Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes.

Slavin, B G; Ong, J M; Kern, P A

doi:10.1016/s0022-2275(20)41151-4

Cited by 261Lipid metabolism and biosynthesisLipid metabolism and disordersPeroxisome Proliferator-Activated Receptors

Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes.

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Slavin, B G, Ong, J M, Kern, P A·1994·Journal of Lipid Research

DOI 10.1016/s0022-2275(20)41151-4

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Abstract

Hormone-sensitive lipase (HSL) mediates the lipolysis of triacylglycerol from mammalian adipocytes, resulting in the release of non-esterified fatty acids and glycerol. Although numerous studies have examined the hormonal regulation of HSL, the measurement of HSL mRNA levels in response to hormonal regulators has not been studied. This study was designed to determine the effects of epinephrine, growth hormone, glucagon, and dexamethasone on HSL expression by measuring HSL mRNA levels and glycerol release in primary cultures of rat adipocytes. Exposure of adipocytes to epinephrine at 10(-7) M and 10(-5) M for 4 h resulted in an increase in medium glycerol (209 +/- 46%, and 284 +/- 58% of control, P < 0.001, respectively). However, no change in HSL mRNA levels occurred due to the epinephrine treatment. Similarly, the peptides glucagon (10(-7) M and 10(-5) M for 4 h) and growth hormone (100 ng/ml for 24 h) resulted in increased medium glycerol and had no effect on HSL mRNA levels in adipocytes. Dexamethasone was added to adipocyte cultures for 4 and 24 h, and resulted in a dose-dependent increase of medium glycerol (102 +/- 8%, 138 +/- 8% (P < 0.001), and 168 +/- 24% (P < 0.001) for 10(-8) M, 10(-7) M, and 10(-6) M, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)

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Hormone-sensitive lipase, a major regulator of adipose tissue lipolysis, was demonstrated to be regulated by GCs.
“hormone-sensitive lipase, a major regulator of adipose tissue lipolysis was demonstrated to be regulated by GCs [42]”
From Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial (2011) · cites this paper as [42]

