Cited by 334Cancer-related Molecular PathwaysCell death mechanisms and regulationSignaling Pathways in Disease

The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.

THE MANY ROLES OF c-Myc IN APOPTOSIS

Thompson, E. Brad·1998·Annual Review of Physiology

Open this paper in CoChat — free account

Abstract

▪ Abstract The proto-oncogene c-myc encodes a transcription factor c-Myc, which is of great importance in controlling cell growth and vitality. The quantity of c-Myc is carefully controlled by many mechanisms, and its actions to induce and repress genes are modulated by interactions with other regulatory proteins. Understanding the kinetic and quantitative relationships that determine how and what genes c-Myc regulates is essential to understanding how Myc is involved in apoptosis. Reduction of c-myc expression and its inappropriate expression can be associated with cellular apoptosis. This review outlines the nature and regulation of the c-myc gene and of c-Myc and presents the systems and conditions in which Myc-related apoptotic events occur. Hypotheses of the mechanisms by which expression and repression of c-myc lead to apoptosis are discussed.

Integrity signals

Registry

Crossref · 10.1146/annurev.physiol.60.1.575

Cites

159 of 159 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Induction of apoptosis in fibroblasts by c-myc protein
Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M. W., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,941
Thymocyte apoptosis induced by p53-dependent and independent pathways
Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993) · Nature · doi:10.1038/362849a0 · Cited by 2,271
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
Yonish-Rouach, E., Resnftzky, D., Lotem, J., Sachs, L., Kimchi, A., & Oren, M. (1991) · Nature · doi:10.1038/352345a0 · Cited by 2,079
c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth
Shim, H., Dolde, C., Lewis, B. C., Wu, C.-S., Dang, G., Jungmann, R. A., Dalla-Favera, R., & Dang, C. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6658 · Cited by 1,092
Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.
Askew, D. S., Ashmun, R. A., Simmons, B. C., & Cleveland, J. L. (1991) · PubMed · Cited by 867
Myc Function and Regulation
Marcu, K. B., Bossone, S., & Patel, A. J. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.004113 · Cited by 802
A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death
Ham, J., Babij, C., Whitfield, J. R., Pfarr, C. M., Lallemand, D., Yaniv, M., & Rubin, L. L. (1995) · Neuron · doi:10.1016/0896-6273(95)90331-3 · Cited by 795
Proteins of the Myc Network: Essential Regulators of Cell Growth and Differentiation
Arsenian‐Henriksson, M., & Lüscher, B. (1996) · Advances in cancer research · doi:10.1016/s0065-230x(08)60353-x · Cited by 781
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
Littlewood, T. D., Hancock, D. C., Danielian, P. S., Parker, M. G., & Evan, G. I. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.10.1686 · Cited by 780
Reactive oxygen species and programmed cell death
Jacobson, M. D. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)20008-8 · Cited by 754

Flagged first, then by citations

Show all 159 references

Research works printed but not linked: 55

Lemaitre JM, 1996, Adv. Cancer Res., 70, 96
Shrivastava A, 1995, Curr. Top. Microbiol. Immunol., 194, 273
Plet A, 1992, Oncogene, 7, 1847
Eastman-Reks SB, 1986, Cancer Res., 46, 2457
Rhee K, 1995, Cancer Res., 55, 4188
Thompson EA, 1991, Cancer Res., 51, 5551
Medh RD, 1997, Cancer Res.
Ayala-Torres S, 1997, Mol. Cell. Biol.
Dean M, 1988, Curr. Top. Microbiol. Immunol., 141, 216
Cory S, 1987, Oncogene Res., 1, 61
Askew DS, 1991, Oncogene, 6, 1915
Kimura S, 1995, Cancer Res., 55, 1379
Ohta H, 1995, Cancer Res., 55, 691
Davidoff AN, 1993, Anticancer Res., 13, 1167
Samid D, 1992, Cancer Res., 52, 1988
Sumitani K, 1997, Anticancer Res., 17, 865
Zhao X, 1995, Sci. China-Ser. B, 38, 580
Fornari FA, 1994, Cell Growth Differ., 5, 723
Van Waardenburg RC, 1996, Anticancer Res., 16, 1963
Cerutti J, 1996, Clin. Cancer Res., 2, 119
Heufelder AE, 1995, Invest. Ophthalmol. Visual Sci., 36, 1420
Williams SA, 1996, Leukemia, 10, 1980
Watson PH, 1991, Cancer Res., 51, 3996
Loke SL, 1988, Curr. Topics Microbiol. Immunol., 141, 282
Chiarugi V, 1996, Tumori, 82, 205
Lotem J, 1996, Leukemia, 10, 925
10.1016/S0065-230X(08)60353-X · DOI
Koskinen PJ, 1993, Semin. Cancer Biol., 4, 3
Onclercq R, 1989, Oncogene Res., 4, 293
Nishikura K, 1990, Oncogene, 5, 981
Shiota G, 1995, Res. Commun. Mol. Pathol. Pharmacol., 90, 17
Amundadottir LT, 1996, Oncogene, 13, 757
Hundley JE, 1997, Cancer Res., 57, 600
Morgenbesser SD, 1994, Semin. Cancer Biol., 5, 21
Green DR, 1992, Semin. Immunol., 4, 379
Wang Y, 1993, Cell Growth Differ., 4, 467
Sakamuro D, 1995, Oncogene, 11, 2411
Hsu B, 1995, Oncogene, 11, 175
Czaja MJ, 1996, Am. J. Physiol., 270, G60
Reynolds JE, 1994, Cancer Res., 54, 6348
Packham G, 1995, Curr. Topics Microbiol. Immunol., 194, 283
Packham G, 1994, Mol. Cell. Biol., 14, 41
10.1016/0968-0004(96)20008-8 · DOI
10.1182/blood.V83.5.1179.1179 · DOI
10.1210/me.10.3.306 · DOI
Singh N, 1995, Oncol. Res., 7, 353
Freemerman AJ, 1996, Mol. Pharmacol., 49, 788
Bortner DM, 1995, Cell Growth Differ., 6, 1579
Adams PD, 1996, Curr. Top. Microbiol. Immunol., 208, 79
Lebowitz PF, 1997, Cancer Res., 57, 708
Esteve P, 1995, Oncogene, 11, 2657
Jimenez B, 1995, Oncogene, 10, 811
Fukasawa K, 1995, Oncogene, 10, 1
Jansen B, 1997, Cancer Res., 57, 362
Fernandes RS, 1996, Anticancer Res., 16, 1691

Sorted by citations

Items 101–200 of 334

c-Myc is essential for hematopoietic stem cell differentiation and regulates Lin−Sca-1+c-Kit− cell generation through p21
Baena, E., Ortiz, M., Martínez‐A, C., & de Alborán, I. M. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.05.015 · Cited by 51
Apoptosis and liver diseases: Recent concepts of mechanism and significance1
Ockner, R. K. (2001) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2001.02426.x · Cited by 47
The centella asiatica juice effects on DNA damage, apoptosis and gene expression in hepatocellular carcinoma (HCC)
Hussin, F., Eshkoor, S. A., Rahmat, A. B., Othman, F., & Akim, A. M. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-32 · Cited by 48
Sensitivity of neuroprogenitor cells to chemical-induced apoptosis using a multiplexed assay suitable for high-throughput screening
Druwe, I. L., Freudenrich, T. M., Wallace, K., Shafer, T. J., & Mundy, W. R. (2015) · Toxicology · doi:10.1016/j.tox.2015.03.011 · Cited by 46
Secreted Frizzled-related protein 4 (sFRP4) chemo-sensitizes cancer stem cells derived from human breast, prostate, and ovary tumor cell lines
Deshmukh, A. P., Kumar, S., Arfuso, F., Newsholme, P., & Dharmarajan, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-02256-4 · Cited by 48
Increased p27Kip1 Cyclin-Dependent Kinase Inhibitor Gene Expression Following Anti-IgM Treatment Promotes Apoptosis of WEHI 231 B Cells
Wu, M., Bellas, R. E., Shen, J., Yang, W. E., & Sonenshein, G. E. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6530 · Cited by 46
Iron metabolism and the tumor microenvironment: A new perspective on cancer intervention and therapy (Review)
bu, X., & Wang, L. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5480 · Cited by 54
“Other regulatory factors include oncogenes such as c‑MYC, which directly binds to a conserved E box in intron 1 of TFRC (19), and HIF‑1, which activates TFRC expression under specific conditions, such as iron‑deficient conditions, by binding to an upstream hypoxia response element (20).”
ANP32A regulates histone H3 acetylation and promotes leukemogenesis
Yang, X., Lu, B., Sun, X., Han, C., Fu, C., Xu, K., Wang, M., Li, D., Chen, Z., Opal, P., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0010-7 · Cited by 44
G1 Phase-Dependent Expression of Bcl-2 mRNA and Protein Correlates with Chemoresistance of Human Cancer Cells
Gao, G., & Dou, Q. P. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12472-8 · Cited by 43
Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation
Qian, X., Zhu, L., Xu, M., Liu, H., Yu, X., Shao, Q., & Qin, J. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110588 · Cited by 41
Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes
Ceballos, E., Muñoz-Alonso, M. J., Berwanger, B., Acosta, J. C., Hernández, R., Krause, M., Hartmann, O., Eilers, M., & León, J. (2005) · Oncogene · doi:10.1038/sj.onc.1208652 · Cited by 43
What retroviruses teach us about the involvement of c-Myc in leukemias and lymphomas
Dudley, J., Mertz, J., Rajan, L., Lozano, M. M., & Broussard, D. R. (2002) · Leukemia · doi:10.1038/sj.leu.2402451 · Cited by 40
Mechanisms of T-cell Apoptosis Induced by Glucocorticoids
Thompson, E. B. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(99)00187-3 · Cited by 41
Self-citation
Constitutive expression of ectopic c-Myc delays glucocorticoid-evoked apoptosis of human leukemic CEM-C7 cells
Medh, R. D., Wang, A., Zhou, F. L., & Thompson, E. B. (2001) · Oncogene · doi:10.1038/sj.onc.1204680 · Cited by 41
“Depending on the cell type and conditions being studied, either deregulated overexpression or suppression of c-Myc can lead to apoptosis (Shi et al., 1992; Thompson, 1998).”
BackgroundSelf-citation
Neuroblastoma: The impact of biology and cooperation leading to personalized treatments
Owens, C., & Irwin, M. S. (2012) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2012.683483 · Cited by 41
A site-specific self-assembled light-up rotor probe for selective recognition and stabilization of c-MYC G-quadruplex DNA
Deiana, M., Chand, K., Jamroškovič, J., Das, R. N., Obi, I. R., Chorell, E., & Sabouri, N. (2020) · Nanoscale · doi:10.1039/d0nr03404e · Cited by 39
Transferrin ensures survival of ovarian carcinoma cells when apoptosis is induced by TNFα, FasL, TRAIL, or Myc
Fassl, S., Leisser, C., Huettenbrenner, S., Maier, S., Rosenberger, G., Strasser, S., Grusch, M., Fuhrmann, G., Leuhuber, K., Polgar, D., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1207047 · Cited by 38
“…enzymes (Wu et al., 1999), became limited and this may explain the dual role of c-Myc in the induction of cell proliferation and of apoptosis (Thompson, 1998; Fuhrmann et al., 1999), (c) Expression of H-ferritin protein after Myc:ER activation (by 4-OHT), or exposure to TNFa, FasL, and TRAIL.”
Background
The role of Pim kinase in immunomodulation.
Liu, Z., Han, M., Ding, K., & Fu, R. (2020) · PubMed Central · Cited by 37
Cell death signaling in the cerebellum in Creutzfeldt-Jakob disease
Puig, B., & Ferrer, I. (2001) · Acta Neuropathologica · doi:10.1007/s004010100368 · Cited by 37
Microarray Analysis of E-Box Binding-Related Gene Expression in Young and Replicatively Senescent Human Fibroblasts
Semov, A., Marcotte, R., Semova, N., Ye, X., & Wang, E. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5515 · Cited by 37
Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127–189 of c-myc
Alarcon-Vargas, D., Tansey, W. P., & Ronai, Z. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205543 · Cited by 36
“Given that c-myc has also been implicated in promoting apoptosis (Askew et al., 1991; Evan et al., 1992; Thompson, 1998), the mechanisms that underlie the regulation of c-myc stability, as illustrated here for MEKK1 and its related kinases, is expected to play a pivotal role in Figure 4 DMEKK1…”
Background
Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells
Dalberg, U. N., Markholst, H., & Hornum, L. (2007) · International Immunology · doi:10.1093/intimm/dxm009 · Cited by 35
“Other examples of this are the proto-oncogenes c-Myc ( 27 ) and Ras (28) and cdk inhibitors such as p21 and p27 (29).”
Background
Survival of Adult Generated Hippocampal Neurons Is Altered in Circadian Arrhythmic Mice
Rakai, B. D., Chrusch, M. J., Spanswick, S. C., Dyck, R. H., & Antle, M. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099527 · Cited by 35
“Many genes involved in growth and apoptosis are regulated by the transcription factor Myc, which binds to E-boxes to regulate gene expression [36].”
Background
Oxidative stress-mediated p53/p21WAF1/CIP1 pathway may be involved in microcystin-LR-induced cytotoxicity in HepG2 cells
Ma, J., Li, Y., Wu, M., & Li, X. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.12.051 · Cited by 34
Cdc25A phosphatase suppresses apoptosis induced by serum deprivation
Fuhrmann, G., Leisser, C., Rosenberger, G., Grusch, M., Huettenbrenner, S., Halama, T., Mosberger, I., Sasgary, S., Cerni, C., & Krupitza, G. (2001) · Oncogene · doi:10.1038/sj.onc.1204499 · Cited by 34
“Therefore it is assumed that cell cycle regulation and apoptosis ought to be tightly connected and might share some early biochemical pathways and molecular mechanisms such as p53 dependence (King and Cidlowsky, 1998) or c-Myc transcriptional activity (Thompson, 1998).”
Background
γ-Tocotrienol inhibits cell viability through suppression of β-catenin/Tcf signaling in human colon carcinoma HT-29 cells
Xu, W., Du, M., Zhao, Y., Wang, Q., Sun, W., & Chen, B. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.04.003 · Cited by 33
“The proto-oncogene c-myc encodes a transcription factor, c-Myc, which is of great importance in controlling cell growth and vitality [50].”
Background
Significance of c-Myc and Bcl-2 Protein Expression in Nasopharyngeal Carcinoma
Yu, Y., Dong, W., Li, X., Yu, E., Zhou, X., & Li, S. (2003) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.129.12.1322 · Cited by 33
Apoptosis Induced by Oxysterol in CEM Cells Is Associated with Negative Regulation of c-Myc
Ayala‐Torres, S., Zhou, F. L., & Thompson, E. B. (1999) · Experimental Cell Research · doi:10.1006/excr.1998.4308 · Cited by 33
Self-citation
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics
Deng, Z., & Richardson, D. R. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000795 · Cited by 32
“Moreover, Myc family members can amplify transcription by interacting with the promoter regions of downstream target genes (Lin et al., 2012; Nie et al., 2012, 2020).”
Background
c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death
de Alborán, I. M., Baena, E., & Martínez‐A, C. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401319 · Cited by 32
“Overexpression of c-myc induces apoptosis in fibroblasts and myeloid cell lines in low serum conditions.(1,2,9) More recently, Hueber et al.”
Background
Non-steroidal anti-inflammatory drugs and apoptosis in the gastrointestinal tract: potential role of the pentose phosphate pathways
Porter, S. N., Howarth, G. S., & Butler, R. N. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00237-5 · Cited by 32
Glucocorticoid mediated transcriptional repression of c-myc in apoptotic human leukemic CEM cells
Zhou, F. L., Medh, R. D., & Thompson, E. B. (2000) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00080-7 · Cited by 32
“The regulation of the c-myc gene and its products occurs by various mechanisms, including transcriptional, post-transcriptional, translational and combinations of these [1,10].”
BackgroundSelf-citation
Immunohistochemical Markers for Prognosis of Average-risk Pediatric Medulloblastomas. The Effect of Apoptotic Index, TrkC, and C-myc Expression
Korshunov, A., Savostikova, M. V., & Ozerov, S. S. (2002) · Journal of Neuro-Oncology · doi:10.1023/a:1016226319068 · Cited by 32
“Up-regulation of c-myc protein has also been implicated in triggering apoptosis pathways and various associations between both these processes have been established [36,37].”
Background
Myc-Induced Liver Tumors in Transgenic Zebrafish Can Regress in tp53 Null Mutation
Sun, L., Nguyễn, A. T., Spitsbergen, J. M., & Gong, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117249 · Cited by 31
RETRACTED ARTICLE: Syndecan-1 suppresses cell growth and migration via blocking JAK1/STAT3 and Ras/Raf/MEK/ERK pathways in human colorectal carcinoma cells
Wang, S., Zhang, X., Wang, G., Cao, B., Yang, H., Jin, L., Cui, M., & Mao, Y. (2019) · BMC Cancer · doi:10.1186/s12885-019-6381-y · Cited by 31
Retracted
Cell Death in MMTV-c-myc Transgenic Mouse Mammary Tumors May Not Be Typical Apoptosis
Liao, D. J., & Dickson, R. B. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000090153.13977.ae · Cited by 32
c-Myc Oncoprotein: A Dual Pathogenic Role in Neoplasia and Cardiovascular Diseases?
Claudio Napoli, A., Lermant, L. O., de Nigris, F., & Sica, V. (2002) · Neoplasia · doi:10.1038/sj.neo.7900232 · Cited by 31
“interactions with other regulatory proteins [2-8,48].”
Background
A balance of Mad and Myc expression dictates larval cell apoptosis and adult stem cell development during Xenopus intestinal metamorphosis
Okada, M., Miller, T. C. R., Wen, L., & Shi, Y. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.198 · Cited by 30
Effects of histone deacetylase inhibitor FR901228 on the expression level of telomerase reverse transcriptase in oral cancer
Murakami, J., Asaumi, J., Kawai, N., Tsujigiwa, H., Yanagi, Y., Nagatsuka, H., Inoue, T., Kokeguchi, S., Kawasaki, S., Kuroda, M., et al. (2005) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-004-0976-x · Cited by 30
“Next, we sought to discover whether or not the effect of FR901228 on hTERT expression is related to a mechanism through one of the main hTERT transcription activators, c-myc, whose repression has been implicated in several apoptosis pathways [32].”
Background
Prognostic value of plasminogen activator inhibitor‐1 in head and neck squamous cell carcinoma
Speleman, L., Kerrebijn, J. D. F., Look, M. P., Meeuwis, C. A., Foekens, J. A., & Berns, E. M. J. J. (2006) · Head & Neck · doi:10.1002/hed.20527 · Cited by 30
Multiorgan mRNA misexpression in murine autosomal recessive polycystic kidney disease
Gattone, V. H., Ricker, J. L., Trambaugh, C. M., & Klein, R. M. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00632.x · Cited by 30
“Elevated c-myc expression is associated with increased rates of apoptosis and proliferatio”
Background
The Role of PKM2 in Multiple Signaling Pathways Related to Neurological Diseases
Zhang, X., Lei, Y., Zhou, H., Liu, H., & Xu, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03901-y · Cited by 30
“…by mediating the β-catenin/T-cell factor 4 (TCF4) signaling cascade under the conditions of ischemic injury. β-catenin and its induced TCF4 are combined with upregulating gene induction of Myc , CCND1 , and Sgk1 , thereby regulating cell proliferation and anti-apoptotic effects [30, 113–115] (Fig.”
The evaluation of the anti-cancer activity of ixazomib on Caco2 colon solid tumor cells, comparison with bortezomib
Engür, S., & Dikmen, M. (2017) · Acta Clinica Belgica · doi:10.1080/17843286.2017.1302623 · Cited by 29
Synergistic cooperation between c-Myc and Bcl-2 in lymph node progression of T1 human breast carcinomas
Sierra, À., Castellsagué, X., Escobedo, A., Moreno, A., Drudis, T., & Fabra, À. (1999) · Breast Cancer Research and Treatment · doi:10.1023/a:1006120006471 · Cited by 29
“suppressor of the apoptotic action of c-Myc, without affecting its ability to promote cell proliferation [5].”
Background
Racial disparity in prostate cancer in the African American population with actionable ideas and novel immunotherapies
Dovey, Z. S., Nair, S. S., Chakravarty, D., & Tewari, A. K. (2021) · Cancer Reports · doi:10.1002/cnr2.1340 · Cited by 29
Biological functions and research progress of eIF4E
Chen, X., An, Y., Tan, M., Xie, D., Liu, L., & Xu, B. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1076855 · Cited by 26
“c-Myc It promotes cell cycle progression, transforming cells in G1 phase into S phase, and regulates cell apoptosis (18).”
Background
Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation
Newman, E. A., Chukkapalli, S., Bashllari, D., Thomas, T. T., Noord, R. A. V., Lawlor, E. R., Hoenerhoff, M. J., Opipari, A. W., & Opipari, V. P. (2017) · Cell Death and Disease · doi:10.1038/s41419-017-0004-9 · Cited by 26
Novel approaches to the treatment of small-cell lung cancer
Zangemeister‐Wittke, U., & Stahel, R. A. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050398 · Cited by 26
Changes in expression and immunolocalization of protein associated with toxic bile salts-induced apoptosis in rat hepatocytes
Oh, S., Yun, K., Nan, J., Sohn, D., & Lee, B. (2003) · Archives of Toxicology · doi:10.1007/s00204-002-0415-x · Cited by 26
“Therefore, the results of our present study and of others (Ryan et al. 1994; Thompson 1998 ) strongly suggest that Bcl-2 and c-Myc inhibit hepatocellular apoptosis at later stages of BDL by sequestering p53 in the cytoplasm.”
BackgroundResult
Early whole-genome transcriptional response induced by benzo[a]pyrene diol epoxide in a normal human cell line
Lu, X., Shao, J., Li, H., & Yu, Y. (2009) · Genomics · doi:10.1016/j.ygeno.2008.12.007 · Cited by 25
“Deregulation of this gene was associated with cellular apoptosis [31].”
Background
A novel form of the RelA nuclear factor κB subunit is induced by and forms a complex with the proto-oncogene c-Myc
Chapman, N., Webster, G., Gillespie, P. J., Wilson, B. J., Crouch, D. H., & Perkins, N. D. (2002) · Biochemical Journal · doi:10.1042/bj20020444 · Cited by 24
Comparison of antiproliferative and apoptotic effects of a novel proteasome inhibitor MLN2238 with bortezomib on K562 chronic myeloid leukemia cells
Engür, S., Dikmen, M., & Öztürk, Y. (2015) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2015.1122616 · Cited by 24
PATHWAYS OF APOPTOSIS AND THE MODULATION OF CELL DEATH IN CANCER
Fisher, D. E. (2001) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(05)70258-6 · Cited by 24
Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression
Pollard, H., Yang, Q., Dalgard, C. L., Eidelman, O., Jozwik, C., Pollard, B., & Srivastava, M. (2013) · Journal of Carcinogenesis · doi:10.4103/1477-3163.112268 · Cited by 24
“Both c‐MYC mRNA and c‐MYC protein have short half‐lives, of approximately 30 min, respectively.[20] Of the known transcriptional drivers for c‐MYC, one of the most critical appears to be nuclear factor of activated T‐cells (NFAT).”
Background
Proliferation and apoptosis in the evolution of endemic and acquired immunodeficiency syndrome-related Kaposi's sarcoma
Kaaya, E. E., Castaños‐Vélez, E., Heiden, T., Ekman, M., Catrina, A., Kitinya, J. N., Andersson, L. C., & Biberfeld, P. (2000) · Medical Oncology · doi:10.1007/bf02782199 · Cited by 24
Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer
Ding, H., Pei, Y., Li, Y., Xu, W., Mei, L., Hou, Z., Guang, Y., Cao, L., Li, P., Cao, H., et al. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116512 · Cited by 23
Toll-like receptor agonists induce apoptosis in mouse B-cell lymphoma cells by altering NF-κB activation
Arunkumar, N., Liu, C., Hang, H., & Song, W. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2013.14 · Cited by 23
Induction of apoptosis in bone marrow cells after treatment of mice with WR-2721 and gamma-rays: Relationship to the cell cycle
Mazur, L., Augustynek, A., Halicka, H. D., & Deptała, A. (2003) · Cell Biology and Toxicology · doi:10.1023/a:1022013630420 · Cited by 23
c-Myc degradation induced by DNA damage results in apoptosis of CHO cells
Jiang, M., Li, Y., Yang, Y., & Wu, J. (2003) · Oncogene · doi:10.1038/sj.onc.1206501 · Cited by 23
“Several studies found that lowered c-Myc content in different cell systems such as Jurkat cells or B-lymphoid cells led to apoptosis (Wood et al., 1994; Sonenshein, 1997; and reviewed by Thompson, 1998a).”
Background
Cell cycle perturbation in a human hepatoblastoma cell line constitutively expressing Hepatitis C virus core protein
Ruggieri, A., Murdolo, M., Harada, T., Miyamura, T., & Rapicetta, M. (2003) · Archives of Virology · doi:10.1007/s00705-003-0202-x · Cited by 23
“In addition, c-myc oncogene has been reported to transform primary cells in cooperation with ras oncogene and when overexpressed c-myc may also induce apoptosis [2, 7, 37 ].”
Background
Importance of Sp1 consensus motifs in the MYCN promoter
Inge, T. H., Casson, L. K., Priebe, W., Trent, J. O., Georgeson, K. E., Miller, D. M., & Bates, P. J. (2002) · Surgery · doi:10.1067/msy.2002.125387 · Cited by 22
Analysis of the c‐myc, K‐ras and p53 Genes in Methylcholanthrene induced Mouse Sarcomas
Watanabe, H. K., Shimokado, K., Asahara, T., Dohi, K., & Niwa, O. (1999) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1999.tb00663.x · Cited by 22
c-Myc overexpression increases cell size and impairs cartilage differentiation during chick limb development.
Piedra, M., Delgado, M. D., Ros, M. A., & León, J. (2002) · PubMed · Cited by 22
Mmip-2/Rnf-17 enhances c-Myc function and regulates some target genes in common with glucocorticoid hormones
Yin, X.-Y., Grove, L. E., & Prochownik, E. V. (2001) · Oncogene · doi:10.1038/sj.onc.1204417 · Cited by 19
“The seemingly paradoxical ®nding that GCs down-regulate c-Myc, yet induce apoptosis in a cMyc-dependent manner in some systems (Thompson, 1998), might be explained by assuming that the overlap of c-myc- and GC-regulated genes includes some which play particularly important roles in apoptosis.”
Background
Regulation of p27Kip1 accumulation in murine B-lymphoma cells: role of c-Myc and calcium.
Donjerković, D., Zhang, L., & Scott, D. W. (1999) · PubMed · Cited by 21
p53, Cyclin-D1, β-catenin, APC and c-myc in Tumor Tissue from Colorectal and Gastric Cancer Patients with Suspected Lynch Syndrome by the Bethesda Criteria
Marculino, T. F. S., Pimenta, C. A. M., Neto, R. A., Castelo, P. M., Silva, M. D. S., Forones, N. M., & Oshima, C. T. F. (2020) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2020.21.2.343 · Cited by 19
“…cells had frequently defects in the G1/S phase, leading to unregulated growth, development and progression of the tumor (White et al., 2012; Luo et al., 2017) The β-catenin protein acts on the Wnt signaling pathway and can induce the expression of the proteins cyclin-D1 and c-Myc (Thompson, 1998).”
Background
Syndecan-1 Depletion Has a Differential Impact on Hyaluronic Acid Metabolism and Tumor Cell Behavior in Luminal and Triple-Negative Breast Cancer Cells
Valla, S., Hassan, N., Vitale, D. L., Madanes, D., Spinelli, F. M., Teixeira, F. C. O. B., Greve, B., Espinoza‐Sánchez, N. A., Cristina, C., Alaniz, L. D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115874 · Cited by 20
“Moreover, the combination of Sdc-1 depletion and HA treatment resulted in a synergistic upregulation of cMyc expression, which may have further contributed to the anti-apoptotic effect [57].”
Background
Thyroid hormone receptor α controls larval intestinal epithelial cell death by regulating the CDK1 pathway
Tanizaki, Y., Zhang, H., Shibata, Y., & Shi, Y. (2022) · Communications Biology · doi:10.1038/s42003-022-03061-0 · Cited by 20
Bcl-2 and N-Myc Coexpression Increases IGF-IR and Features of Malignant Growth in Neuroblastoma Cell Lines
Jasty, R., van Golen, C., Lin, H.-J., Solomon, G., Heidelberger, K. P., Polverini, P. J., Opipari, A. W., Feldman, E. L., & Castle, V. P. (2001) · Neoplasia · doi:10.1038/sj.neo.7900171 · Cited by 20
“Indeed the mechanism by which c-myc induces apoptosis appears to be closely associated with its effects on the cell cycle ( reviewed in Thompson [36] ).”
Background
Degradation of apoptotic cells and fragments in HL‐60 suspension cultures after induction of apoptosis by camptothecin and ethanol
Baisch, H., Bollmann, H., & Bornkessel, S. (1999) · Cell Proliferation · doi:10.1046/j.1365-2184.1999.3250303.x · Cited by 20
Prostate Specific Antigen. Current clinical application and future prospects
Duskova, K., & Veselý, Š. (2014) · Biomedical Papers · doi:10.5507/bp.2014.046 · Cited by 19
The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells
Rosenberger, G., Fuhrmann, G., Grusch, M., Fassl, S., Elford, H. L., Smid, K., Peters, G. J., Szekeres, T., & Krupitza, G. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00901-2 · Cited by 19
“1 cells and tightly links proliferation to apoptosis [35–37], because c-myc activation forces dormant cells to transit from growth arrest into cell cycle [35, 38].”
Background
Deregulated c-Myb expression in murine myeloid leukemias prevents the up-regulation of p15INK4b normally associated with differentiation
Schmidt, M. E., Koller, R. P., Haviernik, P., Bies, J., Maciag, K., & Wolff, L. (2001) · Oncogene · doi:10.1038/sj.onc.1204821 · Cited by 19
“…promoting cell growth, c-Myb can counteract apoptosis by up-regulating the anti-apoptotic gene Bcl-2 (Frampton et al., 1996; Taylor et al., 1996; Schmidt et al., 2000), thus keeping cells with proliferative potential alive and counteracting apoptotic e ects of Myc over-expression (Thompson, 1998).”
Background
Oligodeoxynucleotide 5mers containing a 5'-CpG induce apoptosis through a mitochondrial mechanism in T lymphocytic leukaemia cells
TIDD, D. M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.11.2242 · Cited by 19
Escherichia coliEnterotoxin B Subunit Triggers Apoptosis of CD8+T Cells by Activating Transcription Factor c-Myc
Soriani, M., Williams, N., & Hirst, T. R. (2001) · Infection and Immunity · doi:10.1128/iai.69.8.4923-4930.2001 · Cited by 19
“It has recently become apparent that NF-kB can activate cell death pathways (13, 26) by transcriptional activation of one of its target genes, c-myc (9, 38, 43).”
BackgroundInfluential
The role of programmed cell death in osteosarcoma: From pathogenesis to therapy
Liu, S., Liu, C., Wang, Y., Chen, J., He, Y., Hu, K., Li, T., Yang, J., Peng, J., & Hao, L. (2024) · Cancer Medicine · doi:10.1002/cam4.7303 · Cited by 20
“135,136 c-Myc has a dual role in apoptosis.”
Background
Pregnancy and Cancer: Cellular Biology and Mechanisms Affecting the Placenta
Oliveira, M. D. M. S., Salgado, C. D. M., Viana, L. R., & Gomes‐Marcondes, M. C. C. (2021) · Cancers · doi:10.3390/cancers13071667 · Cited by 17
“Oestrogen is also responsible for the inhibition of the upregulation of antiapoptotic proteins Bcl-2 and Bcl-x [69,78].”
Background
Cytotoxic Effect of L-Methioninase from Brevibacterium linens BL2 in Combination with Etoposide against Glioblastoma Cells
İpek, S. L., Alkış, M. D. Ö., & Göktürk, D. (2023) · Applied Sciences · doi:10.3390/app13169382 · Cited by 18
Recovery of biological signals lost in single-cell batch integration with CellANOVA
Zhang, Z., Mathew, D., Lim, T., Mason, K., Martinez, C. M., Huang, S., Wherry, E. J., Suszták, K., Minn, A. J., Ma, Z., et al. (2024) · Nature Biotechnology · doi:10.1038/s41587-024-02463-1 · Cited by 30
Novel transcript profiling of diffuse alveolar damage induced by hyperoxia exposure in mice: normalization by glyceraldehyde 3-phosphate dehydrogenase
Shimada, I., Matsui, K., Brinkmann, B., Hohoff, C., Hiraga, K., Tabuchi, Y., Takasaki, I., Kato, I., Kawaguchi, H., Takasawa, K., et al. (2008) · International Journal of Legal Medicine · doi:10.1007/s00414-008-0226-6 · Cited by 18
“It is generally accepted that Myc overexpression can induce the production of ROS in mitochondria, leading to DNA damage and genomic instability such as gene amplification and polyploidy [ 41 ].”
Background
Induction of the apoptosis of HL-60 promyelocytic leukemia cells by Eurya emarginata
Park, S. Y., Yang, H. C., Moon, J. Y., Lee, N. H., Kim, S. J., Kang, J., Lee, Y. K., Park, D. B., Yoo, E. S., & Kang, H. K. (2003) · Cancer Letters · doi:10.1016/j.canlet.2003.09.034 · Cited by 18
“c-Myc is widely known as a crucial regulator of cell proliferation in normal and neoplastic cells, but until recently, its apoptotic properties, which appear to be intrinsic, were not fully appreciated [27,28].”
Background
Pyruvate Kinase M2: A Potential Regulator of Cardiac Injury Through Glycolytic and Non-glycolytic Pathways
Zeng, C., Wu, J., & Li, J.-M. (2024) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001568 · Cited by 19
“78 Previous studies have shown that the b -catenin/TCF4 signaling pathway activates 35 and upregulates genes such as c-Myc, 79 cyclin D1, 80 and Sgk1, 81 which have anti-apoptotic effects on cardiomyocytes.”
Background
Gene Regulatory Scenarios of Primary 1,25-Dihydroxyvitamin D3 Target Genes in a Human Myeloid Leukemia Cell Line
Ryynänen, J., Seuter, S., Campbell, M. J., & Carlberg, C. (2013) · Cancers · doi:10.3390/cancers5041221 · Cited by 17
“Depending on the cellular model the Myc protein acts either as a pro- or an anti-survival factor [39].”
Background
Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity
Kim, H., Jeong, S., Lee, J., Kim, B.-E., Kim, J. W., Jeong, S., & Kim, I. (2000) · Experimental & Molecular Medicine · doi:10.1038/emm.2000.32 · Cited by 16
“Reduction of c-myc expression and its inappropriate expression can be associated with cellular apoptosis (Thompson, 1998).”
Background
B-Myc: N-Terminal Recognition of Myc Binding Proteins
Burton, R. A., Mattila, S., Taparowsky, E. J., & Post, C. B. (2006) · Biochemistry · doi:10.1021/bi060379n · Cited by 16
Methamphetamine increases expression of the apoptotic c-myc and l-myc genes in the mouse brain
Thiriet, N., Jayanthi, S., McCoy, M. T., Ladenheim, B., & Cadet, J. L. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00093-6 · Cited by 16
Nuclear factor kappaB cooperates with c-Myc in promoting murine hepatocyte survival in a manner independent of p53 tumor suppressor function.
Bellas, R. E., & Sonenshein, G. E. (1999) · PubMed · Cited by 16
Modification of the sensitivity to cisplatin with c-myc over-expression or down-regulation in colon cancer cells
Funato, T., Kozawa, K., Kaku, M., & Sasaki, T. (2001) · Anti-Cancer Drugs · doi:10.1097/00001813-200111000-00006 · Cited by 16
“Thus the induction of apoptosis by cisplatin is related to cisplatin sensitivity and the expression of c-myc, because the c-myc gene is a well-known factor in the induction of apoptosis.(26) High c-myc levels are necessary for cisplatin-induced apoptosis in resistant 1 2 3 4”
Background
Emodin inhibiting epithelial‐mesenchymal transition in pulmonary fibrosis through the c‐MYC / miR ‐182‐5p/ ZEB2 axis
Yang, J., Jiang, G., Ni, K., Fan, L., Tong, W., & Yang, J. (2022) · Phytotherapy Research · doi:10.1002/ptr.7680 · Cited by 15
“It not only mediates the occurrence and development of many cancers (Dang, 2012; McKeown & Bradner, 2014; Thompson, 1998), but also has been found an important role in fibrosis.”
Background
Role of Orai‐family channels in the activation and regulation of transcriptional activity
Nieto‐Felipe, J., Macias‐Díaz, A., Sánchez-Collado, J., Berna‐Erro, A., Jardín, I., Salido, G. M., López, J. J., & Rosado, J. A. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.30971 · Cited by 15
“5 | C‐MYC The transcription factor c‐myc, which is encoded by the proto‐oncogene c‐myc, is involved in vital processes for the cell such as cell growth, proliferation, and apoptosis as it is an important modulator of cell cycle progression through G1 phase (E. B. Thompson, 1998).”
Background
Antisense Oligodeoxynucleotide Directed against c-myb Has Anticancer Activity and Potentiates the Antiproliferative Effect of Conventional Anticancer Drugs Acting by Different Mechanisms in Human Colorectal Cancer Cells
Abaza, M. S. I., Al‐Attiyah, R., Al-Saffar, A. M., Al‐Sawan, S., & Moussa, N. M. (2003) · Tumor Biology · doi:10.1159/000076139 · Cited by 15
Induction of apoptosis dependent on caspase activities and growth arrest in HL-60 cells by PGA2
Kim, H., Rhim, H., Jeong, S., Kim, J. W., & Kim, I. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00064-3 · Cited by 15
Expression of Transcriptional Repressor Protein mSin3A But Not mSin3B Is Induced during Neuronal Apoptosis
Korhonen, P., Tapiola, T., Suuronen, T., & Salminen, A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9629 · Cited by 15
Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc
Fitzgerald, M. J., Arsura, M., Bellas, R. E., Yang, W. E., Wu, M., Chin, L., Mann, K. K., DePinho, R. A., & Sonenshein, G. E. (1999) · Oncogene · doi:10.1038/sj.onc.1202611 · Cited by 15
“These ®ndings indicate that the LZ is the major structural determinant governing dMax heterodimerization activity. dMax induces apoptosis in WEHI 231 cells WEHI 231 B cells are a commonly used paradigm for studying control of cell suicide (Thompson, 1998).”
Background
c-myc Protooncogene
Gardner, L. B., Lee, L. A., & Dang, C. V. (2002) · Elsevier eBooks · doi:10.1016/b0-12-227555-1/00055-1 · Cited by 15
The induction of apoptosis by a newly synthesized diosgenyl saponin through the suppression of estrogen receptor-α in MCF-7 human breast cancer cells
Chun, J., Han, L., Xu, M. Y., Wang, B., Cheng, M. S., & Kim, Y. S. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0279-z · Cited by 14
“Additionally, the ER-a-mediated reduction of c-Myc contributed to cellular apoptosis and a cell cycle arrest (Lukas et al. 1996; Thompson 1998).”
Background
Network Pharmacology–Based Prediction and Pharmacological Validation of Effects of Astragali Radix on Acetaminophen-Induced Liver Injury
Peng, Y. Y., Zhu, G., Ma, Y., Huang, K., Chen, G., Liu, C., & Tao, Y. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.697644 · Cited by 14
pVHL-Mediated Transcriptional Repression of c-Myc by Recruitment of Histone Deacetylases
Hwang, I., Roe, J., Seol, J.-H., Kim, H.-R., Cho, E., & Youn, H. (2012) · Molecules and Cells · doi:10.1007/s10059-012-2268-3 · Cited by 14
“…between HIF1α and c-Myc is reported to induce metabolic switching (Dang et al., 2008). c-Myc, a proto-oncogene, regulates 15% of all protein expression of genes covering the cell cycle, apoptosis, development and signal transduction (Cho et al., 2010; Facchini and Penn, 1998; Thompson, 1998).”
Background
Cell death during lymphocyte development and activation
DEALBORAN, I. (2003) · Seminars in Immunology · doi:10.1016/s1044-5323(03)00032-0 · Cited by 14
Interferon-γ induces proliferation but not apoptosis in murine astrocytes through the differential expression of the myc proto-oncogene family
Rubio, N., & Torres, C. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00177-1 · Cited by 14

Authors: Thompson, E. B.
Affiliations: The University of Texas Medical Branch at Galveston (US)
Corresponding author: Thompson, E. Brad
ORCID: Thompson, E. Brad
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 1998-10
Volume: 60
Issue: 1
Pages: 575-600
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.physiol.60.1.575
OpenAlex: W2104373533
Cited by: 328
References: 159
Citations by year: 2026: 6 · 2025: 8 · 2024: 24 · 2023: 31 · 2022: 17 · 2021: 10 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 6 · 2015: 10 · 2014: 3 · 2013: 6 · 2012: 3
FWCI: 3.50
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: c-Myc, c-myc proto-oncogene, apoptosis, transcription factor regulation, gene expression regulation, gene repression, cell growth regulation, transcriptional regulation
MeSH terms: Proto-Oncogene Mas, Animals, Humans, Genes, myc, Proto-Oncogene Proteins c-myc, Apoptosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

THE MANY ROLES OF c-Myc IN APOPTOSIS

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks