Cited by 597Medicinal Plant ResearchMedicinal plant effects and applicationsNatural product bioactivities and synthesis

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New Substances of Plant Origin which Increase Nonspecific Resistance

Brekhman, I I, Dardymov, I V·1969·Annual Review of Pharmacology

DOI 10.1146/annurev.pa.09.040169.002223

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Safety of red ginseng and herb extract complex (RHC) in menopausal women: A randomized, double-blind, placebo-controlled trial
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“고려인삼은 생체의 저항력을 높여 외부로부터 침입하는 물 리적 (추위나 더위 등), 화학적 (각종 독성물 노출 등), 그리고 생물적 (세균이나 virus 등) 스트레스를 방어하여 비정상적 신 체조건을 정상화 시키는 작용이 있다 (Brekhman and Dardymov, 1969).”
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“In 1969, American scientist Brekhman expanded the definition of adaptogens to the following statements: 1) Adaptogens should appropriately reduce external stress-induced damage; 2) After a single dose or multiple doses, adaptogens must exhibit a stimulatory response and effectively improve the depressed state of the b…”
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“Criteria for Classifying a Substance as an Adaptogen Brekhman and Dardymov (1969) put forth three criteria for a substance to be classified as an Adaptogen: a) It has to be safe with minimal adverse effects on the body. b) It should exert a non-specific response to combat stress. c) It expresses a normalizing action r…”
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“Tel: 82-63-270-2608, Fax: 82-63-270- 2614, E-mail: sks909@hanmail.net studies of saponin began in earnest after Brekhman and Dardymov (1969) identified saponin glycosides as the principal component responsible for the medicinal effects of saponin; as a result of this research, the structure and…”
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Maggini, S., Wishart, K., & Wintergerst, E. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418680-4.00025-7 · Cited by 1
Eleutherosides Extraction from Acanthopanax sessiliflorus Seeman and Eleutherococcus senticosus Maxim Using an Enzymatic Process
Kim, N., Park, J.-S., Lee, D.-S., et al. (2016) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2016.45.9.1273 · Cited by 1
“이 두 물질은 외 부의 스트레스에 대한 비특이적 적응력을 갖는 ‘adaptogenic activity’에 있어서 인삼과 비슷하고 독성은 거의 없다고 보 고되었으며, 특히 acanthoside D로 알려진 eleutheroside E는 현재 한국 식품의약품안전처에 건강기능 식품원료로서 개별인정형 원료로 등록되어(2), 체력강화, T세포 증가를 통한 면역력 증대, 학습능력 향상, 간 기능 개선, 콜레스테롤 수치 저하, 항암 효과 등이 보고된 바 있다(12,22,23).”
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Kim, M.-S., Cho, S., & Lee, S. (2020) · JoLS Journal of Life Sciences · doi:10.5352/jls.2020.30.1.70 · Cited by 1
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The Study on Anti-cancer Effects of Distilling Fresh-ginseng Herbal acupuncture against implanted Sarcoma-180 in vivo and A549 human epithelial lung cancer cells in vitro
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Anju, & Ghosh, A. K. (2021) · International Journal of Clinical Biochemistry and Research · doi:10.18231/j.ijcbr.2021.042 · Cited by 2
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Botto, J.-M. (2023) · Phytothérapie · doi:10.3166/phyto-2022-0364 · Cited by 1
Evaluation of Rhodiola rosea Root Fraction as a Functional Cosmetic Ingredient
Yige, H., & Lee, J.-A. (2023) · Journal of the Korean Society of Cosmetology · doi:10.52660/jksc.2023.29.3.574 · Cited by 1
“…*Corresponding author: Ji-An Lee Tel : +82-2-940-7821 E-mail : jianlee@skuniv.ac.kr 접수일(2023년 2월 13일)/수정일(2023년 3월 13일)/채택일(2023년 5월 1일) 홍경천 뿌리 분획물의 기능성화장품 원료로서의 평가 575 의 rosavins 성분도 Rhodiola species 중 유일하게 홍경천에서만 검출되는 대표적인 아답토젠 성분이며(Brekhman & Dardymov, 1969; Khanum et al., 2005), 이외에도 홍경천에는…”
Anti-Atopic Dermatitis Effects of Acanthopanax divaricatus var. albeofructus Extracts
Hong, C.-E., & Lyu, S. (2023) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2023.52.12.1233 · Cited by 1
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Thondala, B., Pawar, H., & Panjwani, U. (2023) · Springer eBooks · doi:10.1007/978-981-99-7652-2_19 · Cited by 2

Authors: Brekhman, I. I., & Dardymov, I. V.
Venue: Annual Review of Pharmacology
Publisher: Annual Reviews
Published: 1969-04
Volume: 9
Issue: 1
Pages: 419-430
ISSN: 0066-4251 (ISSN-L)
DOI: 10.1146/annurev.pa.09.040169.002223
OpenAlex: W2102596758
Cited by: 595
References: 0
Citations by year: 2026: 7 · 2025: 11 · 2024: 12 · 2023: 19 · 2022: 12 · 2021: 24 · 2020: 27 · 2019: 6 · 2018: 18 · 2017: 15 · 2016: 10 · 2015: 15 · 2014: 23 · 2013: 24 · 2012: 26
FWCI: 1.45
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal plant effects and applications
Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
Keywords: plant extracts, non-specific immunity, immunostimulants, phytochemicals, host defense
MeSH terms: Animals, Chemistry, Drug Resistance, Microbial, Glycosides, Nucleic Acids, Plant Extracts, Plants, Protein Biosynthesis, Mice, Chemical Phenomena

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