The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
AXON RETRACTION AND DEGENERATION IN DEVELOPMENT AND DISEASE
Abstract
The selective elimination of axons, dendrites, axon and dendrite branches, and synapses, without loss of the parent neurons, occurs during normal development of the nervous system as well as in response to injury or disease in the adult. The widespread developmental phenomena of exuberant axonal projections and synaptic connections require both small-scale and large-scale axon pruning to generate precise adult connectivity, and they provide a mechanism for neural plasticity in the developing and adult nervous system, as well as a mechanism to evolve differences between species in a projection system. Such pruning is also required to remove axonal connections damaged in the adult, to stabilize the affected neural circuits, and to initiate their repair. Pruning occurs through either retraction or degeneration. Here we review examples of these phenomena and consider potential cellular and molecular mechanisms that underlie axon retraction and degeneration and how they might relate to each other in development and disease.
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Cites
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Metadata
- Authors
- Luo, L., & O'Leary, D. D. M.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2005-07-21
- Volume
- 28
- Issue
- 1
- Pages
- 127-156
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2100728233
- Cited by
- 844
- References
- 133
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Luo, L., & O'Leary, D. D. M. (2005). AXON RETRACTION AND DEGENERATION IN DEVELOPMENT AND DISEASE. Annual Review of Neuroscience. https://doi.org/10.1146/annurev.neuro.28.061604.135632
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.