Cited by 109Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancerNeurogenesis and neuroplasticity mechanisms

Granulocyte-Macrophage Colony-Stimulating Factor Induces an Expression Program in Neonatal Microglia That Primes Them for Antigen Presentation

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Re, Fabio, Belyanskaya, Svetlana L, Riese, Richiard J, Cipriani, Barbara, Fischer, Falko R, Granucci, Francesca, Ricciardi-Castagnoli, Paola, Brosnan, Celia +3 more·2002·The Journal of Immunology

Abstract

Neonatal microglial cells respond to GM-CSF and M-CSF by acquiring different morphologies and phenotypes. To investigate the extent and consequences of this process, a global gene expression analysis was performed, with significant changes in transcript levels confirmed by biochemical analyses. Primary murine microglial cells underwent substantial expression reprogramming after treatment with GM-CSF or M-CSF with many differentially expressed transcripts important in innate and adaptive immunity. In particular, many gene products involved in Ag presentation were induced by GM-CSF, but not M-CSF, thus potentially priming relatively quiescent microglia cells for Ag presentation. This function of GM-CSF is distinct from its primary function in cell proliferation and survival.

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Crossref · 10.4049/jimmunol.169.5.2264

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Colony-stimulating factors have opposite effects on MHCII, and subsequently on neuroinflammation, in mouse and human microglia.

    “Moreover, colony-stimulating factors have been shown to have opposite effects on MHCII, and subsequently, on neuroinflammation, in mouse and human microglia.20, 21”

    From Tubular human brain organoids to model microglia-mediated neuroinflammation (2021) · cites this paper as [21]

    The Ag presentation section reports that GM-CSF increased class II MHC protein in neonatal mouse microglia, while M-CSF did not; the Discussion links GM-CSF to proinflammatory activity. The paper does not establish opposite MHCII effects in mouse versus human microglia or show that such a difference subsequently changes neuroinflammation. (LLM, conf=0.87)

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Authors
Re, F., Belyanskaya, S. L., Riese, R. J., Cipriani, B., Fischer, F. R., Granucci, F., Ricciardi-Castagnoli, P., Brosnan, C., Stern, L. J., Strominger, J. L., & Santambrogio, L.
Affiliations
  • Dana-Farber Cancer Institute (US)
  • Brigham and Women's Hospital (US)
  • Albert Einstein College of Medicine (US)
  • Justus-Liebig-Universität Gießen (DE)
  • University of Milano-Bicocca (IT)
  • Department of Biotechnology and Bioscience, University of Milano-Bicocca , Milan ,
  • Massachusetts Institute of Technology (US)
Corresponding author
  • Re, Fabio
  • Santambrogio, Laura
Venue
The Journal of Immunology
Published
2002-09-01
Volume
169
Issue
5
Pages
2264-2273
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
OpenAlex
W2116369972
Cited by
109
References
56
Citations by year
2025: 3 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 4 · 2015: 4 · 2014: 2 · 2013: 10 · 2012: 4
FWCI
6.24
Type
journal article
Language
en
Open access
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
  • Zenodo (CERN European Organization for Nuclear Research) (other-oa)
Funders
  • National Institutes of Health (5r35ca047554-13, AI48833)
  • National Cancer Institute (R35CA47554)
  • National Institute of Allergy and Infectious Diseases (R01-AI-48832, R01-AI48833, R01AI048833, R01AI048832)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
GM-CSF, microglia, macrophage colony-stimulating factor, gene expression reprogramming, antigen presentation, microglial activation, innate immunity, adaptive immunity
MeSH terms
Animals, Animals, Newborn, Cathepsins, Cells, Cultured, Dendritic Cells, Macrophages, Mice, Inbred Strains, Phagocytosis, Receptors, Immunologic, Biomarkers, Macrophage Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Cytokines, Microglia, Antigen Presentation, Receptors, Cytokine, Chemokines, Receptors, Chemokine, Oligonucleotide Array Sequence Analysis, Matrix Metalloproteinases, Gene Expression Profiling, Mice

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