Semaphorins and the dynamic regulation of synapse assembly, refinement, and function

Pyramidal neurons: dendritic structure and synaptic integration

Spruston, N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2286 · Cited by 1,688 · see citing works

Regulation of synaptic connectivity by glia.

Eroglu, C., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09612 · Cited by 813 · see citing works

Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development.

Gu, C.-H., Rodríguez, E., Reimert, D. V., Shu, T., Fritzsch, B., Richards, L. J., Kolodkin, A., & Ginty, D. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00169-2 · Cited by 756 · see citing works

From Synapse to Nucleus: Calcium-Dependent Gene Transcription in the Control of Synapse Development and Function

Greer, P. L., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.002 · Cited by 661 · see citing works

Cell adhesion molecules: signalling functions at the synapse

Dalva, M. B., McClelland, A. C., & Kayser, M. S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2075 · Cited by 620 · see citing works

Exuberance in the development of cortical networks

Innocenti, G. M., & Price, D. J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1790 · Cited by 512 · see citing works

Dynamic Aspects of CNS Synapse Formation

McAllister, A. K. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112830 · Cited by 368 · see citing works

Stereotyped Pruning of Long Hippocampal Axon Branches Triggered by Retraction Inducers of the Semaphorin Family

Bagri, A., Cheng, H.-J., Yaron, A., Pleasure, S. J., & Tessier‐Lavigne, M. (2003) · Cell · doi:10.1016/s0092-8674(03)00267-8 · Cited by 319 · see citing works

Electrical Activity Modulates Growth Cone Guidance by Diffusible Factors

Ming, G., Henley, J. R., Tessier‐Lavigne, M., Song, H., & Poo, M.-M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00217-3 · Cited by 270 · see citing works

Genetic Analysis of the Mechanisms Controlling Target Selection: Complementary and Combinatorial Functions of Netrins, Semaphorins, and IgCAMs

Winberg, M. L., Mitchell, K. J., & Goodman, C. S. (1998) · Cell · doi:10.1016/s0092-8674(00)81187-3 · Cited by 260 · see citing works

Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS

Tran, T. S., Rubio, M. E., Clem, R. L., Johnson, D., Case, L. C., Tessier‐Lavigne, M., Huganir, R. L., Ginty, D. D., & Kolodkin, A. L. (2009) · Nature · doi:10.1038/nature08628 · Cited by 238 · see citing works

An RNAi-Based Approach Identifies Molecules Required for Glutamatergic and GABAergic Synapse Development

Paradis, S., Harrar, D. B., Lin, Y., Koon, A. C., Chatterjee, J. H., Griffith, E. C., Zhu, L., Brass, L. F., Chen, C., & Greenberg, M. E. (2007) · Neuron · doi:10.1016/j.neuron.2006.12.012 · Cited by 231 · see citing works

Guidance Molecules in Synapse Formation and PlasticityPreprint

Shen, K., & Cowan, C. W. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001842 · Cited by 227 · see citing works

Semaphorin3A Regulates Neuronal Polarization by Suppressing Axon Formation and Promoting Dendrite Growth

Shelly, M., Cancedda, L., Lim, B. K., Popescu, A. T., Cheng, P., Gao, H., & Poo, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.041 · Cited by 217 · see citing works

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina

Matsuoka, R. L., Nguyen-Ba-Charvet, K. T., Parray, A., Badea, T. C., Chédotal, A., & Kolodkin, A. L. (2011) · Nature · doi:10.1038/nature09675 · Cited by 202 · see citing works

Specificity of sensory–motor connections encoded by Sema3e–Plxnd1 recognition

Pecho‐Vrieseling, E., Sigrist, M., Yoshida, Y., Jessell, T. M., & Arber, S. (2009) · Nature · doi:10.1038/nature08000 · Cited by 173 · see citing works

cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic map

Nicol, X., Voyatzis, S., Muzerelle, A., Narboux‐Nême, N., Südhof, T. C., Miles, R., & Gaspar, P. (2007) · Nature Neuroscience · doi:10.1038/nn1842 · Cited by 170 · see citing works

Graded Expression of Semaphorin-1a Cell-Autonomously Directs Dendritic Targeting of Olfactory Projection Neurons

Komiyama, T., Sweeney, L. B., Schuldiner, O., García, K. C., & Luo, L. (2007) · Cell · doi:10.1016/j.cell.2006.12.028 · Cited by 166 · see citing works

Class 5 Transmembrane Semaphorins Control Selective Mammalian Retinal Lamination and Function

Matsuoka, R. L., Chivatakarn, O., Badea, T. C., Samuels, I. S., Cahill, H. B., Katayama, K., Kumar, S. R., Suto, F., Chédotal, A., Peachey, N. S., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.009 · Cited by 165 · see citing works

Secreted Semaphorins Modulate Synaptic Transmission in the Adult Hippocampus

Sahay, A., Kim, C., Sepkuty, J. P., Cho, E., Huganir, R. L., Ginty, D. D., & Kolodkin, A. L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5255-04.2005 · Cited by 149 · see citing works

On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms

Sun, L. O., Jiang, Z., Rivlin‐Etzion, M., Hand, R., Brady, C. M., Matsuoka, R. L., Yau, K., Feller, M. B., & Kolodkin, A. L. (2013) · Science · doi:10.1126/science.1241974 · Cited by 142 · see citing works

Bi-directional signaling by Semaphorin 1a during central synapse formation in Drosophila

Godenschwege, T. A., Hu, H., Shan-Crofts, X., Goodman, C. S., & Murphey, R. K. (2002) · Nature Neuroscience · doi:10.1038/nn976 · Cited by 118 · see citing works

An Activity-Regulated microRNA, miR-188, Controls Dendritic Plasticity and Synaptic Transmission by Downregulating Neuropilin-2

Lee, K., Kim, J. H., Kwon, O. B., An, K., Ryu, J., Cho, K., Suh, Y. H., & Kim, H.-S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6471-11.2012 · Cited by 114 · see citing works

Semaphorin 3E–Plexin-D1 signaling controls pathway-specific synapse formation in the striatum

Ding, J., Oh, W., Sabatini, B. L., & Gu, C. (2011) · Nature Neuroscience · doi:10.1038/nn.3003 · Cited by 110 · see citing works

Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex

Low, L. K., Liu, X.-B., Faulkner, R. L., Coble, J., & Cheng, H.-J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803849105 · Cited by 95 · see citing works

Semaphorin 5B mediates synapse elimination in hippocampal neurons

O’Connor, T. P., Cockburn, K., Wang, W., Tapia, L., Currie, E., & Bamji, S. X. (2009) · Neural Development · doi:10.1186/1749-8104-4-18 · Cited by 95 · see citing works

Stereotyped Axon Pruning via Plexin Signaling Is Associated with Synaptic Complex Elimination in the Hippocampus

Liu, X.-B., Low, L. K., Jones, E. G., & Cheng, H.-J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2648-05.2005 · Cited by 91 · see citing works

DrosophilaPlexin B is a Sema-2a receptor required for axon guidance

Ayoob, J. C., Terman, J. R., & Kolodkin, A. L. (2006) · Development · doi:10.1242/dev.02380 · Cited by 83 · see citing works

Semaphorin3A regulates synaptic function of differentiated hippocampal neurons

Bouzioukh, F., Daoudal, G., Falk, J., Debanne, D., Rougon, G. N., & Castellani, V. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04783.x · Cited by 82 · see citing works

The RacGAP β2-Chimaerin Selectively Mediates Axonal Pruning in the Hippocampus

Riccomagno, M. M., Hurtado, A., Wang, H., Macopson, J. G. J., Griner, E., Betz, A., Brose, N., Kazanietz, M. G., & Kolodkin, A. L. (2012) · Cell · doi:10.1016/j.cell.2012.05.018 · Cited by 76 · see citing works

Secreted Semaphorins from Degenerating Larval ORN Axons Direct Adult Projection Neuron Dendrite Targeting

Sweeney, L. B., Chou, Y.-H., Wu, Z., Joo, W. J., Komiyama, T., Potter, C. J., Kolodkin, A. L., García, K. C., & Luo, L. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.026 · Cited by 72 · see citing works

Multiple Interactions Control Synaptic Layer Specificity in the Drosophila Visual System

Pecot, M. Y., Tadros, W., Nern, A., Bader, M., Chen, Y., & Zipursky, S. L. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.007 · Cited by 66 · see citing works

Interaxonal Interaction Defines Tiled Presynaptic Innervation in C. elegans

Mizumoto, K., & Shen, K. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.031 · Cited by 65 · see citing works

Semaphorin 4B interacts with the post‐synaptic density protein PSD‐95/SAP90 and is recruited to synapses through a C‐terminal PDZ‐binding motif

Burkhardt, C., Müller, M., Badde, A., Garner, C. C., Gundelfinger, E. D., & Püschel, A. W. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.05.079 · Cited by 64 · see citing works

Sema4C, a Transmembrane Semaphorin, Interacts with a Post-synaptic Density Protein, PSD-95

Inagaki, S., Ohoka, Y., Sugimoto, H., Fujioka, S., Amazaki, M., Kurinami, H., Miyazaki, N., Tohyama, M., & Furuyama, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009051200 · Cited by 63 · see citing works

Specificity of Monosynaptic Sensory-Motor Connections Imposed by Repellent Sema3E-PlexinD1 Signaling

Fukuhara, K., Imai, F., Ladle, D. R., Katayama, K., Leslie, J. R., Arber, S., Jessell, T. M., & Yoshida, Y. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.005 · Cited by 57 · see citing works

