Cited by 979Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudySubstance Abuse Treatment and Outcomes

The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.

Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

Open access

Benowitz, Neal L.·2009·Annual Review of Pharmacology and Toxicology

DOI 10.1146/annurev.pharmtox.48.113006.094742PMC PMC2946180

Open this paper in CoChat — free account

Abstract

Nicotine sustains tobacco addiction, a major cause of disability and premature death. Nicotine binds to nicotinic cholinergic receptors, facilitating neurotransmitter release and thereby mediating the complex actions of nicotine in tobacco users. Dopamine, glutamate, and gamma aminobutyric acid release are particularly important in the development of nicotine dependence, and corticotropin-releasing factor appears to contribute to nicotine withdrawal. Nicotine dependence is highly heritable. Genetic studies indicate roles for nicotinic receptor subtypes, as well as genes involved in neuroplasticity and learning, in development of dependence. Nicotine is primarily metabolized by CYP 2A6, and variability in rate of metabolism contributes to vulnerability to tobacco dependence, response to smoking cessation treatment, and lung cancer risk. Tobacco addiction is much more common in persons with mental illness and substance abuse disorders, representing a high proportion of current smokers. Pharmacotherapeutic approaches to tobacco addiction include nicotine replacement, bupropion, and varenicline, the latter a selective nicotine receptor partial agonist.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1146/annurev.pharmtox.48.113006.094742

Cites

90 of 90 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
Smoking and Mental Illness: A Population-Based Prevalence Study
Lasser, K., Boyd, J. W., Woolhandler, S., Himmelstein, D. U., McCormick, D., & Bor, D. H. (2000) · JAMA · doi:10.1001/jama.284.20.2606 · Cited by 2,508
The Health Consequences of Smoking: A Report of the Surgeon General
Office on Smoking (2004) · Cited by 2,414
Signs and Symptoms of Tobacco Withdrawal
Hughes, J. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800030107013 · Cited by 1,669
Metabolism and Disposition Kinetics of Nicotine
Hukkanen, J., Jacob, P., & Benowitz, N. L. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.3 · Cited by 1,583
Self-citation
A Clinical Practice Guideline for Treating Tobacco Use and Dependence: 2008 Update
(2008) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2008.04.009 · Cited by 1,410
Synaptic plasticity and addiction
Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397
Is there a common molecular pathway for addiction?
Nestler, E. J. (2005) · Nature Neuroscience · doi:10.1038/nn1578 · Cited by 1,388
Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
Gonzales, D. (2006) · JAMA · doi:10.1001/jama.296.1.47 · Cited by 1,361
Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine
Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320

Show all 90 references

Research works printed but not linked: 4

Cent. Dis. Control Prev, 2002, MMWR, 51, 637
Colton CW, 2006, Prev. Chronic Dis., 3, A42
Slemmer JE, 2000, J. Pharmacol. Exp. Ther., 295, 321
Cahill K, 2007, Cochrane Database Syst. Rev., 2007, CD005353

Sorted by citations

The Methylation Effect in Medicinal Chemistry
Barreiro, E. J., Kümmerle, A. E., & Fraga, C. A. M. (2011) · Chemical Reviews · doi:10.1021/cr200060g · Cited by 1,032
Association of Electronic Cigarette Use With Initiation of Combustible Tobacco Product Smoking in Early Adolescence
Leventhal, A. M., Strong, D. R., Kirkpatrick, M. G., Unger, J. B., Sussman, S., Riggs, N. R., Stone, M. D., Khoddam, R., Samet, J. M., & Audrain-McGovern, J. (2015) · JAMA · doi:10.1001/jama.2015.8950 · Cited by 913
Plants Secondary Metabolites: The Key Drivers of the Pharmacological Actions of Medicinal Plants
Hussein, R. A., & El‐Anssary, A. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.76139 · Cited by 494
Lung carcinogenesis by tobacco smoke
Hecht, S. S. (2012) · International Journal of Cancer · doi:10.1002/ijc.27816 · Cited by 502
Cognitive Effects of Nicotine
Sofouglu, M., Herman, A. I., Robinson, C. D., & Waters, A. J. (2014) · Lincoln (University of Nebraska) · Cited by 417
Role of plant alkaloids on human health: A review of biological activities
Debnath, B., Singh, W. S., Das, M., Goswami, S., Singh, M. K., Maiti, D., & Manna, K. (2018) · Materials Today Chemistry · doi:10.1016/j.mtchem.2018.05.001 · Cited by 394
Reward, addiction, withdrawal to nicotine
De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366
“…nucleus INTRODUCTION AND SUMMARY Tobacco use is the leading cause of preventable death in developed countries (Benowitz 2008, Mathers & Loncar 2006, Peto et al. 1996), and nicotine is the main addictive component (Benowitz 2009, Dani et al. 2009, Dani & Heinemann 1996, Mansvelder & McGehee 2002).”
Background
One Is Not Enough: Understanding and Modeling Polysubstance Use
Crummy, E. A., O’Neal, T. J., Baskin, B. M., & Ferguson, S. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00569 · Cited by 351
Cognitive Effects of Nicotine: Recent Progress
Valentine, G. W., & Sofuoglu, M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171103152136 · Cited by 302
Electronic cigarettes and health outcomes: umbrella and systematic review of the global evidence
Banks, E., Yazidjoglou, A., Brown, S., Nguyen, N. M., Martin, M., Beckwith, K., Daluwatta, A., Campbell, S., & Joshy, G. (2023) · The Medical Journal of Australia · doi:10.5694/mja2.51890 · Cited by 317
Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors
Zoli, M., Pucci, S., Vilella, A., & Gotti, C. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170912110450 · Cited by 219
Smoking, quitting, and psychiatric disease: A review
Aubin, H., Rollema, H., Svensson, T. H., & Winterer, G. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.007 · Cited by 241
The Past, Present, and Future of Nicotine Addiction Therapy
Prochaska, J. J., & Benowitz, N. L. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-111314-033712 · Cited by 245
Self-citation
The emerging phenomenon of electronic cigarettes
Caponnetto, P., Campagna, D., Papale, G. A., Russo, C., & Polosa, R. (2012) · Expert Review of Respiratory Medicine · doi:10.1586/ers.11.92 · Cited by 210
In Vitro Particle Size Distributions in Electronic and Conventional Cigarette Aerosols Suggest Comparable Deposition Patterns
Zhang, Y., Sumner, W., & Chen, D. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts165 · Cited by 185
Health-Related Effects Reported by Electronic Cigarette Users in Online Forums
Hua, M., Alfi, M., & Talbot, P. (2013) · Journal of Medical Internet Research · doi:10.2196/jmir.2324 · Cited by 173
Pre‐clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence
Rollema, H., Shrikhande, A., Ward, K., Tingley III, F., Coe, J., O'Neill, B., Tseng, E., Wang, E., Mather, R., Hurst, R., et al. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00682.x · Cited by 162
Mining data on usage of electronic nicotine delivery systems (ENDS) from YouTube videos
Hua, M., Yip, H., & Talbot, P. (2011) · Tobacco Control · doi:10.1136/tobaccocontrol-2011-050226 · Cited by 165
Effects of Varenicline on Smoking Cue–Triggered Neural and Craving Responses
Franklin, T. R., Wang, Z., Suh, J. J., Hazan, R., Cruz, J., Li, Y., Goldman, M., Detre, J. A., O’Brien, C. P., & Childress, A. R. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.190 · Cited by 170
Perceived relative harm of electronic cigarettes over time and impact on subsequent use. A survey with 1-year and 2-year follow-ups
Brose, L. S., Brown, J., Hitchman, S. C., & McNeill, A. D. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.10.014 · Cited by 157
Electronic nicotine delivery systems: is there a need for regulation?
Trtchounian, A., & Talbot, P. (2010) · Tobacco Control · doi:10.1136/tc.2010.037259 · Cited by 144
Nicotine, cigarette smoking and cardiac arrhythmia: an overview
D’Alessandro, A., Boeckelmann, I., Hammwhöner, M., & Goette, A. (2011) · European Journal of Preventive Cardiology · doi:10.1177/1741826711411738 · Cited by 142
Nicotine Addiction: Neurobiology and Mechanism
Tiwari, R. K., Sharma, V., Pandey, R. K., & Shukla, S. S. (2020) · Journal of pharmacopuncture · doi:10.3831/kpi.2020.23.001 · Cited by 147
Heated tobacco products for smoking cessation and reducing smoking prevalence
Tattan‐Birch, H., Hartmann‐Boyce, J., Kock, L. S., Simonavicius, E., Brose, L. S., Jackson, S. E., Shahab, L., & Brown, J. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013790.pub2 · Cited by 147
Nicotinic plant poisoning
Schep, L. J., Slaughter, R. J., & Beasley, D. M. G. (2009) · Clinical Toxicology · doi:10.1080/15563650903252186 · Cited by 133
Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior
Tuesta, L. M., Fowler, C. D., & Kenny, P. J. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.026 · Cited by 135
Andrographolide protects against cigarette smoke‐induced oxidative lung injury via augmentation of Nrf2 activity
Guan, S., Tee, W. S. N., Ng, D. S. W., Chan, T., Peh, H. Y., Ho, W. E., Cheng, C., Mak, J., & Wong, W. S. F. (2012) · British Journal of Pharmacology · doi:10.1111/bph.12054 · Cited by 130
Catalytic Mechanism of Cytochrome P450 for 5′-Hydroxylation of Nicotine: Fundamental Reaction Pathways and Stereoselectivity
Li, D., Huang, X., Han, K., & Zhan, C. (2011) · Journal of the American Chemical Society · doi:10.1021/ja111657j · Cited by 126
Review of Pharmacological Treatment in Mood Disorders and Future Directions for Drug Development
Li, X., Frye, M. A., & Shelton, R. C. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.198 · Cited by 131
Nicotine consumption is regulated by a human polymorphism in dopamine neurons
Morel, C., Fattore, L., Pons, S., Hay, Y. A., Marti, F., Lambolez, B., De Biasi, M., Lathrop, M., Fratta, W., Maskos, U., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.158 · Cited by 123
Neurobiological Mechanisms of Nicotine Reward and Aversion
Wills, L. P., Ables, J. L., Braunscheidel, K. M., Caligiuri, S. P. B., Elayouby, K. S., Fillinger, C., Ishikawa, M., Moen, J. K., & Kenny, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000299 · Cited by 134
A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism
Loukola, A., Buchwald, J., Gupta, R., Palviainen, T., Hällfors, J., Tikkanen, E., Korhonen, T., Ollikainen, M., Sarin, A., Ripatti, S., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005498 · Cited by 123
The Concise Guide to PHARMACOLOGY 2013/14: Ligand‐Gated Ion Channels
Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12446 · Cited by 120
Smoking Cessation Pharmacogenetics: Analysis of Varenicline and Bupropion in Placebo-Controlled Clinical Trials
King, D. P., Paciga, S. A., Pickering, E. H., Benowitz, N. L., Bierut, L. J., Conti, D. V., Kaprio, J. A., Lerman, C. E., & Park, P. W. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.232 · Cited by 119
Self-citation
The wonderland of neuronal nicotinic acetylcholine receptors
Bertrand, D., & Terry, A. V. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.12.008 · Cited by 121
Evolution of tobacco products: recent history and future directions
O’Connor, R. J., Schneller-Najm, L. M., Felicione, N. J., Talhout, R., Goniewicz, M. L., & Ashley, D. L. (2022) · Tobacco Control · doi:10.1136/tobaccocontrol-2021-056544 · Cited by 128
E-Cigarettes: Promise or Peril?
Riker, C. A., Lee, K., Darville, A. K., & Hahn, E. J. (2012) · Nursing Clinics of North America · doi:10.1016/j.cnur.2011.10.002 · Cited by 113
Biochemistry of nicotine metabolism and its relevance to lung cancer
Murphy, S. E. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100722 · Cited by 116
Pyridine alkaloids with activity in the central nervous system
Lin, S. X., Curtis, M. A., & Sperry, J. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115820 · Cited by 106
Systematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation
Weinberger, A. H., Smith, P. H., ALLEN, S. S., Cosgrove, K., Saladin, M. E., Gray, K. M., Mazure, C. M., Wetherington, C. L., & McKee, S. A. (2015) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntu249 · Cited by 106
The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB–BDNF Signaling Pathway
Motaghinejad, M., Motevalian, M., Fatima, S., Faraji, F., & Mozaffari, S. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2323-8 · Cited by 103
Sleep quality in cigarette smokers and nonsmokers: findings from the general population in central China
Liao, Y., Xie, L., Chen, X., Kelly, B. C., Qi, C., Pan, C., Yang, M., Hao, W., Liu, T., & Tang, J. (2019) · BMC Public Health · doi:10.1186/s12889-019-6929-4 · Cited by 103
Respiratory Impact of Electronic Cigarettes and Low-Risk Tobacco
Thirión-Romero, I. I., Pérez‐Padilla, R., Zabert, G. E., & Barrientos‐Gutiérrez, I. (2019) · Revista de investigaci�n Cl�nica · doi:10.24875/ric.18002616 · Cited by 105
Dopamine D2 receptor agonists inhibit lung cancer progression by reducing angiogenesis and tumor infiltrating myeloid derived suppressor cells
Hoeppner, L. H., Wang, Y., Sharma, A. K., Javeed, N., Keulen, V. P. V., Wang, E., Yang, P., Roden, A. C., Peikert, T., Molina, J. R., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.08.008 · Cited by 100
In Vivo Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107: Preclinical Considerations in Alzheimer's Disease
Bitner, R. S., Bunnelle, W. H., Decker, M. W., Drescher, K. U., Kohlhaas, K. L., Markosyan, S., Marsh, K. C., Nikkel, A. L., Browman, K., Radek, R., et al. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.167213 · Cited by 97
Problematic social media use and mental health (depression, anxiety, and insomnia) among Lebanese adults: Any mediating effect of stress?
Malaeb, D. N., Salameh, P., Barbar, S., Awad, E., Haddad, C., Hallit, R. R., Sacre, H., Akel, M., Obeïd, S., & Hallit, S. R. (2020) · Perspectives In Psychiatric Care · doi:10.1111/ppc.12576 · Cited by 105
Chronic tobacco smoking and neuropsychological impairments: A systematic review and meta-analysis
Conti, A. A., McLean, L., Tolomeo, S., Steele, J. D., & Baldacchino, A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.017 · Cited by 107
Intravenous nicotine self-administration and cue-induced reinstatement in mice: Effects of nicotine dose, rate of drug infusion and prior instrumental training
Fowler, C. D., & Kenny, P. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.012 · Cited by 103
Electronic cigarettes: an aid in smoking cessation, or a new health hazard?
Farsalinos, K. E. (2017) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465817744960 · Cited by 99
Discovery and development of varenicline for smoking cessation
Jordan, C. J., & Xi, Z. (2018) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2018.1458090 · Cited by 103
Direct Quantitative Analysis of Nicotine Alkaloids from Biofluid Samples using Paper Spray Mass Spectrometry
Wang, H., Ren, Y., McLuckey, M. N., Manicke, N. E., Park, J., Zheng, L., Shi, R., Cooks, R. G., & Ouyang, Z. (2013) · Analytical Chemistry · doi:10.1021/ac402798m · Cited by 92
Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence
Hancock, D. B., Reginsson, G. W., Gaddis, N. C., Chen, X., Saccone, N. L., Lutz, S. M., Qaiser, B., Sherva, R., Steinberg, S., Zink, F., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.149 · Cited by 85
Electronic cigarette: a possible substitute for cigarette dependence
Caponnetto, P., Russo, C., Bruno, C. M., Alamo, A., Amaradio, M. D., & Polosa, R. (2015) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2013.104 · Cited by 86
Alpha7 Nicotinic Receptors as Therapeutic Targets in Schizophrenia
Tregellas, J. R., & Wylie, K. P. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty034 · Cited by 95
Nicotine dependence and psychological distress: outcomes and clinical implications in smoking cessation
Cosci, F. (2011) · Psychology Research and Behavior Management · doi:10.2147/prbm.s14243 · Cited by 91
Metabolic flux analysis of secondary metabolism in plants
Shih, M.-L., & Morgan, J. A. (2020) · Metabolic Engineering Communications · doi:10.1016/j.mec.2020.e00123 · Cited by 85
Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity
Morel, C., Fernández, S. P., Pantouli, F., Meye, F. J., Marti, F., Tolu, S., Parnaudeau, S., Marie, H., Tronche, F., Maskos, U., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.145 · Cited by 88
Nicotine: From Discovery to Biological Effects
Sansone, L., Milani, F., Fabrizi, R., Belli, M., Cristina, M., Zagà, V., de Iure, A., Cicconi, L., Bonassi, S., & Russo, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914570 · Cited by 99
Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors
Pang, X.-Y., Liu, L., Ngolab, J., Zhao-Shea, R., McIntosh, J. M., Gardner, P. D., & Tapper, A. R. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.039 · Cited by 89
Assessment of Local Tobacco Consumption by Liquid Chromatography–Tandem Mass Spectrometry Sewage Analysis of Nicotine and Its Metabolites, Cotinine and trans-3′-Hydroxycotinine, after Enzymatic Deconjugation
Rodríguez-Álvarez, T., Rodil, R., Rico, M. L., Cela, R., & Quintana, J. B. (2014) · Analytical Chemistry · doi:10.1021/ac503330c · Cited by 84
E‐cigarettes, nicotine, the lung and the brain: multi‐level cascading pathophysiology
Herman, M. A., & Tarran, R. (2020) · The Journal of Physiology · doi:10.1113/jp278388 · Cited by 94
Posttraumatic stress disorder and cigarette smoking: A systematic review
Kearns, N. T., Carl, E., Stein, A. T., Vujanovic, A. A., Zvolensky, M. J., Smits, J. A. J., & Powers, M. B. (2018) · Depression and Anxiety · doi:10.1002/da.22828 · Cited by 88
Hypocretin/Orexin Signaling in the Hypothalamic Paraventricular Nucleus is Essential for the Expression of Nicotine Withdrawal
Plaza‐Zabala, A., Flores, Á., Maldonado, R. J., & Berrendero, F. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.025 · Cited by 81
Nicotine in Senescence and Atherosclerosis
Centner, A. M., Bhide, P. G., & Salazar, G. (2020) · Cells · doi:10.3390/cells9041035 · Cited by 86
Identification of wounding and topping responsive small RNAs in tobacco (Nicotiana tabacum)
Tang, S., Wang, Y., Li, Z., Gui, Y., Xiao, B., Xie, J., Zhu, Q., & Fan, L. (2012) · BMC Plant Biology · doi:10.1186/1471-2229-12-28 · Cited by 79
Simple, fast and sensitive LC–MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites
Piller, M., Gilch, G., Scherer, G., & Scherer, M. (2014) · Journal of Chromatography B · doi:10.1016/j.jchromb.2014.01.025 · Cited by 78
COgnitive-Pulmonary Disease
Cleutjens, F. A. H. M., Janssen, D. J. A., Ponds, R., Dijkstra, J. B., & Wouters, E. F. �. (2014) · BioMed Research International · doi:10.1155/2014/697825 · Cited by 83
Is the inhibition of nicotinic acetylcholine receptors by bupropion involved in its clinical actions?
Arias, H. R. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.05.015 · Cited by 76
Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors
Koudsi, N. A., Hoffmann, E. B., Assadzadeh, A., & Tyndale, R. F. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-009-0762-0 · Cited by 77
Nicotine and electronic cigarette (E‐Cig) exposure decreases brain glucose utilization in ischemic stroke
Sifat, A. E., Vaidya, B., Kaisar, M. A., Cucullo, L., & Abbruscato, T. J. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14561 · Cited by 76
Managing smoking cessation
Reid, R. D., Pritchard, G., Walker, K. L., Aitken, D., Mullen, K., & Pipe, A. (2016) · Canadian Medical Association Journal · doi:10.1503/cmaj.151510 · Cited by 76
E-Cigarettes and Cardiopulmonary Health
Tarran, R., Barr, R. G., Benowitz, N. L., Bhatnagar, A., Chu, H. W., Dalton, P., Doerschuk, C. M., Drummond, M., Gold, D. R., Goniewicz, M. L., et al. (2021) · Function · doi:10.1093/function/zqab004 · Cited by 85
Self-citation
Biosynthesis and synthetic biology of psychoactive natural products
Jamieson, C. S., Misa, J., Tang, Y., & Billingsley, J. M. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00065a · Cited by 74
Menthol Binding and Inhibition of α7-Nicotinic Acetylcholine Receptors
Ashoor, A., Nordman, J. C., Veltri, D., Yang, K. S., Kury, L. A., Шуба, Я. М., Mahgoub, M., Howarth, F. C., Sadek, B. S., Shehu, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067674 · Cited by 73
Dye-Modified Metal–Organic Framework as a Recyclable Luminescent Sensor for Nicotine Determination in Urine Solution and Living Cell
Yan, D., Lou, Y., Yang, Y., Chen, Z., Yiping, C., Guo, Z., Zhan, H., & Chen, B. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b17310 · Cited by 73
Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia
Wallace, T. L., & Bertrand, D. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.736498 · Cited by 73
Death due to ingestion of nicotine-containing solution: Case report and review of the literature
Solarino, B., Rosenbaum, F., Rießelmann, B., Buschmann, C. T., & Tsokos, M. (2009) · Forensic Science International · doi:10.1016/j.forsciint.2009.11.003 · Cited by 70
A Randomised Study to Investigate the Nicotine Pharmacokinetics of Oral Nicotine Pouches and a Combustible Cigarette
McEwan, M., Azzopardi, D., Gale, N., Camacho, O. M., Hardie, G., Fearon, I. M., & Murphy, J. (2022) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-021-00742-9 · Cited by 70
CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study
Yuan, J., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger, J. K., Jin, A., Adams‐Haduch, J. M., Hecht, S. S., Koh, W., & Murphy, S. E. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx012 · Cited by 69
Epidemiology, radiology, and genetics of nicotine dependence in COPD
Kim, D. K., Hersh, C. P., Washko, G. R., Hokanson, J. E., Lynch, D. A., Newell, J. D., Murphy, J. R., Crapo, J. D., Silverman, E. K., & the COPD Gene Investigators (2011) · Respiratory Research · doi:10.1186/1465-9921-12-9 · Cited by 70
The co-occurrence of nicotine and other substance use and addiction among youth and adults in the United States: implications for research, practice, and policy
Richter, L., Pugh, B., Smith, P. H., & Ball, S. A. (2016) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2016.1193511 · Cited by 69
Flavors Enhance Nicotine Vapor Self-administration in Male Mice
Cooper, S. Y., Akers, A. T., & Henderson, B. J. (2020) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntaa165 · Cited by 68
The mutagenic effect of tobacco smoke on male fertility
Omolaoye, T. S., Shahawy, O. E., Skosana, B. T., Boillat, T., Loney, T., & du Plessis, S. S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16331-x · Cited by 71
Effect of Mild-to-Moderate Smoking on Viral Load, Cytokines, Oxidative Stress, and Cytochrome P450 Enzymes in HIV-Infected Individuals
Ande, A., McArthur, C. P., Ayuk, L. N., Awasom, C. N., Achu, P. N., Njinda, A., Sinha, N., Rao, S., Agudelo, M., Nookala, A. R., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122402 · Cited by 67
A Role for Hypocretin/Orexin Receptor-1 in Cue-Induced Reinstatement of Nicotine-Seeking Behavior
Plaza‐Zabala, A., Flores, Á., Martín‐García, E., Saravia, R., Maldonado, R. J., & Berrendero, F. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.72 · Cited by 67
Chronic Exposure to Nicotine Is Associated with Reduced Reward-Related Activity in the Striatum but not the Midbrain
Rose, E. J., Ross, T. J., Salmeron, B. J., Lee, M., Shakleya, D. M., Huestis, M. A., & Stein, E. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.013 · Cited by 67
Rodent models for nicotine withdrawal
Chellian, R., Behnood‐Rod, A., Bruijnzeel, D. M., Wilson, R., Pandy, V., & Bruijnzeel, A. W. (2021) · Journal of Psychopharmacology · doi:10.1177/02698811211005629 · Cited by 71
Blood-to-brain influx transport of nicotine at the rat blood-brain barrier: involvement of a pyrilamine-sensitive organic cation transport process.
Tega, Y., Akanuma, S., Kubo, Y., Terasaki, T., & Hosoya, K. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2012.11.014 · Cited by 48
Nicotine pouches: a review for the dental team
Jackson, J. M., Weke, A., & Holliday, R. (2023) · BDJ · doi:10.1038/s41415-023-6383-7 · Cited by 64
Age-associated changes in nicotine dependence
Park, S., Lee, J.-Y., Song, T. M., & Cho, S. (2012) · Public Health · doi:10.1016/j.puhe.2012.02.007 · Cited by 62
The Influence of Smoking and Cessation on the Human Reproductive Hormonal Balance
Jandíková, H., Dušková, M., & Stárka, L. (2017) · Physiological Research · doi:10.33549/physiolres.933724 · Cited by 65
Molecular insights into the benefits of nicotine on memory and cognition (Review)
Alhowail, A. H. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12037 · Cited by 65
Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes
D’Ruiz, C. D., Graff, D. W., & Yan, X. S. (2015) · BMC Public Health · doi:10.1186/s12889-015-2349-2 · Cited by 64
Electrophysiological Perspectives on the Therapeutic Use of Nicotinic Acetylcholine Receptor Partial Agonists
Papke, R. L., Trocmé, C., Guendisch, D., Rubaiy, S. A. A. A., & Bloom, S. A. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.177485 · Cited by 61
Pharmacodynamic and pharmacokinetic assessment of electronic cigarettes, combustible cigarettes, and nicotine gum: implications for abuse liability
Stiles, M. F., Campbell, L. R., Graff, D. W., Jones, B. A., Fant, R. V., & Henningfield, J. E. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4665-y · Cited by 59
Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort
Franklin, T. R., Wang, Z., Li, Y., Suh, J. J., Goldman, M., Lohoff, F. W., Cruz, J., Hazan, R., Jens, W., Detre, J. A., et al. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00277.x · Cited by 59
Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations
Mündel, T. (2017) · Sports Medicine · doi:10.1007/s40279-017-0764-5 · Cited by 71
Harm perceptions of electronic cigarettes and nicotine: A nationally representative cross-sectional survey of young people in Great Britain
East, K. A., Brose, L. S., McNeill, A. D., Cheeseman, H., Arnott, D., & Hitchman, S. C. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.08.016 · Cited by 58
Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine
Mathews, J., Chang, A. (., Devlin, L., & Levin, M. G. (2023) · Patterns · doi:10.1016/j.patter.2023.100737 · Cited by 61
Nicotinic receptor modulation to treat alcohol and drug dependence
Rahman, S., Engleman, E. A., & Bell, R. L. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00426 · Cited by 60

Authors: Benowitz, N. L.
Affiliations: San Francisco General Hospital (US)
Corresponding author: Benowitz, Neal L.
ORCID: Benowitz, Neal L.
Venue: Annual Review of Pharmacology and Toxicology
Publisher: Annual Reviews
Published: 2009-02-01
Volume: 49
Issue: 1
Pages: 57-71
ISSN: 0362-1642 (ISSN-L)
1545-4304
DOI: 10.1146/annurev.pharmtox.48.113006.094742
PMC: PMC2946180
OpenAlex: W2137599927
Cited by: 979
References: 90
Citations by year: 2026: 75 · 2025: 89 · 2024: 91 · 2023: 89 · 2022: 72 · 2021: 70 · 2020: 60 · 2019: 56 · 2018: 42 · 2017: 55 · 2016: 37 · 2015: 42 · 2014: 43 · 2013: 39 · 2012: 35
FWCI: 2.95
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Annual Review of Pharmacology and Toxicology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Public Health Service
National Institute on Drug Abuse (DA20830, DA02277, R01DA002277, U01DA020830, R37DA002277)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: nicotine, tobacco dependence, nicotine dependence, nicotinic acetylcholine receptors, nicotine withdrawal, dopamine release, glutamate release, GABA release, corticotropin-releasing factor, genetic susceptibility, CYP2A6, nicotine metabolism, lung cancer risk, smoking cessation, mental illness, substance abuse, nicotine replacement therapy, bupropion, varenicline, partial agonists
MeSH terms: Varenicline, Animals, Benzazepines, Nonprescription Drugs, Ganglionic Stimulants, Humans, Nicotine, Quinoxalines, Smoking, Tobacco Use Disorder, Bupropion, Behavior, Addictive, Nicotinic Agonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks