The DOI matches its Crossref record.
Regulation of the Synthesis of Steroidogenic Enzymes in Adrenal Cortical Cells by ACTH
Abstract
Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and ...Read More
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In short, the hypothalamus produces corticotropin-releasing hormone (CRH) that stimulates corticotrope cells in the anterior pituitary to biosynthesize and release adrenocorticotropic hormone (ACTH) that in turn stimulates the adrenal gland to produce steroid hormones, specifically DHEA and cortisol [21,22].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [22]
Citations
Cited by
Sorted by citations
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Smith, S. M., & Vale, W. W. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/ssmith · Cited by 1,948
“Specifically, ACTH promotes the conversion of cholesterol into δ-5 pregnenolone during the initial step of glucocorticoid biosynthesis.(61,64)”
BackgroundRegulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response
Herman, J. P., McKlveen, J. M., Ghosal, S., Kopp, B., Wulsin, A., Makinson, R., Scheimann, J., & Myers, B. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c150015 · Cited by 1,819
“Binding of ACTH to MC2R produces adenylate cyclase-dependent increases in intracellular cAMP levels, which causes a rapid increase in cholesterol biosynthesis (149).”
Lifton, R. P., Dluhy, R. G., Powers, M., Rich, G. M., Cook, S., Ulick, S., & Lalouel, J.-M. (1992) · Nature · doi:10.1038/355262a0 · Cited by 1,158
StAR protein and the regulation of steroid hormone biosynthesis.
Stocco, D. M. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.193 · Cited by 917
Glucocorticoids in T Cell Development and Function
Ashwell, J. D., Lu, F. W. M., & Vacchio, M. S. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.309 · Cited by 777
Metadata
- Authors
- Simpson, E. R., & Waterman, M. R.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- ORCID
- Simpson, Evan R.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1988-10
- Volume
- 50
- Issue
- 1
- Pages
- 427-440
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2125701765
- Cited by
- 506
- References
- 0
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 11 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 11 · 2015: 7 · 2014: 16 · 2013: 8 · 2012: 8
- FWCI
- 20.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am028350-05)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 13234, HD-11149)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- ACTH, steroidogenic enzymes, adrenal cortex, enzyme synthesis regulation, steroidogenesis, glucocorticoid feedback, macrophage polarization
- MeSH terms
- Adrenal Cortex, Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Animals, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
