The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
D IETARY C ONJUGATED L INOLEIC A CID IN H EALTH: Physiological Effects and Mechanisms of Action
Abstract
▪ Abstract Conjugated linoleic acid (CLA) is a group of polyunsaturated fatty acids found in beef, lamb, and dairy products that exist as positional and stereo-isomers of octadecadienoate (18:2). Over the past two decades numerous health benefits have been attributed to CLA in experimental animal models including actions to reduce carcinogenesis, atherosclerosis, onset of diabetes, and body fat mass. The accumulation of CLA isomers and several elongated/desaturated and β-oxidation metabolites have been found in tissues of animals fed diets with CLA. Molecular mechanisms of action appear to include modulation of eicosanoid formation as well as regulation of the expression of genes coding for enzymes known to modulate macronutrient metabolism. This review focuses on health benefits, metabolism, and potential mechanisms of action of CLA and postulates the implications regarding dietary CLA for human health.
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Cites
Effect of conjugated linoleic acid on body composition in mice
Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W. (1997) · Lipids · doi:10.1007/s11745-997-0109-x · Cited by 1,163
Park, Y., Storkson, J. M., Albright, K. J., Liu, W., & Pariza, M. W. (1999) · Lipids · doi:10.1007/s11745-999-0358-8 · Cited by 815
Cited by
N UTRITIONAL R EGULATION OF M ILK F AT S YNTHESIS
Bauman, D. E., & Griinari, J. M. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073408 · Cited by 1,163
den Hartigh, L. (2019) · Nutrients · doi:10.3390/nu11020370 · Cited by 371
O'Shea, E. F., Cotter, P. D., Stanton, C., Ross, R. P., & Hill, C. (2012) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.05.025 · Cited by 305
Conjugated linoleic acid biosynthesis by human-derived Bifidobacterium species
Coakley, M., Ross, R. P., Nordgren, M., Fitzgerald, G., Devery, R., & Stanton, C. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2003.01814.x · Cited by 299
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
Nava Lauson, C. B., Tiberti, S., Corsetto, P. A., Conte, F., Tyagi, P., Machwirth, M., Ebert, S., Loffreda, A., Scheller, L., Sheta, D., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.013 · Cited by 291
Metadata
- Authors
- Belury, M. A.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2002-07
- Volume
- 22
- Issue
- 1
- Pages
- 505-531
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2138299029
- Cited by
- 814
- References
- 2
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: D IETARY C ONJUGATED L INOLEIC A CID IN H EALTH: Physiological Effects and Mechanisms of Action. https://app.cochat.ai/papers/10.1146/annurev.nutr.22.021302.121842
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- Belury, M. A. (2002). D IETARY C ONJUGATED L INOLEIC A CID IN H EALTH: Physiological Effects and Mechanisms of Action. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nutr.22.021302.121842
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