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CHEMICAL PHYSIOLOGY OF BLOOD FLOW REGULATION BY RED BLOOD CELLS: The Role of Nitric Oxide and S-Nitrosohemoglobin
Abstract
▪ Abstract Blood flow in the microcirculation is regulated by physiological oxygen (O 2) gradients that are coupled to vasoconstriction or vasodilation, the domain of nitric oxide (NO) bioactivity. The mechanism by which the O 2 content of blood elicits NO signaling to regulate blood flow, however, is a major unanswered question in vascular biology. While the hemoglobin in red blood cells (RBCs) would appear to be an ideal sensor, conventional wisdom about its chemistry with NO poses a problem for understanding how it could elicit vasodilation. Experiments from several laboratories have, nevertheless, very recently established that RBCs provide a novel NO vasodilator activity in which hemoglobin acts as an O 2 sensor and O 2-responsive NO signal transducer, thereby regulating both peripheral and pulmonary vascular tone. This article reviews these studies, together with biochemical studies, that illuminate the complexity and adaptive responsiveness of NO reactions with hemoglobin. Evidence for the pivotal role of S-nitroso (SNO) hemoglobin in mediating this response is discussed. Collectively, the reviewed work sets the stage for a new understanding of RBC-derived relaxing activity in auto-regulation of blood flow and O 2 delivery and of RBC dysfunction in disorders characterized by tissue O 2 deficits, such as sickle cell disease, sepsis, diabetes, and heart failure.
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“Nitrite administered before or during cardiac ischemia has been shown to protect cardiac function and attenuate infarct size in a number of small and large animal models (226, 374, 864).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [864]
In the citing paper
“Notably, other nitrogen-centered molecules, such as nitrite, have been shown to promote S-nitrosation of complex I and attenuate ischemia/reperfusion injury (864).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [864]
Citations
Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
Hébert, P. C., Wells, G., Blajchman, M. A., Marshall, J., Martin, C., Pagliarello, G., Tweeddale, M., Schweitzer, I., & Yetisir, E. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400601 · Cited by 5,187
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Perutz, M. F. (1970) · Nature · doi:10.1038/228726a0 · Cited by 2,914
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744
Self-citationBesarab, A., Bolton, W. K., Browne, J. K., Egrie, J. C., Nissenson, A. R., Okamoto, D. M., Schwab, S. J., & Goodkin, D. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808273390903 · Cited by 1,930
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Anemia and Blood Transfusion in Critically Ill Patients
Vincent, J. (2002) · JAMA · doi:10.1001/jama.288.12.1499 · Cited by 1,794
Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
Bolotina, V. M., Najibi, S., Palacino, J. J., Pagano, P. J., & Cohen, R. A. (1994) · Nature · doi:10.1038/368850a0 · Cited by 1,690
S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
Jia, L., Bonaventura, C., Bonaventura, J., & Stamler, J. S. (1996) · Nature · doi:10.1038/380221a0 · Cited by 1,592
Self-citationStamler, J. S., Simon, D. I., Osborne, J. A., Mullins, M. E., Jaraki, O., Michel, T. M., Singel, D. J., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.444 · Cited by 1,471
Self-citationBlood Flow Regulation by S -Nitrosohemoglobin in the Physiological Oxygen Gradient
Stamler, J. S., Jia, L., Eu, J. P., McMahon, T. J., Demchenko, I. T., Bonaventura, J., Gernert, K., & Piantadosi, C. A. (1997) · Science · doi:10.1126/science.276.5321.2034 · Cited by 1,050
Self-citationRelationship of Blood Transfusion and Clinical Outcomes in Patients With Acute Coronary Syndromes
Rao, S. V. (2004) · JAMA · doi:10.1001/jama.292.13.1555 · Cited by 999
Myers, P. R., Minor, R. L., Guerra, R., Bates, J. N., & Harrison, D. G. (1990) · Nature · doi:10.1038/345161a0 · Cited by 973
Blood Transfusion in Elderly Patients with Acute Myocardial Infarction
Wu, W. C., Rathore, S. S., Wang, Y., Radford, M. J., & Krumholz, H. M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010615 · Cited by 935
Effect of Stored-Blood Transfusion on Oxygen Delivery in Patients With Sepsis
Marik, P. E. (1993) · JAMA · doi:10.1001/jama.1993.03500230106037 · Cited by 792
Simulation of the diffusion and reaction of endogenously produced nitric oxide.
Lancaster, J. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8137 · Cited by 689
Oxidation of nitrogen-oxides by bound dioxygen in hemoproteins
Doyle, M. P., & Hoekstra, J. W. (1981) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(00)80291-3 · Cited by 643
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
Kleinbongard, P., Dejam, A., Lauer, T., Rassaf, T., Schindler, A., Picker, O., Scheeren, T., Gödecke, A., Schrader, J., Schulz, R., et al. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00406-4 · Cited by 586
Lauer, T., Preik, M., Rassaf, T., Strauer, B. E., Deussen, A., Feelisch, M., & Kelm, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221381098 · Cited by 585
Export by red blood cells of nitric oxide bioactivity
Pawloski, J. R., Hess, D. T., & Stamler, J. S. (2001) · Nature · doi:10.1038/35054560 · Cited by 579
Self-citationReactions between nitric oxide and haemoglobin under physiological conditions
Gow, A. J., & Stamler, J. S. (1998) · Nature · doi:10.1038/34402 · Cited by 562
Self-citationTHE STEREOCHEMICAL MECHANISM OF THE COOPERATIVE EFFECTS IN HEMOGLOBIN REVISITED
Perutz, M. F., Wilkinson, A. J., Paoli, M., & Dodson, G. G. (1998) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.27.1.1 · Cited by 562
S-nitrosylation in health and disease
Foster, M. W., McMahon, T., & Stamler, J. S. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00028-5 · Cited by 558
Self-citationEssential Roles of S-Nitrosothiols in Vascular Homeostasis and Endotoxic Shock
Liu, L., Yan, Y., Zeng, M., Zhang, J., Hanes, M. A., Ahearn, G. S., McMahon, T., Dickfeld, T. L., Marshall, H. E., Que, L. G., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00131-x · Cited by 546
Self-citationIdentification of the enzymatic mechanism of nitroglycerin bioactivation
Chen, Z., Zhang, J., & Stamler, J. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122225199 · Cited by 545
Self-citationIchinose, F., Roberts, J. D., & Zapol, W. M. (2004) · Circulation · doi:10.1161/01.cir.0000134595.80170.62 · Cited by 540
Longitudinal Gradients in Periarteriolar Oxygen Tension
Duling, B. R., & Berne, R. M. (1970) · Circulation Research · doi:10.1161/01.res.27.5.669 · Cited by 468
Nitric oxide in the human respiratory cycle
McMahon, T., Moon, R. E., Luschinger, B. P., Carraway, M. S., Stone, A. E., Stolp, B. W., Gow, A. J., Pawloski, J. R., Watke, P., Singel, D. J., et al. (2002) · Nature Medicine · doi:10.1038/nm718 · Cited by 462
Self-citationSkeletal muscle blood flow in humans and its regulation during exercise
Saltin, B., Rådegran, G., Koskolou, M. D., & Roach, R. C. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.0293e.x · Cited by 459
Gladwin, M. T., Shelhamer, J. H., Schechter, A. N., Pease-Fye, M. E., Waclawiw, M. A., Panza, J. A., Ognibene, F. P., & Cannon, R. O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11482 · Cited by 441
The oxyhemoglobin reaction of nitric oxide
Gow, A. J., Luchsinger, B. P., Pawloski, J. R., Singel, D. J., & Stamler, J. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9027 · Cited by 418
Self-citationFeelisch, M., Rassaf, T., Mnaimneh, S., Singh, N., Bryan, N. S., Jourd'Heuil, D., & Kelm, M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0363com · Cited by 401
The kinetics and equilibria of the reactions of nitric oxide with sheep haemoglobin
Gibson, Q. H., & Roughton, F. J. W. (1957) · The Journal of Physiology · doi:10.1113/jphysiol.1957.sp005777 · Cited by 396
Influence of reduced red cell deformability on regional blood flow
Simchon, S., Jan, K. M., & Chien, S. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.253.4.h898 · Cited by 389
Role of red blood cells in thrombosis
Andrews, D. A., & Low, P. S. (1999) · Current Opinion in Hematology · doi:10.1097/00062752-199903000-00004 · Cited by 349
Nagababu, E., Ramasamy, S., Abernethy, D. R., & Rifkind, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307572200 · Cited by 349
Expired Nitric Oxide Levels During Treatment of Acute Asthma
Massaro, A. F., Gaston, B. M., Kita, D., Fanta, C. H., Stamler, J. S., & Drazen, J. M. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.2.7633745 · Cited by 347
Self-citationKinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
Doyle, M. P., Pickering, R. A., DeWeert, T. M., Hoekstra, J. W., & Pater, D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43285-1 · Cited by 334
Erythrocyte and the Regulation of Human Skeletal Muscle Blood Flow and Oxygen Delivery
González‐Alonso, J., Olsen, D. B., & Saltin, B. (2002) · Circulation Research · doi:10.1161/01.res.0000044939.73286.e2 · Cited by 331
S-Nitrosothiols signal the ventilatory response to hypoxia
Lipton, A. S., Johnson, M. A., Macdonald, T. L., Lieberman, M. W., Gozal, D., & Gaston, B. M. (2001) · Nature · doi:10.1038/35093117 · Cited by 321
A Novel Reaction Mechanism for the Formation of S-Nitrosothiol in Vivo
Gow, A. J., Buerk, D. G., & Ischiropoulos, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.5.2841 · Cited by 303
Intravascular flow decreases erythrocyte consumption of nitric oxide
Liao, J. C., Hein, T. W., Vaughn, M. W., Huang, K., & Kuo, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8757 · Cited by 301
Sydow, K., Daiber, A., Oelze, M., Chen, Z., August, M., Wendt, M., Ullrich, V., Mülsch, A., Schulz, E., Keaney, J. F., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419267 · Cited by 300
Self-citationBasal and Stimulated Protein S-Nitrosylation in Multiple Cell Types and Tissues
Gow, A. J., Chen, Q., Hess, D. T., Day, B. J., Ischiropoulos, H., & Stamler, J. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100746200 · Cited by 294
Self-citationCooperativity in the dissociation of nitric oxide from hemoglobin.
Moore, E. G., & Gibson, Q. H. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33557-3 · Cited by 292
Nitric oxide's reactions with hemoglobin: a view through the SNO-storm
Gladwin, M. T., Lancaster, J. R., Freeman, B. Α., & Schechter, A. N. (2003) · Nature Medicine · doi:10.1038/nm0503-496 · Cited by 290
Gladwin, M. T., Ognibene, F. P., Pannell, L. K., Nichols, J. S., Pease‐Fye, M. E., Shelhamer, J. H., & Schechter, A. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180155397 · Cited by 269
Ruschitzka, F. T., Wenger, R. H., Stallmach, T., Quaschning, T., de Wit, C., Wagner, K. F., Labugger, R., Kelm, M., Noll, G., Rülicke, T., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11609 · Cited by 257
Allosteric Effects in Haemoglobin
Imai, K. (1982) · Medical Entomology and Zoology · Cited by 244
Hemoglobin-based blood substitutes: oxygen carriers, pressor agents, or oxidants?
Alayash, A. I. (1999) · Nature Biotechnology · doi:10.1038/9849 · Cited by 228
Controlled Safety Study of a Hemoglobin-Based Oxygen Carrier, DCLHb, in Acute Ischemic Stroke
Saxena, R. R., Wijnhoud, A. D., Carton, H., Hacke, W., Kaste, M., Przybelski, R. J., Stern, K. N., & Koudstaal, P. J. (1999) · Stroke · doi:10.1161/01.str.30.5.993 · Cited by 224
Ascaris haemoglobin is a nitric oxide-activated ‘deoxygenase’
Minning, D. M., Gow, A. J., Bonaventura, J., Braun, R. D., Dewhirst, M. W., Goldberg, D. E., & Stamler, J. S. (1999) · Nature · doi:10.1038/46822 · Cited by 217
Self-citationJoshi, M. S., Ferguson, T. B., Han, T. H., Hyduke, D. R., Liao, J. C., Rassaf, T., Bryan, N., Feelisch, M., & Lancaster, J. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152149699 · Cited by 216
Role of erythrocyte in regulating local O 2 delivery mediated by hemoglobin oxygenation
Jagger, J. E., Bateman, R. M., Ellsworth, M. L., & Ellis, C. G. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.6.h2833 · Cited by 215
Allosteric Effects in Haemoglobin
Gutfreund, H. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)81262-3 · Cited by 211
S-Nitrosothiols and the Bioregulatory Actions of Nitrogen Oxides Through Reactions with Thiol Groups
Stamler, J. S. (1995) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79130-7_4 · Cited by 205
Self-citationLuchsinger, B. P., Rich, E. N., Gow, A. J., Williams, E. M., Stamler, J. S., & Singel, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0233287100 · Cited by 202
Self-citationEVIDENCE FOR TISSUE OXYGEN DEMAND AS THE MAJOR FACTOR CAUSING AUTOREGULATION.
Guyton, A. C., Carrier, O., & Walker, J. (1964) · PubMed · Cited by 181
Roach, R. C., Koskolou, M. D., Calbet, J. A. L., & Saltin, B. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.2.h438 · Cited by 177
González‐Alonso, J., Richardson, R. S., & Saltin, B. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0331l.x · Cited by 177
S -Nitrosothiols in the Blood: Roles, Amounts, and Methods of Analysis
Stamler, J. S. (2004) · Circulation Research · doi:10.1161/01.res.0000122071.55721.bc · Cited by 170
Self-citationBiological activity of nitric oxide in the plasmatic compartment
Wang, X., Tanus-Santos, J. E., Reiter, C. D., Dejam, A., Shiva, S., Smith, R. D., Hogg, N., & Gladwin, M. T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402201101 · Cited by 164
Gladwin, M. T., Wang, X., Reiter, C. D., Yang, B. K., Vivas, E. X., Bonaventura, C., & Schechter, A. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203236200 · Cited by 160
Blitzer, M. L., Loh, E., Roddy, M.-A., Stamler, J. S., & Creager, M. A. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(96)00218-5 · Cited by 159
Self-citationSpectral transitions of nitrosyl hemes during ligand binding to hemoglobin.
Hille, R., Olson, J. S., & Palmer, G. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86436-0 · Cited by 158
NO adducts in mammalian red blood cells: too much or too little?
Rassaf, T., Bryan, N. S., Maloney, R. E., Specian, V., Kelm, M., Kalyanaraman, B., Rodriguez, J., & Feelisch, M. (2003) · Nature Medicine · doi:10.1038/nm0503-481 · Cited by 151
Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro.
Gaston, B. M., Drazen, J. M., Jansen, A., Sugarbaker, D. A., Loscalzo, J., Richards, W., & Stamler, J. S. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38951-2 · Cited by 151
Self-citationHall, D. M., Buettner, G. R., MATTHES, R. D., & GISOLFI, C. V. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.2.548 · Cited by 148
Functional Coupling of Oxygen Binding and Vasoactivity inS-Nitrosohemoglobin
McMahon, T., Stone, A. E., Bonaventura, J., Singel, D. J., & Stamler, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000532200 · Cited by 140
Self-citationHematocrit, blood pressure, and hypertension. The Gubbio Population Study.
Círillo, M., Laurenzi, M. W., Trevisan, M., & Stamler, J. (1992) · Hypertension · doi:10.1161/01.hyp.20.3.319 · Cited by 139
Self-citationElectron Paramagnetic Resonance and Oxygen Binding Studies of α-Nitrosyl Hemoglobin
Yonetani, T., Tsuneshige, A., Zhou, Y., & Chen, X. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20323 · Cited by 138
Thermodynamic Theory of Site-Specific Binding Processes in Biological Macromolecules
Di, E. (1995) · Cambridge University Press eBooks · doi:10.1017/cbo9780511524837 · Cited by 136
Biochemical Characterization of HumanS-Nitrosohemoglobin
Patel, R. P., Hogg, N., Spencer, N. Y., Kalyanaraman, B., Matalon, S., & Darley-Usmar, V. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15487 · Cited by 133
Vasorelaxation by Red Blood Cells and Impairment in Diabetes
James, P. E., Lang, D., Tufnell-Barret, T., Milsom, A. B., & Frenneaux, M. P. (2004) · Circulation Research · doi:10.1161/01.res.0000122044.21787.01 · Cited by 125
Liu, X., Samouilov, A., Lancaster, J. R., & Zweier, J. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201939200 · Cited by 123
Sun, J., Xu, L., Eu, J. P., Stamler, J. S., & Meissner, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211940200 · Cited by 121
Self-citationNO-synthase and nitrite-reductase components of nitric oxide cycle.
Reutov, V. P., & Sorokina, E. G. (1998) · PubMed · Cited by 118
Crawford, J. H., Chacko, B. K., Pruitt, H. M., Piknova, B., Hogg, N., & Patel, R. P. (2004) · Blood · doi:10.1182/blood-2004-03-0880 · Cited by 111
Crystal Structure of the S-Nitroso Form of Liganded Human Hemoglobin,
Chan, N., Rogers, P. H., & Arnone, A. (1998) · Biochemistry · doi:10.1021/bi9816711 · Cited by 110
Influence of vessel size on the sensitivity of porcine coronary microvessels to nitroglycerin
Sellke, F. W., Myers, P. R., Bates, J. N., & Harrison, D. G. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.258.2.h515 · Cited by 108
Cell-Free and Erythrocytic S -Nitrosohemoglobin Inhibits Human Platelet Aggregation
Pawloski, J. R., Swaminathan, R. V., & Stamler, J. S. (1998) · Circulation · doi:10.1161/01.cir.97.3.263 · Cited by 105
Self-citationRed Blood Cell Nitric Oxide as an Endocrine Vasoregulator
Datta, B. N., Tufnell-Barret, T., Bleasdale, R. A., Jones, C. J. H., Beeton, I., Paul, V., Frenneaux, M. P., & James, P. E. (2004) · Circulation · doi:10.1161/01.cir.0000124450.07016.1d · Cited by 102
Nitric oxide reaction with red blood cells and hemoglobin under heterogeneous conditions
Han, T. H., Hyduke, D. R., Vaughn, M. W., Fukuto, J. M., & Liao, J. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122118299 · Cited by 100
Reactions of Deoxy-, Oxy-, and Methemoglobin with Nitrogen Monoxide
Herold, S., & Röck, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210275200 · Cited by 99
Role of oxygen in arteriolar functional vasodilation in hamster striated muscle
Gorczynski, R. J., & Duling, B. R. (1978) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1978.235.5.h505 · Cited by 96
ESR spectral transition by arteriovenous cycle in nitric oxide hemoglobin of cytokine-treated rats
Kosaka, H., Sawai, Y., Sakaguchi, H., Kumura, E., Harada, N., Watanabe, M., & Shiga, T. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.266.5.c1400 · Cited by 95
Arteriolar oxygen reactivity: where is the sensor?
Jackson, W. F. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.253.5.h1120 · Cited by 93
Nitric oxide binding to oxygenated hemoglobin under physiological conditions
Huang, Z., Louderback, J. G., Goyal, M., Azizi, F., King, S. B., & Kim‐Shapiro, D. B. (2001) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(01)00227-6 · Cited by 91
Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin,
Chan, N., Kavanaugh, J. S., Rogers, P. H., & Arnone, A. (2003) · Biochemistry · doi:10.1021/bi030172j · Cited by 89
A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
Hébert, P. C., Wells, G. A., Blajchman, M. A., Marshall, J. C., Martin, C. M., Pagliarello, G., Tweeddale, M., Schweitzer, I., & Yetisir, E. (1999) · The Journal of Urology · doi:10.1097/00005392-199907000-00110 · Cited by 89
Mechanisms of Ferriheme Reduction by Nitric Oxide: Nitrite and General Base Catalysis1
Fernandez, B. O., Lorković, I. M., & Ford, P. C. (2004) · Inorganic Chemistry · doi:10.1021/ic049532x · Cited by 84
Deem, S. A., Swenson, E. R., Alberts, M. K., Hedges, R. G., & Bishop, M. J. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9707165 · Cited by 81
Different Metabolizing Ability of Thiol Reactants in Human and Rat Blood
Rossi, R., Milzani, A., Dalle‐Donne, I., Giannerini, F., Giustarini, D., Lusini, L., Colombo, R., & Simplicio, P. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005156200 · Cited by 81
Pawloski, J. R., & Stamler, J. S. (2002) · Transfusion · doi:10.1046/j.1537-2995.2002.00278.x · Cited by 78
Self-citationXu, X., Cho, M., Spencer, N. Y., Patel, N. K., Huang, Z., Shields, H. W., King, S. B., Gladwin, M. T., Hogg, N., & Kim‐Shapiro, D. B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2033883100 · Cited by 77
[11] Concerted nitric oxide/oxygen delivery by hemoglobin
McMahon, T., & Stamler, J. S. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)01073-3 · Cited by 76
Self-citationAbnormal metabolic fate of nitric oxide in Type I diabetes mellitus
Milsom, A. B., Jones, C., Goodfellow, J., Frenneaux, M. P., Peters, J. R., & James, P. E. (2002) · Diabetologia · doi:10.1007/s00125-002-0956-9 · Cited by 75
Tsoukias, N. M., Kavdia, M., & Popel, A. S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00525.2003 · Cited by 74
S-Nitrosohemoglobin in the Fetal Circulation May Represent a Cycle for Blood Pressure Regulation
Funai, E. F., Davidson, A., Seligman, S. P., & Finlay, T. H. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7565 · Cited by 74
Nitrite catalyzes ferriheme protein reductive nitrosylation
Fernandez, B. O., & Ford, P. C. (2003) · Journal of the American Chemical Society · doi:10.1021/ja036693b · Cited by 74
Characterisation of S‐nitrosohaemoglobin by mass spectrometry
Ferranti, P., Malorni, A., Mamone, G., Sannolo, N., & Marino, G. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01258-6 · Cited by 73
Erythrocyte consumption of nitric oxide in presence and absence of plasma-based hemoglobin
Tsoukias, N. M., & Popel, A. S. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01080.2001 · Cited by 70
Vasoactivity of S-nitrosohemoglobin: role of oxygen, heme, and NO oxidation states
Crawford, J. H., White, C. R., & Patel, R. P. (2003) · Blood · doi:10.1182/blood-2002-12-3825 · Cited by 60
Oxidation reaction of human oxyhemoglobin with nitrite: a reexamination
Spagnuolo, C. C., Rinelli, P., Coletta, M., Chiancone, E., & Ascoli, F. (1987) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(87)90270-6 · Cited by 55
Measurement of S-nitrosoalbumin by gas chromatography–mass spectrometry
Tsikas, D., Sandmann, J., Gutzki, F., Stichtenoth, D. O., & Frölich, J. C. (1999) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(99)00058-4 · Cited by 55
Nitric oxide, S-nitrosothiols and hemoglobin: is methodology the key?
Giustarini, D., Milzani, A., Colombo, R., Dalle‐Donne, I., & Rossi, R. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.04.009 · Cited by 55
Intracellular Po 2 and Its Regulation in Resting Skeletal Muscle of the Guinea Pig
Whalen, W. J., & Nair, P. (1967) · Circulation Research · doi:10.1161/01.res.21.3.251 · Cited by 54
Copper and oxidation of hemoglobin: a comparison of horse and human hemoglobins
Rifkind, J. M., Lauer, L. D., Chiang, S. C., & Li, N. C. (1976) · Biochemistry · doi:10.1021/bi00669a021 · Cited by 52
Singel, D. J., & Stamler, J. S. (2004) · Nature · doi:10.1038/430297a · Cited by 51
Self-citationNitrosyl hemoglobin in blood of normoxic and hypoxic sheep during nitric oxide inhalation
Takahashi, Y. K., Kobayashi, H., Tanaka, N., Sato, T., Takizawa, N., & Tomita, T. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.1.h349 · Cited by 50
Romeo, A. A., Capobianco, J. A., & English, A. M. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0289752 · Cited by 49
Measurement of S-nitrosoalbumin by gas chromatography–mass spectrometry
Tsikas, D., Sandmann, J., & Frölich, J. C. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00121-6 · Cited by 48
A Model of Nitric Oxide Capillary Exchange
Tsoukias, N. M., & Popel, A. S. (2003) · Microcirculation · doi:10.1038/sj.mn.7800210 · Cited by 45
Chain nonequivalence in binding of nitric oxide to hemoglobin
Taketa, F., Antholine, W. E., & Chen, J. Y. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30393-9 · Cited by 45
Involvement of superoxide anion in the reaction mechanism of haemoglobin oxidation by nitrite
Tomoda, A., Tsuji, A., & Yoneyama, Y. (1981) · Biochemical Journal · doi:10.1042/bj1930169 · Cited by 42
Evaluation of systemic blood NO dynamics by EPR spectroscopy: HbNO as an endogenous index of NO
Kirima, K., Tsuchiya, K., Séi, H., Hasegawa, T., Shikishima, M., Motobayashi, Y., Morita, K., Yoshizumi, M., & Tamaki, T. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01010.2002 · Cited by 41
Roccatello, D., Mengozzi, G., Alfieri, V., Pignone, E., Menegatti, E., Cavalli, G., Cesano, G., Rossi, D., Fromica, M., Inconis, T., et al. (1997) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/12.2.292 · Cited by 41
Fago, A., Crumbliss, A. L., Peterson, J., Pearce, L. L., & Bonaventura, C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2032603100 · Cited by 40
Hemoglobin–nitric oxide cooperativity: is no the third respiratory ligand?
Kim‐Shapiro, D. B. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.030 · Cited by 39
Gaston, B. M., & Hare, J. M. (2003) · New England Journal of Medicine · doi:10.1056/nejm200307243490419 · Cited by 38
CO Ligation Intermediates and the Mechanism of Hemoglobin Cooperativity
Perrella, M., & Di, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.2605 · Cited by 38
Casadevall, M., Piqué, J. M., Cirera, I., Goldin, E., Elizalde, I., Panés, J., Cuesta, M. M., Bosch, J., Terés, J., & Rodés, J. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8613005 · Cited by 37
Jaszewski, A. R., Fann, Y. C., Chen, Y., Sato, K., Corbett, J. T., & Mason, R. P. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00324-1 · Cited by 36
Enhancement of S-Nitrosylation in Glycosylated Hemoglobin
Padrón, J. R., Peiró, C., Cercas, E., Llergo, J. L., & Sánchez‐Ferrer, C. F. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2617 · Cited by 35
Release of Nitric Oxide from S-Nitrosohemoglobin. Electron Transfer as a Response to Deoxygenation
Pezacki, J. P., Ship, N. J., & Kluger, R. (2001) · Journal of the American Chemical Society · doi:10.1021/ja015716o · Cited by 35
Kinetics of Nitric Oxide Binding to R-State Hemoglobin
Huang, Z., Ucer, K. B., Murphy, T., Williams, R. T., King, S. B., & Kim‐Shapiro, D. B. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6730 · Cited by 34
Schubert, A., O’Hara, J. F., Przybelski, R. J., Tetzlaff, J. E., Marks, K. E., Mascha, E. J., & Novick, A. C. (2002) · Artificial Cells Blood Substitutes and Biotechnology · doi:10.1081/bio-120006118 · Cited by 33
Kruszyna, R., Kruszyna, H. G., Smith, R. P., Thron, C. D., & Wilcox, D. E. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-5347(25)00329-5 · Cited by 33
Resistance to O2 diffusion in anemic red muscle: roles of flux density and cell PO2
Honig, C. R., & Gayeski, T. E. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.265.3.h868 · Cited by 32
Kosaka, H., & Seiyama, A. (1997) · Nature Medicine · doi:10.1038/nm0497-456 · Cited by 30
EDRF: nitrosylated compound or authentic nitric oxide
Bates, J. N., Harrison, D. G., Myers, P. R., & Minor, R. L. (1991) · Steinkopff eBooks · doi:10.1007/978-3-642-72461-9_3 · Cited by 29
Changes in intermediate haemoglobins during autoxidation of haemoglobin
Tomoda, A., Yoneyama, Y., & Tsuji, A. (1981) · Biochemical Journal · doi:10.1042/bj1950485 · Cited by 28
In vitro formation of S‐nitrosohemoglobin in red cells by inducible nitric oxide synthase
Mamone, G., Sannolo, N., Malorni, A., & Ferranti, P. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01527-6 · Cited by 23
Identification of Nitric Oxide (NO) in Human Blood
Freeman, G., Dyer, R. L., Juhos, L. T., JOHN, G. A. S., & Anbar, M. (1978) · Archives of Environmental Health An International Journal · doi:10.1080/00039896.1978.10667303 · Cited by 21
Interaction of copper(II) with hemoglobins in the unliganded conformation
Manoharan, P. T., Alston, K., & Rifkind, J. M. (1989) · Biochemistry · doi:10.1021/bi00444a003 · Cited by 15
Nitrosylhemoglobin formation after infusion of NO solutions: ESR studies in pigs
Aldini, G., Orioli, M., Facino, R. M., Clement, M. G., Albertini, M., Mazzola, S., Pirrone, F., & Carini, M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.042 · Cited by 14
Kagan, V. E., Day, B. W., Elsayed, N. M., & Gorbunov, N. V. (1996) · Nature · doi:10.1038/383030b0 · Cited by 12
Reductive nitrosylation and S-nitrosation of hemoglobin in inhomogeneous nitric oxide solutions
Han, T. H., Fukuto, J. M., & Liao, J. C. (2004) · Nitric Oxide · doi:10.1016/j.niox.2004.03.003 · Cited by 11
Reply to "NO adducts in mammalian red blood cells: too much or too little?"
Stamler, J. S., Hess, D. T., & Singel, D. J. (2003) · Nature Medicine · doi:10.1038/nm0503-482 · Cited by 10
Self-citationMcMahon, T., Pawloski, J. R., Hess, D. T., Piantadosi, C. A., Luchsinger, B. P., Singel, D. J., & Stamler, J. S. (2003) · Blood · doi:10.1182/blood-2003-04-1058 · Cited by 9
Self-citationFormation of nitrosothiols from gaseous nitric oxide at pH 7.4
Palmerini, C. A., Saccardi, C., Arienti, G., & Palombari, R. (2002) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.10028 · Cited by 9
Rates of release of nitric oxide from HbSNO and internal electron transfer
Ship, N. J., Pezacki, J. P., & Kluger, R. (2003) · Bioorganic Chemistry · doi:10.1016/s0045-2068(02)00509-6 · Cited by 7
Palmerini, C. A., Arienti, G., & Palombari, R. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.03.020 · Cited by 4
Chemical interaction of nitric oxide and human hemoglobin
Luchsinger, B. P. (2004) · Montana State University ScholarWorks (Montana State University) · Cited by 2
Research works printed but not linked: 14
- Bates JN, 1991, Basic Res. Cardiol., 86, 17
- Gaston B, 1994, J. Pharmacol. Exp. Ther., 268, 978
- Stamler JS, 1995, Curr. Top. Microbiol. Immunol., 196, 19
- Sellke FW, 1990, Am. J. Physiol., 258, H515
- Jackson WF, 1987, Am. J. Physiol., 253, H1120
- Guyton AC, 1964, Circ. Res., 15, 60
- Roach RC, 1999, Am. J. Physiol., 276, H438
- Deleted in press
- Coburn R, 1967, Fed. Proc., 26, 334 (Abstr.)
- Kruszyna R, 1987, J. Pharmacol. Exp. Ther., 241, 307
- Reutov VP, 1998, Biochemistry (Mosc), 63, 874
- 10.1021/ja036693b · DOI · Paper page
- Chen B, 1999, Tsin. Sci. Tech., 4, 3024
- Foster MW, 2004, Hypertension
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Metadata
- Authors
- Singel, D. J., & Stamler, J. S.
- Affiliations
- Montana State University (US)
- Howard Hughes Medical Institute (US)
- ORCID
- Stamler, Jonathan S.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2005-03-17
- Volume
- 67
- Issue
- 1
- Pages
- 99-145
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W1828441724
- Cited by
- 481
- References
- 146
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 16 · 2023: 13 · 2022: 22 · 2021: 16 · 2020: 10 · 2019: 18 · 2018: 15 · 2017: 18 · 2016: 13 · 2015: 20 · 2014: 23 · 2013: 28 · 2012: 30
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL042444, 5P01-HL42444)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Keywords
- erythrocytes, nitric oxide, hemoglobin, oxygen sensing, vasodilation, vasoconstriction, microcirculation, S-nitrosohemoglobin, blood flow regulation, oxygen delivery, autoregulation, sickle cell disease, sepsis, diabetes mellitus, heart failure
- MeSH terms
- Blood Circulation, Erythrocytes, Hemoglobins, Humans, Microcirculation, Nitric Oxide
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