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Cited by 844

The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.

AXON RETRACTION AND DEGENERATION IN DEVELOPMENT AND DISEASE

Luo, Liqun, O'Leary, Dennis D.M.·2005·Annual Review of Neuroscience

Abstract

The selective elimination of axons, dendrites, axon and dendrite branches, and synapses, without loss of the parent neurons, occurs during normal development of the nervous system as well as in response to injury or disease in the adult. The widespread developmental phenomena of exuberant axonal projections and synaptic connections require both small-scale and large-scale axon pruning to generate precise adult connectivity, and they provide a mechanism for neural plasticity in the developing and adult nervous system, as well as a mechanism to evolve differences between species in a projection system. Such pruning is also required to remove axonal connections damaged in the adult, to stabilize the affected neural circuits, and to initiate their repair. Pruning occurs through either retraction or degeneration. Here we review examples of these phenomena and consider potential cellular and molecular mechanisms that underlie axon retraction and degeneration and how they might relate to each other in development and disease.

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Crossref · 10.1146/annurev.neuro.28.061604.135632

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Metadata

Authors
Luo, L., & O'Leary, D. D. M.
Venue
Annual Review of Neuroscience
Published
2005-07-21
Volume
28
Issue
1
Pages
127-156
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
OpenAlex
W2100728233
Cited by
844
References
133
FWCI
1.55
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: AXON RETRACTION AND DEGENERATION IN DEVELOPMENT AND DISEASE. https://app.cochat.ai/papers/10.1146/annurev.neuro.28.061604.135632
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Luo, L., & O'Leary, D. D. M. (2005). AXON RETRACTION AND DEGENERATION IN DEVELOPMENT AND DISEASE. Annual Review of Neuroscience. https://doi.org/10.1146/annurev.neuro.28.061604.135632

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.