Cited by 481Hemoglobin structure and functionNitric Oxide and Endothelin EffectsBlood properties and coagulation

The DOI matches its Crossref record; 145 of the 146 references it cites were found in a registry or an index.

CHEMICAL PHYSIOLOGY OF BLOOD FLOW REGULATION BY RED BLOOD CELLS: The Role of Nitric Oxide and S-Nitrosohemoglobin

Singel, David J., Stamler, Jonathan S.·2005·Annual Review of Physiology

DOI 10.1146/annurev.physiol.67.060603.090918

Open this paper in CoChat — free account

Abstract

▪ Abstract Blood flow in the microcirculation is regulated by physiological oxygen (O 2) gradients that are coupled to vasoconstriction or vasodilation, the domain of nitric oxide (NO) bioactivity. The mechanism by which the O 2 content of blood elicits NO signaling to regulate blood flow, however, is a major unanswered question in vascular biology. While the hemoglobin in red blood cells (RBCs) would appear to be an ideal sensor, conventional wisdom about its chemistry with NO poses a problem for understanding how it could elicit vasodilation. Experiments from several laboratories have, nevertheless, very recently established that RBCs provide a novel NO vasodilator activity in which hemoglobin acts as an O 2 sensor and O 2-responsive NO signal transducer, thereby regulating both peripheral and pulmonary vascular tone. This article reviews these studies, together with biochemical studies, that illuminate the complexity and adaptive responsiveness of NO reactions with hemoglobin. Evidence for the pivotal role of S-nitroso (SNO) hemoglobin in mediating this response is discussed. Collectively, the reviewed work sets the stage for a new understanding of RBC-derived relaxing activity in auto-regulation of blood flow and O 2 delivery and of RBC dysfunction in disorders characterized by tissue O 2 deficits, such as sickle cell disease, sepsis, diabetes, and heart failure.

Integrity signals

Registry

Crossref · 10.1146/annurev.physiol.67.060603.090918

Cites

145 of 145 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
Hébert, P. C., Wells, G., Blajchman, M. A., Marshall, J., Martin, C., Pagliarello, G., Tweeddale, M., Schweitzer, I., & Yetisir, E. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400601 · Cited by 5,187
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of Allostery
Perutz, M. F. (1970) · Nature · doi:10.1038/228726a0 · Cited by 2,914
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744
Self-citation
The Effects of Normal as Compared with Low Hematocrit Values in Patients with Cardiac Disease Who Are Receiving Hemodialysis and Epoetin
Besarab, A., Bolton, W. K., Browne, J. K., Egrie, J. C., Nissenson, A. R., Okamoto, D. M., Schwab, S. J., & Goodkin, D. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808273390903 · Cited by 1,930
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Anemia and Blood Transfusion in Critically Ill Patients
Vincent, J. (2002) · JAMA · doi:10.1001/jama.288.12.1499 · Cited by 1,794
Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
Bolotina, V. M., Najibi, S., Palacino, J. J., Pagano, P. J., & Cohen, R. A. (1994) · Nature · doi:10.1038/368850a0 · Cited by 1,690
S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
Jia, L., Bonaventura, C., Bonaventura, J., & Stamler, J. S. (1996) · Nature · doi:10.1038/380221a0 · Cited by 1,592
Self-citation

Show all 146 references

Research works printed but not linked: 14

Bates JN, 1991, Basic Res. Cardiol., 86, 17
Gaston B, 1994, J. Pharmacol. Exp. Ther., 268, 978
Stamler JS, 1995, Curr. Top. Microbiol. Immunol., 196, 19
Sellke FW, 1990, Am. J. Physiol., 258, H515
Jackson WF, 1987, Am. J. Physiol., 253, H1120
Guyton AC, 1964, Circ. Res., 15, 60
Roach RC, 1999, Am. J. Physiol., 276, H438
Deleted in press
Coburn R, 1967, Fed. Proc., 26, 334 (Abstr.)
Kruszyna R, 1987, J. Pharmacol. Exp. Ther., 241, 307
Reutov VP, 1998, Biochemistry (Mosc), 63, 874
10.1021/ja036693b · DOI · Paper page
Chen B, 1999, Tsin. Sci. Tech., 4, 3024
Foster MW, 2004, Hypertension

Sorted by citations

Items 101–200 of 480

Reversal of hemoglobin-induced vasoconstriction with sustained release of nitric oxide
Cabrales, P., Han, G., Nacharaju, P., Friedman, A., & Friedman, J. M. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00665.2010 · Cited by 88
Nitric oxide deficiency in pulmonary hypertension: pathobiology and implications for therapy
Tonelli, A. R., Haserodt, S., Aytekin, M., & Dweik, R. A. (2013) · Pulmonary Circulation · doi:10.4103/2045-8932.109911 · Cited by 86
Nitric Oxide/Reactive Oxygen Species Generation and Nitroso/Redox Imbalance in Heart Failure: From Molecular Mechanisms to Therapeutic Implications
Nediani, C., Raimondi, L., Borchi, E., & Cerbai, E. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3198 · Cited by 83
The renal microcirculation in sepsis
Ergin, B., Kapucu, A., Demirci‐Tansel, C., & İnce, C. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu105 · Cited by 85
Buried S-Nitrosocysteine Revealed in Crystal Structures of Human Thioredoxin,
Weichsel, A., Brailey, J. L., & Montfort, W. R. (2007) · Biochemistry · doi:10.1021/bi061878r · Cited by 83
Blue Laser Light Increases Perfusion of a Skin Flap Via Release of Nitric Oxide from Hemoglobin
Mittermayr, R., Osipov, A. N., Piskernik, C., Haindl, S., Dungel, P., Weber, C., IuA, V., Redl, H. R., & Kozlov, A. V. (2007) · Molecular Medicine · doi:10.2119/2006-00035.mittermayr · Cited by 82
iNOS-Selective Inhibitors For Cancer Prevention: Promise And Progress
Janakiram, N. B., & Rao, C. V. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.168 · Cited by 82
Effect of Processing and Storage on Red Blood Cell Function In Vivo
Doctor, A., & Spinella, P. C. (2012) · Seminars in Perinatology · doi:10.1053/j.semperi.2012.04.005 · Cited by 81
Oxygen, evolution and redox signalling in the human brain; quantum in the quotidian
Bailey, D. M. (2018) · The Journal of Physiology · doi:10.1113/jp276814 · Cited by 78
Measurement of Nitric Oxide Levels in the Red Cell
Wang, X., Bryan, N. S., MacArthur, P. H., Rodriguez, J., Gladwin, M. T., & Feelisch, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603953200 · Cited by 80
Detection of Human Red Blood Cell-bound Nitric Oxide
Rogers, S. C., Khalatbari, A., Gapper, P. W., Frenneaux, M. P., & James, P. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501179200 · Cited by 77
Photobiomodulation and nitric oxide signaling
Kashiwagi, S., Morita, A., Yokomizo, S., Ogawa, E., Komai, E., Huang, P. L., Bragin, D. E., & Atochin, D. N. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.11.005 · Cited by 83
An association between vasomotion and oxygen extraction
Thorn, C. E., Kyte, H., Slaff, D. W., & Shore, A. C. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01316.2010 · Cited by 78
Predict and analyze S-nitrosylation modification sites with the mRMR and IFS approaches
Li, B., Hu, L., Niu, S., Cai, Y., & Chou, K. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.12.003 · Cited by 76
Gene Duplication and Evolutionary Innovations in Hemoglobin-Oxygen Transport
Storz, J. F. (2016) · Physiology · doi:10.1152/physiol.00060.2015 · Cited by 76
Erythrocyte metabolism
Chatzinikolaou, P. N., Margaritelis, N. V., Paschalis, V., Theodorou, A. A., Vrabas, I. S., Kyparos, A., D’Alessandro, A., & Nikolaidis, M. G. (2024) · Acta Physiologica · doi:10.1111/apha.14081 · Cited by 79
Nitric Oxide Transport in Blood: A Third Gas in the Respiratory Cycle
Doctor, A., & Stamler, J. S. (2011) · Comprehensive physiology · doi:10.1002/cphy.c090009 · Cited by 78
Self-citation
Stimulation of rat erythrocyte P2X7receptor induces the release of epoxyeicosatrienoic acids
Jiang, H., Zhu, A. G., Mamczur, M., Falck, J. R., Lerea, K. M., & McGiff, J. C. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707311 · Cited by 75
Physiologic Impact of Circulating RBC Microparticles upon Blood-Vascular Interactions
Said, A. S., Rogers, S. C., & Doctor, A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2017.01120 · Cited by 73
Interactions of NO with Hemoglobin: From Microbes to Man
Angelo, M., Hausladen, A., Singel, D. J., & Stamler, J. S. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)36008-x · Cited by 71
Self-citation
Application of nanotechnology for enhancing photodynamic therapy via ameliorating, neglecting, or exploiting tumor hypoxia
Hu, D., Pan, M., Yu, Y., Sun, A., Shi, K., Qu, Y., & Qian, Z. (2020) · Open Research (University of Surrey) · doi:10.1002/viw2.6 · Cited by 72
Oxygen regulates the band 3–ankyrin bridge in the human erythrocyte membrane
Stefanovic, M., Puchulu‐Campanella, E., Kodippili, G. C., & Low, P. S. (2012) · Biochemical Journal · doi:10.1042/bj20120869 · Cited by 72
In vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycine
Nadtochiy, S. M., Burwell, L. S., Ingraham, C. A., Spencer, C. M., Friedman, A. E., Pinkert, C. A., & Brookes, P. S. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.01.012 · Cited by 74
MHD oscillatory channel flow, heat and mass transfer in a physiological fluid in presence of chemical reaction
Misra, J. C., & Adhikary, S. D. (2015) · Alexandria Engineering Journal · doi:10.1016/j.aej.2015.10.005 · Cited by 71
The potential role of the red blood cell in nitrite-dependent regulation of blood flow
Patel, R. P., Hogg, N., & Kim-Shapiro, D. B. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq323 · Cited by 70
Disorders of the synthesis of human fetal hemoglobin
Manca, L., & Masala, B. (2008) · IUBMB Life · doi:10.1002/iub.4 · Cited by 70
Quantifying the l-arginine paradox in vivo
Vukosavljevic, N., Jaron, D., Barbee, K. A., & Buerk, D. G. (2005) · Microvascular Research · doi:10.1016/j.mvr.2005.10.006 · Cited by 71
Transport and Peripheral Bioactivities of Nitrogen Oxides Carried by Red Blood Cell Hemoglobin: Role in Oxygen Delivery
Sonveaux, P., Lobysheva, I. I., Féron, O., & McMahon, T. J. (2007) · Physiology · doi:10.1152/physiol.00042.2006 · Cited by 71
Nitric Oxide Bioavailability in the Microcirculation: Insights from Mathematical Models
Tsoukias, N. M. (2008) · Microcirculation · doi:10.1080/10739680802010070 · Cited by 65
Insufficient nitric oxide bioavailability: a hypothesis to explain adverse effects of red blood cell transfusion
Roback, J. D., Neuman, R. B., Quyyumi, A. A., & Sutliff, R. L. (2011) · Transfusion · doi:10.1111/j.1537-2995.2011.03094.x · Cited by 66
Proteomic analysis of protein S ‐nitrosylation
Torta, F. T., Usuelli, V., Malgaroli, A., & Bachi, A. (2008) · PROTEOMICS · doi:10.1002/pmic.200800089 · Cited by 63
Nitric oxide from nitrite reduction by hemoglobin in the plasma and erythrocytes
Chen, K., Piknova, B., Pittman, R. N., Schechter, A. N., & Popel, A. S. (2007) · Nitric Oxide · doi:10.1016/j.niox.2007.09.088 · Cited by 65
S-Nitrosylation-induced Conformational Change in Blackfin Tuna Myoglobin
Schreiter, E. R., Rodríguez, M. M., Weichsel, A., Montfort, W. R., & Bonaventura, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701363200 · Cited by 64
Hemoglobin S-nitrosylation plays an essential role in cardioprotection
Zhang, R., Hess, D. T., Reynolds, J. D., & Stamler, J. S. (2016) · Journal of Clinical Investigation · doi:10.1172/jci90425 · Cited by 62
Self-citation
The oxygen dissociation curve of blood in COVID-19
Boning, D. G., Kuebler, W. M., & Bloch, W. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00079.2021 · Cited by 62
Complex Signatures of Selection and Gene Conversion in the Duplicated Globin Genes of House Mice
Storz, J. F., Baze, M. M., Waite, J. L., Hoffmann, F. G., Opazo, J. C., & Hayes, J. P. (2007) · Genetics · doi:10.1534/genetics.107.078550 · Cited by 63
Nitric oxide synthases, S-nitrosylation and cardiovascular health: From molecular mechanisms to therapeutic opportunities (Review)
Treuer, A. V., & González, D. R. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2968 · Cited by 61
Parallel evolution of Nitric Oxide signaling: Diversity of synthesis and memory pathways
Moroz, L. L. (2011) · Frontiers in bioscience · doi:10.2741/3837 · Cited by 59
The Microcirculation of the Septic Kidney
Zafrani, L., Payen, D. M., Azoulay, É., & İnce, C. (2015) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2015.01.008 · Cited by 60
Mechanism of N–N Bond Formation by Transition Metal–Nitrosyl Complexes: Modeling Flavodiiron Nitric Oxide Reductases
Stappen, C. V., & Lehnert, N. (2018) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.7b02333 · Cited by 61
Redefining Roles: A Paradigm Shift in Tryptophan–Kynurenine Metabolism for Innovative Clinical Applications
Tanaka, M., Szabó, Á., & Vécsei, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312767 · Cited by 65
Regulation of coronary resistance vessel tone in response to exercise.
Duncker, D. J., Bache, R. J., & Merkus, D. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.10.007 · Cited by 59
Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes
Kumar, V., Martin, F., Hahn, M. G., Schäfer, M., Stamler, J. S., Stasch, J., & van den Akker, F. (2013) · Biochemistry · doi:10.1021/bi301657w · Cited by 59
Self-citation
Distribution, adaptation and physiological meaning of thiols from vertebrate hemoglobins
Reischl, E., Dafré, A. L., Franco, J. L., & Filho, D. W. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.07.015 · Cited by 58
Thermography-based blood flow imaging in human skin of the hands and feet: a spectral filtering approach
Сагайдачный, А. А., Фомин, А. В., Usanov, D. A., & Skripal’, A. V. (2017) · Physiological Measurement · doi:10.1088/1361-6579/aa4eaf · Cited by 61
Association between erythrocyte parameters and metabolic syndrome in urban Han Chinese: a longitudinal cohort study
Wu, S., Lin, H., Zhang, C., Zhang, Q., Zhang, D., Zhang, Y., Meng, W., Zhu, Z., Tang, F., Xue, F., et al. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-989 · Cited by 58
Flow-Mediated Vasodilation in End-Stage Renal Disease
Verbeke, F., Pannier, B., Guérin, A. P., Boutouyrie, P., Laurent, S., & London, G. M. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01260211 · Cited by 58
Structure and function of heme proteins regulated by diverse post-translational modifications
Lin, Y. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.01.009 · Cited by 58
Nitric oxide synthase deficiency and the pathophysiology of muscular dystrophy
Tidball, J. G., & Wehling‐Henricks, M. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.274878 · Cited by 58
Vascular Effects of the Red Blood Cell Storage Lesion
Roback, J. D. (2011) · Hematology · doi:10.1182/asheducation-2011.1.475 · Cited by 57
Recent advances in in situ oxygen-generating and oxygen-replenishing strategies for hypoxic-enhanced photodynamic therapy
Qin, S., Xu, Y., Li, H., Chen, H., & Yuan, Z. (2022) · Biomaterials Science · doi:10.1039/d1bm00317h · Cited by 56
A century of exercise physiology: key concepts on coupling respiratory oxygen flow to muscle energy demand during exercise
Ferretti, G., Fagoni, N., Taboni, A., Vinetti, G., & di Prampero, P. E. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-04901-x · Cited by 67
Regulation of oxygen delivery to the body via hypoxic vasodilation
Kulandavelu, S., Balkan, W., & Hare, J. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506523112 · Cited by 55
Erythropoietin activates nitric oxide synthase in murine erythrocytes
Mihov, D., Vogel, J., Gassmann, M., & Bogdanova, A. Y. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00543.2008 · Cited by 55
Essential role of hemoglobin beta-93-cysteine in posthypoxia facilitation of breathing in conscious mice
Gaston, B. M., May, W. J., Sullivan, S., Yemen, S., Marozkina, N. V., Palmer, L. A., Bates, J. N., & Lewis, S. J. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01050.2013 · Cited by 54
Regulation of cardiovascular cellular processes by S-nitrosylation
Schulman, I. H., & Hare, J. M. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.04.002 · Cited by 52
Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function
Ishibashi, T., Sakai, T., Sato, B., Hara, K., Hara, Y., Naritomi, Y., Koyanagi, S., Hara, H., & Nagao, T. (2014) · Vascular Health and Risk Management · doi:10.2147/vhrm.s68844 · Cited by 50
Preclinical Evaluation of the Metabolism and Disposition of RRx-001, a Novel Investigative Anticancer Agent
Scicinski, J. J., Oronsky, B. T., Taylor, M., Luo, G., Musick, T. J., Marini, J., Adams, C. M., & Fitch, W. L. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.046755 · Cited by 50
Nitric Oxide and the Cardiovascular System
Bohlen, H. G. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140052 · Cited by 54
The acidic tumor microenvironment promotes the reconversion of nitrite into nitric oxide: towards a new and safe radiosensitizing strategy
Frérart, F., Sonveaux, P., Rath, G., Smoos, A., Meqor, A., Charlier, N., Jordan, B. F., Saliez, J., Noël, A., Dessy, C., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4001 · Cited by 49
Prediction of Nitrosocysteine Sites Using Position and Composition Variant Features
Khan, Y. D., Batool, A., Rasool, N., Khan, S. A., & Chou, K. (2018) · Letters in Organic Chemistry · doi:10.2174/1570178615666180802122953 · Cited by 49
Lactic Acidosis Related to Pharmacotherapy and Human Diseases
Zanza, C., Facelli, V., Romenskaya, T., Bottinelli, M., Caputo, G., Piccioni, A., Franceschi, F., Saviano, A., Ojetti, V., Savioli, G., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15121496 · Cited by 49
Cell signaling in marine diatoms
Vardi, A. (2008) · Communicative & Integrative Biology · doi:10.4161/cib.1.2.6867 · Cited by 49
Numerical investigation of blood flow. Part II: In capillaries
Jafari, A., Zamankhan, P., Mousavi, S. M., & Kolari, P. J. (2008) · Communications in Nonlinear Science and Numerical Simulation · doi:10.1016/j.cnsns.2008.04.007 · Cited by 49
Nitric oxide in blood
Elahi, M. M., Naseem, K. M., & Matata, B. M. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05660.x · Cited by 53
Nitric oxide formation versus scavenging: the red blood cell balancing act
Owusu, B. Y., Stapley, R., & Patel, R. P. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.234906 · Cited by 48
Red blood cells stored for increasing periods produce progressive impairments in nitric oxide–mediated vasodilation
Alexander, J. T., El-Ali, A. M., Newman, J. L., Karatela, S., Predmore, B. L., Lefer, D. J., Sutliff, R. L., & Roback, J. D. (2013) · Transfusion · doi:10.1111/trf.12111 · Cited by 48
Reversible S-nitrosylation in an engineered azurin
Tian, S., Liu, J., Cowley, R. E., Hosseinzadeh, P., Marshall, N., Yu, Y., Robinson, H. H., Nilges, M. J., Blackburn, N. J., Solomon, E. I., et al. (2016) · Nature Chemistry · doi:10.1038/nchem.2489 · Cited by 48
Role of nitric oxide scavenging in vascular response to cell-free hemoglobin transfusion
Sampei, K., Ulatowski, J. A., Asano, Y., Kwansa, H. E., Bucci, E. M., & Koehler, R. C. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00251.2005 · Cited by 48
From the Gastrointestinal Tract (GIT) to the Kidneys: Live Bacterial Cultures (Probiotics) Mediating Reductions of Uremic Toxin Levels via Free Radical Signaling
Vitetta, L., Linnane, A. W., & Gobe, G. C. (2013) · Toxins · doi:10.3390/toxins5112042 · Cited by 47
Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell
Sun, C., Yang, J., Kleschyov, A. L., Zhuge, Z., Carlström, M., Pernow, J., Wajih, N., Isbell, T. S., Oh, J., Cabrales, P., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.039284 · Cited by 47
Protein S-Nitrosation: Biochemistry, Identification, Molecular Mechanisms, and Therapeutic Applications
Ye, H., Wu, J., Liang, Z., Zhang, Y., & Huang, Z. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c02194 · Cited by 50
Nuclear Resonance Vibrational Spectroscopy Applied to [Fe(OEP)(NO)]: The Vibrational Assignments of Five-Coordinate Ferrous Heme−Nitrosyls and Implications for Electronic Structure
Lehnert, N., Galinato, M. G. I., Paulat, F., Richter-Addo, G. B., Sturhahn, W., Xu, N., & Zhao, J. Y. (2010) · Inorganic Chemistry · doi:10.1021/ic902181e · Cited by 46
Nitric oxide in red blood cell adaptation to hypoxia
Zhao, Y., Wang, X., Noviana, M., & Hou, M. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy055 · Cited by 47
Nitric oxide generated by red blood cells following exposure to shear stress dilates isolated small mesenteric arteries under hypoxic conditions
Ülker, P., Gündüz, F., Meiselman, H. J., & Baskurt, O. K. (2013) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-2012-1618 · Cited by 46
Red blood cell age and potentiation of transfusion‐related pathology in trauma patients
Weinberg, J. A., Barnum, S. R., & Patel, R. P. (2011) · Transfusion · doi:10.1111/j.1537-2995.2011.03098.x · Cited by 45
Erythrocyte-dependent regulation of human skeletal muscle blood flow: role of varied oxyhemoglobin and exercise on nitrite, S-nitrosohemoglobin, and ATP
Dufour, S. P., Patel, R. P., Brandon, A., Teng, X., Pearson, J., Barker, H., Ali, L., Yuen, A. H. Y., Smolenski, R. T., & González-Alonso, J. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00389.2010 · Cited by 45
Hemoglobin α in the blood vessel wall
Butcher, J. T., Johnson, T., Beers, J. M., Columbus, L. M., & Isakson, B. E. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.04.019 · Cited by 44
Role of Circulating S -Nitrosothiols in Control of Blood Pressure
Foster, M. W., Pawloski, J. R., Singel, D. J., & Stamler, J. S. (2004) · Hypertension · doi:10.1161/01.hyp.0000150160.41992.71 · Cited by 44
Self-citation
The Effect of Altitude-Induced Hypoxia on Heart Disease: Do Acute, Intermittent, and Chronic Exposures Provide Cardioprotection?
Anderson, J. D., & Honigman, B. (2011) · High Altitude Medicine & Biology · doi:10.1089/ham.2010.1021 · Cited by 43
S-nitrosylation therapy to improve oxygen delivery of banked blood
Reynolds, J. D. H., Bennett, K. M., Cina, A. J., Diesen, D. L., Henderson, M. B., Matto, F., Plante, A., Williamson, R. A., Zandinejad, K., It, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306489110 · Cited by 41
Self-citation
Oxygen Regulation of Tumor Perfusion by S -Nitrosohemoglobin Reveals a Pressor Activity of Nitric Oxide
Sonveaux, P., Kaz, A. M., Snyder, S. A., Richardson, R. A., Cárdenas-Navia, L. I., Braun, R. D., Pawloski, J. R., Tozer, G. M., Bonaventura, J., McMahon, T., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000168740.04986.a7 · Cited by 42
Self-citation
Hypoxic adaptation during development: relation to pattern of neurological presentation and cognitive disability
Kirkham, F. J., & Datta, A. K. (2006) · Developmental Science · doi:10.1111/j.1467-7687.2006.00507.x · Cited by 41
Effects of storage‐aged red blood cell transfusions on endothelial function in hospitalized patients
Neuman, R., Hayek, S. S., Rahman, A. M., Poole, J. C., Menon, V., Sher, S., Newman, J. L., Karatela, S., Polhemus, D. J., Lefer, D. J., et al. (2014) · Transfusion · doi:10.1111/trf.12919 · Cited by 41
Nitric oxide production pathways in erythrocytes and plasma
Chen, K., & Popel, A. S. (2009) · Biorheology · doi:10.3233/bir-2009-0531 · Cited by 40
The Relationship between Hemoglobin Levels and Endothelial Functions in Diabetes Mellitus
Sönmez, A., Yılmaz, M. İ., Sağlam, M., Kılıç, S., Eyileten, T., Üçkaya, G., Çağlar, K., Oğuz, Y., Vural, A., Yenicesu, M., et al. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05080709 · Cited by 41
The Redox Process in Red Blood Cells: Balancing Oxidants and Antioxidants
Daraghmeh, D. N., & Karaman, R. (2024) · Antioxidants · doi:10.3390/antiox14010036 · Cited by 41
Stress and chewing affect blood flow and oxygen levels in the rat brain
Miyake, S., Wada-Takahashi, S., Honda, H., Takahashi, S., Sasaguri, K., Sato, S., & Lee, M. (2012) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2012.06.008 · Cited by 39
The transfusion problem: role of aberrant S‐nitrosylation
Reynolds, J. D. H., Hess, D. T., & Stamler, J. S. (2011) · Transfusion · doi:10.1111/j.1537-2995.2011.03097.x · Cited by 37
Self-citation
Influence of red blood cell-derived microparticles upon vasoregulation.
Said, A. S., & Doctor, A. (2017) · Europe PMC (PubMed Central) · doi:10.2450/2017.0353-16 · Cited by 38
Nitric Oxide and S-Nitrosylation in Cardiac Regulation: G Protein-Coupled Receptor Kinase-2 and β-Arrestins as Targets
Kayki‐Mutlu, G., & Koch, W. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020521 · Cited by 39
The Hematocrit Paradox - How Does Blood Doping Really Work?
Boning, D. G., Maassen, N., & Pries, A. R. (2010) · International Journal of Sports Medicine · doi:10.1055/s-0030-1255063 · Cited by 38
Is methemoglobin an inert bystander, biomarker or a mediator of oxidative stress—The example of anemia?
Hare, G. M. T., Tsui, A. K. Y., Crawford, J. H., & Patel, R. P. (2013) · Redox Biology · doi:10.1016/j.redox.2012.12.003 · Cited by 37
SNO-hemoglobin and hypoxic vasodilation
Stamler, J. S., Singel, D. J., & Piantadosi, C. A. (2008) · Nature Medicine · doi:10.1038/nm1008-1008 · Cited by 37
Self-citation
NOS inhibition blunts and delays the compensatory dilation in hypoperfused contracting human muscles
Casey, D. P., & Joyner, M. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00680.2009 · Cited by 36
Heat and Mass Transfer on Unsteady MHD Oscillatory Flow of Blood Through Porous Arteriole
Krishna, M. V., Swarnalathamma, B. V., & Prakash, J. (2017) · Lecture notes in mechanical engineering · doi:10.1007/978-981-10-5329-0_14 · Cited by 36
Nitric Oxide Regulation of Microvascular Oxygen
Buerk, D. G. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1551 · Cited by 36
Inhaled nitric oxide improves systemic microcirculation in infants with hypoxemic respiratory failure
Top, A. P. C., İnce, C., Schouwenberg, P. H. M., & Tibboel, D. (2011) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e31820ac0b3 · Cited by 35
Evidence of enhanced non-enzymatic generation of nitric oxide on the skin surface of acupuncture points: An innovative approach in humans
Ma, S., Li, X.-Y., Sakurai, T., & Pandjaitan, M. (2007) · Nitric Oxide · doi:10.1016/j.niox.2007.05.004 · Cited by 35
Cryopreserved red blood cells are superior to standard liquid red blood cells
Hampton, D., Wiles, C., Fabricant, L. J., Kiraly, L. N., Differding, J. A., Underwood, S. J., Le, D. T., Watters, J. M., & Schreiber, M. A. (2014) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000000268 · Cited by 36

Authors: Singel, D. J., & Stamler, J. S.
Affiliations: Montana State University (US)
Howard Hughes Medical Institute (US)
ORCID: Stamler, Jonathan S.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 2005-03-17
Volume: 67
Issue: 1
Pages: 99-145
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.physiol.67.060603.090918
OpenAlex: W1828441724
Cited by: 481
References: 146
Citations by year: 2026: 2 · 2025: 4 · 2024: 16 · 2023: 13 · 2022: 22 · 2021: 16 · 2020: 10 · 2019: 18 · 2018: 15 · 2017: 18 · 2016: 13 · 2015: 20 · 2014: 23 · 2013: 28 · 2012: 30
FWCI: 2.37
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (P01HL042444, 5P01-HL42444)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Hematology › Blood properties and coagulation
Keywords: erythrocytes, nitric oxide, hemoglobin, oxygen sensing, vasodilation, vasoconstriction, microcirculation, S-nitrosohemoglobin, blood flow regulation, oxygen delivery, autoregulation, sickle cell disease, sepsis, diabetes mellitus, heart failure
MeSH terms: Blood Circulation, Erythrocytes, Hemoglobins, Humans, Microcirculation, Nitric Oxide

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

CHEMICAL PHYSIOLOGY OF BLOOD FLOW REGULATION BY RED BLOOD CELLS: The Role of Nitric Oxide and S-Nitrosohemoglobin

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks