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New Substances of Plant Origin which Increase Nonspecific Resistance

Brekhman, I I, Dardymov, I V·1969·Annual Review of Pharmacology

DOI 10.1146/annurev.pa.09.040169.002223

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“@itbhu.ac.in l rights reserved. stressful factors by promoting non-specific resistance of the body (Brekhman and Dardymov, 1969).”
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“…an organism to stress, augmenting resistance to physical, biological, chemical and psychological stresses, and increasing concentration, performance and endurance during fatigue (Brekhman and Dardymov 1968; Panossian 2003; Panossian and Wikman 2005; Panossian and Wagner 2005; Olsson et al. 2008).”
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“ginseng and other members of the Ariliaceae family (Brekhman and Dardymov 1969), in contrast, P.”
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“After discovering ginseng as a medical plant in Manchuria (China) over 5000 years ago, its whole roots were first taken as a food and 2000 years later, early Chinese used ginseng as a general tonic and adaptogen helping the body to resist the adverse influence of a wide range of physical, chemical, and biological fact…”
Background
No Ergogenic Effects of Ginseng (Panax Ginseng C.A. Meyer) during Graded Maximal Aerobic Exercise
Engels, H.-J., & Wirth, J. C. (1997) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(97)00271-x · Cited by 96
Ginseng and aluminium hydroxide act synergistically as vaccine adjuvants
Rivera, E., Hu, S., & Concha, C. (2003) · Vaccine · doi:10.1016/s0264-410x(02)00518-2 · Cited by 93
Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis
Bonilla, D. A., Moreno, Y., Gho, C., Petro, J. L., Odriozola-Martínez, A., & Kreider, R. B. (2021) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk6010020 · Cited by 106
“Brekhman and Dardymov [3] proposed in 1969 the term adaptogen as an innocuous agent that increases in a nonspecific way the resistance against harmful factors or physical, chemical, biological and psychological “stressors”, normalizing the homeostasis of individuals.”
Background
Investigation of the effects of different organosolv pulping methods on antioxidant capacity and extraction efficiency of lignin
Lü, Q., Liu, W., Yang, L., Zu, Y., Zu, B., Zhu, M., Zhang, Y., Zhang, X., Zhang, R., Sun, Z. P., et al. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.07.116 · Cited by 92
EFFECT OF PANAX GINSENG ROOT ON EXHAUSTIVE EXERCISE IN MICE
Saitō, H., Yoshida, Y., & Takagi, K. (1974) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.24.119 · Cited by 90
Adaptogenic activity of a novel, withanolide‐free aqueous fraction from the roots of Withania somnifera Dun.
Singh, B., Saxena, A. K., Chandan, B. K., Gupta, D., Bhutani, K. K., & Anand, K. K. (2001) · Phytotherapy Research · doi:10.1002/ptr.858 · Cited by 89
“15, 311–318 (2001) Antistress drugs appear to have a corticosteroid sparing effect as observed in our experimental evaluations (Table 8) and from other studies (Brekhman and Dardymov, 1969; Bhargava and Singh, 1981).”
BackgroundResult
Thymoquinone protects dopaminergic neurons against MPP+ and rotenone
Radad, K., Moldzio, R., Taha, M., & Rausch, W. (2008) · Phytotherapy Research · doi:10.1002/ptr.2708 · Cited by 88
Ginsenosides protect pulmonary vascular endothelium against free radical — induced injury
Kim, H., Chen, X., & Gillis, C. N. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)92253-t · Cited by 88
Ginseng extract in aluminium hydroxide adjuvanted vaccines improves the antibody response of pigs to porcine parvovirus and Erysipelothrix rhusiopathiae
Rivera, E., Daggfeldt, A., & Hu, S. (2002) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(02)00269-6 · Cited by 86
Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice
Kimura, Y., & Sumiyoshi, M. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.08.027 · Cited by 87
Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic
Suliman, N. A., Taib, C. N. M., Moklas, M. A. M., Adenan, M. I., Baharuldin, M. T. H., & Basir, R. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/4391375 · Cited by 85
“rosea is considered to be an “adaptogen” that enhances endurance, resistance, and protest against stressful situation [143].”
Background
Ginseng--is there a use in clinical medicine?
Chong, S. K. F., & Oberholzer, V. G. (1988) · Postgraduate Medical Journal · doi:10.1136/pgmj.64.757.841 · Cited by 83
Withania Somnifera(Ashwagandha), a Rejuvenating Herbal Drug Which Enhances Survival During Stress (an Adaptogen)
Singh, N., Nath, R., Lata, A., Singh, S. P., Kohli, R. P., & Kp, B. (1982) · International Journal of Crude Drug Research · doi:10.3109/13880208209083282 · Cited by 84
Adaptogens: Tonic Herbs for Fatigue and Stress
Panossian, A. G. (2003) · Alternative and Complementary Therapies · doi:10.1089/107628003322658610 · Cited by 84
Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells
Panossian, A., Hamm, R., Kadioglu, O., Wikman, G., & Efferth, T. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00016 · Cited by 81
“ORIGINAL RESEARCH ARTICLE published: 20 February 2013 doi: 10.3389/fnins.2013.00016 Synergy and antagonism of active constituents of ADAPT-232 on transcriptional level of metabolic regulation of isolated neuroglial cells”
BackgroundInfluential
The effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes
Gaffney, B. T., Hügel, H., & Rich, P. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01394-7 · Cited by 79
Herbal medicine: Is it an alternative or an unknown? A brief review of popular herbals used by patients in a pain and symptom management practice setting
Leak, J. A. (1999) · Current Review of Pain · doi:10.1007/s11916-999-0017-x · Cited by 79

Authors: Brekhman, I. I., & Dardymov, I. V.
Venue: Annual Review of Pharmacology
Publisher: Annual Reviews
Published: 1969-04
Volume: 9
Issue: 1
Pages: 419-430
ISSN: 0066-4251 (ISSN-L)
DOI: 10.1146/annurev.pa.09.040169.002223
OpenAlex: W2102596758
Cited by: 595
References: 0
Citations by year: 2026: 7 · 2025: 11 · 2024: 12 · 2023: 19 · 2022: 12 · 2021: 24 · 2020: 27 · 2019: 6 · 2018: 18 · 2017: 15 · 2016: 10 · 2015: 15 · 2014: 23 · 2013: 24 · 2012: 26
FWCI: 1.45
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal plant effects and applications
Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
Keywords: plant extracts, non-specific immunity, immunostimulants, phytochemicals, host defense
MeSH terms: Animals, Chemistry, Drug Resistance, Microbial, Glycosides, Nucleic Acids, Plant Extracts, Plants, Protein Biosynthesis, Mice, Chemical Phenomena

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New Substances of Plant Origin which Increase Nonspecific Resistance

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