The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations
Abstract
Mitochondrial oxidative damage contributes to a range of degenerative diseases. Consequently, the selective inhibition of mitochondrial oxidative damage is a promising therapeutic strategy. One way to do this is to invent antioxidants that are selectively accumulated into mitochondria within patients. Such mitochondria-targeted antioxidants have been developed by conjugating the lipophilic triphenylphosphonium cation to an antioxidant moiety, such as ubiquinol or α-tocopherol. These compounds pass easily through all biological membranes, including the blood-brain barrier, and into muscle cells and thus reach those tissues most affected by mitochondrial oxidative damage. Furthermore, because of their positive charge they are accumulated several-hundredfold within mitochondria driven by the membrane potential, enhancing the protection of mitochondria from oxidative damage. These compounds protect mitochondria from damage following oral delivery and may therefore form the basis for mitochondria-protective therapies. Here we review the background and work to date on this class of mitochondria-targeted antioxidants.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“MitoQ rapidly crosses the blood– brain barrier and neuronal membranes and concentrates several hundred-fold in mitochondria driven by the high membrane potential across the inner mitochondrial membrane (IMM; Murphy and Smith, 2007).”
From The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease (2011) · cites this paper as Murphy and Smith, 2007
In the citing paper
“The recently developed, mitochondria-targeted antioxidant MitoQ (mitoquinone mesylate: [10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cycloheexadienlyl) decyl triphenylphosphonium methanesulfonate]) possesses these qualities (James et al., 2005, 2007; Murphy and Smith, 2007).”
From The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease (2011) · cites this paper as Murphy and Smith, 2007
In the citing paper
“Although in most cases this semiquinone is rapidly oxidized, its reaction with oxygen leads to superoxide production at this site (567, 678).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [678]
In the citing paper
“Although the majority of electrons entering the ETC ultimately reduce oxygen to water at complex IV, a small proportion (~2–11%) of electrons escape from the chain at complex I or III to generate superoxide (34, 115, 678).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [678]
In the citing paper
“Importantly, specific complex III inhibitors, such as Antimycin A, can stabilize this semiquinone radical, significantly enhancing superoxide production by complex III (678).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [678]
In the citing paper
“Moreover, treatment with MitoQ, a substance known to scavenge matrix mtROS (see Section 6) [314,315], gave contrasting results: only IL-1β cleavage was reduced, whereas TNF and IL-10 levels remained unaltered.”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [314]
In the citing paper
“whereas MitoQ is an analog of ubiquinone and prevents lipid peroxidation in mitochondrial membranes [314,315].”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [314]
In the citing paper
“MitoTEMPO is a combination of the antioxidant TEMPO attached to the TPP group and hence dismutates O2●− to H2O2 in the mitochondrial matrix [314,391]”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [314]
In the citing paper
“MitoTEMPO and MitoQ both are targeted to and accumulated in mitochondria due to their TPP group.”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [314]
Citations
Cites
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(96)00423-1 · Cited by 11,484
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388
BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER
Gottesman, M. M., & PASTAN, I. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.002125 · Cited by 3,569
The Pathophysiology of Mitochondrial Cell Death
Green, D. R., & Kroemer, G. (2004) · Science · doi:10.1126/science.1099320 · Cited by 3,487
Mitochondrial diseases in man and mouse
Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060
Strategies of antioxidant defense
SIES, H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18025.x · Cited by 1,976
Research works printed but not linked: 4
- Nicholls DG, 2002, Bioenergetics 3
- Ross MF, 2005, Biochemistry, 70, 222
- Pletjushkina OY, 2006, Biochemistry, 71, 60
- Calabrese EJ, 2006, Curr. Opin. Drug Discov. Dev, 9, 117
Cited by
Sorted by citations
Items 901–1,000 of 1,000
Mitochondria-Targeted Antioxidants
Smith, R. A. J., Hartley, R. C., & Murphy, M. P. (2012) · Oxidative stress and disease · doi:10.1201/b12308-8 · Cited by 9
Self-citationPredicting and Understanding the Pathology of Single Nucleotide Variants in Human COQ Genes
Wang, S., Jain, A., Novales, N. A., Nashner, A. N., Tran, F., & Clarke, C. F. (2022) · Antioxidants · doi:10.3390/antiox11122308 · Cited by 7
Amorim, R., Magalhães, C. C., Benfeito, S., Cagide, F., Tavares, L. C., Santos, K., Sardão, V. A., Datta, S., Cortopassi, G. A., Baldeiras, I., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115953 · Cited by 7
Photodynamic Therapy with Water-Soluble Cationic Fullerene Derivatives
Wang, M., Huang, Y., Sperandio, F. F., Huang, L., Sharma, S. K., Mróz, P., Hamblin, M. R., & Chiang, L. Y. (2015) · Springer series in biomaterials science and engineering · doi:10.1007/978-3-319-22861-7_5 · Cited by 7
Recent approaches to target apoptosis in neurological disorders
Sodhi, R. K., Grewal, A. K., Madan, J., Singh, T. G., & Kumar, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815762-6.00008-1 · Cited by 7
Wallace, D. C., Lott, M. T., & Procaccio, V. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00013-6 · Cited by 8
Anti-Oxidant Drugs: Novelties and Clinical Implications in Cerebellar Ataxias
Barca, E., Emmanuele, V., DiMauro, S., Toscano, A., & Quinzii, C. M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666171109125643 · Cited by 7
Mitophagy could fight Parkinson’s disease through antioxidant action
Rita, A. D., & Strappazzon, F. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0095 · Cited by 7
Neto, J. C., Lucantoni, F., González, L. V., Falomir, E., Miravet, J. F., & Galindo, F. (2025) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00554 · Cited by 6
Zhang, L., Xu, W., Zeng, Y., Wang, L., Luo, J., Zhou, X., Mei, Q., Qin, D., Wu, A., Wu, J., et al. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01092-3 · Cited by 6
Nguyen, S. T., Otoi, T., Namula, Z., Widodo, O. S., Tharasanit, T., Chatdarong, K., Nakayama, Y., Nagahara, M., Nakai, A., Hirata, M., et al. (2025) · Animals · doi:10.3390/ani15172497 · Cited by 6
Mathieu, B., Rondeau, J. D., Mignion, L., Sonveaux, P., & Gallez, B. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103871 · Cited by 6
Air pollution as a key risk factor for alzheimer’s disease: A comprehensive review
Zhu, X., Guo, C., Zhang, Y., & Wei, Y. (2025) · Environmental Technology & Innovation · doi:10.1016/j.eti.2025.104555 · Cited by 6
Qin, M.-N., & Ya-nan, D. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2025.1700911 · Cited by 6
Sulaiman, S. H., Omer, R. A., Barzani, K. I. S., Barzani, H. A. H., Ashfaq, M., Smerat, A., & Feizi‐Dehnayebi, M. (2026) · Chemical Physics Impact · doi:10.1016/j.chphi.2026.101054 · Cited by 6
Qian, J., Li, Y., Wang, Y., Ye, Q., & Luo, H.-B. (2023) · Redox Report · doi:10.1080/13510002.2023.2259246 · Cited by 6
Duan, K., Wang, T., You, J., Wang, H., Wang, Z., Huang, Z., Zhang, J., Sun, Y., Xiong, Y., Guan, K., et al. (2024) · Immunology · doi:10.1111/imm.13827 · Cited by 6
Hattan, C. M., Shojaie, J., Lau, S. S., & Anders, M. W. (2012) · Synthetic Communications · doi:10.1080/00397911.2011.587078 · Cited by 6
Li, L., Brichard, L., Larsen, L., Menon, D. K., Smith, R. A. J., Murphy, M. P., & Aigbirhio, F. I. (2013) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.3109 · Cited by 6
Self-citationPharmacological Targeting of the Mitochondrial Permeability Transition Pore for Cardioprotection
Silva, F. S. G., Costa, C. F., Marques, R., Oliveira, P. J., & Pereira, G. C. (2018) · Springer eBooks · doi:10.1007/978-3-319-73344-9_20 · Cited by 7
Cairns, A. G., McQuaker, S. J., Murphy, M. P., & Hartley, R. C. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1262-0_6 · Cited by 6
Self-citationMitochondrial targeting of potent nanoparticulated drugs in combating diseases
Mandal, A. K. (2022) · Journal of Biomaterials Applications · doi:10.1177/08853282221111656 · Cited by 6
Clinical trials in mitochondrial diseases
Karaa, A., & Klopstock, T. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-12-821751-1.00002-6 · Cited by 6
Leung, P.-Y., Chen, W., Sari, A. N., Sitaram, P., Wu, P., Tsai, S., & Park, J. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i7.714 · Cited by 7
Lee, R., Lee, W.-Y., & Park, H.-J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094923 · Cited by 8
Cell-Penetrating Peptides Targeting Mitochondria
Cerrato, C. P., & Langel, Ü. (2018) · Springer eBooks · doi:10.1007/978-3-319-73344-9_26 · Cited by 6
Programmed cell death as a target to interrupt the aging program
Severin, F. F., & Skulachev, V. P. (2011) · Advances in Gerontology · doi:10.1134/s2079057011010139 · Cited by 6
Cham, E. D., Peng, T., & Jou, M. (2024) · Biology · doi:10.3390/biology13080639 · Cited by 5
Liu, X., Yang, J., Song, X., Zhang, H., Wang, Z., Ma, J., Guo, L., Du, X., & Cui, H. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.109214 · Cited by 5
Wang, Z., Wang, L. E., Ji, M., 娄杰, Yuan, Y., Cui, Y., Xiang, G., & Zhou, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1734880 · Cited by 5
Goel, K. K., Rawat, P., Murti, Y., Mahajan, S., Kandhari, H., Kumar, B., & Dwivedi, A. R. (2024) · ChemistrySelect · doi:10.1002/slct.202401707 · Cited by 5
Patel, N. T., Satapathy, T., Sahu, P., Satapathy, A., Bhardwaj, S. K., Satapathy, A., Yadav, N., Chandrakar, K., & Chandrakar, M. (2025) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v15i10.7424 · Cited by 6
The Role of Antioxidant on Health and Age-Related Diseases in Aging
Tan, B. L., & Norhaizan, M. E. (2021) · Springer eBooks · doi:10.1007/978-3-030-82859-2_7 · Cited by 5
Nutraceuticals a Food for Thought in the Treatment of Parkinson’s Disease
Bansal, K., Singh, S., Singh, V., & Bajpai, M. (2023) · Current Nutrition & Food Science · doi:10.2174/1573401319666230515104325 · Cited by 5
Intrinsic Factors Behind the Long‐COVID: V. Immunometabolic Disorders
Adilović, M., Hromić‐Jahjefendić, A., Mahmutović, L., Šutković, J., Rubio‐Casillas, A., Redwan, E. M. M. M., & Uversky, V. N. (2024) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30683 · Cited by 5
Drugs that Kill Cancer Stem-like Cells
Zobalová, R., Stantic, M., Stapelberg, M., Prokopová, K., Dong, L., Truksa, J., & Neužil, J. (2011) · InTech eBooks · doi:10.5772/13588 · Cited by 5
Imaging Mitochondrial Hydrogen Peroxide in Living Cells
Lippert, A. R., Dickinson, B. C., & New, E. J. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2257-4_21 · Cited by 5
Garifullin, R., Blokhin, D. S., Ishkaeva, R. A., Petrova, N. V., Kusova, A. M., Klochkov, V. V., & Abdullin, T. I. (2018) · European Biophysics Journal · doi:10.1007/s00249-018-1327-x · Cited by 5
Wang, M., Xu, F., Su, Y. R., Geng, Y., Qian, X., Xue, X., Kong, Y., Yu, Z., Liu, H., & Su, Z. G. (2022) · Angewandte Chemie · doi:10.1002/ange.202203843 · Cited by 5
Сахаутдинов, И. М., Malikova, R. N., Nugumanov, T. R., Biglova, Y. N., Atangulov, A. B., & Yunusov, M. S. (2018) · Chemistry of Natural Compounds · doi:10.1007/s10600-018-2384-1 · Cited by 5
Priyanka, K., & Singh, S. K. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.05.002 · Cited by 5
Transport and metabolism of some cationic ubiquinone antioxidants (MitoQn) in Caco-2 cell monolayers
Li, Y., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2008) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03190873 · Cited by 5
From phosphonium salts to binuclear ortho-palladated phosphorus ylides
Naghipour, A., Badpa, K., & Notash, B. (2014) · Polyhedron · doi:10.1016/j.poly.2014.11.029 · Cited by 5
Константиновна, Ф. Е., Avetisyan, A. V., Izyumov, D. S., Korotetskaya, M. V., Ташлицкий, В. Н., Skulachev, V. P., & Chernyak, B. V. (2011) · Cell and Tissue Biology · doi:10.1134/s1990519x11010056 · Cited by 5
Benien, P., Almuteri, M., Shah, S., Böhlke, M., Mehanna, A., & D’Souza, G. G. M. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1262-0_7 · Cited by 4
Guan, Q., Yu, L., Wang, P., Hu, Q., & Tan, C. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00219 · Cited by 4
Wu, C., Ding, Z., Li, X., Xu, Y., Chen, H., Ruan, H., Zhou, P., Xu, Z., & Xiang, H. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118608 · Cited by 4
Hatami, M., Masoudi, R., Asadzadeh, N., & Sharafi, M. (2025) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2025.107967 · Cited by 4
MitoQ Mitigates Radiation‐Induced Testicular Injury: Molecular Docking and Toxicity Implications
Ibrahim, A. A., El-Gazzar, M. G., & Karam, H. M. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70447 · Cited by 4
Eagleson, K. L., & Levitt, P. R. (2025) · eNeuro · doi:10.1523/eneuro.0172-25.2025 · Cited by 4
Xie, J., Xiao, Y.-Y., Peng, B., Chen, X., Zhang, X., Chen, D., Song, L., Xu, M., Liao, W., & Zhang, X. (2026) · Chemical Communications · doi:10.1039/d5cc06431g · Cited by 4
Delrue, C., Vinckier, M., Speeckaert, R., Marzocco, S., & Speeckaert, M. M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083472 · Cited by 4
Zhao, X., Huang, X., Huang, C., Wang, X., Yang, Y., Dang, R., Zhang, S., Deng, Y., Yan, P., Zhou, Y., et al. (2024) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2024.2366867 · Cited by 4
Exploiting endobiotic metabolic pathways to target xenobiotic antioxidants to mitochondria
Anders, M. W. (2012) · Mitochondrion · doi:10.1016/j.mito.2012.10.015 · Cited by 4
Antonenko, Y. N., Nechaeva, N. L., Baksheeva, V. E., Rokitskaya, T. I., Plotnikov, E. Y., Kotova, Е. А., & Zorov, D. B. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.02.028 · Cited by 4
Culcasi, M., Delehedde, C., Esgulian, M., Cassien, M., Chocry, M., Rockenbauer, A., Pietri, S., & Laurent, S. (2023) · ChemBioChem · doi:10.1002/cbic.202200749 · Cited by 4
Rahman, M. M., Sarker, M. T., Ahmed, S., Uddin, M. N., Islam, M. R., Islam, M. R., Das, S., Mukherjee, N., Hemeg, H. A., Rauf, A., et al. (2023) · Process Biochemistry · doi:10.1016/j.procbio.2023.07.007 · Cited by 4
Ondrasik, R. M., Chen, Q., Navitsky, K., Chau, W. L., Devine, I., Lau, O., Galbreath, T., Barsotti, R., & Young, L. H. (2013) · American Peptide Symposium (APS) · doi:10.17952/23aps.2013.064 · Cited by 4
Towards Small Molecules as Therapies for Alzheimer’s Disease and Other Neurodegenerative Disorders
Aziz, O., Bürli, R. W., Fischer, D. F., Frearson, J. A., & Wall, M. D. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-803959-5.50004-0 · Cited by 5
Mitochondrial Targeting of Antioxidants
Zinovkin, R. A., Bakeeva, L. E., Chernyak, B. V., Egorov, M. V., Исаев, Н. К., Kolosova, N. G., Korshunova, G. A., Манских, В. Н., Moshkin, M. P., Plotnikov, E. Y., et al. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_9 · Cited by 3
Recent Advances in Nanoformulated Chemotherapeutic Drug Delivery (2015‐2019)
Dorababu, A. (2019) · ChemistrySelect · doi:10.1002/slct.201901064 · Cited by 4
Fernandes, E., Benfeito, S., Cagide, F., Gonçalves, H., Bernstorff, S., Nieder, J. B., Oliveira, M. E. C. D. R., Borges, F., & Lúcio, M. (2021) · Nanotechnology Science and Applications · doi:10.2147/nsa.s289355 · Cited by 4
Zhang, B., Liu, J., Bai, X.-Y., Huang, Y.-J., Xu, N., & Ren, T. (2021) · Bioinorganic Chemistry and Applications · doi:10.1155/2021/4763944 · Cited by 4
RetractedJarvis, R. M., Göttert, J., Jarvis, R. M., Göttert, J., Murphy, M. P., & Ledgerwood, E. C. (2007) · Free Radical Research · doi:10.1080/10715760701557153 · Cited by 4
Self-citationDai, D., Chiao, Y. A., Wessells, R. J., Bodmer, R., Szeto, H. H., & Rabinovitch, P. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00017-4 · Cited by 4
How to cancel the program of body aging?
Skulachev, V. P. (2010) · Russian Journal of General Chemistry · doi:10.1134/s1070363210070492 · Cited by 4
Зенков, Н. К., Брониславовна, М. Е., Кандалинцева, Н. В., & Prosenko, A. E. (2009) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-009-0574-3 · Cited by 4
Jadhav, S. B., Sandoval-Acuña, C., Pacior, Y., Potomova, P., Klanicová, K., Blažková, K., Sedláček, R., Štursa, J., Werner, L., & Truksa, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.17.575692 · Cited by 4
Çelen, M. C., Tuncer, S., Akkoca, A., & Dalkılıç, N. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41045 · Cited by 3
Sepay, N., Kim, H., Moon, J., & Im, J. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00696 · Cited by 3
Bradford, T. S., Liu, D., Tour, J. M., & Pál, R. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c01318 · Cited by 3
Catalase: The golden key to regulate oxidative stress in breast cancer
Liu, J., Chen, W.-J., Lan, Y.-Z., & Liu, J. L. (2025) · World Journal of Clinical Oncology · doi:10.5306/wjco.v16.i10.110126 · Cited by 3
Squillace, A., Fernando, M. G., Sullivan, K. E., Kiat, H., & Martins, R. N. (2026) · Antioxidants · doi:10.3390/antiox15010078 · Cited by 4
Kim, B., Kang, H., Park, J., 박, 수., Youn, H., & Youn, B. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02314-1 · Cited by 3
Antioxidants effects in health: The bright and the dark sides
Fakhri, S., & Farzaei, M. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819096-8.00061-6 · Cited by 3
Design, synthesis and antitumor effects of lupeol quaternary phosphonium salt derivatives
Chen, Z., Luo, R., Xu, T., Wang, L., Deng, S., Wu, J., Wang, H., Lin, Y., & Bu, M. (2024) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2024.117934 · Cited by 3
Nguyen, S. V., Planalp, R. P., & Vashisth, H. (2025) · Biointerphases · doi:10.1116/6.0004197 · Cited by 3
Li, X., Xi, J., Liu, Y., Liu, Y., Liu, Q., Li, B., Tian, Z., Yan, H., Wang, Y., & Fang, J. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.138331 · Cited by 3
Vitamin E Analogues as Prototypic Mitochondria-Targeting Anti-cancer Agents
Dong, L., & Neužil, J. (2014) · Springer eBooks · doi:10.1007/978-94-017-8984-4_7 · Cited by 3
Eremeyev, S. A., Kargin, V. I., Motovilov, K. A., Tashlitsky, V. N., Markov, V. Y., Korshunova, G. A., Sumbatyan, N. V., Vyssokikh, M. Y., & Yaguzhinsky, L. S. (2009) · Biochemistry (Moscow) · doi:10.1134/s0006297909100071 · Cited by 3
[The role of chondrocyte mitochondrial biogenesis in the pathogenesis of osteoarthritis].
Zhou, S., Si, H., Peng, L., & Shen, B. (2022) · PubMed · doi:10.7507/1002-1892.202109091 · Cited by 3
Water oxidation at low potential exploiting a nitroxide/oxoammonium ion redox couple as mediator
Barbon, A., Isse, A. A., Gennaro, A., Carmieli, R., Bilkis, I. I., & Weiner, L. M. (2022) · Materials Advances · doi:10.1039/d2ma00668e · Cited by 3
Ferrocene-anchored poly(norbornene) for ATP sensing using indicator displacement assay
Liu, Y., Tu, M., Lang, W., Guo, Q., Li, Y., & Cao, Q. (2023) · Dyes and Pigments · doi:10.1016/j.dyepig.2023.111268 · Cited by 3
Moniriyan, F., Sabounchei, S. J., Badpa, K., Bayat, M., Soltani, E., Gable, R. W., Karamian, R., Asadbegy, M., & Farida, S. H. M. (2023) · Journal of Coordination Chemistry · doi:10.1080/00958972.2023.2278432 · Cited by 3
Mitochondrial‐targeted antioxidant ingestion acutely blunts VO2max in physically inactive females
Hughes, R. P., Carlini, N. A., Fleenor, B. S., & Harber, M. P. (2023) · Physiological Reports · doi:10.14814/phy2.15871 · Cited by 3
Bennett, M. G. A., Meakin, A. S., Botting, K. J., Niu, Y., Ford, S. G., Murphy, M. P., Wiese, M. D., Giussani, D. A., & Morrison, J. L. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030285 · Cited by 3
Self-citationMitochondria for Cardiovascular Therapy: A Deep Dive into Drug Targets and Therapeutic Approaches
Semenzato, M., & Naón, D. (2025) · Current Pharmacology Reports · doi:10.1007/s40495-025-00405-2 · Cited by 3
Antioxidant Action of Mobile Electron Carriers of the Respiratory Chain
ISELI, L., Rodrigues, T., Cesar, H., Juliana, C., Felipe, S., Mayara, K., & Moraes, V. (2012) · InTech eBooks · doi:10.5772/31384 · Cited by 3
Mild mitochondrial uncoupling as potentially effective intervention to slow aging
Padalko, V. (2014) · Oxidants and Antioxidants in Medical Science · doi:10.5455/oams.161213.rv.012 · Cited by 3
MRI reveals slow clearance of dead cell transplants in mouse forelimb muscles
Zhang, Y., Zhang, H., Ding, L., Zhang, H., Zhang, P., Jiang, H., Tan, B., & Deng, Z. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7100 · Cited by 3
Ji, X., Khdour, O. M., & Hecht, S. M. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0481 · Cited by 3
Therapeutics of Alzheimer’s Disease
Herrera-Rivero, M., & Emiliano, G. (2011) · InTech eBooks · doi:10.5772/27990 · Cited by 3
Frolov, A. E., Sviryaeva, I. V., Ruuge, E. K., Trubitsin, B. V., & Tikhonov, A. N. (2010) · Russian Journal of Physical Chemistry A · doi:10.1134/s0036024410090189 · Cited by 3
Mitochondria-Targeted Vitamin E Antioxidant: An Agent for Cardiovascular Protection
Rocha, M., Garcia-Bou, R., Enguix, N., Hernández‐Mijares, A., Esplugues, J. V., & Víctor, V. M. (2009) · Vascular Disease Prevention · doi:10.2174/1567270000906010036 · Cited by 3
Skulachev, V. P., Bogachev, A. V., & Kasparinsky, F. O. (2012) · Springer eBooks · doi:10.1007/978-3-642-33430-6_15 · Cited by 3
Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria
Teixeira, J., Soares, P., Benfeito, S., Murphy, M. P., Oliveira, P. J., & Borges, F. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2288-8_6 · Cited by 3
Self-citationHuang, Z., Lan, Q., Hua, Y., Chen, Z., Zhang, H., Lin, Z., & Xia, H. (2017) · Organometallics · doi:10.1021/acs.organomet.7b00699 · Cited by 3
Studies on Mitochondria Directed Plastoquinones
Feniouk, B. A., & Skulachev, V. P. (2018) · Springer eBooks · doi:10.1007/978-3-319-73344-9_23 · Cited by 3
Kargin, V. I., Motovilov, K. A., Vyssokikh, M. Y., & Yaguzhinsky, L. S. (2008) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747808010066 · Cited by 3
Kim, H., Kim, S. T., Park, D. B., Cho, H., Asadujjaman, M., & Jee, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911901 · Cited by 3
Metadata
- Authors
- Murphy, M. P., & Smith, R. A. J.
- Affiliations
- MRC Mitochondrial Biology Unit (GB)
- University of Otago (NZ)
- ORCID
- Murphy, Michael P.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2007-02-01
- Volume
- 47
- Issue
- 1
- Pages
- 629-656
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2140014506
- Cited by
- 1,173
- References
- 130
- Citations by year
- 2026: 64 · 2025: 62 · 2024: 72 · 2023: 42 · 2022: 65 · 2021: 67 · 2020: 61 · 2019: 57 · 2018: 61 · 2017: 62 · 2016: 67 · 2015: 67 · 2014: 62 · 2013: 59 · 2012: 68
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Annual Review of Pharmacology and Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- mitochondria-targeted antioxidants, triphenylphosphonium cation, lipophilic cations, mitochondrial oxidative damage, ubiquinol, alpha-tocopherol, mitochondrial membrane potential, blood-brain barrier, oral drug delivery, degenerative diseases, mitochondrial protection
- MeSH terms
- Antioxidants, Cations, Drug Carriers, Humans, Membrane Potentials, Mitochondria, Tissue Distribution, Drug Delivery Systems, Reactive Oxygen Species, Mitochondrial Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
