Cited by 334Cancer-related Molecular PathwaysCell death mechanisms and regulationSignaling Pathways in Disease

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THE MANY ROLES OF c-Myc IN APOPTOSIS

Thompson, E. Brad·1998·Annual Review of Physiology

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Abstract

▪ Abstract The proto-oncogene c-myc encodes a transcription factor c-Myc, which is of great importance in controlling cell growth and vitality. The quantity of c-Myc is carefully controlled by many mechanisms, and its actions to induce and repress genes are modulated by interactions with other regulatory proteins. Understanding the kinetic and quantitative relationships that determine how and what genes c-Myc regulates is essential to understanding how Myc is involved in apoptosis. Reduction of c-myc expression and its inappropriate expression can be associated with cellular apoptosis. This review outlines the nature and regulation of the c-myc gene and of c-Myc and presents the systems and conditions in which Myc-related apoptotic events occur. Hypotheses of the mechanisms by which expression and repression of c-myc lead to apoptosis are discussed.

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Authors: Thompson, E. B.
Affiliations: The University of Texas Medical Branch at Galveston (US)
Corresponding author: Thompson, E. Brad
ORCID: Thompson, E. Brad
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 1998-10
Volume: 60
Issue: 1
Pages: 575-600
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.physiol.60.1.575
OpenAlex: W2104373533
Cited by: 328
References: 159
Citations by year: 2026: 6 · 2025: 8 · 2024: 24 · 2023: 31 · 2022: 17 · 2021: 10 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 6 · 2015: 10 · 2014: 3 · 2013: 6 · 2012: 3
FWCI: 3.50
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: c-Myc, c-myc proto-oncogene, apoptosis, transcription factor regulation, gene expression regulation, gene repression, cell growth regulation, transcriptional regulation
MeSH terms: Proto-Oncogene Mas, Animals, Humans, Genes, myc, Proto-Oncogene Proteins c-myc, Apoptosis

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THE MANY ROLES OF c-Myc IN APOPTOSIS

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