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease.
Després, J. P., Moorjani, S., Lupien, P. J., Tremblay, A., Nadeau, A., & Bouchard, C. (1990) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.10.4.497 · Cited by 1,248 · see citing works
Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed
Gunning, P. W., Ponte, P. A., Okayama, H., Engel, J. N., Blau, H. M., & Kedes, L. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.5.787-795.1983 · Cited by 1,200 · see citing works
Effect of Growth Hormone on Carbohydrate and Lipid Metabolism
Davidson, M. B. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-2-115 · Cited by 573 · see citing works
EFFECT OF GROWTH HORMONE ON PLASMA FATTY ACIDS*
Raben, M. S., & Hollenberg, C. H. (1959) · Journal of Clinical Investigation · doi:10.1172/jci103824 · Cited by 448 · see citing works
Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet.
Egan, J. J., Greenberg, A. S., Chang, M. K., Wek, S. A., Moos, M. C., & Londos, C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8537 · Cited by 408 · see citing works
Metabolism of adipose tissue in intraabdominal depots of nonobese men and women
Rebuffé-Scrive, M., Andersson, B., Olbe, L. C., & Björntorp, P. A. (1989) · Metabolism · doi:10.1016/0026-0495(89)90198-4 · Cited by 310 · see citing works
Hormone-Sensitive Lipase: Sequence, Expression, and Chromosomal Localization to 19 cent-q13.3
Holm, C., Kirchgessner, T. G., Svenson, K. L., Fredrikson, G., Nilsson, S., Miller, C. G., Shively, J. E., Heinzmann, C., Sparkes, R. S., Mohandas, T. K., et al. (1988) · Science · doi:10.1126/science.3420405 · Cited by 307 · see citing works
Effect of Growth Hormone and Dexamethasone on Lipolysis and Metabolism in Isolated Fat Cells of the Rat
Fain, J. N., KOVACEV, V. P., & Scow, R. O. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97175-9 · Cited by 271 · see citing works
Muscle and Adipose Tissue Morphology and Metabolism in Cushing’s Syndrome*
Rebuffé-Scrive, M., Krotkiewski, M., Elfverson, J., & Björntorp, P. A. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-6-1122 · Cited by 260 · see citing works
Hormonal regulation of hormone-sensitive lipase in intact adipocytes: identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin.
Strålfors, P., Björgell, P., & Belfrage, P. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.11.3317 · Cited by 232 · see citing works
Effects of Glucocorticoids on Metabolism of Adipose Tissue in Vitro
Fain, J. N., Scow, R. O., & Chernick, S. S. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83960-1 · Cited by 219 · see citing works
Hormone-sensitive lipase — A multipurpose enzyme in lipid metabolism
Yeaman, S. J. (1990) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(90)90067-n · Cited by 217 · see citing works
Studies on Rat Adipose Tissue in Vitro
Leboeuf, B., Renold, A. E., & Cahill, G. F. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60270-4 · Cited by 213 · see citing works
Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis
Kr, F., Doerrler, W. T., Dinarello, C. A., Fiers, W., & Grünfeld, C. (1992) · Endocrinology · doi:10.1210/endo.130.1.1370149 · Cited by 197 · see citing works
Studies on Rat Adipose Tissue in Vitro
Jeanrenaud, B., & Renold, A. E. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64601-0 · Cited by 192 · see citing works
Insulin increases the synthetic rate and messenger RNA level of lipoprotein lipase in isolated rat adipocytes.
Ong, J. M., Kirchgessner, T. G., Schotz, M. C., & Kern, P. A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37651-8 · Cited by 191 · see citing works
Self-citation
Obesity and lipid metabolism
Després, J. (1991) · Current Opinion in Lipidology · doi:10.1097/00041433-199102000-00003 · Cited by 159 · see citing works
Studies on Rat Adipose Tissue in Vitro
Jeanrenaud, B., & Renold, A. E. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69625-5 · Cited by 156 · see citing works
Facilitation by Adenosine of the Action of Insulin on the Accumulation of Adenosine 3′:5′‐Monophosphate, Lipolysis, and Glucose Oxidation in Isolated Fat Cells
Schwabe, U., Schönhöfer, P. S., & Ebert, R. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03647.x · Cited by 147 · see citing works
Differentiation and function of rat adipocyte precursor cells in primary culture.
Björntorp, P. A., Karlsson, M., Pettersson, P., & Sypniewska, G. (1980) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34799-4 · Cited by 128 · see citing works
Control of lipolysis and its relevance to development of obesity in man
Amer, P. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040507 · Cited by 123 · see citing works
Radiometric assays for glycerol, glucose, and glycogen
Bradley, D. C., & Kaslow, H. R. (1989) · Analytical Biochemistry · doi:10.1016/0003-2697(89)90081-x · Cited by 119 · see citing works
The Role of Glucose and Glycosylation in the Regulation of Lipoprotein Lipase Synthesis and Secretion in Rat Adipocytes
Ong, J. M., & Kern, P. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94047-0 · Cited by 80 · see citing works
Self-citation
Growth Hormone and Lipolysis: A Reevaluation*
GOODMAN, H. M., & GRICHTING, G. (1983) · Endocrinology · doi:10.1210/endo-113-5-1697 · Cited by 80 · see citing works
The regulation of lipoprotein lipase gene expression by dexamethasone in isolated rat adipocytes
Ong, J. M., Simsolo, R. B., Saffari, B., & Kern, P. A. (1992) · Endocrinology · doi:10.1210/endo.130.4.1547742 · Cited by 63 · see citing works
Self-citation
Coordinate Control of Lipolysis by Prostaglandin E2 and Prostacyclin in Rat Adipose Tissue
Chatzipanteli, K., Rudolph, S., & Axelrod, L. (1992) · Diabetes · doi:10.2337/diab.41.8.927 · Cited by 61 · see citing works
Evidence for a dual mechanism of lipolysis activation by epinephrine in rat adipose tissue.
Wise, L. S., & Jungas, R. L. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40866-0 · Cited by 56 · see citing works
Studies on the role of RNA and protein synthesis in the lipolytic action of growth hormone in isolated fat cells
Fain, J. N. (1967) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(67)90007-6 · Cited by 55 · see citing works
Effects of Growth Hormone on the Lipolytic Response of Adipose Tissue to Theophylline1
GOODMAN, H. M. (1968) · Endocrinology · doi:10.1210/endo-82-5-1027 · Cited by 53 · see citing works
Evidence for a Role of Protein Kinase C in the Stimulation of Lipolysis by Growth Hormone and Isoproterenol*
Gorin, E., Tai, L.-R., Honeyman, T. W., & GOODMAN, H. M. (1990) · Endocrinology · doi:10.1210/endo-126-6-2973 · Cited by 42 · see citing works
Developmental regulation of hormone-sensitive lipase mRNA in the rat: changes in steroidogenic tissues.
Kraemer, F. B., Tavangar, K., & Hoffman, A. R. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41960-1 · Cited by 39 · see citing works
Nucleotide sequence of rat adipose hormone sensitive lipase cDNA
Holm, C., Kirchgessner, T. G., Svenson, K. L., Lusis, A. J., Belfrage, P., & Schotz, M. C. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.20.9879 · Cited by 39 · see citing works
Metabolic Actions of Pituitary Hormones
Engel, F. L., & Kostyo, J. L. (1964) · Elsevier eBooks · doi:10.1016/b978-0-12-395716-0.50010-3 · Cited by 32 · see citing works
Adenosine and lipolysis.
Bb, F. (1981) · PubMed · Cited by 31 · see citing works
Hormonal control of lipid degradation
Belfrage, P. (1985) · Elsevier eBooks · doi:10.1016/b978-0-408-10857-7.50011-7 · Cited by 23 · see citing works
The involvement of RNA synthesis and cyclic AMP in the activation of fat cell lipolysis by growth hormone and glucocorticoids.
Fain, J. N., & Saperstein, R. (1970) · PubMed · Cited by 22 · see citing works
Regulation of Lipid Metabolism by Cyclic Nucleotides
Fain, J. N. (1982) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-68393-0_2 · Cited by 17 · see citing works
Detection of hormone-sensitive lipase in various tissues. II. Regulation in the rat testis by human chorionic gonadotropin.
Kraemer, F. B., Patel, S., Singh-Bist, A., Gholami, S., Saedi, M., & Sztalryd, C. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39984-3 · Cited by 16 · see citing works
The mechanisms of hormone and drug actions on fatty acid release from adipose tissue.
Davies, J. I., & Souness, J. E. (1981) · PubMed · Cited by 10 · see citing works
Role of cyclic AMP in human adipose tissue lipolysis.
Burns, T. W., Terry, B. E., Pe, L., & Robison, G. A. (1980) · PubMed · Cited by 9 · see citing works

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Duncan, R. E., Ahmadian, M., Jaworski, K., Sarkadi-Nagy, E., & Sul, H. S. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093734 · Cited by 1,021 · see citing works
11β-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action
Chapman, K., Holmes, M., & Seckl, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00020.2012 · Cited by 887 · see citing works
Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores.
Zechner, R., Kienesberger, P. C., Haemmerle, G., Zimmermann, R., & Lass, A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800031-jlr200 · Cited by 576 · see citing works
Molecular Mechanisms Regulating Hormone-Sensitive Lipase and Lipolysis
Holm, C., Østerlund, T., Laurell, H., & Contreras, J. A. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.365 · Cited by 565 · see citing works
The effects of glucocorticoids on adipose tissue lipid metabolism
Peckett, A. J., Wright, D. C., & Riddell, M. C. (2011) · Metabolism · doi:10.1016/j.metabol.2011.06.012 · Cited by 548 · see citing works
Glucocorticoids, metabolism and metabolic diseases
Vegiopoulos, A., & Herzig, S. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.015 · Cited by 535 · see citing works
Hormone-sensitive lipase
Kraemer, F. B., & Shen, W.-J. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200009-jlr200 · Cited by 511 · see citing works
Novel insights into glucocorticoid‐mediated diabetogenic effects: towards expansion of therapeutic options?
Van Raalte, D. H., Ouwens, D. M., & Diamant, M. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2008.02067.x · Cited by 439 · see citing works
Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes
Quesada, I., Tudurí, E., Ripoll, C., & Nadal, Á. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0290 · Cited by 413 · see citing works
Mechanisms of Glucocorticoid-Induced Insulin Resistance
Geer, E. B., Islam, J., & Buettner, C. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.10.005 · Cited by 392 · see citing works
Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome
Macfarlane, D. P., Forbes, S., & Walker, B. R. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0054 · Cited by 385 · see citing works
Novel Form of Lipolysis Induced by Leptin
Wang, M.-Y., Lee, Y., & Unger, R. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17541 · Cited by 364 · see citing works
Molecular mechanisms of insulin resistance and associated diseases
Mlinar, B., Marc, J., Janež, A., & Pfeifer, M. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.07.005 · Cited by 297 · see citing works
Direct Effect of Glucocorticoids on Lipolysis in Adipocytes
Xu, C., He, J., Jiang, H., Zu, L., Zhai, W., Pu, S., & Xu, G. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0464 · Cited by 291 · see citing works
Expression of the mRNA Coding for 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue from Obese Patients: Anin SituHybridization Study
Paulmyer‐Lacroix, O., Boullu, S., Oliver, C., Alessi, M., & Grino, M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8614 · Cited by 241 · see citing works
Systemic Glucocorticoid Therapy: a Review of its Metabolic and Cardiovascular Adverse Events
Fardet, L., & Fève, B. (2014) · Drugs · doi:10.1007/s40265-014-0282-9 · Cited by 239 · see citing works
Adipogenic and lipolytic effects of chronic glucocorticoid exposure
Campbell, J. E., Peckett, A. J., D'souza, A. M., Hawke, T. J., & Riddell, M. C. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00045.2010 · Cited by 228 · see citing works
Fatty acid mobilization from adipose tissue during exercise
Horowitz, J. F. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00143-7 · Cited by 227 · see citing works
Aquaporin Adipose, a Putative Glycerol Channel in Adipocytes
Kishida, K., Kuriyama, H., Funahashi, T., Shimomura, I., Kihara, S., Ouchi, N., Nishida, M., Nishizawa, H., Matsuda, M., Takahashi, M., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001119200 · Cited by 227 · see citing works
Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans
Djurhuus, C. B., Gravholt, C. H., Nielsen, S., Mengel, A., Christiansen, J. S., Schmitz, O. E., & Møller, N. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00544.2001 · Cited by 219 · see citing works
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Janah, L., Kjeldsen, S. A. S., Galsgaard, K. D., Winther‐Sørensen, M., Stojanovska, E., Pedersen, J., Knop, F. K., Holst, J. J., & Albrechtsen, N. J. W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133314 · Cited by 205 · see citing works
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Gathercole, L. L., Lavery, G. G., Morgan, S. A., Cooper, M. S., Sinclair, A. J., Tomlinson, J. W., & Stewart, P. M. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1050 · Cited by 196 · see citing works
GLP-1/glucagon receptor co-agonism for treatment of obesity
Sánchez-Garrido, M. A., Brandt, S. J., Clemmensen, C., Müller, T. D., DiMarchi, R. D., & Tschöp, M. H. (2017) · Diabetologia · doi:10.1007/s00125-017-4354-8 · Cited by 175 · see citing works
Obesity and corticosteroids: 11β-Hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease
Morton, N. M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.09.024 · Cited by 163 · see citing works
Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism
Qi, D., & Rodrigues, B. B. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00453.2006 · Cited by 162 · see citing works
Adipocyte hormone-sensitive lipase: a major regulator of lipid metabolism
Langin, D., Holm, C., & Lafontan, M. (1996) · Proceedings of The Nutrition Society · doi:10.1079/pns19960013 · Cited by 155 · see citing works
Regulation of Lipogenesis by Glucocorticoids and Insulin in Human Adipose Tissue
Gathercole, L. L., Morgan, S. A., Bujalska, I. J., Hauton, D., Stewart, P. M., & Tomlinson, J. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026223 · Cited by 150 · see citing works
The glucocorticoid receptor: cause of or cure for obesity?
John, K., Marino, J. S., Sánchez, E. R., & Hinds, T. D. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00478.2015 · Cited by 144 · see citing works
Glucocorticoid-Induced Fatty Liver Disease
Rahimi, L., Rajpal, A., & Ismail‐Beigi, F. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s247379 · Cited by 148 · see citing works
Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management
Scaroni, C., Zilio, M., Foti, M., & Boscaro, M. (2017) · Endocrine Reviews · doi:10.1210/er.2016-1105 · Cited by 140 · see citing works
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Tomlinson, J., Finney, J., Gay, C., Hughes, B. A., Hughes, S. V., & Stewart, P. M. (2008) · Diabetes · doi:10.2337/db08-0495 · Cited by 131 · see citing works
The glucocorticoid contribution to obesity
Spencer, S. J., & Tilbrook, A. J. (2011) · Stress · doi:10.3109/10253890.2010.534831 · Cited by 128 · see citing works
Emodin, a natural product, selectively inhibits 11β‐hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet‐induced obese mice
Feng, Y., Huang, S., Dou, W., Zhang, S., Chen, J., Shen, Y., Shen, J., & Leng, Y. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00826.x · Cited by 126 · see citing works
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Fernando, H. A., Chin, H.-F., Ton, S. H., & Kadir, K. A. (2013) · Journal of Diabetes Research · doi:10.1155/2013/190395 · Cited by 125 · see citing works
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Samra, J. S., Clark, M. L., Humphreys, S. M., MacDonald, I. A., Bannister, P. A., & Frayn, K. N. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.2.4547 · Cited by 123 · see citing works
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Several agents and pathways regulate lipolysis in adipocytes.
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Role of glucocorticoids and the glucocorticoid receptor in metabolism: Insights from genetic manipulations
Rose, A. J., Vegiopoulos, A., & Herzig, S. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.02.010 · Cited by 110 · see citing works
The metabolic role of growth hormone in humans with particular reference to fasting
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Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial
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Acute insulin resistance following injury
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Schmidt, M. V., Paez‐Pereda, M., Holsboer, F., & Hausch, F. (2012) · ChemMedChem · doi:10.1002/cmdc.201200137 · Cited by 99 · see citing works
Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Vivo Limits Glucocorticoid Exposure to Human Adipose Tissue and Decreases Lipolysis
Tomlinson, J., Sherlock, M., Hughes, B., Hughes, S. V., Kilvington, F., Bartlett, W. A., Courtney, R., Rejto, P. A., Carley, W. W., & Stewart, P. M. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2325 · Cited by 98 · see citing works
Protein Phosphatase 5 Mediates Lipid Metabolism through Reciprocal Control of Glucocorticoid Receptor and Peroxisome Proliferator-activated Receptor-γ (PPARγ)
Hinds, T. D., Stechschulte, L. A., Cash, H. A., Whisler, D., Banerjee, A. T., Yong, W., Khuder, S. S., Kaw, M., Shou, W., Najjar, S. M., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.311662 · Cited by 96 · see citing works
Relationships between lipolysis induced by various lipolytic agents and hormone-sensitive lipase in rat fat cells
Morimoto, C., Kameda, K., Tsujita, T., & Okuda, H. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32343-9 · Cited by 96 · see citing works
FAT CELLS
Ramsay, T. G. (1996) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70358-3 · Cited by 95 · see citing works
Reduced Glucocorticoid Production Rate, Decreased 5α-Reductase Activity, and Adipose Tissue Insulin Sensitization After Weight Loss
Tomlinson, J. W., Finney, J., Hughes, B. A., Hughes, S. V., & Stewart, P. M. (2008) · Diabetes · doi:10.2337/db08-0094 · Cited by 91 · see citing works
Regulation of lipoprotein lipase and hormone-sensitive lipase activity and gene expression in adipose and muscle tissue by growth hormone treatment during weight loss in obese patients
Richelsen, B., Pedersen, S. B., Kristensen, K., Børglum, J. D., Nørrelund, H., Christiansen, J. S., & Jørgensen, J. O. L. (2000) · Metabolism · doi:10.1053/meta.2000.6738 · Cited by 88 · see citing works
Functional Alterations in Endocrine Pancreas of Rats With Different Degrees of Dexamethasone-Induced Insulin Resistance
Rafacho, A., Giozzet, V. A. G., Boschero, A. C., & Bosqueiro, J. R. (2008) · Pancreas · doi:10.1097/mpa.0b013e31815ba826 · Cited by 87 · see citing works
Changes in lipolysis and hormone-sensitive lipase expression caused by procyanidins in 3T3-L1 adipocytes
Ardèvol, A., Bladé, C., Salvadó, M. J., & Arola, L. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801130 · Cited by 85 · see citing works
A novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis
Bujalska, I. J., Gathercole, L., Tomlinson, J., Darimont, C., Ermolieff, J., Fanjul, A. N., Rejto, P. A., & Stewart, P. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0050 · Cited by 85 · see citing works
Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes
Gathercole, L., & Stewart, P. M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.03.060 · Cited by 82 · see citing works
Striking the balance: GLP-1/glucagon co-agonism as a treatment strategy for obesity
Hope, D. C. D., Vincent, M. L., & Tan, T. M. M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.735019 · Cited by 81 · see citing works
Effects of Recombinant Human Growth Hormone Therapy in Obesity in Adults: A Metaanalysis
Mekala, K. C., & Tritos, N. A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1357 · Cited by 97 · see citing works
Chronic social stress, hedonism and vulnerability to obesity: Lessons from Rodents
Coccurello, R., D'Amato, F. R., & Moles, A. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.018 · Cited by 78 · see citing works
Calcium and cAMP are second messengers in the adipokinetic hormone-induced lipolysis of triacylglycerols in Manduca sexta fat body
Arrese, E. L., Flowers, M. T., Gazard, J. L., & Wells, M. A. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32460-3 · Cited by 79 · see citing works
Regulation of hormone-sensitive lipase in streptozotocin-induced diabetic rats
Sztalryd, C., & Kraemer, F. B. (1995) · Metabolism · doi:10.1016/0026-0495(95)90135-3 · Cited by 76 · see citing works
Glucocorticoid Modulation of Insulin Signaling in Human Subcutaneous Adipose Tissue
Gathercole, L. L., Bujalska, I. J., Stewart, P. M., & Tomlinson, J. W. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1399 · Cited by 73 · see citing works
Evidence That the 11 β-Hydroxysteroid Dehydrogenase (11 β-HSD1) Is Regulated by Pentose Pathway Flux
McCormick, K. L., Wang, X., & Mick, G. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506026200 · Cited by 72 · see citing works
The mechanism of effect of growth hormone on preadipocyte and adipocyte function
Nam, S. Y., & Lobie, P. E. (2000) · Obesity Reviews · doi:10.1046/j.1467-789x.2000.00015.x · Cited by 72 · see citing works
Lipodystrophy: A paradigm for understanding the consequences of "overloading" adipose tissue
Lim, K., Haider, A., Adams, C., Sleigh, A., & Savage, D. B. (2020) · Physiological Reviews · doi:10.1152/physrev.00032.2020 · Cited by 68 · see citing works
Glucocorticoids Fail to Cause Insulin Resistance in Human Subcutaneous Adipose Tissue In Vivo
Hazlehurst, J. M., Gathercole, L. L., Nasiri, M., Armstrong, M. J., Borrows, S., Yu, J., Wagenmakers, A. J. M., Stewart, P. M., & Tomlinson, J. W. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3523 · Cited by 66 · see citing works
FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs
Kim, K. H., & Lee, M. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0160 · Cited by 63 · see citing works
Metabolism and secretory function of white adipose tissue: effect of dietary fat
do Nascimento, C. M. O., Ribeiro, E. B., & Oyama, L. M. (2009) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652009000300010 · Cited by 62 · see citing works
[2] Regulation of hormone-sensitive lipase activity in adipose tissue
Holm, C., Langin, D., Manganiello, V., Belfrage, P., & Degerman, E. (1997) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(97)86004-1 · Cited by 61 · see citing works
Glucagon's Metabolic Action in Health and Disease
Zeigerer, A., Sekar, R., Kleinert, M., Nason, S. R., Habegger, K. M., & Müller, T. D. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200013 · Cited by 76 · see citing works
Genomic and Non-Genomic Actions of Glucocorticoids on Adipose Tissue Lipid Metabolism
Mir, N., Chin, S. A., Riddell, M. C., & Beaudry, J. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168503 · Cited by 58 · see citing works
Antiobesity Effect of Kochujang (Korean Fermented Red Pepper Paste) Extract in 3T3-L1 Adipocytes
Ahn, I., Do, M., Kim, S., Jung, H.-S., Kim, Y., Kim, H. J., & Park, K.-Y. (2006) · Journal of Medicinal Food · doi:10.1089/jmf.2006.9.15 · Cited by 56 · see citing works
How Do Glucocorticoids Regulate Lipid Metabolism?
de Guia, R. M., & Herzig, S. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2895-8_6 · Cited by 54 · see citing works
Nutrient regulation of glucagon secretion: involvement in metabolism and diabetes
Marroquí, L., Alonso‐Magdalena, P., Merino, B., Fuentes, E., Nadal, Á., & Quesada, I. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000031 · Cited by 55 · see citing works
Contributions of White and Brown Adipose Tissues to the Circadian Regulation of Energy Metabolism
Heyde, I., Begemann, K., & Oster, H. (2021) · Endocrinology · doi:10.1210/endocr/bqab009 · Cited by 54 · see citing works
A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure
Ceddia, R. P., & Collins, S. (2020) · Clinical science · doi:10.1042/cs20190579 · Cited by 44 · see citing works
The use of decapitated insects to study lipid mobilization in adult Manduca sexta: Effects of adipokinetic hormone and trehalose on fat body lipase activity
Arrese, E. L., Rojas-Rivas, B. I., & Wells, M. A. (1996) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(96)00024-0 · Cited by 50 · see citing works
Cold Exposure Partially Corrects Disturbances in Lipid Metabolism in a Male Mouse Model of Glucocorticoid Excess
van den Beukel, J. C., Boon, M. R., Steenbergen, J., Rensen, P. C. N., Meijer, O. C., Themmen, A. P. N., & Grefhorst, A. (2015) · Endocrinology · doi:10.1210/en.2015-1092 · Cited by 49 · see citing works
Endurance exercise training increases adipose tissue glucocorticoid exposure: adaptations that facilitate lipolysis
Campbell, J. E., Fediuc, S., Hawke, T. J., & Riddell, M. C. (2009) · Metabolism · doi:10.1016/j.metabol.2009.01.002 · Cited by 49 · see citing works
Genes mediating glucocorticoid effects and mechanisms of their regulation
Geley, S., Fiegl, M., Hartmann, B. L., & Kofler, R. (1996) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/3-540-61343-9_7 · Cited by 49 · see citing works
Fructose consumption enhances glucocorticoid action in rat visceral adipose tissue
Bursać, B. N., Djordjevic, A. D., Teofilović, A., Milutinović, D. V., Veličković, N. A., Nestorović, N. M., & Matić, G. M. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.09.002 · Cited by 47 · see citing works
Meta-analysis reveals glucocorticoid levels reflect variation in metabolic rate, not ‘stress’
Jimeno, B., & Verhulst, S. (2023) · eLife · doi:10.7554/elife.88205 · Cited by 52 · see citing works
11β-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue
Wang, Y., Yan, C., Liu, L., Wang, W., Du, H., Fan, W., Lutfy, K., Jiang, M., Friedman, T. C., & Liu, Y. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00205.2014 · Cited by 45 · see citing works
Stressing diabetes? The hidden links between insulinotropic peptides and the HPA axis
Diz-Chaves, Y., Gil‐Lozano, M., Toba, L., Fandiño, J., Ogando, H., González-Matías, L. C., & Mallo, F. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0118 · Cited by 44 · see citing works
Fat-brain connections: Adipocyte glucocorticoid control of stress and metabolism
de Kloet, A. D., & Herman, J. P. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.005 · Cited by 42 · see citing works
Effects of Growth Hormone Administration in Human Obesity
Shadid, S., & Jensen, M. D. (2003) · Obesity Research · doi:10.1038/oby.2003.27 · Cited by 42 · see citing works
Effects of morning rise in cortisol concentration on regulation of lipolysis in subcutaneous adipose tissue
Samra, J. S., Clark, M. L., Humphreys, S. M., Macdonald, I. A., Matthews, D. R., & Frayn, K. N. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.6.e996 · Cited by 40 · see citing works
Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales
Ball, H. C., Londraville, R. L., Prokop, J. W., George, J. C., SUYDAM, R. S., Vinyard, C. J., Thewissen, J. G. M., & Duff, R. J. (2016) · Journal of Comparative Physiology B · doi:10.1007/s00360-016-1029-6 · Cited by 40 · see citing works
Lack of Hexose-6-Phosphate Dehydrogenase Impairs Lipid Mobilization from Mouse Adipose Tissue
Bujalska, I. J., Hewitt, K., Hauton, D., Lavery, G. G., Tomlinson, J., Walker, E. A., & Stewart, P. M. (2008) · Endocrinology · doi:10.1210/en.2007-1705 · Cited by 40 · see citing works
Insulin increases angiotensinogen expression in human abdominal subcutaneous adipocytes
Harte, A. L., McTernan, P. G., McTernan, C. L., Crocker, J., Starcynski, J., Barnett, A. H., Matyka, K. A., & Kumar, S. (2003) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2003.00274.x · Cited by 38 · see citing works
Insights into incretin-based therapies for treatment of diabetic dyslipidemia
Stemmer, K., Finan, B., DiMarchi, R. D., Tschöp, M. H., & Müller, T. D. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.05.008 · Cited by 39 · see citing works
Tissue-Specific Difference in the Molecular Mechanisms for the Development of Acute Insulin Resistance after Injury
Li, L., Thompson, L. H., Zhao, L., & Messina, J. L. (2008) · Endocrinology · doi:10.1210/en.2008-0742 · Cited by 39 · see citing works
Increased Triacylglycerol Lipase Activity in Adipose Tissue of Lean and Obese Men During Endurance Exercise
Petridou, A., Chatzinikolaou, A., Avloniti, A., Jamurtas, A., Loules, G., Papassotiriou, I., Fatouros, I., & Mougios, V. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00168 · Cited by 37 · see citing works
Stimulation of Mitochondrial Fatty Acid Oxidation by Growth Hormone in Human Fibroblasts1
Leung, K., & Ho, K. K. Y. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4459 · Cited by 37 · see citing works
Stimulation of human omental adipose tissue lipolysis by growth hormone plus dexamethasone
Fain, J. N., Cheema, P. S., Tichansky, D. S., & Madan, A. K. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.05.014 · Cited by 36 · see citing works
Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment
Heffernan, M., Thorburn, A. W., Fam, B. C., Summers, R. J., Conway-Campbell, B. L., Waters, M. J., & Ng, F. M. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801740 · Cited by 36 · see citing works
Inhibition of lipolysis during acute GH exposure increases insulin sensitivity in previously untreated GH-deficient adults
Segerlantz, M., Bramnert, M., Manhem, P., Laurila, E., & Groop, L. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490511 · Cited by 36 · see citing works
Adipose tissue in cortisol excess: What Cushing’s syndrome can teach us?
Bavaresco, A., Mazzeo, P., Lazzara, M., & Barbot, M. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116137 · Cited by 40 · see citing works
Cortisol in tissue and systemic level as a contributing factor to the development of metabolic syndrome in severely obese patients
Constantinopoulos, P., Michalaki, M. A., Kottorou, A. E., Habeos, I. G., Psyrogiannis, A. I., Kalfarentzos, F., & Kyriazopoulou, V. E. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0626 · Cited by 35 · see citing works
Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms
Salamone, I. M., Quattrocelli, M., Barefield, D. Y., Page, P., Tahtah, I., Hadhazy, M., Tomar, G., & McNally, E. M. (2022) · Journal of Clinical Investigation · doi:10.1172/jci149828 · Cited by 34 · see citing works

Regulation of Hormone-Sensitive Lipase Expression by Glucose in 3T3-F442A Adipocytes
Raclot, T., Dauzats, M., & Langin, D. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8469 · Cited by 30 · see citing works
Regulation of hormone-sensitive lipase expression by saturated fatty acids and hormones in bovine mammary epithelial cells
Yonezawa, T., Haga, S., Kobayashi, Y., Katoh, K., & Obara, Y. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.075 · Cited by 17 · see citing works
Hormone-sensitive lipase expression and activity in relation to lipolysis in human fat cells
Large, V., Arner, P., Reynisdottir, S., Grober, J., van Harmelen, V., Holm, C., & Langin, D. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32199-4 · Cited by 106 · see citing works
Growth hormone alters lipolysis and hormone-sensitive lipase activity in 3T3-F442A adipocytes
Dietz, J., & Schwartz, J. (1991) · Metabolism · doi:10.1016/0026-0495(91)90006-i · Cited by 123 · see citing works
Inhibition of hormone-sensitive lipase gene expression by cAMP and phorbol esters in 3T3-F442A and BFC-1 adipocytes
Plée‐Gautier, E., Grober, J., Duplus, E., Langin, D., & Forest, C. D. (1996) · Biochemical Journal · doi:10.1042/bj3181057 · Cited by 35 · see citing works

Authors: Slavin, B. G., Ong, J. M., & Kern, P. A.
Affiliations: University of Southern California (US)
ORCID: Kern, P A
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 1994-09
Volume: 35
Issue: 9
Pages: 1535-1541
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1016/s0022-2275(20)41151-4
OpenAlex: W2185515430
Cited by: 261
References: 44
Citations by year: 2026: 2 · 2025: 6 · 2024: 4 · 2023: 15 · 2022: 10 · 2021: 9 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 12 · 2016: 12 · 2015: 13 · 2014: 17 · 2013: 12 · 2012: 8
FWCI: 2.56
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 9529 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK 39176)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: hormone-sensitive lipase, adipocytes, lipolysis, epinephrine, glucagon, growth hormone, dexamethasone, glycerol release, hormonal regulation
MeSH terms: Adipose Tissue, Animals, Cells, Cultured, Sterol Esterase, Dexamethasone, Epinephrine, Glucagon, Glycerol, Hormones, Male, RNA Processing, Post-Transcriptional, RNA, Messenger, Growth Hormone, Gene Expression Regulation, Enzymologic, Rats

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Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes.

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