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CHEMICAL PHYSIOLOGY OF BLOOD FLOW REGULATION BY RED BLOOD CELLS: The Role of Nitric Oxide and S-Nitrosohemoglobin
Abstract
▪ Abstract Blood flow in the microcirculation is regulated by physiological oxygen (O 2) gradients that are coupled to vasoconstriction or vasodilation, the domain of nitric oxide (NO) bioactivity. The mechanism by which the O 2 content of blood elicits NO signaling to regulate blood flow, however, is a major unanswered question in vascular biology. While the hemoglobin in red blood cells (RBCs) would appear to be an ideal sensor, conventional wisdom about its chemistry with NO poses a problem for understanding how it could elicit vasodilation. Experiments from several laboratories have, nevertheless, very recently established that RBCs provide a novel NO vasodilator activity in which hemoglobin acts as an O 2 sensor and O 2-responsive NO signal transducer, thereby regulating both peripheral and pulmonary vascular tone. This article reviews these studies, together with biochemical studies, that illuminate the complexity and adaptive responsiveness of NO reactions with hemoglobin. Evidence for the pivotal role of S-nitroso (SNO) hemoglobin in mediating this response is discussed. Collectively, the reviewed work sets the stage for a new understanding of RBC-derived relaxing activity in auto-regulation of blood flow and O 2 delivery and of RBC dysfunction in disorders characterized by tissue O 2 deficits, such as sickle cell disease, sepsis, diabetes, and heart failure.
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“Nitrite administered before or during cardiac ischemia has been shown to protect cardiac function and attenuate infarct size in a number of small and large animal models (226, 374, 864).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [864]
In the citing paper
“Notably, other nitrogen-centered molecules, such as nitrite, have been shown to promote S-nitrosation of complex I and attenuate ischemia/reperfusion injury (864).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [864]
Citations
Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
Hébert, P. C., Wells, G., Blajchman, M. A., Marshall, J., Martin, C., Pagliarello, G., Tweeddale, M., Schweitzer, I., & Yetisir, E. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400601 · Cited by 5,187
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Perutz, M. F. (1970) · Nature · doi:10.1038/228726a0 · Cited by 2,914
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744
Self-citationBesarab, A., Bolton, W. K., Browne, J. K., Egrie, J. C., Nissenson, A. R., Okamoto, D. M., Schwab, S. J., & Goodkin, D. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808273390903 · Cited by 1,930
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Anemia and Blood Transfusion in Critically Ill Patients
Vincent, J. (2002) · JAMA · doi:10.1001/jama.288.12.1499 · Cited by 1,794
Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
Bolotina, V. M., Najibi, S., Palacino, J. J., Pagano, P. J., & Cohen, R. A. (1994) · Nature · doi:10.1038/368850a0 · Cited by 1,690
S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
Jia, L., Bonaventura, C., Bonaventura, J., & Stamler, J. S. (1996) · Nature · doi:10.1038/380221a0 · Cited by 1,592
Self-citation
Research works printed but not linked: 14
- Bates JN, 1991, Basic Res. Cardiol., 86, 17
- Gaston B, 1994, J. Pharmacol. Exp. Ther., 268, 978
- Stamler JS, 1995, Curr. Top. Microbiol. Immunol., 196, 19
- Sellke FW, 1990, Am. J. Physiol., 258, H515
- Jackson WF, 1987, Am. J. Physiol., 253, H1120
- Guyton AC, 1964, Circ. Res., 15, 60
- Roach RC, 1999, Am. J. Physiol., 276, H438
- Deleted in press
- Coburn R, 1967, Fed. Proc., 26, 334 (Abstr.)
