Cited by 506Adrenal Hormones and DisordersStress Responses and CortisolHormonal Regulation and Hypertension

The DOI matches its Crossref record.

Regulation of the Synthesis of Steroidogenic Enzymes in Adrenal Cortical Cells by ACTH

Simpson, Evan R., Waterman, Michael R.·1988·Annual Review of Physiology

Open this paper in CoChat — free account

Abstract

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and ...Read More

Integrity signals

Registry

Crossref · 10.1146/annurev.ph.50.030188.002235

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Smith, S. M., & Vale, W. W. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/ssmith · Cited by 1,948
“Specifically, ACTH promotes the conversion of cholesterol into δ-5 pregnenolone during the initial step of glucocorticoid biosynthesis.(61,64)”
Background
Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response
Herman, J. P., McKlveen, J. M., Ghosal, S., Kopp, B., Wulsin, A., Makinson, R., Scheimann, J., & Myers, B. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c150015 · Cited by 1,819
“Binding of ACTH to MC2R produces adenylate cyclase-dependent increases in intracellular cAMP levels, which causes a rapid increase in cholesterol biosynthesis (149).”
A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
Lifton, R. P., Dluhy, R. G., Powers, M., Rich, G. M., Cook, S., Ulick, S., & Lalouel, J.-M. (1992) · Nature · doi:10.1038/355262a0 · Cited by 1,158
StAR protein and the regulation of steroid hormone biosynthesis.
Stocco, D. M. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.193 · Cited by 917
Glucocorticoids in T Cell Development and Function
Ashwell, J. D., Lu, F. W. M., & Vacchio, M. S. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.309 · Cited by 777
The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock
Oster, H., Damerow, S., Kiessling, S., Jakubcakova, V., Abraham, D., Tian, J., Hoffmann, M. W., & Eichele, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.002 · Cited by 528
“…biosynthesis Network of enzymes and regulators of corticosterone production (modified from Delarue et al., 2001; Gallo-Payet and Payet, 2003; Manna and Stocco, 2005; Parker and Schimmer, 1997; Payne and Hales, 2004; Richards, 2001; Sewer and Waterman, 2001; Stocco, 2001; Stocco et al., 2005 ).”
A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s.
Morohashi, K.-I., Honda, S., Inomata, Y., Handa, H., & Omura, T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37129-7 · Cited by 537
Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought
Stocco, D. M., Wang, X., Jo, Y., & Manna, P. R. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0532 · Cited by 538
Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones
Hu, J., Zhang, Z., Shen, W., & Azhar, S. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-47 · Cited by 562
“More chronic, long-term regulation of steroidogenesis also occurs at the level of the transcription of the genes for the steroidogenic enzymes to enhance, which results in the enhanced synthetic capacity of the cell [41-45].”
Background
Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia
Caron, K. M., Soo, S.-C., Wetsel, W. C., Stocco, D. M., Clark, B. J., & Parker, K. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11540 · Cited by 449
Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review
Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450
“adrenal gland to produce steroid hormones, specifically DHEA and cortisol [21,22].”
Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily.
Honda, S., Morohashi, K.-I., Nomura, M., Takeya, H., Kitajima, M., & Omura, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53202-6 · Cited by 408
Developmental defects of the ventromedial hypothalamic nucleus and pituitary gonadotroph in the Ftz‐F1 disrupted mice
Shinoda, K., Lei, H., Yoshii, H., Nomura, M., Nagano, M., Shiba, H., Sasaki, H., Osawa, Y., Ninomiya, Y., Niwa, O., et al. (1995) · Developmental Dynamics · doi:10.1002/aja.1002040104 · Cited by 357
Adrenocorticotropin (ACTH)- and Non-ACTH-Mediated Regulation of the Adrenal Cortex: Neural and Immune Inputs
Bornstein, S. R., & Chrousos, G. P. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.5.5631 · Cited by 354
Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase
Lifton, R. P., Dluhy, R. G., Powers, M., Rich, G. M., Gutkin, M. C., Fallo, F., Gill, J. R., Feld, L. G., Ganguly, A., Laidlaw, J. C., et al. (1992) · Nature Genetics · doi:10.1038/ng0992-66 · Cited by 329
Ectopic and Abnormal Hormone Receptors in Adrenal Cushing's Syndrome
Lacroix, A., N’Diaye, N., Tremblay, J., & Hamet, P. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.1.0420 · Cited by 350
“CYP 17 (P450c17), CYP21A2 (P450c21), and CYP11B1 (P450c11) (24, 26, 38).”
Mitochondrial Ion Channels
O'Rourke, B. P. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.031905.163804 · Cited by 319
Circadian rhythm of adrenal glucocorticoid: its regulation and clinical implications
Chung, S., Son, G. H., & Kim, K. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.02.003 · Cited by 305
Identical origin of adrenal cortex and gonad revealed by expression profiles of Ad4BP/SF‐1
Hatano, O., Takakusu, A., Nomura, M., & Morohashi, K. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.00254.x · Cited by 298
“Although their developmental relationship is highly interesting when considering their common function of synthesizing steroid hormones (Dufau 1988; Richard & Hedin 1988; Simpson & Waterman 1988 ), no definitive conclusions have been drawn on the developmental relationship of these tissues.”
Background
Sex-dependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development
Hatano, O., Takayama, K., Imai, T., Waterman, M. R., Takakusu, A., Omura, T., & Morohashi, K.-I. (1994) · Development · doi:10.1242/dev.120.10.2787 · Cited by 269
Self-citation
Forty Years of Cytochrome P450
Omura, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1887 · Cited by 270
Developmental roles of the steroidogenic acute regulatory protein (StAR) as revealed by StAR knockout mice
Hasegawa, T., Zhao, L., Caron, K. M., Majdic, G., Suzuki, T., Shizawa, S., Sasano, H., & Parker, K. L. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.9.0515 · Cited by 263
Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors
Goh, G., Scholl, U. I., Healy, J. M., Choi, M., Prasad, M. L., Nelson-Williams, C. J., Kunstman, J. W., Korah, R. M., Suttorp, A., Dietrich, D., et al. (2014) · Nature Genetics · doi:10.1038/ng.2956 · Cited by 263
“The resulting cAMP binds the regulatory subunit of PKA, inducing release of the PKA catalytic subunit, allowing phosphorylation of downstream targets such as CREB 20,21 .”
The Orphan Nuclear Receptor NGFI-B Regulates Expression of the Gene Encoding Steroid 21-Hydroxylase
Wilson, T. E., Mouw, A. R., Weaver, C. A., Milbrandt, J., & Parker, K. L. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.2.861 · Cited by 246
Adrenocortical cell lines
Rainey, W. E., Saner, K. J., & Schimmer, B. P. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.12.020 · Cited by 238
Characterization of the Promoter Region of the Mouse Gene Encoding the Steroidogenic Acute Regulatory Protein
Caron, K. M., Ikeda, Y., Soo, S.-C., Stocco, D. M., Parker, K. L., & Clark, B. J. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.2.9880 · Cited by 243
Multifactorial regulation of the hypothalamic-pituitary-adrenal axis during development
Rosenfeld, P., Suchecki, D., & Levine, S. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80196-4 · Cited by 231
Regulation of the Primate Fetal Adrenal Cortex*
Pepe, G. J., & Albrecht, E. D. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-1-151 · Cited by 209
Cyclic AMP-dependent and -independent Regulation of Cholesterol Side Chain Cleavage Cytochrome P-450 (P-450scc) in Rat Ovarian Granulosa Cells and Corpora Lutea.
Oonk, R. B., Krasnow, J. S., Beattie, W. G., & Richards, J. S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88275-1 · Cited by 194
Melanocortin receptors: their functions and regulation by physiological agonists and antagonists
ABDEL‐MALEK, Z. A. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000868 · Cited by 183
Hypothalamic‐Pituitary‐Adrenal (HPA) Axis and Aging
Gupta, D., & Morley, J. E. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130049 · Cited by 210
“Within 24 h of exposure, ACTH exerts effects at the transcriptional level to increase synthesis of all steroidogenic CYP enzymes— CYP11A1, CYP17A1, CYP21A2 as well as CYP11B1 and hence stimulates GC production (227,252); it also increases adrenal weight by inducing both hyperplasia and hypertrophy.”
Spatio-Temporal Expression Patterns of Steroidogenic Acute Regulatory Protein (StAR) During Follicular Development in the Rat Ovary
Fuhrmann, T. R., Timberg, R., King, S. R., Hales, K. H., Hales, D. B., Stocco, D. M., & Orly, J. (1998) · Endocrinology · doi:10.1210/endo.139.1.5694 · Cited by 182
“Furthermore, in light of our results, it is tempting to speculate that in cells of the adrenal cortex, where proteins of the P450scc machinery are constitutively expressed at high levels (1, 53), diurnal changes in ACTH probably regulate StAR-”
CCAAT Enhancer-binding Protein β and GATA-4 Binding Regions within the Promoter of the Steroidogenic Acute Regulatory Protein (StAR) Gene Are Required for Transcription in Rat Ovarian Cells
Silverman, E., Eimerl, S., & Orly, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17987 · Cited by 177
Different Isozymes of Mouse 11/ß-Hydroxylase Produce Mineralocorticoids and Glucocorticoids
Domalik, L. J., Chaplin, D., Kirkman, M. S., Wu, R. C., Liu, W., Howard, T. A., Seldin, M. F., & Parker, K. L. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-12-1853 · Cited by 171
ACTH induces up-regulation of ACTH receptor mRNA in mouse and human adrenocortical cell lines
Mountjoy, K. G., Bird, I. M., Rainey, W. E., & Cone, R. D. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90160-0 · Cited by 170
Major pharmacological distinction of the ACTH receptor from other melanocortin receptors
Schiöth, H. B., Chhajlani, V., Muceniece, R., Klusa, V. Z., & Wikberg, J. E. S. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00370-0 · Cited by 168
Corticosterone mediates the condition-dependent component of melanin-based coloration
Roulin, A., Almasi, B., Rossi-Pedruzzi, A., Ducrest, A., Wakamatsu, K., Mikšı́k, I., Blount, J. D., Jenni‐Eiermann, S., & Jenni, L. (2007) · Animal Behaviour · doi:10.1016/j.anbehav.2007.09.007 · Cited by 170
“Melanocortins regulate not only the production of melanin (Jimbow et al. 2000; Rees 2003) but also a number of other physiological functions including the stress response principally through ACTH, which is part of the hypothalamicepituitaryeadrenal axis (HPA) (Simpson & Waterman 1988).”
Influential
Adrenal steroidogenesis in very low birth weight preterm infants
Hingre, R. V., Groß, S., Hingre, K. S., Mayes, D. M., & Richman, R. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.2.8106610 · Cited by 172
PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response
Belgardt, B., Husch, A., Rother, E., Ernst, M. B., Wunderlich, F. T., Hampel, B., Klöckener, T., Alessi, D. R., Kloppenburg, P., & Brüning, J. C. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.01.006 · Cited by 159
Regulation of corticotropin receptor number and messenger RNA in cultured human adrenocortical cells by corticotropin and angiotensin II.
Lebrethon, M. C., Naville, D., Bégeot, M., & Saez, J. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117168 · Cited by 153
Normal and Premature Adrenarche
Rosenfield, R. L. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab009 · Cited by 170
Steroid deficiency syndromes in mice with targeted disruption of Cyp11a1
Hu, M.-C., Hsu, N.-C., El Hadj, N. B., Pai, C.-I., Chu, H.-P., Wang, C.-K. L., & Chung, B.-C. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0055 · Cited by 153
Regulation of human adrenal carcinoma cell (NCI-H295) production of C19 steroids
Rainey, W. E., Bird, I. M., Sawetawan, C., Hanley, N. A., McCarthy, J. L., McGee, E. A., Wester, R., & Mason, J. I. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.3.8396576 · Cited by 159
Corticotropin positively regulates its own receptors and cAMP response in cultured bovine adrenal cells.
Penhoat, A., Jaillard, C., & Saez, J. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.4978 · Cited by 149
Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice
Crawford, P. A., Sadovsky, Y., Woodson, K., Lee, S. L., & Milbrandt, J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4331 · Cited by 145
Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300
Monté, D., DeWitte, F., & Hum, D. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.8.4585 · Cited by 147
Turnover of Mitochondrial Steroidogenic Acute Regulatory (StAR) Protein by Lon Protease: The Unexpected Effect of Proteasome Inhibitors
Granot, Z., Kobiler, O., Melamed‐Book, N., Eimerl, S., Bahat, A., Lü, B., Braun, S., Maurizi, M. R., Suzuki, C. K., Oppenheim, A. B., et al. (2007) · Molecular Endocrinology · doi:10.1210/me.2005-0458 · Cited by 141
Biochemical diversity of cAMP-dependent transcription of steroid hydroxylase genes in the adrenal cortex.
Waterman, M. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46850-0 · Cited by 135
Self-citation
The adrenal peripheral clock: Glucocorticoid and the circadian timing system
Son, G. H., Chung, S., & Kim, K. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.003 · Cited by 136
“Different sets of steroidogenic genes are expressed in each zone to produce different kinds of steroid hormones from cholesterol, a common precursor of all steroids [185].”
Discovery of novel melanocortin4 receptor selective MSH analogues
Schiöth, H. B., Mutulis, F., Muceniece, R., Prūsis, P., & Wikberg, J. E. S. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701804 · Cited by 137
“The melanocortic peptides, ACTH (adrenocorticotropin) and MSH (melanocyte stimulating hormone), are primarily known for their role in the regulation of adrenal steroid production (Simpson & Waterman, 1988), and skin pigmentation (Eberle, 1988).”
Background
Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree.
Pascoe, L., Jeunemaı̂tre, X., Lebrethon, M. C., Curnow, K. M., Gómez-Sánchez, C. E., Gasc, J., Saez, J. M., & Corvol, P. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118279 · Cited by 134
“lase activities in this zone, is controlled by secretion of ACTH from the anterior pituitary (4).”
Background
Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage
Crawford, P. A., Sadovsky, Y., & Milbrandt, J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.7.3997 · Cited by 134
“The reverse primer used for SF-1 (1-277) was a primer that introduces a stop codon after codon 277, and that used for SF-1 (DBD) was a primer that introduces a stop codon after codon 104.”
BackgroundMethodInfluential
Endocrine Cascade in Insect Metamorphosis
Gilbert, L. I., Rybczynski, R., & Tobe, S. S. (1996) · Elsevier eBooks · doi:10.1016/b978-012283245-1/50004-x · Cited by 135
Prothoracicotropic Hormone
Rybczynski, R. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00033-8 · Cited by 133
Transcriptional regulation of the bovine CYP17 (P-450(17)alpha) gene. Identification of two cAMP regulatory regions lacking the consensus cAMP-responsive element (CRE).
Lund, J., Ahlgren, R., Wu, D.-H., Kagimoto, M., Simpson, E. R., & Waterman, M. R. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39767-4 · Cited by 130
Self-citation
Glucocorticoid-Remediable Aldosteronism
McMahon, G. T., & Dluhy, R. G. (2003) · Cardiology in Review · doi:10.1097/01.crd.0000096417.42861.ce · Cited by 126
Control of Differentiation, Transformation, and Apoptosis in Granulosa Cells by Oncogenes, Oncoviruses, and Tumor Suppressor Genes
Amsterdam, A., & Selvaraj, N. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.4.0306 · Cited by 137
An E Box Element Is Required for the Expression of the ad4bp Gene, a Mammalian Homologue of ftz-f1 Gene, Which Is Essential for Adrenal and Gonadal Development
Nomura, M., Bärtsch, S., Nawata, H., Omura, T., & Morohashi, K.-I. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7453 · Cited by 119
The ontogenesis of the steroidogenic tissues
Morohashi, K. (1997) · Genes to Cells · doi:10.1046/j.1365-2443.1997.1060304.x · Cited by 121
Effects of repeated maternal separations on the adrenocortical response to stress of preweanling rats
Rosenfeld, P., Wetmore, J. B., & Levine, S. D. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90415-x · Cited by 122
Current knowledge on the acute regulation of steroidogenesis
Selvaraj, V., Stocco, D. M., & Clark, B. J. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy102 · Cited by 118
T-type Ca2+ channels are required for adrenocorticotropin-stimulated cortisol production by bovine adrenal zona fasciculata cells.
Enyeart, J. J., Mlinar, B., & Enyeart, J. A. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.8.8232302 · Cited by 119
Androgenic hormones during prolonged physical stress, sleep, and energy deficiency
Opstad, P. K. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.5.1314847 · Cited by 127
Mitochondrial specificity of the early steps in steroidogenesis
Miller, W. L. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00212-x · Cited by 111
Reciprocal Regulation of a Glucocorticoid Receptor-Steroidogenic Factor-1 Transcription Complex on the Dax-1 Promoter by Glucocorticoids and Adrenocorticotropic Hormone in the Adrenal Cortex
Gummow, B. M., Scheys, J. O., Cancelli, V. R., & Hammer, G. D. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0461 · Cited by 114
Neurosteroid, GABAergic and hypothalamic pituitary adrenal (HPA) axis regulation: what is the current state of knowledge in humans?
Crowley, S. K., & Girdler, S. S. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3572-8 · Cited by 115
“The difference in time course of response for ACTH and ALLO-THDOC is consistent with the evidence that the formation of ALLOTHDOC requires availability of deoxycorticosterone from the adrenal cortex, the synthesis of which is under the control of ACTH (Simpson and Waterman 1988).”
Hormone-stimulated steroidogenesis is coupled to mitochondrial benzodiazepine receptors. Tropic hormone action on steroid biosynthesis is inhibited by flunitrazepam
Papadopoulos, V., Nowzari, F. B., & Krueger, K. E. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67848-8 · Cited by 118
Characterization of the promoter/regulatory region of the bovine CYP11A (P-450scc) gene. Basal and cAMP-dependent expression.
Ahlgren, R., Simpson, E. R., Waterman, M. R., & Lund, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39768-6 · Cited by 105
Self-citation
Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function
Bland, M. L., Fowkes, R. C., & Ingraham, H. A. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0333 · Cited by 105
“Given that ACTH is the primary regulator of steroidogenic gene expression and adrenal mass (25), elevated basal ACTH levels observed in SF-1 / mice most likely drive the increased function observed in SF-1 / adrenals (8).”
Background
ACTH-receptor expression, regulation and role in adrenocortial tumor formation
Beuschlein, F., Faßnacht, M., Klink, A., Allolio, B., & Reincke, M. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1440199 · Cited by 103
“After long-term stimulation, ACTH increases the output of adrenal fasciculata cells by increasing the expression of several key steroidogenic enzymes ( 8 ).”
Background
Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme.
Rice, D. A., Kirkman, M. S., Aitken, L. D., Mouw, A. R., Schimmer, B. P., & Parker, K. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38455-8 · Cited by 103
Ectopic pro-opiomelanocortin syndrome
Beuschlein, F., & Hammer, G. D. (2002) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(01)00025-1 · Cited by 101
“After longterm stimulation corticotropin, in excess, provokes profound increases in the expression of several key steroidogenic enzymes, namely P450 side chain cleavage enzyme, P450 11b-hydroxylase, P450 21-hydroxylase, and 3b-hydroxysteroid dehydrogenase [181,302], which in turn lead to the overt hypercor tisolism di…”
Background
The Peripheral Benzodiazepine Receptors: A Review
Beurdeley‐Thomas, A., Miccoli, L., Oudard, S. M., Dutrillaux, B., & Poupon, M. F. (2000) · Journal of Neuro-Oncology · doi:10.1023/a:1006456715525 · Cited by 103
“Instead, the rate at with the cholesterol is transported to the inner mitochondrial membrane determines the rate of steroid production [96].”
Circulating Androgens in Women: Exercise-Induced Changes
Enea, C., Boisseau, N., Fargeas-Gluck, M. A., Diaz, V., & Dugué, B. (2011) · Sports Medicine · doi:10.2165/11536920-000000000-00000 · Cited by 103
Survey of the Adrenal Homolog in Teleosts
Gallo, V. P., & Civinini, A. (2003) · International review of cytology · doi:10.1016/s0074-7696(03)30003-8 · Cited by 101
Molecular and functional properties of mitochondrial benzodiazepine receptors
Krueger, K. E. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00016-x · Cited by 100
Organelle plasticity and interactions in cholesterol transport and steroid biosynthesis
Issop, L., Rone, M. B., & Papadopoulos, V. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.12.003 · Cited by 103
“Although steroidogenic cells constitutively produce a certain amount of steroids, this process is accelerated by the pituitary trophic hormones, adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), and follicle stimulating hormone (FSH), which induce the production of cyclic AMP (cAMP) (Jefcoate, 2002; Simpso…”
Background
Eel (Anguilla japonica) testis 11β-hydroxylase gene is expressed in interrenal tissue and its product lacks aldosterone synthesizing activity
Jiang, J., Young, G., Kobayashi, T., & Nagahama, Y. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00147-6 · Cited by 98
Rat cholesterol side-chain cleavage cytochrome P-450 (P-450scc) gene. Structure and regulation by cAMP in vitro.
Oonk, R. B., Parker, K. L., Gibson, J. L., & Richards, J. S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45718-3 · Cited by 95
Regulation of stress response is heritable and functionally linked to melanin‐based coloration
Almasi, B., Jenni, L., Jenni‐Eiermann, S., & Roulin, A. (2010) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2010.01969.x · Cited by 103
The High-Affinity cAMP-Specific Phosphodiesterase 8B Controls Steroidogenesis in the Mouse Adrenal Gland
Tsai, L.-C. L., Shimizu‐Albergine, M., & Beavo, J. A. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.069104 · Cited by 95
Interleukin-1 Inhibits Cholesterol Side-Chain Cleavage Cytochrome P450 Expression in Primary Cultures of Leydig Cells*
Lin, T., WANG, D., Nagpal, M. L., CALKINS, J. H., CHANG, W., & Chi, R. (1991) · Endocrinology · doi:10.1210/endo-129-3-1305 · Cited by 96
Two Sp1-binding Sites Mediate cAMP-induced Transcription of the Bovine CYP11A Gene through the Protein Kinase A Signaling Pathway
Venepally, P., & Waterman, M. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25402 · Cited by 91
Self-citation
Circadian blueprint of metabolic pathways in the brain
Greco, C. M., & Sassone‐Corsi, P. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0096-y · Cited by 94
Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes
Ruggiero, C., & Lalli, E. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00024 · Cited by 106
“The adrenocorticotropic hormone (ACTH) belongs to this regulatory circuitry, being one of the most potent physiological modulators of adrenal cortex steroidogenesis and trophicity (1, 2).”
Background
A Star Search: Implications in Controlling Steroidogenesis1
Stocco, D. M. (1997) · Biology of Reproduction · doi:10.1095/biolreprod56.2.328 · Cited by 88
Regulation of Steroid Hydroxylase Gene Expression Is Multifactorial in Nature
Waterman, M. R., & Simpson, E. R. (1989) · Elsevier eBooks · doi:10.1016/b978-0-12-571145-6.50016-9 · Cited by 86
Self-citation
Mitochondrial protein import and the genesis of steroidogenic mitochondria
Midzak, A., Rone, M., Aghazadeh, Y., Culty, M., & Papadopoulos, V. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.12.007 · Cited by 89
Selectivity of Cyclic [d-Nal7] and [d-Phe7] Substituted MSH Analogues for the Melanocortin Receptor Subtypes
Schiöth, H. B., Muceniece, R., Mutulis, F., Prūsis, P., Lindeberg, G., Sharma, S. D., Hruby, V. J., & Wikberg, J. E. S. (1997) · Peptides · doi:10.1016/s0196-9781(97)00079-x · Cited by 87
Proteolysis of Normal and Mutated Steroidogenic Acute Regulatory Proteins in the Mitochondria: the Fate of Unwanted Proteins
Granot, Z., Geiss‐Friedlander, R., Melamed‐Book, N., Eimerl, S., Timberg, R., Weiss, A. M., Hales, K. H., Hales, D. B., Stocco, D. M., & Orly, J. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0074 · Cited by 87
Nuclear Receptors Nor1 and NGFI-B/Nur77 Play Similar, Albeit Distinct, Roles in the Hypothalamo-Pituitary-Adrenal Axis1
Fernandez, P. M., Brunel, F., Jimenez, M. A., Saez, J. M., Cereghini, S., & Zakin, M. M. (2000) · Endocrinology · doi:10.1210/endo.141.7.7562 · Cited by 85
A brief history of the search for the protein(s) involved in the acute regulation of steroidogenesis
Stocco, D. M., Zhao, A. H., Tu, L. N., Morohaku, K., & Selvaraj, V. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.07.036 · Cited by 85
Product of Side-chain Cleavage of Cholesterol, Isocaproaldehyde, Is an Endogenous Specific Substrate of Mouse Vas Deferens Protein, an Aldose Reductase-like Protein in Adrenocortical Cells
Lefrançois‐Martinez, A., Tournaire, C., Martinez, A., Berger, M., Daoudal, S., Tritsch, D., VEYSSIERE, G., & Jean, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.32875 · Cited by 82
Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells
Hanukoglu, I., Suh, B. S., Himmelhoch, S., & Amsterdam, A. (1990) · The Journal of cell biology · doi:10.1083/jcb.111.4.1373 · Cited by 81
“Their inductive effects can be duplicated by stimulation with cAMP suggesting that this may be an intracellular messenger of the gonadotropins (8, 32, 36).”
Background
Characterization of Cytochrome P450 Enzymes in Human Breast Tissue from Reduction Mammaplasties1
Hellmold, H., Rylander‐Rudqvist, T., Magnusson, M., Reihnér, E., Warner, M. N., & Gustafsson, J.-Α. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4647 · Cited by 82
PKA catalytic subunit mutations in adrenocortical Cushing’s adenoma impair association with the regulatory subunit
Calebiro, D., Hannawacker, A., Lyga, S., Bathon, K., Zabel, U., Ronchi, C. L., Beuschlein, F., Reincke, M., Lorenz, K., Allolio, B., et al. (2014) · Nature Communications · doi:10.1038/ncomms6680 · Cited by 77
The Ectopic Expression of the Gastric Inhibitory Polypeptide Receptor Is Frequent in Adrenocorticotropin-Independent Bilateral Macronodular Adrenal Hyperplasia, but Rare in Unilateral Tumors
Groussin, L., Perlemoine, K., Contesse, V., Lefèbvre, H., Tabarin, A., Thiéblot, P., Schlienger, J. L., LUTON, J. P., BERTAGNA, X. Y., & Bertherat, J. Y. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8458 · Cited by 82
“stimulation of the cAMP pathway (2), increased adrenocor-”
Background
ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms?
Frīdmanis, D., Roga, A., & Kloviņš, J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00013 · Cited by 82
“Thus, a large amount of knowledge was accumulated well before the discovery of the receptor itself, and some of these early studies revealed that the receptor was also present in murine fat cells (40–42) and in addition to increasing corticosteroid production (1, 43), activation of the ACTHR is accompanied by the acti…”
Background
Glucocorticoid-remediable aldosteronism (GRA): Diagnosis, variability of phenotype and regulation of potassium homeostasis
Dluhy, R. G., & Lifton, R. P. (1995) · Steroids · doi:10.1016/0039-128x(94)00010-a · Cited by 78
Hormonal Regulation of MicroRNA Expression in Steroid Producing Cells of the Ovary, Testis and Adrenal Gland
Hu, Z., Shen, W., Cortez, Y., Tang, X., Liu, L.-F., Kraemer, F. B., & Azhar, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078040 · Cited by 80
“Adrenal and gonadal steroidogenesis is predominantly controlled by trophic hormones (ACTH and LH/FSH, respectively) and is subject to both acute [3], [6–9] and chronic regulation [2], [3], [10–13].”
Background

Authors: Simpson, E. R., & Waterman, M. R.
Affiliations: The University of Texas Southwestern Medical Center (US)
ORCID: Simpson, Evan R.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 1988-10
Volume: 50
Issue: 1
Pages: 427-440
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.ph.50.030188.002235
OpenAlex: W2125701765
Cited by: 506
References: 0
Citations by year: 2026: 3 · 2025: 5 · 2024: 5 · 2023: 11 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 11 · 2015: 7 · 2014: 16 · 2013: 8 · 2012: 8
FWCI: 20.22
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01am028350-05)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 13234, HD-11149)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: ACTH, steroidogenic enzymes, adrenal cortex, enzyme synthesis regulation, steroidogenesis, glucocorticoid feedback, macrophage polarization
MeSH terms: Adrenal Cortex, Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Animals, Humans

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of the Synthesis of Steroidogenic Enzymes in Adrenal Cortical Cells by ACTH

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks