Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

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The Emergence of a Novel Synthetic Nicotine Analog 6‐Methyl Nicotine (6‐MN) in Proclaimed Tobacco‐ and Nicotine‐Free Pouches Available in Europe

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Metabolomic Analysis of Nicotine‐Induced Metabolic Disruptions and Their Amelioration by Resveratrol

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Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

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Nicotinic acetylcholine receptors α7 and α9 modifies tobacco smoke risk for multiple sclerosis

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Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response

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Smoking Cessation Intervention in a Cardiovascular Hospital Based Clinical Setting

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Classification Tree Analysis as a Method for Uncovering Relations BetweenCHRNA5A3B4andCHRNB3A6in Predicting Smoking Progression in Adolescent Smokers

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Combination nicotine replacement therapy: strategies for initiation and tapering

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Treatment With Bupropion and Varenicline for Smoking Cessation and the Risk of Acute Cardiovascular Events and Injuries: a Swedish Case-Crossover Study

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Use Behaviors, Dependence, and Nicotine Exposure Associated with Ad Libitum Cigar Smoking

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Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers

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Smoking Addiction and Strategies for Cessation

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Smoke signals: A study of the neurophysiological reaction of smokers and non-smokers to smoking cues inserted into antismoking public service announcements

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Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery

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Neuregulin signaling pathway in smoking behavior

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Combat, Posttraumatic Stress Disorder, and Smoking Trajectory in a Cohort of Male Australian Army Vietnam Veterans

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Nicotine drug discrimination and nicotinic acetylcholine receptors in differentially reared rats

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Comparison of Strategies to Overcome Drug Resistance: Learning from Various Kingdoms

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Chronic Exposure to E-Cigarettes Elevates CYP2A5 Activity, Protein Expression, and Cotinine-Induced Production of Reactive Oxygen Species in Mice

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Systematic Review of Naturally Derived Substances That Act as Inhibitors of the Nicotine Metabolizing Enzyme Cytochrome P450 2A6

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Disentangling the effects of nicotine versus non‐nicotine constituents of tobacco smoke on major depressive disorder: A multivariable Mendelian randomisation study

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Smoking, Obesity, and Post-Cessation Weight Gain: Neurobiological Intersection and Treatment Recommendations

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E-Zigaretten – Funktionsweise, Inhaltsstoffe und die Vaping-assoziierte akute Lungenschädigung

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The changing relationship between health risk behaviors and depression among birth cohorts of Canadians 65+, 1994–2014

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Smoking prevention within social work organizations: a qualitative study about youngsters’ and youth workers’ perceptions

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Neurocircuitry underlying the actions of glucagon-like peptide 1 and peptide YY3–36 in the suppression of food, drug-seeking, and anxiogenesis

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Biomarkers of Nicotine and Toxicant Exposure by E-Liquid Nicotine Concentration Level among US Adult Exclusive E-Cigarette Users

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CYP2A6Longitudinal Effects in Young Smokers

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Prenatal Stress as a Factor of the Development of Addictive States

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Risk Factors and Medical Symptoms Associated With Electronic Vapor Product Use Among Adolescents and Young Adults

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Cognitive Effects of Nicotine

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Specificity of Varenicline in Blocking Mesolimbic Circuit Activation to Natural and Drug Rewards

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Comparison of the Effectiveness of Varenicline, Extended-Release Bupropion and Nicotine Replacement Therapy on The Success and the Maintenance of a Smoking Cessation Program

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Impact of Repeated Nicotine and Alcohol Coexposure on in Vitro and in Vivo Chlorpyrifos Dosimetry and Cholinesterase Inhibition

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E-cigarettes, synthetic nicotine, heated-tobacco and smokeless nicotine delivery products: the nicotine landscape beyond combustible cigarettes

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Addressing the arguments against implementation of smoke‐free policies in psychiatric facilities

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Animal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence

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Identification of nicotine-seeking and avoiding larval zebrafish using a new three-choice behavioral assay

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Epidemiology of Traditional Cigarette and E-Cigarette Use Among Adolescents in Poland: Analysis of Sociodemographic Risk Factors

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The Bidirectional Interplay Between Substances of Abuse and Gut Microbiome Homeostasis

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High-efficiency adsorption of caffeine and nicotine in aqueous phases by functionalized MIL-101 nanostructures: experimental and density functional theory study

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Relationship between skin melanin index and nicotine pharmacokinetics in African American smokers

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Distinct Temporal Structure of Nicotinic ACh Receptor Activation Determines Responses of VTA Neurons to Endogenous ACh and Nicotine

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Galantamine as a Treatment Option for Nicotine Addiction

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Association between pesticide exposure and neurobehavioral performance of agricultural workers: A cross‐sectional study

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Gelsolin is a potential cellular target for cotinine to regulate the migration and apoptosis of A549 and T24 cancer cells

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The novel nicotinic receptor antagonist, N,N′-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [3H]norepinephrine overflow from rat hippocampal slices

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Interaction of Depression and Nicotine Addiction on the Severity of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study.

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Tardive Dyskinesia Associated with Bupropion

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Application of a pharmacokinetic/pharmacogenetic approach to assess the nicotine metabolic profile of smokers in the real-life setting

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Learning and memory performance following acute intranasal insulin administration in abstinent smokers

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Secondary Metabolites: Treasure Trove for Future Medicine

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Altered local intrinsic neural activity and molecular architecture in internet use disorders

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Prevalence, safety, and role of nicotine pouches in smoking cessation among smokers and the public in Saudi Arabia

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Prevalência e fatores associados ao tabagismo em mulheres privadas de liberdade, numa prisão, Centro-Oeste do Brasil

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Effects of acute and chronic nicotine administration on probability discounting

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Pharmacokinetic differences in nicotine and nicotine salts mediate reinforcement-related behavior: an animal model study

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The Difference of Addictive Behavior of Free-Base Nicotine and Nicotine Salts in Mice Base on an Aerosol Self-Administration Model

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Characterization of a novel oronasal-restricted nicotine vaping self-administration model in mice

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The Novel Potential Therapeutic Utility of Montelukast in Alleviating Autistic Behavior Induced by Early Postnatal Administration of Thimerosal in Mice

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An investigation of factors encouraging and deterring EC use: a thematic analysis of accounts from UK adults

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Transitions in Smoking Behaviour and the Design of Cessation Schemes

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Effects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N

Gaffin, R. D., Chowdhury, S. A. K., Lofrano‐Alves, M. S., Dias, F. A. L., Ribeiro, C. T., Fogaça, R. T. H., Wieczorek, D. F., & Wolska, B. M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00277.2010 · Cited by 7

Assumptions about Consumers, Producers, and Regulators: What They Tell Us about Ourselves

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The Use of Non-Invasive Brain Stimulation in Drug Addictions

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Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles

Sciuscio, D., Hoeng, J., Peitsch, M. C., & Vanscheeuwijck, P. (2019) · Inhalation Toxicology · doi:10.1080/08958378.2019.1662526 · Cited by 7

The Incentives to Quit tobacco in Pregnancy (IQuiP) protocol: piloting a financial incentive-based smoking treatment for women attending substance use in pregnancy antenatal services

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Tobacco smoke exposure enhances reward sensitivity in male and female rats

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Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance

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Cross Talks between CNS and CVS Diseases: An Alliance to Annihilate

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E-cigarette use reasons and associated e-cigarette use dependence among college students: A longitudinal examination

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Multi-omics signature of healthy versus unhealthy lifestyles reveals associations with diseases

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Biomarkers of Exposure to Tobacco-Related Toxicants among Adult Nicotine Pouch Users

Dai, H. D., & Young, B. R. (2025) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntaf185 · Cited by 6

Sais de Nicotina e Nicotina Sintética: Novos Desafios para um Velho Problema

da Silva, A. L. O., & Moreira, J. C. (2022) · Revista Brasileira de Cancerologia · doi:10.32635/2176-9745.rbc.2022v68n4.2846 · Cited by 6

The Fagerström Test for Nicotine Dependence, as a prognostic factor, in current smokers with and without COPD: A cross-sectional study in northern Greece

Papadopoulou, E., Haidich, A., Mathioudakis, A. G., Tsavlis, D., Papadopoulou, K., Oikonomidou, R., Bogiatzidis, P., & Τryfon, S. (2024) · Chronic Respiratory Disease · doi:10.1177/14799731241235213 · Cited by 6

Cigarette smoke extract exacerbates progression of osteoarthritic‐like changes in cartilage explant cultures

Sawvell, E., Martinez, A. V., Walker, L., Wu, Y. R., Burnikel, B. G., & Mercuri, J. J. (2024) · Journal of Orthopaedic Research® · doi:10.1002/jor.25828 · Cited by 6

Preventive effects of crocin, a natural compound from saffron, against nicotine‑induced oxidative stress and neurobehavioral disturbances

Motaghinejad, M., Motevalian, M., & Sureda, A. (2024) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2024-2538 · Cited by 7

The Effects of Nicotine and Cannabinoids on Cytokines

Miller, G., Pareek, O., Penman, S. L., & Thanos, P. K. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128293077240529111824 · Cited by 6

Nicotine-Induced Transient Activation of Monocytes Facilitates Immunosuppressive Macrophage Polarization that Restrains T Helper 17 Cell Expansion

Zhan, L., Luo, S., Wang, H., Wang, J., Pan, X., Lin, Y. H., Jin, B., Liang, Y., & Chen, P. (2024) · Inflammation · doi:10.1007/s10753-024-02191-3 · Cited by 6

Significantly more intense pain in methadone-maintained patients who are addicted to nicotine

Liu, L.-Z., Tan, L., Xu, Y., Liu, X.-B., Chen, W.-C., Zhu, J.-H., Lü, J., & Zhong, B. (2017) · Oncotarget · doi:10.18632/oncotarget.19222 · Cited by 6

The Co-occurrence of Nicotine With Other Substance Use and Addiction: Risks, Mechanisms, Consequences, and Implications for Practice, With a Focus on Youth

Richter, L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813035-3.00047-2 · Cited by 5

A survey of users of the IQOS tobacco vaporizer: perceived dependence and perceived effects on cigarette withdrawal symptoms

Queloz, S., & Etter, J. (2020) · Journal of Addictive Diseases · doi:10.1080/10550887.2020.1847994 · Cited by 6

Soluble epoxide hydrolase deletion attenuated nicotine-induced arterial stiffness via limiting the loss of SIRT1

Hu, S., Luo, J., Fu, M., Luo, L., Cai, Y., Li, W., Li, Y., Dong, R., Yang, Y., Tu, L., et al. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00979.2020 · Cited by 7

Central Australian Aboriginal women's placental and neonatal outcomes following maternal smokeless tobacco, cigarette or no tobacco use

Ratsch, A., Bogossian, F. E., Burmeister, E. A., & Steadman, K. J. (2021) · Australian and New Zealand Journal of Public Health · doi:10.1111/1753-6405.13186 · Cited by 6

In Vitro Production of Alkaloids

Meena, S., Kanthaliya, B., Joshi, A., Khan, F., Choudhary, S., & Arora, J. (2022) · Springer eBooks · doi:10.1007/978-981-16-8858-4_6 · Cited by 6

Expression, correlation, and prognostic significance of different nicotinic acetylcholine receptors, programed death ligand 1, and dopamine receptor D2 in lung adenocarcinoma

Pal, K., Hussain, T., Xie, H., Li, S., Yang, P., Mansfield, A. S., Lou, Y., Chowdhury, S., & Mukhopadhyay, D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.959500 · Cited by 6

Adequacy of nicotine replacement and success quitting tobacco in clinical populations: An observational study

Veldhuizen, S., Behal, A., Zawertailo, L. A., & Selby, P. L. (2023) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2023.109796 · Cited by 6

Transdermal Nicotine Poisoning: A Rare Case Report of Occupational Exposure

Becam, J., Martin, E. R., Pouradier, G., Doudka, N., Solas, C., Guilhaumou, R., & Fabresse, N. (2023) · Toxics · doi:10.3390/toxics11050464 · Cited by 6

Distinct resting-state functional connectivity patterns of Anterior Insula affected by smoking in mild cognitive impairment

Zhang, T., Zeng, Q., Li, K., Liu, X., Fu, Y., Qiu, T., Huang, P., Luo, X., Liu, Z., Peng, G., et al. (2023) · Brain Imaging and Behavior · doi:10.1007/s11682-023-00766-6 · Cited by 6

Comparing the effects of three neonicotinoids on embryogenesis of the South African clawed frog Xenopus laevis

Flach, H., Brendler, C., Schöpf, M., Xu, L., Schneider, J., Dewald, K., Dietmann, P., Kühl, M., & Kühl, S. J. (2024) · Current Research in Toxicology · doi:10.1016/j.crtox.2024.100169 · Cited by 6

Preventive Effects of Crocin, a Key Carotenoid Component in Saffron, Against Nicotine-Triggered Neurodegeneration in Rat Hippocampus: Possible Role of Autophagy and Apoptosis

Gholami, M., Klionsky, D. J., & Motaghinejad, M. (2024) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_41_23 · Cited by 6

Identifying beliefs about smoking in patients with peripheral vascular disease

Lopes-Costa, E., & Amato‐Vealey, E. J. (2016) · Journal of Vascular Nursing · doi:10.1016/j.jvn.2016.07.003 · Cited by 6

Clinical Pharmacology of Nicotine: Implications for Understanding, Preventing, and Treating Tobacco Addiction

Benowitz, N. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2008.3 · Cited by 515

Neurobiology and Mechanisms of Nicotine Addiction

Gogineni, H. P., Sachs, D. P. L., & Brunzell, D. H. (2023) · Respiratory medicine · doi:10.1007/978-3-031-24914-3_3 · Cited by 2

Uncovering the basis of nicotine addiction

Greener, M. (2012) · Nurse Prescribing · doi:10.12968/npre.2012.10.2.80 · Cited by 2

Genetics of Nicotine Addiction

Bloom, A. J., & Goate, A. (2014) · Wiley eBooks · doi:10.1002/9780470015902.a0024636

Impact of Genetic Variability in Nicotinic Acetylcholine Receptors on Nicotine Addiction and Smoking Cessation Treatment

Russo, P., Cesario, A., Rutella, S., Veronesi, G., Spaggiari, L., Galetta, D., Margaritora, S., Granone, P., & Greenberg, D. (2010) · Current Medicinal Chemistry · doi:10.2174/092986711793979715 · Cited by 26