- Kruszyna R, 1987, J. Pharmacol. Exp. Ther., 241, 307
- Reutov VP, 1998, Biochemistry (Mosc), 63, 874
- 10.1021/ja036693b · DOI · Paper page
- Chen B, 1999, Tsin. Sci. Tech., 4, 3024
- Foster MW, 2004, Hypertension
Cited by
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Li, Y., Zhou, S., Jian, X., Zhang, X., & Song, Y. (2021) · Microchimica Acta · doi:10.1007/s00604-021-05009-3 · Cited by 14
Zhang, R., Hausladen, A., Qian, Z., Liao, X., Premont, R. T., & Stamler, J. S. (2021) · JCI Insight · doi:10.1172/jci.insight.155234 · Cited by 14
Self-citationReeves, B. D., Hilmer, J. K., Mellmann, L., Hartzheim, M., Poffenberger, K., Johnson, K., Joshi, N., Singel, D. J., & Grieco, P. A. (2013) · Tetrahedron Letters · doi:10.1016/j.tetlet.2013.08.011 · Cited by 14
Self-citationThe role of β93 Cys in the inhibition of Hb S fiber formation
Knee, K. M., Roden, C. K., Flory, M. R., & Mukerji, I. (2007) · Biophysical Chemistry · doi:10.1016/j.bpc.2007.02.002 · Cited by 14
The 1998 Nobel Prize—discovery of the role of nitric oxide as a signalling molecule
Zetterström, R. H. (2009) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.01121.x · Cited by 16
Bliss, S. P. (2015) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2015.04.006 · Cited by 14
Fens, M. H. A. M., Cabrales, P., Scicinski, J. J., Larkin, S. K., Suh, J. H., Kuypers, F. A., Oronsky, N. C., Lybeck, M., Oronsky, A. L., & Oronsky, B. T. (2016) · Medical Oncology · doi:10.1007/s12032-016-0798-9 · Cited by 14
Nitric Oxide Regulation of Cardiovascular Physiology and Pathophysiology
Dulce, R. A., Kulandavelu, S., Schulman, I. H., Fritsch, J., & Hare, J. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00024-7 · Cited by 14
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Isbell, T. S., Koenitzer, J. R., Crawford, J. H., White, C. R., Kraus, D. W., & Patel, R. P. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)96047-3 · Cited by 14
Kaul, S. (2009) · Circulation · doi:10.1161/circulationaha.108.846113 · Cited by 14
Nasir, M., Bég, O. A., Al-Dossari, M., Sarhan, N. M., Kuharat, S., Waqas, M., Zamri, N., & Daminova, G. (2024) · Diamond and Related Materials · doi:10.1016/j.diamond.2024.111447 · Cited by 13
Research opportunities in optimizing storage of red blood cell products
Wagner, S. J., Glynn, S. A., Welniak, L. A., & NHLBI Working Group on Strategies to Optimize Red Blood Cell Products (2013) · Transfusion · doi:10.1111/trf.12244 · Cited by 13
Berto, T. C., & Lehnert, N. (2011) · Inorganic Chemistry · doi:10.1021/ic2003854 · Cited by 13
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Said, A. S., Rogers, S. C., & Doctor, A. (2015) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000225 · Cited by 14
Shadrina, M. S., Peslherbe, G. H., & English, A. M. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00369 · Cited by 13
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Diesen, D. L., & Stamler, J. S. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.03.739 · Cited by 13
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Szilagyi, R. K., & Schwab, D. E. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.127 · Cited by 13
Martínková, M., Igarashi, J., & Shimizu, T. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.07.055 · Cited by 13
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Tanoğlu, A., & Kara, M. (2015) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000434 · Cited by 13
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Deonikar, P., & Kavdia, M. (2009) · Annals of Biomedical Engineering · doi:10.1007/s10439-009-9823-x · Cited by 12
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Nagababu, E., Scott, A. V., Johnson, D. J., Goyal, A., Lipsitz, J. A., Barodka, V. M., Berkowitz, D. E., & Frank, S. M. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001392 · Cited by 12
Bentley, R. F., Walsh, J. J., Drouin, P., Velickovic, A., Kitner, S. J., Fenuta, A. M., & Tschakovsky, M. E. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00952.2016 · Cited by 12
Emel’yanova, N. S., Gutsev, L. G., Pokidova, O. V., Shestakov, A. F., Санина, Н. А., & Aldoshin, S. M. (2021) · Inorganica Chimica Acta · doi:10.1016/j.ica.2021.120361 · Cited by 12
Zhou, Q., Dai, C., Zhu, Y., Han, T., Zhou, J., Zhao, L., Wang, X., Han, L., Qu, J., & Li, W. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-21-1971 · Cited by 12
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Bohlen, H. G. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00628.x · Cited by 12
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Liu, Y., Sun, C., Honavar, J., Townes, T. M., & Patel, R. P. (2013) · Europe PMC (PubMed Central) · Cited by 12
Blasi, R. A. D., Tonelli, E., Arcioni, R., Mercieri, M., Cigognetti, L., Romano, R., & Pinto, G. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2404-0 · Cited by 12
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Shahab, M., & Jamesdaniel, S. (2022) · Pharmaceuticals · doi:10.3390/ph15060649 · Cited by 11
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Reynolds, J. D. H., Posina, K., Zhu, L., Jenkins, T. L., Matto, F., Hausladen, A., Kashyap, V. S., Schilz, R. J., Zhang, R., Mannick, J. B., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2220769120 · Cited by 11
Self-citationEffects of dexmedetomidine on the deformability of erythrocytes in vitro and in anesthesia
Yang, X., LIU, J., Ji, J., & Xie, J. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1633 · Cited by 11
Frérart, F., Lobysheva, I. I., Gallez, B., Dessy, C., & Féron, O. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0388 · Cited by 12
Yao, B., Liu, D., Chai, W., Wang, X.-T., & Zhang, H. (2019) · Intensive Care Medicine Experimental · doi:10.1186/s40635-018-0215-0 · Cited by 11
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Zhao, Y., Wang, X., Wang, R., Chen, D., Noviana, M., & Zhu, H. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27359 · Cited by 10
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Bég, O. A., & Roy, A. K. (2022) · Chinese Journal of Physics · doi:10.1016/j.cjph.2022.04.003 · Cited by 9
Zarenkiewicz, J., Pérez‐Ternero, C., Kojasoy, V., McGinity, C. L., Khodade, V. S., Lin, J., Tantillo, D. J., Toscano, J. P., Hobbs, A. J., & Fukuto, J. M. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.06.245 · Cited by 10
Jiang, J., Corbett, J. T., Hogg, N., & Mason, R. P. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.06.024 · Cited by 8
Sulok, C. D., Bauer, J. L., Speelman, A. L., Weber, B., & Lehnert, N. (2011) · Inorganica Chimica Acta · doi:10.1016/j.ica.2011.09.039 · Cited by 9
Bohlen, H. G. (2011) · Microcirculation · doi:10.1111/j.1549-8719.2011.00127.x · Cited by 9
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Madsen, P. L., Sejersen, C., Nyberg, M., Sørensen, M. H., Hellsten, Y., Gæde, P., & Bojer, A. S. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1294369 · Cited by 10
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Ponka, P., & Sheftel, A. D. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_10 · Cited by 8
Caretti, A., Fantacci, M., Caccia, D., Perrella, M., Lowe, K. C., & Samaja, M. (2008) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2007.12.011 · Cited by 8
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Razi, O., Teixeira, A. M., Tartibian, B., Zamani, N., & Knechtle, B. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04610-1 · Cited by 8
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Reynolds, J. D. H., Premont, R. T., & Stamler, J. S. (2019) · Circulation · doi:10.1161/circulationaha.119.041389 · Cited by 6
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Kim‐Shapiro, D. B., & Gladwin, M. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00006-5 · Cited by 5
Buerk, D. G., Liu, Y., Zaccheo, K. A., Barbee, K. A., & Jaron, D. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01053 · Cited by 6
Spinella, P. C., Sniecinski, R. M., Trachtenberg, F. L., Inglis, H. C., Ranganathan, G., Heitman, J. W., Szlam, F., Danesh, A., Stone, M., Keating, S. M., et al. (2019) · Transfusion · doi:10.1111/trf.15228 · Cited by 5
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Zaidi, S. K., Hoda, M. N., Tabrez, S. S. M., & Khan, M. I. (2022) · Antioxidants · doi:10.3390/antiox11102051 · Cited by 4
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Metadata
- Authors
- Singel, D. J., & Stamler, J. S.
- Affiliations
- Montana State University (US)
- Howard Hughes Medical Institute (US)
- ORCID
- Stamler, Jonathan S.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2005-03-17
- Volume
- 67
- Issue
- 1
- Pages
- 99-145
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W1828441724
- Cited by
- 481
- References
- 146
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 16 · 2023: 13 · 2022: 22 · 2021: 16 · 2020: 10 · 2019: 18 · 2018: 15 · 2017: 18 · 2016: 13 · 2015: 20 · 2014: 23 · 2013: 28 · 2012: 30
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL042444, 5P01-HL42444)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Keywords
- erythrocytes, nitric oxide, hemoglobin, oxygen sensing, vasodilation, vasoconstriction, microcirculation, S-nitrosohemoglobin, blood flow regulation, oxygen delivery, autoregulation, sickle cell disease, sepsis, diabetes mellitus, heart failure
- MeSH terms
- Blood Circulation, Erythrocytes, Hemoglobins, Humans, Microcirculation, Nitric Oxide
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