Presynaptic Activity and CaMKII Modulate Retrograde Semaphorin Signaling and Synaptic Refinement

Carrillo, R. A., Olsen, D. P., Yoon, K. S., & Keshishian, H. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.005 · Cited by 55 · see citing works

Class 3 Semaphorin Mediates Dendrite Growth in Adult Newborn Neurons through Cdk5/FAK Pathway

Ng, T., Ryu, J. R., Sohn, J. H., Tan, T., Song, H., Ming, G., & Goh, E. L. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065572 · Cited by 53 · see citing works

The class 4 Semaphorin Sema4D promotes the rapid assembly of GABAergic synapses in rodent hippocampus

Kuzirian, M., Moore, A. R., Staudenmaier, E. K., Friedel, R. H., & Paradis, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0989-13.2013 · Cited by 53 · see citing works

Semaphorin 3A induces CaV2.3 channel-dependent conversion of axons to dendrites

Nishiyama, M., Togashi, K., von Schimmelmann, M. J., Lim, C., Maeda, S.-I., Yamashita, N., Goshima, Y., Ishii, S., & Hong, K. (2011) · Nature Cell Biology · doi:10.1038/ncb2255 · Cited by 49 · see citing works

Semaphorin4F interacts with the synapse‐associated protein SAP90/PSD‐95

Schultze, W., Eulenburg, V., Leßmann, V., Herrmann, L., Dittmar, T., Gundelfinger, E. D., Heumann, R., & Erdmann, K. S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00447.x · Cited by 45 · see citing works

Sema4D localizes to synapses and regulates GABAergic synapse development as a membrane-bound molecule in the mammalian hippocampus

Raissi, A. J., Staudenmaier, E. K., David, S. S., Hu, L. S., & Paradis, S. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.08.004 · Cited by 35 · see citing works

Role of microRNAs in Semaphorin function and neural circuit formation

Baudet, M., Bellon, A., & Holt, C. E. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.11.004 · Cited by 25 · see citing works

Neuropilin-1 biases dendrite polarization in the retina

Kita, E. M., Bertolesi, G. E., Hehr, C. L., Johnston, J., & McFarlane, S. (2013) · Development · doi:10.1242/dev.088286 · Cited by 18 · see citing works

Sculpting Neural Circuits by Axon and Dendrite Pruning

Riccomagno, M. M., & Kolodkin, A. L. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013038 · Cited by 366 · see citing works

Neuron-glia signaling in synapse elimination

Wilton, D. K., Dissing-Olesen, L., & Stevens, B. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050306 · Cited by 332 · see citing works

Synaptic Specificity, Recognition Molecules, and Assembly of Neural Circuits

Sanes, J. R., & Zipursky, S. L. (2020) · Cell · doi:10.1016/j.cell.2020.04.008 · Cited by 327 · see citing works

Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2

Zhou, X., Wahane, S., Friedl, M.-S., Kluge, M., Friedel, C. C., Avrampou, K., Zachariou, V., Guo, L., Zhang, B., He, X., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0597-7 · Cited by 275 · see citing works

Rewiring the taste system

Lee, H. X., Macpherson, L. J., Parada, C. A., Zuker, C. S., & Ryba, N. J. P. (2017) · Nature · doi:10.1038/nature23299 · Cited by 141 · see citing works

Neuron-Glia Interactions in Neural Plasticity: Contributions of Neural Extracellular Matrix and Perineuronal Nets

Dzyubenko, E., Gottschling, C., & Faissner, A. (2016) · Neural Plasticity · doi:10.1155/2016/5214961 · Cited by 134 · see citing works

Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4

Tan, C., Lu, N., Wang, C., Chen, D.-Y., Sun, N.-H., Lyu, H., Körbelin, J., Shi, W., Fukunaga, K., Lu, Y., et al. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.036 · Cited by 126 · see citing works

Retrograde semaphorin–plexin signalling drives homeostatic synaptic plasticity

Orr, B. O., Fetter, R. D., & Davis, G. W. (2017) · Nature · doi:10.1038/nature24017 · Cited by 111 · see citing works

Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold

Duan, X., Krishnaswamy, A., Laboulaye, M. A., Liu, J., Peng, Y., Yamagata, M., Toma, K., & Sanes, J. R. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.019 · Cited by 105 · see citing works

Structural Perspectives on Axon Guidance

Seiradake, E., Jones, E. Y., & Klein, R. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125008 · Cited by 92 · see citing works

Semaphorins in health and disease

Fard, D., & Tamagnone, L. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.05.006 · Cited by 81 · see citing works

Transmembrane semaphorins, forward and reverse signaling: have a look both ways

Battistini, C., & Tamagnone, L. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2137-x · Cited by 80 · see citing works

Neuroprotective effects of dexmedetomidine against hyperoxia-induced injury in the developing rat brain

Endesfelder, S., Makki, H., von Haefen, C., Spies, C., Bührer, C., & Sifringer, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171498 · Cited by 79 · see citing works

γ‐Aminobutyric acid receptor alpha 1 subunit loss of function causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment

Samarut, É., Swaminathan, A., Riché, R., Liao, M., Hassan-Abdi, R., Renault, S., Allard, M., Dufour, L., Cossette, P., Soussi‐Yanicostas, N., et al. (2018) · Epilepsia · doi:10.1111/epi.14576 · Cited by 76 · see citing works

Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons

Wang, Q., Chiu, S., Koropouli, E., Hong, I., Mitchell, S., Easwaran, T. P., Hamilton, N. R., Gustina, A. S., Zhu, Q., Ginty, D. D., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.029 · Cited by 72 · see citing works

The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

de Winter, F., Kwok, J. C. F., Fawcett, J. W., Vo, T. T., Carulli, D., & Verhaagen, J. (2016) · Neural Plasticity · doi:10.1155/2016/3679545 · Cited by 84 · see citing works

Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair

Xia, J., Swiercz, J. M., Bañón‐Rodríguez, I., Matković, I., Federico, G., Sun, T., Franz, T., Brakebusch, C., Kumanogoh, A., Friedel, R. H., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.02.001 · Cited by 69 · see citing works

Mechanistic advances in axon pathfinding

McCormick, L. E., & Gupton, S. L. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2019.12.003 · Cited by 68 · see citing works

Origin and evolution of plexins, semaphorins, and Met receptor tyrosine kinases

Junqueira Alves, C., Yotoko, K., Zou, H., & Friedel, R. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-38512-y · Cited by 72 · see citing works

The CNS/PNS Extracellular Matrix Provides Instructive Guidance Cues to Neural Cells and Neuroregulatory Proteins in Neural Development and Repair

Melrose, J., Hayes, A. J., & Bix, G. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115583 · Cited by 63 · see citing works

A de novo microdeletion of SEMA5A in a boy with autism spectrum disorder and intellectual disability

Mosca‐Boidron, A., Gueneau, L., Huguet, G., Goldenberg, A., Henry, C., Gigot, N., Pallesi‐Pocachard, E., Falace, A., Duplomb, L., Thévenon, J., et al. (2015) · European Journal of Human Genetics · doi:10.1038/ejhg.2015.211 · Cited by 63 · see citing works

On the Teneurin track: a new synaptic organization molecule emerges

Mosca, T. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00204 · Cited by 60 · see citing works

Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function

Blockus, H., Rolotti, S. V., Szoboszlay, M., Pezé-Heidsieck, E., Ming, T., Schroeder, A., Apóstolo, N., Vennekens, K. M., Katsamba, P. S., Bahna, F. A., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109828 · Cited by 62 · see citing works

Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1

Liu, X., Uemura, A., Fukushima, Y., Yoshida, Y., & Hirashima, M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.008 · Cited by 60 · see citing works

Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion

Alves, C. J., Dariolli, R., Haydak, J. C., Kang, S., Hannah, T. C., Wiener, R. J., DeFronzo, S., Tejero, R., Gusella, G. L., Ramakrishnan, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26296-7 · Cited by 54 · see citing works

Guiding synaptic plasticity: Novel roles for netrin‐1 in synaptic plasticity and memory formation in the adult brain

Glasgow, S. D., Ruthazer, E. S., & Kennedy, T. E. (2020) · The Journal of Physiology · doi:10.1113/jp278704 · Cited by 53 · see citing works

Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons

Meltzer, S., Yadav, S., Lee, J., Soba, P., Younger, S. H., Jin, P., Zhang, W., Parrish, J. Z., Jan, L. Y., & Jan, Y. N. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.020 · Cited by 51 · see citing works

A Dense Starburst Plexus Is Critical for Generating Direction Selectivity

Morrie, R. D., & Feller, M. B. (2018) · Current Biology · doi:10.1016/j.cub.2018.03.001 · Cited by 43 · see citing works

Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10

Venkatasubramanian, L., Guo, Z., Xu, S., Tan, L., Xiao, Q., Nagarkar-Jaiswal, S., & Mann, R. S. (2019) · eLife · doi:10.7554/elife.42692 · Cited by 41 · see citing works

Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury

Mehrotra, P., Jablonski, J., Toftegaard, J., Zhang, Y., Shahini, S., Wang, J., Hung, C. W., Ellis, R., Kayal, G., Rajabian, N., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53276-4 · Cited by 47 · see citing works

Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

Jongbloets, B. C., Lemstra, S., Schellino, R., Broekhoven, M. H., Parkash, J., Hellemons, A. J. C. G. M., Mao, T., Giacobini, P., van Praag, H., Marchis, S. D., et al. (2017) · Nature Communications · doi:10.1038/ncomms14666 · Cited by 42 · see citing works

Axon Guidance Molecules and Neural Circuit Remodeling After Spinal Cord Injury

Hollis, E. R., II (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0416-0 · Cited by 44 · see citing works

Mechanisms regulating dendritic arbor patterning

Ledda, F., & Paratcha, G. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2588-8 · Cited by 44 · see citing works

Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus

McDermott, J. E., Goldblatt, D., & Paradis, S. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.06.008 · Cited by 41 · see citing works

Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease

Huang, Y., Wang, M., Ni, H., Zhang, J., Li, A., Hu, B., Junqueira Alves, C., Wahane, S., Rios de Anda, M., Ho, L., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01664-w · Cited by 42 · see citing works

Close Homolog of L1 Regulates Dendritic Spine Density in the Mouse Cerebral Cortex Through Semaphorin 3B

Mohan, V., Wade, S. D., Sullivan, C. S., Kasten, M. R., Sweetman, C., Stewart, R. K., Truong, Y. K.-N., Schachner, M., Manis, P. B., & Maness, P. F. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2984-18.2019 · Cited by 43 · see citing works

Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy

Lee, P. S.-Y., Gao, N., Dike, M., Shkilnyy, O., Me, R., Zhang, Y., & Yu, F. X. (2019) · Diabetes · doi:10.2337/db18-1172 · Cited by 41 · see citing works

Structure and Function of Roundabout Receptors

Bisiak, F., & McCarthy, A. A. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-28151-9_9 · Cited by 36 · see citing works

Semaphorin3F Drives Dendritic Spine Pruning Through Rho-GTPase Signaling

Duncan, B. W., Mohan, V., Wade, S. D., Truong, Y. K.-N., Kampov-Polevoi, A., Temple, B. R. S., & Maness, P. F. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02373-2 · Cited by 33 · see citing works

Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching

Xu, C., Li, Z., Lyu, C., Hu, Y., McLaughlin, C. N., Wong, K. K. L., Xie, Q., Luginbuhl, D. J., Li, H., Udeshi, N. D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.06.022 · Cited by 32 · see citing works

Activity-Dependent Synaptic Refinement: New Insights from Drosophila

Vonhoff, F., & Keshishian, H. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00023 · Cited by 31 · see citing works

Altered hippocampal-dependent memory and motor function in neuropilin 2–deficient mice

Shiflett, M. W., Gavin, M., & Tran, T. S. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.17 · Cited by 29 · see citing works

Stepwise wiring of the Drosophila olfactory map requires specific Plexin B levels

Li, J., Guajardo, R., Xu, C., Wu, B., Li, H., Li, T., Luginbuhl, D. J., Xie, X., & Luo, L. (2018) · eLife · doi:10.7554/elife.39088 · Cited by 26 · see citing works

Transcriptomic analysis of the hippocampus from six inbred strains of mice suggests a basis for sex‐specific susceptibility and severity of neurological disorders

Vied, C., Ray, S., Badger, C., Bundy, J. L., Arbeitman, M. N., & Nowakowski, R. S. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.23989 · Cited by 24 · see citing works

Development of synaptic connectivity in the retinal direction selective circuit

Morrie, R. D., & Feller, M. B. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.06.009 · Cited by 23 · see citing works

In VivoCalcium Signaling during Synaptic Refinement at theDrosophilaNeuromuscular Junction

Vonhoff, F., & Keshishian, H. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2922-16.2017 · Cited by 22 · see citing works

Genetic Inactivation of Cholinergic C Bouton Output Improves Motor Performance but not Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

Konsolaki, E., Koropouli, E., Tsape, E., Pothakos, K., & Zagoraiou, L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.047 · Cited by 21 · see citing works

Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6‐dependent pathway

Wiegreffe, C., Wahl, T., Joos, N. S., Bonnefont, J., Vanderhaeghen, P., Liu, P., & Britsch, S. (2022) · EMBO Reports · doi:10.15252/embr.202154104 · Cited by 17 · see citing works

Reduced hippocampal inhibition and enhanced autism-epilepsy comorbidity in mice lacking neuropilin 2

Eisenberg, C., Subramanian, D., Afrasiabi, M., Ziobro, P., DeLucia, J., Hirschberg, P. R., Shiflett, M. W., Santhakumar, V., & Tran, T. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01655-6 · Cited by 20 · see citing works

Mechanisms of Development

ten Donkelaar, H. J., & Fritzsch, B. (2023) · Springer eBooks · doi:10.1007/978-3-031-26098-8_2 · Cited by 20 · see citing works

Helicobacter pylori promotes gastric cancer progression by upregulating semaphorin 5A expression via ERK/MMP9 signaling

Pan, G., Wang, X., Wang, Y., Li, R., Geng, L., He, Y., Liu, S., Luo, Y., Wang, L., & Lei, Z. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.06.002 · Cited by 19 · see citing works

