Effect of CLA supplementation on immune function in young healthy volunteers
Abstract
Objectives This study investigated the effect of dietary CLA supplementation (3g/day; 50:50 mix of the two major isomers) on the immune system and plasma lipids and glucose of healthy human (male and female) volunteers.Design Double-blind, randomized, reference-controlled study. SUBJECT AND INTERVENTION: A total of 28 healthy male and female participants aged 25-50 y received either high oleic sunflower oil (reference) or 50% CLA 9-11 and 50% CLA 10-12 CLA isomers (50:50 CLA-triglyceride form). The treatments were given as supplements in soft-gel capsules providing a total 3 g (6 x 500 mg capsules) per day in treatment groups for 12 weeks. A 12-week washout period followed the intervention period.Results Levels of plasma IgA and IgM were increased (P < 0.05 and 0.01 respectively), while plasma IgE levels were decreased (P < 0.05). CLA supplementation also decreased the levels of the proinflammatory cytokines, TNF-alpha and IL-1beta (P < 0.05), but increased the levels of the anti-inflammatory cytokine, IL-10 (P < 0.05). Another aspect of immune function, delayed type hypersensitivity (DTH) response, was decreased during and after CLA supplementation (P < 0.05). However, plasma glucose, lipids, lymphocyte phenotypic results were not affected significantly by CLA.Conclusion This is the first study to show that CLA, a fatty acid naturally found in dairy and meat products, can beneficially affect immune function in healthy human volunteers.Sponsorship This study was supported by Loders-Croklaan, The Netherlands and SEERAD (Scottish Executive Environmental Rural and Agriculture Department).
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- Authors
- Song, H.-J., Grant, I., Rotondo, D., Mohede, I., Sattar, N., Heys, S. D., & Wahle, K. W. J.
- Affiliations
- University of Aberdeen (GB)
- Robert Gordon University (GB)
- University of Strathclyde (GB)
- University of Glasgow (GB)
- Corresponding author
- Wahle, K W J
- Venue
- European Journal of Clinical Nutrition
- Published
- 2005-01-12
- Volume
- 59
- Issue
- 4
- Pages
- 508-517
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- OpenAlex
- W2050217161
- Cited by
- 162
- References
- 35
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 11 · 2016: 4 · 2015: 7 · 2014: 6 · 2013: 13 · 2012: 11
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- conjugated linoleic acid, dietary supplementation, immune function, plasma immunoglobulins, IgA, IgM, IgE, cytokines, TNF-α, IL-1β, IL-10, delayed-type hypersensitivity, inflammatory cytokines, anti-inflammatory cytokines, plasma lipids, plasma glucose, lymphocyte phenotype, healthy young adults
- MeSH terms
- Adult, Blood Glucose, C-Reactive Protein, Double-Blind Method, Female, Humans, Hypersensitivity, Delayed, Immunity, Immunoglobulins, Lipids, Lymphocytes, Male, Reference Values, Sex Factors, Time Factors, Cytokines, Dietary Supplements, Linoleic Acids, Conjugated
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