Distinct cerebellar contributions to intrinsic connectivity networks
Open accessAbstract
Convergent data from various scientific approaches strongly implicate cerebellar systems in nonmotor functions. The functional anatomy of these systems has been pieced together from disparate sources, such as animal studies, lesion studies in humans, and structural and functional imaging studies in humans. To better define this distinct functional anatomy, in the current study we delineate the role of the cerebellum in several nonmotor systems simultaneously and in the same subjects using resting state functional connectivity MRI. Independent component analysis was applied to resting state data from two independent datasets to identify common cerebellar contributions to several previously identified intrinsic connectivity networks (ICNs) involved in executive control, episodic memory/self-reflection, salience detection, and sensorimotor function. We found distinct cerebellar contributions to each of these ICNs. The neocerebellum participates in (1) the right and left executive control networks (especially crus I and II), (2) the salience network (lobule VI), and (3) the default-mode network (lobule IX). Little to no overlap was detected between these cerebellar regions and the sensorimotor cerebellum (lobules V-VI). Clusters were also located in pontine and dentate nuclei, prominent points of convergence for cerebellar input and output, respectively. The results suggest that the most phylogenetically recent part of the cerebellum, particularly crus I and II, make contributions to parallel cortico-cerebellar loops involved in executive control, salience detection, and episodic memory/self-reflection. The largest portions of the neocerebellum take part in the executive control network implicated in higher cognitive functions such as working memory.
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Most of the cerebellum is associated with non-motor or cognitive functions.
“mounting evidence indicates that most of the cerebellum is associated with non-motor or cognitive functions (see Buckner et al., 2011; Habas et al., 2009; O'Reilly et al., 2010; Schmahmann, 2010; Schmahmann and Sherman, 1998).”
From Postural sway and regional cerebellar volume in adults with attention-deficit/hyperactivity disorder (2015) · cites this paper as Habas et al., 2009
The Introduction and Discussion support a substantial non-motor role for the cerebellum, particularly its neocerebellar regions involved in cognitive networks. They do not establish that *most of the entire cerebellum* is associated with non-motor or cognitive functions; the Discussion’s reference to the “major part” is limited to the neocerebellum. (LLM, conf=0.85)
Experimental — accuracy not yet measuredSeparate cerebellar regions are connected with different cerebral areas to form multiple cognitive circuits with topographic functions.
“Current evidence suggests that separate cerebellar regions are connected with different cerebral areas to form multiple cognitive circuits with topographic functions (15, 16).”
From Altered functional connectivity between the cerebellum and the cortico-striato-thalamo-cortical circuit in obsessive-compulsive disorder (2019) · cites this paper as [15]
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- Authors
- Habas, C., Kamdar, N., Nguyen, D., Prater, K., Beckmann, C. F., Menon, V., & Greicius, M. D.
- Affiliations
- Centre hospitalier national d'ophtalmologie des Quinze-Vingts (FR)
- Stanford Medicine (US)
- University of Oxford (GB)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-07-01
- Volume
- 29
- Issue
- 26
- Pages
- 8586-8594
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2742620
- OpenAlex
- W2090017477
- Cited by
- 1,115
- References
- 77
- Citations by year
- 2026: 49 · 2025: 69 · 2024: 42 · 2023: 64 · 2022: 84 · 2021: 110 · 2020: 77 · 2019: 79 · 2018: 75 · 2017: 62 · 2016: 65 · 2015: 58 · 2014: 62 · 2013: 86 · 2012: 50
- FWCI
- 21.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0750340)
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (K23NS048302, NS048302, NS058899, R21NS058899)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD047520, R01HD047520)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- cerebellum, resting-state networks, resting-state functional connectivity, neocerebellum, frontoparietal network, salience network, default mode network, episodic memory, working memory, dentate nucleus, pontine nuclei, cerebellar lobules
- MeSH terms
- Adult, Brain Mapping, Cerebellum, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Models, Neurological, Nerve Net, Neural Pathways, Oxygen, Problem Solving, Psychomotor Performance, Rest, Principal Component Analysis, Young Adult
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