Tempo and mode of gene expression evolution in the brain across primates

Rickelton, K., Zintel, T. M., Pizzollo, J., Miller, E., Ely, J. J., Raghanti, M. A., Hopkins, W. D., Hof, P. R., Sherwood, C. C., Bauernfeind, A. L., et al. (2024) · eLife · doi:10.7554/elife.70276 · Cited by 18 · see citing works

Roundabout receptor 2 maintains inhibitory control of the adult midbrain

Gore, B. B., Miller, S. M., Jo, Y. S., Baird, M. A., Hoon, M., Sanford, C. A., Hunker, A. C., Lu, W., Wong, R., & Zweifel, L. S. (2017) · eLife · doi:10.7554/elife.23858 · Cited by 19 · see citing works

The Sema3A receptor Plexin-A1 suppresses supernumerary axons through Rap1 GTPases

Wang, N., Dhumale, P., Chiang, J., & Püschel, A. W. (2018) · Scientific Reports · doi:10.1038/s41598-018-34092-5 · Cited by 19 · see citing works

Transcriptome Analysis of iPSC-Derived Neurons from Rubinstein-Taybi Patients Reveals Deficits in Neuronal Differentiation

Calzari, L., Barcella, M., Alari, V., Braga, D., Muñoz‐Viana, R., Barlassina, C., Finelli, P., Gervasini, C., Barco, Á., Russo, S., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01983-6 · Cited by 18 · see citing works

Nr4a1 regulates cell-specific transcriptional programs in inhibitory GABAergic interneurons

Huang, M., Pieraut, S., Cao, J., Polli, F. S., Roncacè, V., Shen, G., Ramos-Medina, C., Lee, H., & Maximov, A. (2024) · Neuron · doi:10.1016/j.neuron.2024.03.018 · Cited by 17 · see citing works

Molecular mechanisms regulating synaptic specificity and retinal circuit formation

Graham, H. K., & Duan, X. (2020) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.379 · Cited by 16 · see citing works

Towards an understanding of semaphorin signalling in the spinal cord

O'Malley, A., Shanley, D. K., Kelly, A. T., & Barry, D. (2014) · Gene · doi:10.1016/j.gene.2014.10.005 · Cited by 15 · see citing works

Extrinsic Factors Regulating Dendritic Patterning

Lin, T., Chen, P., Yu, H., Hsu, C., & Lee, C. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.622808 · Cited by 14 · see citing works

Dysregulation of neuropilin-2 expression in inhibitory neurons impairs hippocampal circuit development and enhances risk for autism-related behaviors and seizures

Subramanian, D., Eisenberg, C., Huang, A., Baek, J., Naveed, H., Komatireddy, S., Shiflett, M. W., Tran, T. S., & Santhakumar, V. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02839-4 · Cited by 13 · see citing works

Genetic Deletion of GABAA Receptors Reveals Distinct Requirements of Neurotransmitter Receptors for GABAergic and Glutamatergic Synapse Development

Duan, J., Pandey, S., Li, T., Castellano, D., Gu, X., Li, J., Tian, Q., & Lü, W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00217 · Cited by 13 · see citing works

Semaphorin-Mediated Corticospinal Axon Elimination Depends on the Activity-Induced Bax/Bak-Caspase Pathway

Gu, Z., Koppel, N., Kalamboglas, J., Alexandrou, G., Li, J., Craig, C., Simon, D. J., Tessier‐Lavigne, M., Baccei, M. L., Martin, J. H., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.3190-18.2020 · Cited by 13 · see citing works

Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

Koropouli, E., Wang, Q., Mejı́as, R., Hand, R., Wang, T., Ginty, D. D., & Kolodkin, A. L. (2023) · eLife · doi:10.7554/elife.83217 · Cited by 12 · see citing works

Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation

Adel, S. S., Pranske, Z. J., Kowalski, T. F., Kanzler, N., Ray, R., Carmona, C., & Paradis, S. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103920 · Cited by 11 · see citing works

Aerobic Exercise Induces Alternative Splicing of Neurexins in Frontal Cortex

Innocenzi, E., Cariati, I., Domenico, E. D., Tiberi, E., D’Arcangelo, G., Verdile, V., Paronetto, M. P., Tancredi, V., Barchi, M., Rossi, P., et al. (2021) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk6020048 · Cited by 12 · see citing works

Evolution and Diversity of Semaphorins and Plexins in Choanoflagellates

Junqueira Alves, C., Silva Ladeira, J., Hannah, T., Pedroso Dias, R. J., Zabala Capriles, P. V., Yotoko, K., Zou, H., & Friedel, R. H. (2021) · Genome Biology and Evolution · doi:10.1093/gbe/evab035 · Cited by 11 · see citing works

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Gaspari, S., Quenneville, S., Sánchez-Archidona, A. R., Thorens, B., & Croizier, S. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25312 · Cited by 10 · see citing works

Neuropathological Findings in a Case of Parkinsonism and Developmental Delay Associated with a Monoallelic Variant in PLXNA1

O’Shea, S. A., Hickman, R. A., Cortes, E. P., Vonsattel, J. P., Fahn, S., Okur, V., Alcalay, R. N., & Chung, W. K. (2021) · Movement Disorders · doi:10.1002/mds.28756 · Cited by 10 · see citing works

Dpr10 and Nocte are required for Drosophila motor axon pathfinding

Lobb-Rabe, M., DeLong, K., Salazar, R. J., Zhang, R., Wang, Y., & Carrillo, R. A. (2022) · Neural Development · doi:10.1186/s13064-022-00165-5 · Cited by 10 · see citing works

Optogenetic and Endogenous Modulation of Ca2+ Signaling in Schwann Cells: Implications for Autocrine and Paracrine Neurotrophic Regulation

Numata, T., Tsutsumi, M., & Sato-Numata, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189082 · Cited by 9 · see citing works

Neurovascular patterning cues and implications for central and peripheral neurological disease

Kalani, M. S., Gamboa, N., Taussky, P., Park, M., Couldwell, W., & Mahan, M. (2017) · Surgical Neurology International · doi:10.4103/sni.sni_475_16 · Cited by 9 · see citing works

Cadherins: potential regulators in the faculty of language

Matsunaga, E., & Okanoya, K. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.06.001 · Cited by 8 · see citing works

Functional divergence of Plexin B structural motifs in distinct steps of Drosophila olfactory circuit assembly

Guajardo, R., Luginbuhl, D. J., Han, S., Luo, L., & Li, J. (2019) · eLife · doi:10.7554/elife.48594 · Cited by 8 · see citing works

Axon guidance: semaphorin/neuropilin/plexin signaling

Verhagen, M. G., & Pasterkamp, R. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814407-7.00005-5 · Cited by 8 · see citing works

Plexin-B1 safeguards astrocyte agility and glial alignment to facilitate wound corralling and axon pathfinding in mouse spinal cord injury model

Ni, H., Zhou, Z., Estill, M. S., Halawani, D., Alves, C. J., Shen, L., Xie, N., Friedel, R. H., & Zou, H. (2025) · Nature Communications · doi:10.1038/s41467-025-65095-2 · Cited by 7 · see citing works

Repurposing developmental mechanisms in the adult nervous system

Hunyara, J. L., & Kolodkin, A. L. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.04.006 · Cited by 6 · see citing works

Plexins promote Hedgehog signaling through their cytoplasmic GAP activity

Pinskey, J. M., Hoard, T. M., Zhao, X., Franks, N. E., Frank, Z. C., McMellen, A. N., Giger, R. J., & Allen, B. L. (2022) · eLife · doi:10.7554/elife.74750 · Cited by 6 · see citing works

Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules

Primak, A. L., Дмитриевич, Б. К., Rubina, K. A., Станиславович, Д. С., Neyfeld, E. A., Illarionova, M. E., Semina, E. V., Sheleg, D., Va, T., & Karagyaur, M. N. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1361764 · Cited by 6 · see citing works

Modulation of netrin-1/DCC signaling pathway by Jiawei Kongsheng Zhenzhong Pill improves synaptic structural plasticity in PSD rats

Zhao, Y., Song, A., Liu, G., Chen, Q., Wu, Q., Gao, Z., Li, Z., Yu, H., & Wu, Z. (2025) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2025.02.004 · Cited by 5 · see citing works

Functions of Neuropilins in Wiring the Nervous System and Their Role in Neurological Disorders

Shiflett, M. W., Martinez, E. A., Khdour, H. Y., & Tran, T. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-48824-0_8 · Cited by 4 · see citing works

Cell-surface Milieu Remodeling in Human Dendritic Cell Activation

Udeshi, N. D., Xu, C., Jiang, Z., Gao, S. M., Yin, Q., Luo, W., Carr, S. A., Davis, M. M., & Li, J. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2400089 · Cited by 5 · see citing works

Viral modulation of synaptic pruning: implications for neuropathology and brain function

Aliakbari, S., Asadi, S., Sayyah, M., Naderi, N., Salarvandian, S., Khodagholi, F., & Pourbadie, H. G. (2026) · Journal of Virology · doi:10.1128/jvi.01684-25 · Cited by 4 · see citing works

Generation of Plexin‐ B1 Conditional Knockout Mouse With CRISPR /Cas9 Technology

Ni, H., Kelley, K. A., Xie, N., Zou, H., & Friedel, R. H. (2025) · genesis · doi:10.1002/dvg.70019 · Cited by 3 · see citing works

Activin A enhances neurofunctional recovery following traumatic spinal cord injury by inhibiting autophagy

Yu, L., Yin, Z., Huang, R., Liu, Z., Liu, Y., Zheng, X., Song, S., Wang, Z., He, X., Bai, Y., et al. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01021 · Cited by 2 · see citing works

Differential gene expression profile analysis in corticosterone-treated PC12 cells.

Zhao, J., Zhang, P., Li, L., Chen, S., Joines, A., Wu, D., Wong, M., Shahan, J., Golden, T. A., Wu, N., et al. (2018) · PubMed Central · Cited by 2 · see citing works

Semaphorin Receptors Antagonize Wnt Signaling Through Beta-Catenin DegradationPreprint

Hoard, T. M., Liu, K. A., Cadigan, K. M., Giger, R. J., & Allen, B. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.29.596372 · Cited by 2 · see citing works

TheDrosophilaLarval Neuromuscular Junction: Developmental OverviewPreprint

Ashley, J., & Carrillo, R. A. (2024) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top108449 · Cited by 2 · see citing works

Multiscale Spatial Transcriptomic Atlas of Human Basal Ganglia Cell-Type and Cellular Community OrganizationPreprint

Berackey, B. T., Tan, Z., Wu, G., Das, S. C., Ren, L., Esser, B., Ye, Q., Nafisi, M., Park, S. S., Mendieta, P. A. S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.02.691876 · Cited by 4 · see citing works

Plexin B3 guides axons to cross the midline in vivo

Liu, Z.-Z., Liu, L., Zhu, L.-Y., Zhu, J. K., Luo, J.-Y., Wang, Y.-F., & Xu, H. A. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1292969 · Cited by 1 · see citing works

Coordinated Pre- and Postsynaptic Protein Dynamics Underlie Rapid Sema4D-Induced Inhibitory Synapse Assembly

Pranske, Z. J., & Paradis, S. (2026) · eNeuro · doi:10.1523/eneuro.0140-26.2026 · Cited by 1 · see citing works

Integration of Semaphorin/Plexin activation and amplification by a Neuropilin-like coreceptor ensures robust homeostatic plasticity.

Vicidomini, R., Han, T. H., Hsieh, W.-C., Nguyen, P., Li, J.-F., Giniger, E., & Serpe, M. (2026) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2604252123 · Cited by 1 · see citing works

Regressive Phenomena: Refining Connections

Agnew-Svoboda, W., Kolodkin, A. L., & Riccomagno, M. M. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3474-4_132 · Cited by 1 · see citing works

Semaphorin signaling restricts neuronal regeneration in C. elegans

Harreguy, M. B., Tanvir, Z., Shah, E., Simprevil, B., Tran, T. S., & Haspel, G. (2021) · bioRxiv · doi:10.3389/fcell.2022.814160 · Cited by 1 · see citing works

Regressive Phenomena: Refining Connections

Agnew-Svoboda, W., Kolodkin, A. L., & Riccomagno, M. M. (2022) · Springer eBooks · doi:10.1007/978-3-030-88832-9_132 · Cited by 1 · see citing works

Axon Guidance Signaling Modulates Epithelial to Mesenchymal Transition in Stem Cell-Derived Retinal Pigment EpitheliumPreprint

Sripathi, S. R., Liu, M. M., Hu, M.-W., Wan, J., Cheng, J., Duan, Y., Mertz, J. L., Wahlin, K. J., Maruotti, J., Berlinicke, C. A., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/264705 · Cited by 1 · see citing works

Nr4a1 regulates inhibitory circuit structure and function in the mouse brainPreprint

Huang, M., Pieraut, S., Cao, J., Polli, F. S., Roncacè, V., Shen, G., & Maximov, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.14.496205 · Cited by 1 · see citing works

Human Neuron and Mouse Models Reveal Synaptic Imbalance in Kabuki SyndromePreprint

Wenninger, A., Knopp, J., Frye, S., Weaver, A., McAdams, N., Miller, S., Nomura, T., Whitlark, A., Swantkowski, J., Noble, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.04.616738 · Cited by 1 · see citing works

The multifunctional role of Semaphorin6A during brain development and disease

Verhagen, M. G. (2021) · doi:10.33540/671

Plexins

Worzfeld, T. (2021) · Springer eBooks · doi:10.1007/978-3-030-57401-7_198

Regressive Phenomena: Refining Connections

Agnew-Svoboda, W., Kolodkin, A. L., & Riccomagno, M. M. (2015) · Springer eBooks · doi:10.1007/978-1-4614-6434-1_132-1

Semaphorin Regulation of Neural Circuit Assembly in the Central Nervous System

Hand, R., & Kolodkin, A. L. (2015) · Springer eBooks · doi:10.1007/978-4-431-54385-5_2 · Cited by 2 · see citing works

Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins

Limoni, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116111 · Cited by 17 · see citing works

Semaphorin Signaling in Vertebrate Neural Circuit Assembly

Yoshida, Y. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00071 · Cited by 81 · see citing works

Semaphorin function in neural plasticity and disease

Pasterkamp, R. J., & Giger, R. J. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.06.001 · Cited by 227 · see citing works

Reviewed by:

Burgess, R., Jackson, T., & Washington, F. S. (2012)