Cited by 597Medicinal Plant ResearchMedicinal plant effects and applicationsNatural product bioactivities and synthesis

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New Substances of Plant Origin which Increase Nonspecific Resistance

Brekhman, I I, Dardymov, I V·1969·Annual Review of Pharmacology

DOI 10.1146/annurev.pa.09.040169.002223

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The ginseng's fireness is associated with the lowering activity of liver Na+-K+-ATPase
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“In 1969, Brekhman and Dardymov classified R. carthamoides as an adaptogen, now widely used in herbal medicine to promote resistance to stress, such as trauma, anxiety, and fatigue [13,103,105].”
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Modulatory effect of seabuckthorn leaf extract on oxidative stress parameters in rats during exposure to cold, hypoxia and restraint (C-H-R) stress and post stress recovery
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“Among traditional medicines, ginseng has shown beneficial effects on mental and physical performance, and many athletes have used ginseng without side effects [1, 2].”
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“RAS has been used extensively in China, Russia, Korea and Japan as an adaptogen [2,3].”
Method
The Adaptogens Rhodiola and Schizandra Modify the Response to Immobilization Stress in Rabbits by Suppressing the Increase of Phosphorylated Stress-activated Protein Kinase, Nitric Oxide and Cortisol
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“14–18 R. rosea is one of the most popular herbal medicinal plants with adapto-genic properties.”
Caffeine-Containing, Adaptogenic-Rich Drink Modulates the Effects of Caffeine on Mental Performance and Cognitive Parameters: A Double-Blinded, Placebo-Controlled, Randomized Trial
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“138 According to Breckhman and Dardymov, 139 an adaptogen must have the following: (1) produce a nonspeciﬁc response, (2) have a normalizing effect on the body, and (3) do not inﬂuence normal body functions.”
Ginseng gintonin alleviates neurological symptoms in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis through lysophosphatidic acid 1 receptor
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“This adaptation could be facilitated by adaptogens, which have to meet certain criteria proposed by Brekhman and Dardymov (1969)11.”
Background
Evaluation of the anti-ulcer and antisecretory activity of extracts of aralia elata root and schizandra chinensis fruit in the rat
Hernández, D. E., Hancke, J. L., & Wikman, G. (1988) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(88)90120-1 · Cited by 24
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Kim, Y. C., Lee, J. H., Kim, M. S., et al. (1985) · Archives of Pharmacal Research · doi:10.1007/bf02897566 · Cited by 23
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“Adaptogens are known to boost the energy needed by the organism to effectively cope with aversive stressful situations.”
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Acanthopanax senticosus inhibits nitric oxide production in murine macrophages In Vitro and In Vivo
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“The cortical tissue of roots and shoots is used for various medicinal purposes (Brekhman 1960; Brekhman and Dardymov 1969).”
Background
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“The cortical tissues of the roots and shoots are used for various medicinal purposes (Brekhman 1960; Brekhman and Dardymov 1969 ).”
Background
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Background
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“The substances having such a property are called adaptogens (Brekhman and Dardymov, 1969).”
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“Pharmacognosy Research | March 2010 | Vol 2 | Issue 2 103 group.[5,6] Animals belonging to group I received distilled water (DW) 10 ml/kg (p.”
BackgroundMethod
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“Such substances have been described as ‘adaptogens’ (Brekhman and Dardymov, 1969).”
Background
No adaptogen response of mice to ginseng and eleutherococcus infusions
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“A plant-origin substance increases non-specific resistance [17,18].”
Ginseng extract attenuates early MRI changes after status epilepticus and decreases subsequent reduction of hippocampal volume in the rat brain
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Ginsenoside RG1 and Corticosteroid Receptors in Rat Brain
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Panax ginseng extract modulates sleep in unrestrained rats
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“Such normalizing activity of ginseng is often referred to an "adaptogen"-l ike proper ty (Brekhman and Dardymov 1969).”
Background
Selective Growth Responses of Human Intestinal Bacteria toAraliaceaeExtracts
Ahn, Y.-J., Kim, M., Yamamoto, T., et al. (1990) · Microbial Ecology in Health and Disease · doi:10.3109/08910609009141546 · Cited by 17
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Eleutherococcus senticosus: Studies and effects
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“…widely used plant in folk and traditional medicines for the cardiovascular, immune, nervous, and endocrine systems, and according to the researchers Brekhman & Dardymov (1969) [4], it has the ability to increase the non-specific resistance state, which characterizes it as an adaptogenic substance.”
Background
Functional Properties of 50% Methanol Extracts from Different Parts of Acanthopanax sessiliflorus
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“장, 신진대사의 활성작용을 나타내면서도 부작용 등의 독성은 거 의 없다고 보고되었다(10).”
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“[1] Many traditional folklore studies revealed the potential benefit of plants.[2] Inflammation is a general mechanism in which the body reacts to any injury, infection, or irritation which can be identified by some key features such as redness, warmth, and swelling at the site.”
Background
Importance and quality of roseroot (Rhodiola rosea L.) growing in the European North.
Galambosi, B., Galambosi, Z., Héthelyi, É., Szőke, É., Volodin, V. V., Полетаева, И. И., & Iljina, I. (2010) · Jukuri (Natural Resources Institute Finland (Luke)) · Cited by 15
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“Ecdysteroids can be classified as “adaptogenic substances” ( Brekhman and Dardymov, 1969 ), i.e.”
Background
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Rapid Mass Spectrometric Study of a Supercritical CO2-extract from Woody Liana Schisandra chinensis by HPLC-SPD-ESI-MS/MS
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Withania somnifera (L.) Dunal as Add-On Therapy for COPD Patients: A Randomized, Placebo-Controlled, Double-Blind Study
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Background
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BackgroundInfluential
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“오가피 성분에 관한 연구는 Ovodov(9) 가 오가피의 근피 추출물에서 eleutheroside A, B, B-1, C, D, E, G, I, K, M 등의 saponin을 분리하여 보고한 이후로, lignan, coumarin, diterpene, triterpenoid, phenolic compound 등의 천연물질들이 잎 또는 열매에 풍부하게 함유되어 주목 받고 있는 약재이다(10).”
Rhodiola rosea (SHR-5), Part 2
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In vitro And In vivo Activities of Stem Bark of Methanolic Extract of Ailanthus Excelsa Roxb. in the Management of Asthma
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Authors: Brekhman, I. I., & Dardymov, I. V.
Venue: Annual Review of Pharmacology
Publisher: Annual Reviews
Published: 1969-04
Volume: 9
Issue: 1
Pages: 419-430
ISSN: 0066-4251 (ISSN-L)
DOI: 10.1146/annurev.pa.09.040169.002223
OpenAlex: W2102596758
Cited by: 595
References: 0
Citations by year: 2026: 7 · 2025: 11 · 2024: 12 · 2023: 19 · 2022: 12 · 2021: 24 · 2020: 27 · 2019: 6 · 2018: 18 · 2017: 15 · 2016: 10 · 2015: 15 · 2014: 23 · 2013: 24 · 2012: 26
FWCI: 1.45
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal plant effects and applications
Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
Keywords: plant extracts, non-specific immunity, immunostimulants, phytochemicals, host defense
MeSH terms: Animals, Chemistry, Drug Resistance, Microbial, Glycosides, Nucleic Acids, Plant Extracts, Plants, Protein Biosynthesis, Mice, Chemical Phenomena

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