Cited by 979Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudySubstance Abuse Treatment and Outcomes

The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.

Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

Open access

Benowitz, Neal L.·2009·Annual Review of Pharmacology and Toxicology

DOI 10.1146/annurev.pharmtox.48.113006.094742PMC PMC2946180

Open this paper in CoChat — free account

Abstract

Nicotine sustains tobacco addiction, a major cause of disability and premature death. Nicotine binds to nicotinic cholinergic receptors, facilitating neurotransmitter release and thereby mediating the complex actions of nicotine in tobacco users. Dopamine, glutamate, and gamma aminobutyric acid release are particularly important in the development of nicotine dependence, and corticotropin-releasing factor appears to contribute to nicotine withdrawal. Nicotine dependence is highly heritable. Genetic studies indicate roles for nicotinic receptor subtypes, as well as genes involved in neuroplasticity and learning, in development of dependence. Nicotine is primarily metabolized by CYP 2A6, and variability in rate of metabolism contributes to vulnerability to tobacco dependence, response to smoking cessation treatment, and lung cancer risk. Tobacco addiction is much more common in persons with mental illness and substance abuse disorders, representing a high proportion of current smokers. Pharmacotherapeutic approaches to tobacco addiction include nicotine replacement, bupropion, and varenicline, the latter a selective nicotine receptor partial agonist.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1146/annurev.pharmtox.48.113006.094742

Cites

90 of 90 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
Smoking and Mental Illness: A Population-Based Prevalence Study
Lasser, K., Boyd, J. W., Woolhandler, S., Himmelstein, D. U., McCormick, D., & Bor, D. H. (2000) · JAMA · doi:10.1001/jama.284.20.2606 · Cited by 2,508
The Health Consequences of Smoking: A Report of the Surgeon General
Office on Smoking (2004) · Cited by 2,414
Signs and Symptoms of Tobacco Withdrawal
Hughes, J. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800030107013 · Cited by 1,669
Metabolism and Disposition Kinetics of Nicotine
Hukkanen, J., Jacob, P., & Benowitz, N. L. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.3 · Cited by 1,583
Self-citation
A Clinical Practice Guideline for Treating Tobacco Use and Dependence: 2008 Update
(2008) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2008.04.009 · Cited by 1,410
Synaptic plasticity and addiction
Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397
Is there a common molecular pathway for addiction?
Nestler, E. J. (2005) · Nature Neuroscience · doi:10.1038/nn1578 · Cited by 1,388
Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
Gonzales, D. (2006) · JAMA · doi:10.1001/jama.296.1.47 · Cited by 1,361
Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine
Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320

Show all 90 references

Research works printed but not linked: 4

Cent. Dis. Control Prev, 2002, MMWR, 51, 637
Colton CW, 2006, Prev. Chronic Dis., 3, A42
Slemmer JE, 2000, J. Pharmacol. Exp. Ther., 295, 321
Cahill K, 2007, Cochrane Database Syst. Rev., 2007, CD005353

Sorted by citations

Items 201–300 of 978

Inhibition of Nicotine Metabolism by Cannabidiol (CBD) and 7-Hydroxycannabidiol (7-OH-CBD)
Nasrin, S., Coates, S., Bardhi, K., Watson, C. J. W., Muscat, J. E., & Lazarus, P. J. (2023) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00259 · Cited by 28
Noribogaine reduces nicotine self-administration in rats
Chang, Q., Hanania, T., Mash, D. C., & Maillet, É. L. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115584461 · Cited by 28
Nicotine and Cardiovascular Health: When Poison is Addictive – a WHF Policy Brief
Dorotheo, E. U., Arora, M., Banerjee, A., Bianco, E., Cheah, N. P., Dalmau, R., Eissenberg, T., Hasegawa, K., Naidoo, P., Nazir, N. T., et al. (2024) · Global Heart · doi:10.5334/gh.1292 · Cited by 34
Bacoside A: Role in Cigarette Smoking Induced Changes in Brain
Vani, G., Anbarasi, K., & Shyamaladevi, C. S. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/286137 · Cited by 27
Effects of Chronic Varenicline Treatment on Nicotine, Cocaine, and Concurrent Nicotine+Cocaine Self-Administration
Mello, N. K., Fivel, P. A., Kohut, S. J., & Carroll, F. I. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.325 · Cited by 26
Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene
Wetherill, R. R., Jagannathan, K., Lohoff, F. W., Ehrman, R. N., O’Brien, C. P., Childress, A. R., & Franklin, T. R. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00507.x · Cited by 27
Oral cavity squamous cell carcinoma--an overview.
Kimple, A. J., Welch, C. M., Zevallos, J. P., & Patel, S. N. (2014) · PubMed · Cited by 27
Sex differences and the role of dopamine receptors in the reward-enhancing effects of nicotine and bupropion
Barrett, S. T., Geary, T. N., Steiner, A. N., & Bevins, R. A. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4448-x · Cited by 30
Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida
Tararina, M. A., Janda, K. D., & Allen, K. N. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00963 · Cited by 27
Insights Into Nicotinic Receptor Signaling in Nicotine Addiction: Implications for Prevention and Treatment
Liu, W., & Li, M. D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170801103009 · Cited by 28
Treatment adherence in a lay health adviser intervention to treat tobacco dependence
Hood, N. E., Ferketich, A. K., Paskett, E. D., & Wewers, M. E. (2013) · Health Education Research · doi:10.1093/her/cys081 · Cited by 26
Carcinogenicity of nicotine and signal pathways in cancer progression: a review
Rao, Z., Xu, Y., He, Z., Wang, J., Ji, H., Zhang, Z., Zhou, J., Zhou, T., & Wang, H. (2023) · Environmental Chemistry Letters · doi:10.1007/s10311-023-01668-1 · Cited by 26
A new challenge: suicide attempt using nicotine fillings for electronic cigarettes
Schipper, E. M., de Graaff, L. C. G., Koch, B. C. P., Brkic, Z., Wilms, E. B., Alsma, J., & Schuit, S. C. E. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12495 · Cited by 26
Common polymorphisms in FMO1 are associated with nicotine dependence
Hinrichs, A. L., Murphy, S. E., Wang, J. C. C., Saccone, S. F., Saccone, N. L., Steinbach, J. H., Goate, A., Stevens, V. L., & Bierut, L. J. (2011) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328346886f · Cited by 27
Attenuating Nicotine Reinforcement and Relapse by Enhancing Endogenous Brain Levels of Kynurenic Acid in Rats and Squirrel Monkeys
Secci, M. E., Auber, A., Panlilio, L. V., Redhi, G. H., Thorndike, E. B., Schindler, C. W., Schwarcz, R. M., Goldberg, S. R., & Justinová, Z. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.21 · Cited by 26
E-Cigarettes as a Growing Threat for Children and Adolescents: Position Statement From the European Academy of Paediatrics
Bush, A., Lintowska, A., Mazur, A., Hadjipanayis, A., Grossman, Z., del Torso, S., Michaud, P., Доан, С. І., Romankevych, I. V., Slaats, M., et al. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.698613 · Cited by 30
Similar activity of mecamylamine stereoisomers in vitro and in vivo
Papke, R. L., Stokes, C. A., Muldoon, P. P., & Damaj, M. I. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.10.018 · Cited by 26
A randomised, controlled, two-Centre open-label study in healthy Japanese subjects to evaluate the effect on biomarkers of exposure of switching from a conventional cigarette to a tobacco heating product
Gale, N., McEwan, M., Eldridge, A. C., Sherwood, N., Bowen, E., McDermott, S., Holmes, E., Hedge, A., Hossack, S., Camacho, O. M., et al. (2017) · BMC Public Health · doi:10.1186/s12889-017-4678-9 · Cited by 26
Modeling drug exposure in rodents using e-cigarettes and other electronic nicotine delivery systems
Miliano, C., Scott, E. R., Murdaugh, L. B., Gnatowski, E. R., Faunce, C. L., Anderson, M. S., Reyes, M. M., Gregus, A. M., & Buczynski, M. W. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108458 · Cited by 26
The Role of Pharmacogenetics in Smoking
El‐Boraie, A., & Tyndale, R. F. (2021) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2345 · Cited by 25
Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans: an overview of recent findings
Serra, M., Simola, N., Pollack, A. E., & Costa, G. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.390971 · Cited by 25
Glutamatergic and GABAergic Metabolism in Mouse Brain under Chronic Nicotine Exposure: Implications for Addiction
Shameem, M., & Patel, A. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041824 · Cited by 24
Novel approaches for the treatment of psychostimulant and opioid abuse – focus on opioid receptor-based therapies
Bailey, C. P., & Husbands, S. M. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.964203 · Cited by 25
Nicotine induces mitochondrial fission through mitofusin degradation in human multipotent embryonic carcinoma cells
Hirata, N., Yamada, S., Asanagi, M., Sekino, Y., & Kanda, Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.01.063 · Cited by 25
Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction
Thisted, T., Biesová, Z., Walmacq, C., Stone, E. M., Rodnick-Smith, M., Ahmed, S. S., Horrigan, S. K., van Engelen, B., Reed, C., & Kalnik, M. W. (2019) · BMC Biotechnology · doi:10.1186/s12896-019-0551-5 · Cited by 25
Nicotine Use Disorders in Adolescents
Cavallo, D. A., & Krishnan‐Sarin, S. (2019) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2019.08.002 · Cited by 26
Comparative risk assessment of tobacco smoke constituents using the margin of exposure approach: the neglected contribution of nicotine
Baumung, C., Rehm, J. T., Franke, H., & Lachenmeier, D. W. (2016) · Scientific Reports · doi:10.1038/srep35577 · Cited by 24
Prenatal tobacco exposure and the risk of tobacco smoking and dependence in offspring: a systematic review and meta-analysis
Duko, B., Pereira, G., Tait, R. J., Nyadanu, S. D., Betts, K., & Alati, R. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.108993 · Cited by 22
Smoking cessation and neuropsychiatric adverse events: are family physicians caught between a rock and a hard place?
Els, C., Kunyk, D., & Sidhu, H. S. (2011) · Europe PMC (PubMed Central) · Cited by 24
Fishing for a deeper understanding of nicotine effects using zebrafish behavioural models
Wronikowska‐Denysiuk, O., Michalak, A., Skalicka‐Woźniak, K., Crawford, A. D., & Budzyńska, B. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109826 · Cited by 24
Nicotine Replacement Therapy After Subarachnoid Hemorrhage Is Not Associated With Increased Vasospasm
Carandang, R. A., BARTON, B. A., Rordorf, G. A., Ogilvy, C. S., & Sims, J. R. (2011) · Stroke · doi:10.1161/strokeaha.111.620955 · Cited by 24
The Use of the Integrated Discrete Multiple Organ Co-culture (IdMOC ® ) System for the Evaluation of Multiple Organ Toxicity
Li, A. P. (2009) · Alternatives to Laboratory Animals · doi:10.1177/026119290903700408 · Cited by 24
Mirtazapine attenuates the expression of nicotine-induced locomotor sensitization in rats
Barbosa-Méndez, S., Jurado, N., Matus-Ortega, M., Martiñón, S., Heinze, G., & Salazar‐Juárez, A. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.06.028 · Cited by 23
Polysubstance Use among Patients Enrolling in Methadone Maintenance Treatment Program in a Vietnam Province with Drug-Driven HIV Epidemic
Le, T. A., Pham, D. T. T., Quek, T. T. C., Vu, G. T., Hoang, C. L., Tran, T. T., Nguyen, C. T., Tran, N. H. T., Vuong, Q., Tran, T. H., et al. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16183277 · Cited by 23
Menthol Cigarettes and Smoking Cessation among Adult Smokers in the US
Schneller, L. M., Bansal-Travers, M., Mahoney, M., McCann, S., & O'Connor, R. (2020) · American Journal of Health Behavior · doi:10.5993/ajhb.44.2.12 · Cited by 15
Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice
Tobey, K. M., Walentiny, D. M., Wiley, J. L., Carroll, F. I., Damaj, M. I., Azar, M. R., Koob, G. F., George, O., Harris, L. S., & Vann, R. E. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2703-3 · Cited by 23
Nicotine-, tobacco particulate matter- and methamphetamine-produced locomotor sensitisation in rats
Brennan, K. A., Putt, F., & Truman, P. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3071-3 · Cited by 23
Nicotine replacement therapies: patient safety and persistence
Ferguson, S. G., Gitchell, & Shiffman (2011) · Patient Related Outcome Measures · doi:10.2147/prom.s11545 · Cited by 23
The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings
Saccone, N. L., Baurley, J. W., Bergen, A. W., David, S. P., Elliott, H. R., Foreman, M. G., Kaprio, J. A., Piasecki, T. M., Relton, C. L., Zawertailo, L. A., et al. (2017) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntx096 · Cited by 23
Role of Brain Derived Extracellular Vesicles in Decoding Sex Differences Associated with Nicotine Self-Administration
Koul, S., Schaal, V. L., Chand, S., Pittenger, S. T., Vellichirammal, N. N., Kumar, V., Guda, C., Bevins, R. A., Yelamanchili, S. V., & Pendyala, G. (2020) · Cells · doi:10.3390/cells9081883 · Cited by 23
Nicotine Metabolism-informed Care for Smoking Cessation: A Pilot Precision RCT
Wells, Q. S., Freiberg, M. S., Greevy, R. A., Tyndale, R. F., Kundu, S., Duncan, M. S., King, S., Abney, L. R., Scoville, E., Beaulieu, D. B., et al. (2017) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntx235 · Cited by 23
Transcranial direct current stimulation of the prefrontal cortex reduces cigarette craving in not motivated to quit smokers: A randomized, sham-controlled study
Perri, R. L., & Perrotta, D. (2021) · Addictive Behaviors · doi:10.1016/j.addbeh.2021.106956 · Cited by 23
Switching of Protonation Sites in Hydrated Nicotine via a Grotthuss Mechanism
Okura, Y., Santis, G. D., Hirata, K., Melissas, V. S., Ishiuchi, S., Fujii, M., & Xantheas, S. S. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c08922 · Cited by 22
Nicotinic acetylcholine receptors in chemotherapeutic drugs resistance: An emerging targeting candidate
Nour, M. A., Hajiasgharzadeh, K., Kheradmand, F., Asadzadeh, Z., Bolandi, N., & Baradaran, B. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119557 · Cited by 22
Validation of the Wave 1 and Wave 2 Population Assessment of Tobacco and Health (PATH) Study Indicators of Tobacco Dependence Using Biomarkers of Nicotine Exposure Across Tobacco Products
Strong, D. R., Leas, E. C., Noble, M. L., White, M. M., Glasser, A., Taylor, K. A., Edwards, K. C., Frissell, K. C., Compton, W. M., Conway, K. P., et al. (2021) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntab162 · Cited by 24
Effect of Neuronal Nicotinic Acetylcholine Receptor Genes (CHRN) on Longitudinal Cigarettes per Day in Adolescents and Young Adults
Cannon, D. S., Mermelstein, R. J., Hedeker, D., Coon, H. H., Cook, E. H., McMahon, W. M., Hamil, C. L., Dunn, D. M., & Weiss, R. B. (2013) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntt125 · Cited by 23
Attitudes Toward Smoking Cessation Among Sheltered Homeless Parents
Stewart, H. C., Stevenson, T., Bruce, J. S., Greenberg, B., & Chamberlain, L. J. (2015) · Journal of Community Health · doi:10.1007/s10900-015-0040-2 · Cited by 21
Nicotine Pharmacokinetics in Rat Brain and Blood by Simultaneous Microdialysis, Stable-Isotope Labeling, and UHPLC–HRMS: Determination of Nicotine Metabolites
Xu, Y., Zhang, Q., Li, P., Guangfeng, H., Wang, D., Liu, J., Zhou, H., Chai, G., Lu, B., He, S., et al. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b05078 · Cited by 23
Adolescent nicotine challenge promotes the future vulnerability to opioid addiction: Involvement of lateral paragigantocellularis neurons
Torabi, M., Azizi, H., Ahmadi‐Soleimani, S. M., & Rezayof, A. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116784 · Cited by 22
Binding free energies for nicotine analogs inhibiting cytochrome P450 2A6 by a combined use of molecular dynamics simulations and QM/MM-PBSA calculations
Lu, H., Huang, X., AbdulHameed, M. D. M., & Zhan, C. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.02.037 · Cited by 22
Bidirectional Associations among Nicotine and Tobacco Smoke, NeuroHIV, and Antiretroviral Therapy
Ghura, S., Gross, R., Jordan‐Sciutto, K. L., Dubroff, J. G., Schnoll, R. A., Collman, R. G., & Ashare, R. L. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09897-4 · Cited by 21
Water-Soluble Carbon Dots in Cigarette Mainstream Smoke: Their Properties and the Behavioural, Neuroendocrinological, and Neurotransmitter Changes They Induce in Mice
Zhao, Y., Lü, F., Zhang, Y., Zhang, M., Zhao, Y., Luo, J., Kong, H., & Qu, H. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s291670 · Cited by 21
Nicotine prevents in vivo Aβ toxicity in Caenorhabditis elegans via SKN-1
Lu, X., Zhang, Y., Li, H., Jin, Y., Zhao, L., & Wang, X. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136114 · Cited by 21
Republished: Nicotine and health
Bulletin, D. A. T. (2014) · BMJ · doi:10.1136/bmj.2014.7.0264rep · Cited by 21
The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study
Sandiego, C. M., Matuskey, D., Lavery, M. E., McGovern, E. M., Huang, Y. H., Nabulsi, N., Ropchan, J. R., Picciotto, M. R., Morris, E. D., McKee, S. A., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.223 · Cited by 21
Smoking Decisions: Altered Reinforcement Learning Signals Induced by Nicotine State
Baker, T. E., Zeighami, Y., Dagher, A., & Holroyd, C. B. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty136 · Cited by 22
Adverse childhood experiences and electronic cigarette use among young Australian women
Melka, A. S., Chojenta, C., Holliday, E. G., & Loxton, D. J. (2019) · Preventive Medicine · doi:10.1016/j.ypmed.2019.105759 · Cited by 20
Indolizidine (−)-235B′ and related structural analogs: Discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release
Pivavarchyk, M., Smith, A. M., Zhang, Z., Zhou, D., Wang, X., Toyooka, N., Tsuneki, H., Sasaoka, T., McIntosh, J. M., Crooks, P. A., et al. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.02.018 · Cited by 21
Current approaches to pharmacotherapy for smoking cessation
Hudmon, K. S., Corelli, R. L., & Prokhorov, A. V. (2010) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465809353768 · Cited by 21
A next-generation system for smoke inhalation integrated with a breathing lung-on-chip to model human lung responses to cigarette exposure
Sengupta, A., Schmid, S., Grangier, N., Dorn, A., Hebestreit, M., Hugi, A., Žajdlíková, K., Herbst, A., Losada-Oliva, P., Ortolf-Wahl, H., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-00438-z · Cited by 20
The impact of smoking on oral health and patient assessment of tobacco cessation support from Turkish dentists
Beklen, A., Yildirim, B., Mimaroglu, M., & Yavuz, M. (2021) · Tobacco Induced Diseases · doi:10.18332/tid/136418 · Cited by 22
Application of HPLC-QQQ-MS/MS and New RP-HPLC-DAD System Utilizing the Chaotropic Effect for Determination of Nicotine and Its Major Metabolites Cotinine, and trans-3′-Hydroxycotinine in Human Plasma Samples
Baj, J., Flieger, W., Przygodzka, D., Buszewicz, G., Teresiński, G., Pizoń, M., Maciejewski, R., & Flieger, J. (2022) · Molecules · doi:10.3390/molecules27030682 · Cited by 20
Association of psychological distress with smoking cessation, duration of abstinence from smoking, and use of non-combustible nicotine-containing products: A cross-sectional population survey in Great Britain
Kock, L. S., Brown, J., Cox, S., McNeill, A. D., Robson, D., Shahab, L., Tattan‐Birch, H., & Brose, L. S. (2022) · Addictive Behaviors · doi:10.1016/j.addbeh.2022.107570 · Cited by 25
Is Smoking Associated with Alcohol-Drug Dependence in Patients with Pain and Chronic Pain Patients? An Evidence-Based Structured Review
Fishbain, D. A., Cole, B., Lewis, J. E., & Gao, J. (2012) · Pain Medicine · doi:10.1111/j.1526-4637.2012.01446.x · Cited by 20
Nicotine ameliorates cognitive deficits induced by maternal LPS exposure: A study in rats
Waterhouse, U., Roper, V., Brennan, K. A., & Ellenbroek, B. A. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.025072 · Cited by 19
Effects on abstinence of nicotine patch treatment before quitting smoking: parallel, two arm, pragmatic randomised trial
The Preloading Investigators (2018) · BMJ · doi:10.1136/bmj.k2164 · Cited by 21
E-cigarette device power moderates the effects of non-tobacco flavors and nicotine on product appeal in young adults
Leventhal, A. M., Mason, T. B., Kirkpatrick, M. G., Anderson, M. K., & Levine, M. (2020) · Addictive Behaviors · doi:10.1016/j.addbeh.2020.106403 · Cited by 20
Predictive modeling of response to repetitive transcranial magnetic stimulation in treatment-resistant depression
Benster, L. L., Weissman, C. R., Suprani, F., Toney, K., Afshar, H. T., Stapper, N., Tello, V., Stolz, L. A., Poorganji, M., Daskalakis, Z. J., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03380-w · Cited by 26
Health risks and toxicity mechanisms of medicinal and aromatic plants (MAPs): A comprehensive review of adverse effects on organ systems, genotoxicity and reproductive toxicity
Ezrari, S., Khadda, Z. B., Boutagayout, A., Rehali, M., Jaadan, H., Housni, Z. E., Khoulati, A., Saddari, A., & Maleb, A. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106630 · Cited by 19
Effects of concurrent blockade of OX2 and CB1 receptors in the ventral tegmental area on nicotine-induced place preference in rats
Azizi, F., Fartootzadeh, R., Alaei, H., & Reisi, P. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.07.017 · Cited by 19
E-cigarettes and arrhythmogenesis: a comprehensive review of pre-clinical studies and their clinical implications
Jones, C. A., Wallace, M. J., Bandaru, P., Woodbury, E. D., Mohler, P. J., & Wold, L. E. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad113 · Cited by 19
Electronic nicotine delivery systems (ENDS): A convenient means of smoking?
Sala, M., & Gotti, C. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106885 · Cited by 23
ANAPC1 and SLCO3A1 are associated with nicotine dependence: Meta-analysis of genome-wide association studies
Wang, K.-S., Liu, X., Zhang, Q., & Min De, Z. E. N. G. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.02.003 · Cited by 21
It’s complicated: Examining smokers’ relationships with their cigarette brands.
Johnson, S. E., Coleman, B., & Schmitt, C. L. (2016) · Psychology of Addictive Behaviors · doi:10.1037/adb0000225 · Cited by 19
Cardiac Autonomic Effects of Secondhand Exposure to Nicotine from Electronic Cigarettes
Lee, M.-S. S., Rees, V. W., Koutrakis, P., Wolfson, J. M., Son, Y., Lawrence, J. E., & Christiani, D. C. (2018) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000033 · Cited by 19
Monoamine oxidase inhibitory activity of flavoured e-cigarette liquids
Truman, P., Stanfill, S. B., Heydari, A., Silver, E., & Fowles, J. R. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.09.010 · Cited by 19
Electronic cigarettes and e-cigarette/vaping product use associated lung injury (EVALI)
Shinbashi, M. Y., & Rubin, B. K. (2020) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2020.06.003 · Cited by 20
Intraindividual covariation between e-cigarette and combustible cigarette use in Korean American emerging adults.
Huh, J., & Leventhal, A. M. (2015) · Psychology of Addictive Behaviors · doi:10.1037/adb0000141 · Cited by 19
(E)-Nicotinaldehyde O-Cinnamyloxime, a Nicotine Analog, Attenuates Neuronal Cells Death Against Rotenone-Induced Neurotoxicity
Jurado-Coronel, J. C., Loaiza, A. E., Díaz, J. E., Cabezas, R., Ashraf, G. M., Sahebkar, A., Echeverrı́a, V., González, J., & Barreto, G. E. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1163-0 · Cited by 18
Clinical implications of nicotine as an antimicrobial agent and immune modulator
Pavia, C. S., & Plummer, M. M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110404 · Cited by 18
Biologically Active Compounds Present in Tobacco Smoke: Potential Interactions Between Smoking and Mental Health
Hong, S. W., Teesdale‐Spittle, P. H., Page, R., Ellenbroek, B. A., & Truman, P. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.885489 · Cited by 21
Quantitation of Ten Urinary Nicotine Metabolites, Including 4-Hydroxy-4-(3-pyridyl) Butanoic Acid, a Product of Nicotine 2′-Oxidation, and CYP2A6 Activity in Japanese Americans, Native Hawaiians, and Whites
von Weymarn, L. B., Lu, X., Thomson, N. M., Marchand, L. L., Park, S. L., & Murphy, S. E. (2023) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00413 · Cited by 18
Efficacy and safety of selegiline across different psychiatric disorders: A systematic review and meta-analysis of oral and transdermal formulations
Rossano, F., Caiazza, C., Sobrino, A., Solini, N., Vellucci, A., Zotti, N., Fornaro, M., Gillman, P. K., Cattaneo, C. I., den Eynde, V. V., et al. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.03.012 · Cited by 19
Role of Herbal Medication in Tobacco Cessation Treatment: A Systematic Review and Meta-analysis
Mitra, R., Rai, A., Kumar, A., & Mitra, J. K. (2023) · Addiction and Health · doi:10.34172/ahj.2023.1290 · Cited by 18
Depressive symptoms and the age of initiation of tobacco and marijuana use among adolescents and young adults
Bataineh, B. S., Wilkinson, A. V., Sumbe, A., Clendennen, S. L., Chen, B., Messiah, S. E., & Harrell, M. B. (2023) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2023.110971 · Cited by 18
The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke
Pedneault, M., Labbe, A., Roy‐Gagnon, M., Low, N. C. P., Dugas, E. N., Engert, J. C., & O’Loughlin, J. L. (2013) · Addictive Behaviors · doi:10.1016/j.addbeh.2013.08.033 · Cited by 20
Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5
Chen, X., Owoseni, E., Salamat, J. M., Cederbaum, A. I., & Lu, Y. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.09.012 · Cited by 18
Hypothalamic proteome changes in response to nicotine and its withdrawal are potentially associated with alteration in body weight
Gao, M., Hu, F., Zeng, X.-D., Tang, H.-L., Zhang, H., Jiang, W., Yan, H.-J., Shi, H., Shu, Y., & Long, Y. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.103633 · Cited by 18
Differences in Switching Away From Smoking Among Adult Smokers Using JUUL Products in Regions With Different Maximum Nicotine Concentrations: North America and the United Kingdom
Goldenson, N. I., Ding, Y., Prakash, S., Hatcher, C., Augustson, E. M., & Shiffman, S. M. (2021) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntab062 · Cited by 18
Nicotine and health
(2014) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.2014.7.0264 · Cited by 18
Varenicline in smoking cessation
Tonstad, S., & Rollema, H. (2010) · Expert Review of Respiratory Medicine · doi:10.1586/ers.10.27 · Cited by 18
Caffeine plus nicotine improves motor function, spatial and non-spatial working memory and functional indices in BALB/c male mice
Adeniyi, P. A., Omatsuli, E. P., Akinyemi, A. J., & Ishola, A. O. (2016) · Pathophysiology · doi:10.1016/j.pathophys.2016.08.002 · Cited by 18
Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats
Rezvani, A. H., Tizabi, Y., Slade, S. K., Getachew, B., & Levin, E. D. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.01.022 · Cited by 18
Plant Alkaloids as Promising Anticancer Compounds with Blood–Brain Barrier Penetration in the Treatment of Glioblastoma: In Vitro and In Vivo Models
Ożarowski, M., Karpiński, T. M. M., Czerny, B., Kamiński, A., & Seremak‐Mrozikiewicz, A. (2025) · Molecules · doi:10.3390/molecules30071561 · Cited by 18
Nicotine pouches and youth: emerging patterns and potential cardiovascular risks
Abid, S., Aggarwal, A., Duarte, F., Sethi, S., Iyengar, S., & ZARICH, S. W. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1632313 · Cited by 21
Effects of Cigarette Nicotine Content and Menthol Preference on Perceived Health Risks, Subjective Ratings, and Carbon Monoxide Exposure Among Adolescent Smokers
Denlinger-Apte, R. L., Cassidy, R. N., Colby, S. M., Sokolovsky, A. W., & Tidey, J. W. (2019) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntz127 · Cited by 17
Association between affect and cannabis use varies by social context
Denson, R. K., Hedeker, D., & Mermelstein, R. J. (2022) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2022.109750 · Cited by 17
Electronic Nicotine Delivery System: End to Smoking or Just a New Fancy Cigarette
Kotewar, S. S., Pakhale, A. P., Tiwari, R., Reche, A. R., & Singi, S. R. (2023) · Cureus · doi:10.7759/cureus.43425 · Cited by 17
l-tetrahydropalmatine reduces nicotine self-administration and reinstatement in rats
Faison, S. L., Schindler, C. W., Goldberg, S. R., & Wang, J. B. (2016) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-016-0093-6 · Cited by 19
Smoking Cessation and the Risk of Hyperactive Delirium in Hospitalized Patients: A Retrospective Study
Park, H., Kim, K. W., & Yoon, I. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716652401 · Cited by 18

Authors: Benowitz, N. L.
Affiliations: San Francisco General Hospital (US)
Corresponding author: Benowitz, Neal L.
ORCID: Benowitz, Neal L.
Venue: Annual Review of Pharmacology and Toxicology
Publisher: Annual Reviews
Published: 2009-02-01
Volume: 49
Issue: 1
Pages: 57-71
ISSN: 0362-1642 (ISSN-L)
1545-4304
DOI: 10.1146/annurev.pharmtox.48.113006.094742
PMC: PMC2946180
OpenAlex: W2137599927
Cited by: 979
References: 90
Citations by year: 2026: 75 · 2025: 89 · 2024: 91 · 2023: 89 · 2022: 72 · 2021: 70 · 2020: 60 · 2019: 56 · 2018: 42 · 2017: 55 · 2016: 37 · 2015: 42 · 2014: 43 · 2013: 39 · 2012: 35
FWCI: 2.95
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Annual Review of Pharmacology and Toxicology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Public Health Service
National Institute on Drug Abuse (DA20830, DA02277, R01DA002277, U01DA020830, R37DA002277)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: nicotine, tobacco dependence, nicotine dependence, nicotinic acetylcholine receptors, nicotine withdrawal, dopamine release, glutamate release, GABA release, corticotropin-releasing factor, genetic susceptibility, CYP2A6, nicotine metabolism, lung cancer risk, smoking cessation, mental illness, substance abuse, nicotine replacement therapy, bupropion, varenicline, partial agonists
MeSH terms: Varenicline, Animals, Benzazepines, Nonprescription Drugs, Ganglionic Stimulants, Humans, Nicotine, Quinoxalines, Smoking, Tobacco Use Disorder, Bupropion, Behavior, Addictive, Nicotinic Agonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks