The DOI matches its Crossref record; 221 of the 221 references it cites were found in a registry or an index.
Neurobiology of Feeding and Energy Expenditure
Abstract
Significant advancements have been made in the past century regarding the neuronal control of feeding behavior and energy expenditure. The effects and mechanisms of action of various peripheral metabolic signals on the brain have become clearer. Molecular and genetic tools for visualizing and manipulating individual components of brain homeostatic systems in combination with neuroanatomical, electrophysiological, behavioral, and pharmacological techniques have begun to elucidate the molecular and neuronal mechanisms of complex feeding behavior and energy expenditure. This review highlights some of these advancements that have led to the current understanding of the brain's involvement in the acute and chronic regulation of energy homeostasis.
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In the citing paper
“Increasing body weight above healthy lean levels results in changes in glucose metabolism, insulin sensitivity and hormones, such as leptin, ghrelin, NPY, orexin and hypocretin, [GLP-1] which, in turn, regulate appetite and energy homeostasis”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Gao & Horvath, 2007
In the citing paper
“Specific hypothalamic nuclei, which sense nutrients and modify energy intake and expenditure to maintain a balance, are responsible for regulating this intake ([48](#B48)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [48]
In the citing paper
“These neurons are well known to be involved in feeding and food reward processing [18, 19].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [19]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214
Research works printed but not linked: 17
- Adan RA, 1994, Mol. Pharmacol., 46, 1182
- Brobeck JR, 1943, Yale J. Biol. Med., 15, 831
- 10.1002/(SICI)1096-9861(19981228)402:4<442::AID-CNE2>3.3.CO;2-I · DOI
- 10.1210/en.143.1.239 · DOI · Paper page
- 10.1210/en.142.7.3265 · DOI
- 10.1210/en.143.1.155 · DOI
- Ludwig DS, 1998, Am. J. Physiol., 274, 627
- 10.1210/en.143.2.607 · DOI
- 10.1210/me.11.4.415 · DOI
- 10.1210/me.8.10.1298 · DOI
- 10.1210/me.15.10.1748 · DOI
- Smith GP, 1985, Am. J. Physiol., 249, 638
- 10.1210/en.139.10.4420 · DOI
- Tejwani GA, 1986, NIDA Res. Monogr., 75, 497
- 10.1210/en.132.5.1939 · DOI
- 10.1210/en.141.4.1332 · DOI
- 10.1210/en.138.3.1240 · DOI
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Jänig, W. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.02049-0
Multiple loci of intra- and extra-hypothalamic leptin receptor expression and action in the mouse
Leshan, R. L. (2009) · Deep Blue (University of Michigan)
Computação por assembleias neurais em redes neurais pulsadas.
Ribeiro, J. H. R. (2011) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.3.2011.tde-16032012-112119
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Rathjen, T. (2015) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-6345
Malandrino, M. I. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
A sideway glance: a new role for endoplasmic reticulum chemical chaperones as leptin sensitizers
Gaetani, S. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0138-1
Comportamento alimentare e i suoi disturbi nell’adulto
Basdevant, A., Gougis, S., & Ciangura, C. (2009) · EMC - AKOS - Trattato di Medicina · doi:10.1016/s1634-7358(09)70358-4
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Aerobic capacity muscles its way into the energy balance equation
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Malmberg, J. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
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Martins, L., Whittle, A. J., Nogueiras, R., Vidal‐Puig, A., Diéguez, C., & López, M. (2013) · Springer eBooks · doi:10.1007/978-3-319-01008-3_7
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Metadata
- Authors
- Gao, Q., & Horvath, T. L.
- Affiliations
- Yale University (US)
- Section of Comparative Medicine and Departments of 2Neurobiology and 3Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520;,
- ORCID
- Gao, Qian
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2007-07-01
- Volume
- 30
- Issue
- 1
- Pages
- 367-398
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2124738442
- Cited by
- 346
- References
- 221
- Citations by year
- 2025: 6 · 2024: 8 · 2023: 4 · 2022: 15 · 2021: 14 · 2020: 20 · 2019: 11 · 2018: 20 · 2017: 15 · 2016: 34 · 2015: 21 · 2014: 22 · 2013: 33 · 2012: 22
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG022880, AG-022880)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 060711, DK074386, R01DK074386, R01DK060711)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- feeding behavior, energy expenditure, energy homeostasis
- MeSH terms
- Animals, Appetite Regulation, Energy Metabolism, Feeding Behavior, Hormones, Humans, Hypothalamus, Motivation, Neural Pathways, Leptin, Melanocortins
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