The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
NEURODEGENERATIVE DISEASES: New Concepts of Pathogenesis and Their Therapeutic Implications
Abstract
Neurodegenerative diseases as diverse as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease share a common pathogenetic mechanism involving aggregation and deposition of misfolded proteins, which leads to progressive central nervous system disease. Although the type of aggregated protein and the regional and cellular distribution of deposition vary from disease to disease, these disorders may all be linked by similar pathways of protein aggregation with fibril formation and amyloid deposition. This perspective on pathogenesis suggests that a wide variety of neurodegenerative diseases can be grouped mechanistically as brain amyloidoses, an outlook that yields novel insights into potential therapeutic approaches that may be applicable across the broad spectrum of neurodegenerative disease.
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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
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Self-citationYankner, B. A., Lu, T., & Loerch, P. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.092044 · Cited by 677
DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology, and biomarkers
Lippa, C. F., Duda, J. E., Grossman, M., Hurtig, H. I., Aarsland, D., Boeve, B. F., Brooks, D. J., Dickson, D. W., Dubois, B., Emre, M., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000256715.13907.d3 · Cited by 548
Self-citationIntracellular Coenzymes as Natural Biomarkers for Metabolic Activities and Mitochondrial Anomalies
Heikal, A. A. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.10.1 · Cited by 458
RNA-binding proteins with prion-like domains in health and disease
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Metadata
- Authors
- Skovronsky, D. M., Lee, V. M.-Y., & Trojanowski, J. Q.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2006-02-01
- Volume
- 1
- Issue
- 1
- Pages
- 151-170
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W1985397688
- Cited by
- 425
- References
- 125
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: NEURODEGENERATIVE DISEASES: New Concepts of Pathogenesis and Their Therapeutic Implications. https://app.cochat.ai/papers/10.1146/annurev.pathol.1.110304.100113
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- Skovronsky, D. M., Lee, V. M.-Y., & Trojanowski, J. Q. (2006). NEURODEGENERATIVE DISEASES: New Concepts of Pathogenesis and Their Therapeutic Implications. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev.pathol.1.110304.100113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
