:10.3109/01677063.2014.881358 · Cited by 61
Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics
von Coburg, Y., Kottke, T., Weizel, L., Ligneau, X., & Stark, H. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.09.012 · Cited by 57
Epigenetic Mechanisms of Serotonin Signaling
Holloway, T. D., & González‐Maeso, J. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00033 · Cited by 60
Pyramidal neuron number in layer 3 of primary auditory cortex of subjects with schizophrenia
Dorph‐Petersen, K., Delevich, K. M., Marcsisin, M. J., Zhang, W., Sampson, A. R., Gundersen, H. J. G., Lewis, D. A., & Sweet, R. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.019 · Cited by 57
Self-citation
Dysbindin-1 and Its Protein Family
Talbot, K., Ong, W., Blake, D. J., Tang, J., Louneva, N., Carlson, G. C., & Arnold, S. E. (2009) · Springer eBooks · doi:10.1007/978-0-387-30410-6_5 · Cited by 57
Childhood neglect predicts disorganization in schizophrenia through grey matter decrease in dorsolateral prefrontal cortex
Cancel, A., Comte, M., Truillet, R., Boukezzi, S. C., Rousseau, P., Zendjidjian, X. Y., Sage, T., Lazerges, P., Guedj, É., Khalfa, S., et al. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12455 · Cited by 61
Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene
Luo, X.-J., Mei, L. I., Huang, L., Steinberg, S., Mattheisen, M., Liang, G., Donohoe, G. J., Shi, Y., Chen, C., Yue, W., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.103 · Cited by 56
Background Dopamine Concentration Dependently Facilitates Long-term Potentiation in Rat Prefrontal Cortex through Postsynaptic Activation of Extracellular Signal-Regulated Kinases
Kolomiets, B. P., Marzo, A., Caboche, J., Vanhoutte, P., & Otani, S. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp047 · Cited by 56
Modeling Individual Differences in Brain Development
Becht, A., & Mills, K. L. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.01.027 · Cited by 57
Genetics of monoamine metabolites in baboons: overlapping sets of genes influence levels of 5-hydroxyindolacetic acid, 3-hydroxy-4-methoxyphenylglycol, and homovanillic acid
Rogers, J., Martin, L. J., Comuzzie, A. G., Mann, J. J., Manuck, S. B., Leland, M. M., & Kaplan, J. R. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.017 · Cited by 56
Neurobehavioral and metabolic long-term consequences of neonatal maternal deprivation stress and adolescent olanzapine treatment in male and female rats
Llorente‐Berzal, A., Mela, V., Borcel, É., Valero, M., López‐Gallardo, M., Viveros, M., & Marco, E. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.031 · Cited by 55
Eyeblink Conditioning: A Non-invasive Biomarker for Neurodevelopmental Disorders
Reeb‐Sutherland, B. C., & Fox, N. A. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1905-9 · Cited by 55
Zebrafish: a model system to examine the neurodevelopmental basis of schizophrenia
Morris, J. A. (2009) · Progress in brain research · doi:10.1016/s0079-6123(09)17911-6 · Cited by 55
Schizophrenia in Translation: Disrupted in Schizophrenia (DISC1): Integrating Clinical and Basic Findings
Roberts, R. C. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl063 · Cited by 55
The Relevance of Human Fetal Subplate Zone for Developmental Neuropathology of Neuronal Migration Disorders and Cortical Dysplasia
Kostović, I., Sedmak, G., Vukšić, M., & Judáš, M. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12333 · Cited by 56
The Genetics of Brain Wiring: From Molecule to Mind
Mitchell, K. J. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050113 · Cited by 58
Mapping pathologic circuitry in schizophrenia
Glausier, J. R., & Lewis, D. A. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63639-3.00025-6 · Cited by 53
Self-citation
Region‐ and age‐specific deficits in γ‐aminobutyric acidergic neuron development in the telencephalon of the uPAR–/– mouse
Eagleson, K. L., Bonnin, A., & Levitt, P. R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20647 · Cited by 53
Self-citation
The neuroanatomy of schizophrenia: circuitry and neurotransmitter systems
Fallon, J. H., Opole, I. O., & Potkin, S. G. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00022-7 · Cited by 53
Risperidone reverses phencyclidine induced decrease in glutathione levels and alterations of antioxidant defense in rat brain
Stojković, T., Radonjić, N. V., Velimirović, M., Jevtić, G., POPOVIC, V. M., Doknić, M., & Petronijević, N. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.06.013 · Cited by 53
Movement abnormalities predict transitioning to psychosis in individuals at clinical high risk for psychosis
Callaway, D. A., Perkins, D. O., Woods, S. W., Liu, L., & Addington, J. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.031 · Cited by 53
Incidental neurodevelopmental episodes in the etiology of schizophrenia: An expanded model involving epigenetics and development
Singh, S., McDonald, P., Murphy, B., & O’Reilly, R. (2004) · Clinical Genetics · doi:10.1111/j.1399-0004.2004.00269.x · Cited by 53
The Relationship of Intellectual Functioning and Cognitive Performance to Brain Structure in Schizophrenia
Czepielewski, L. S., Wang, L., Gama, C. S., & Barch, D. M. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw090 · Cited by 53
Constitutive genetic deletion of the growth regulator Nogo-A induces schizophrenia-related endophenotypes
Willi, R., Weinmann, O., Winter, C., Klein, J., Sohr, R., Schnell, L., Yee, B. K., Feldon, J., & Schwab, M. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4393-09.2010 · Cited by 52
Translating ENIGMA schizophrenia findings using the regional vulnerability index: Association with cognition, symptoms, and disease trajectory
Kochunov, P., Fan, F., Ryan, M. C., Hatch, K. S., Tan, S., Jahanshad, N., Thompson, P. M., van Erp, T. G. M., Turner, J. A., Chen, S., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25045 · Cited by 55
Emerging Opportunities for Antipsychotic Drug Discovery in the Postgenomic Era
Marino, M. J., Knutsen, L. J. S., & Williams, M. R. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm701094q · Cited by 52
Neural Correlates of the Risk for Schizophrenia and Bipolar Disorder: A Meta-analysis of Structural and Functional Neuroimaging Studies
Cattarinussi, G., Kubera, K. M., Hirjak, D., Wolf, R. C., & Sambataro, F. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.02.960 · Cited by 56
Schizophrenia: A unique translational opportunity in behavioral neuroendocrinology
Koenig, J. I. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.027 · Cited by 51
Patch-clamp recordings and calcium imaging followed by single-cell PCR reveal the developmental profile of 13 genes in iPSC-derived human neurons
Belinsky, G. S., Rich, M. T., Sirois, C. L., Short, S. M., Pedrosa, E., Lachman, H. M., & Antic, S. D. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.09.014 · Cited by 51
A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia
Smalla, K., Mikhaylova, M., Sahin, J., Hg, B., Bogerts, B., Schmitt, A., van der Schors, R. C., Smit, A. B., Li, K. W., Gundelfinger, E. D., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.60 · Cited by 51
Alterations in hippocampal excitability, synaptic transmission and synaptic plasticity in a neurodevelopmental model of schizophrenia
Sanderson, T. M., Côtel, M.-C., O’Neill, M. J., Tricklebank, M. D., Collingridge, G. L., & Sher, E. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.005 · Cited by 51
Brain development needs sugar: the role of polysialic acid in controlling NCAM functions
Mühlenhoff, M., Oltmann‐Norden, I., Weinhold, B., Hildebrandt, H., & Gerardy‐Schahn, R. (2009) · Biological Chemistry · doi:10.1515/bc.2009.078 · Cited by 51
Hippocampal volume in subjects at clinical high-risk for psychosis: A systematic review and meta-analysis
Walter, A., Suenderhauf, C., Harrisberger, F., Lenz, C., Smieskova, R., Chung, Y., Cannon, T. D., Bearden, C. E., Rapp, C., Bendfeldt, K., et al. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.007 · Cited by 56
DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia
McKinney, B. C., Huang, L., Ding, Y., Lewis, D. A., & Sweet, R. A. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.09.025 · Cited by 54
Self-citation
Two Genes Link Two Distinct Psychoses
Sawa, A., & Snyder, S. H. (2005) · Science · doi:10.1126/science.1121114 · Cited by 51
Morphological correlates to cognitive dysfunction in schizophrenia as studied with Bayesian regression
Lawyer, G., Nyman, H., Agartz, I., Arnborg, S., Jönsson, E. G., Sedvall, G. C., & Hall, H. (2006) · BMC Psychiatry · doi:10.1186/1471-244x-6-31 · Cited by 52
Phosphorylation of the tubulin‐binding protein, stathmin, by Cdk5 and MAP kinases in the brain
Hayashi, K., Pan, Y., Shu, H., Ohshima, T., Kansy, J. W., White, C. L., Tamminga, C. A., Sobel, A., Curmi, P. A., Mikoshiba, K., et al. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04113.x · Cited by 51
Insights into the neurodevelopmental origin of schizophrenia from postmortem studies of prefrontal cortical circuitry
Beneyto, M., & Lewis, D. A. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.08.003 · Cited by 52
Self-citation
Selective deficits in spatial working memory in the neonatal ventral hippocampal lesion rat model of schizophrenia
Brady, A. M., Saul, R. D., & Wiest, M. K. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.08.012 · Cited by 50
From Shortage to Surge: A Developmental Switch in Hippocampal–Prefrontal Coupling in a Gene–Environment Model of Neuropsychiatric Disorders
Hartung, H., Cichon, N., Feo, V. D., Riemann, S., Schildt, S., Lindemann, C., Mulert, C., Gogos, J. A., & Hanganu‐Opatz, I. L. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw274 · Cited by 47
Hippocampus and amygdala volumes in children and young adults at high-risk of schizophrenia: Research synthesis
Ganzola, R., Maziade, M., & Duchesne, S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.030 · Cited by 54
Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro
MacLaren, E. J., Charlesworth, P., Coba, M. P., & Grant, S. G. N. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.12.014 · Cited by 51
DNA methylation evidence against the accelerated aging hypothesis of schizophrenia
McKinney, B. C., Huang, L., Ding, Y., Lewis, D. A., & Sweet, R. A. (2017) · Schizophrenia · doi:10.1038/s41537-017-0017-5 · Cited by 49
Self-citation
Neurodevelopmental Origins of Schizophrenia
Weinberger, D. R., & Levitt, P. R. (2010) · Wiley eBooks · doi:10.1002/9781444327298.ch19 · Cited by 49
Self-citation
Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin1 and their role in schizophrenia
Geddes, A. E., Huang, X., & Newell, K. A. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.02.017 · Cited by 52

Authors: Lewis, D. A., & Levitt, P.
Affiliations: University of Pittsburgh (US)
ORCID: Lewis, David A.
Levitt, Pat
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2002-03
Volume: 25
Issue: 1
Pages: 409-432
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev.neuro.25.112701.142754
OpenAlex: W2112572641
Cited by: 1,163
References: 118
Citations by year: 2026: 17 · 2025: 16 · 2024: 23 · 2023: 17 · 2022: 36 · 2021: 25 · 2020: 36 · 2019: 31 · 2018: 42 · 2017: 77 · 2016: 50 · 2015: 60 · 2014: 60 · 2013: 57 · 2012: 82
FWCI: 7.83
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 45156, P50MH045156)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords: schizophrenia, brain development, genetic susceptibility, environmental risk factors, perinatal adversity, developmental trajectories, neurodegeneration, clinical phenotype
MeSH terms: Adolescent, Animals, Brain, Child, Developmental Disabilities, Child, Preschool, Female, Humans, Male, Models, Neurological, Nervous System Malformations, Pregnancy, Prenatal Exposure Delayed Effects, Schizophrenia, Gene Expression Regulation, Developmental, Genetic Predisposition to Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Schizophrenia as a Disorder of Neurodevelopment

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks