The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Fatty Acids as Modulators of the Immune Response
Abstract
▪ Abstract Research describing fatty acids as modulators of inflammation and immune responses abounds. Many of these studies have focused on one particular group of fatty acids, omega-3. The data from animal studies have shown that these fatty acids can have powerful anti-inflammatory and immunomodulatory activities in a wide array of diseases (e.g., autoimmunity, arthritis, and infection). However, the evidence from human trials is more equivocal. In this review, a historical framework for understanding how and why fatty acids may affect the immune system is provided. Second, highlights of two recent landmark reports from the Agency for Healthcare Research and Quality are presented. These reports critically evaluate the evidence from human clinical trials of omega-3 fatty acids and rheumatoid arthritis, asthma, and a few other immune-mediated diseases. Third, the data from human clinical trials investigating the impact of various bioactive fatty acids on ex vivo and in vivo immune response are reviewed. Limitations in experimental design and immune assays commonly used are discussed. The discordance between expectation and evidence in this field has been a disappointment. Recommendations for improving both animal-based and human studies are provided.
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Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
Xu, H. E., Lambert, M. H., Montana, V. G., Parks, D. J., Blanchard, S. G., Brown, P. J., Sternbach, D. D., Lehmann, J. M., Wisely, G. B., Willson, T. M., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80467-0 · Cited by 1,169
The Science of Reviewing Researcha
OXMAN, A. D., & GUYATT, G. H. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb26342.x · Cited by 472
The role of PPARs in inflammation and immunity
Clark, R. B. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.3.388 · Cited by 337
Trebble, T. M., Wootton, S. A., Miles, E. A., Mullee, M., Arden, N. K., Ballinger, A. B., Stroud, M. A., Burdge, G. C., & Calder, P. C. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.376 · Cited by 179
Effect of CLA supplementation on immune function in young healthy volunteers
Song, H.-J., Grant, I., Rotondo, D., Mohede, I., Sattar, N., Heys, S. D., & Wahle, K. W. J. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602102 · Cited by 162
Pro- and anti-inflammatory cytokines in healthy volunteers fed various doses of fish oil for 1 year
BLOK, W. L., DESLYPERE, J. ‐., DEMACKER, P. N. M., VAN DER VEN‐JONGEKRIJG, J., HECTORS, M. P. C., VAN DER MEER, J. W. M., & KATAN, M. B. (1997) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1997.2240775.x · Cited by 129
Cited by
Fenton, S. E., Ducatman, A., Boobis, A., DeWitt, J. C., Lau, C., Ng, C., Smith, J. S., & Roberts, S. M. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4890 · Cited by 2,445
Yan, Y., Jiang, W., Spinetti, T., Tardivel, A., Castillo, R., Bourquin, C., Guarda, G., Tian, Z., Tschopp, J., & Zhou, R. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.015 · Cited by 784
Chylomicrons promote intestinal absorption of lipopolysaccharides
Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662
Scarmozzino, F., & Visioli, F. (2020) · Foods · doi:10.3390/foods9050675 · Cited by 569
Effects of Omega-3 Fatty Acids on Immune Cells
Gutiérrez, S., Svahn, S. L., & Johansson, M. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205028 · Cited by 525
Metadata
- Authors
- Fritsche, K.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2006-08-01
- Volume
- 26
- Issue
- 1
- Pages
- 45-73
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2150651546
- Cited by
- 316
- References
- 7
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
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