Cited by 321Developmental Biology and Gene RegulationNeonatal Respiratory Health ResearchRenal and related cancers

Epithelial-Mesenchymal Interactions in the Developing Lung

Shannon, John M., Hyatt, Brian A.·2004·Annual Review of Physiology

Abstract

Classical experiments in embryology have shown that normal growth, morphogenetic patterning, and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesoderm. These interactions are mediated by a myriad of diffusible factors that are precisely regulated in their temporal and spatial expression. In this review we first describe factors regulating formation of the embryonic foregut. We then discuss the experiments demonstrating the importance of tissue interactions in lung patterning and differentiation. Finally, we detail the roles that a few key signaling systems-fibroblast growth factors and their receptors, sonic hedgehog and Gli genes, Wnt genes and beta-catenin, and BMP4-play as mediators of epithelial-mesenchymal interactions in the developing lung.

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Crossref · 10.1146/annurev.physiol.66.032102.135749

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118 of 118 references verified0 citation errors · 0 not checkable

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  • Epithelial-mesenchymal interactions trigger the development of various tissues and organs through specific signaling pathways and transcription factors.

    “During the early developmental stages, epithelial-mesenchymal interactions (EMIs) trigger the development of various tissues and organs through specific signaling pathways and transcription factors.”
  • EMIs drive stomach specification, kidney duct patterning, lung development, lacrimal gland bud formation, and teeth bud formation.

    “For example, EMIs drive stomach specification (1), duct patterning of the kidney (2) and lung (3), and bud formation of the lacrimal gland (4) and teeth (5).”

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Authors
Shannon, J. M., & Hyatt, B. A.
Affiliations
Cincinnati Children's Hospital Medical Center (US)
Venue
Annual Review of Physiology
Published
2004-03-01
Volume
66
Issue
1
Pages
625-645
ISSN
  • 0066-4278 (ISSN-L)
  • 1545-1585
OpenAlex
W2137075665
Cited by
321
References
118
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 13 · 2018: 4 · 2017: 13 · 2016: 10 · 2015: 17 · 2014: 14 · 2013: 14 · 2012: 23
FWCI
2.21
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL071898, P50-HL56387, P50HL056387)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Renal and related cancers
Keywords
epithelial-mesenchymal interactions, lung development, lung morphogenesis, lung differentiation, fibroblast growth factor, Sonic hedgehog, Wnt signaling, β-catenin, BMP4, splanchnic mesoderm, endodermal epithelium, signaling molecules
MeSH terms
Animals, Embryo, Mammalian, Endoderm, Epithelium, Embryonic and Fetal Development, Humans, Lung, Mesoderm

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