Cited by 284Sperm and Testicular FunctionReproductive biology and impacts on aquatic speciesReproductive Biology and Fertility

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Mechanisms of Sperm Chemotaxis

Kaupp, U. Benjamin, Kashikar, Nachiket D., Weyand, Ingo·2008·Annual Review of Physiology

DOI 10.1146/annurev.physiol.70.113006.100654

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Abstract

Sperm are attracted by chemical factors that are released by the egg-a process called chemotaxis. Most of our knowledge on sperm chemotaxis originates from the study of marine invertebrates. In recent years, the main features of the chemotactic signaling pathway and the swimming behavior evoked by chemoattractants have been elucidated in sea urchins. In contrast, our understanding of mammalian sperm chemotaxis is still rudimentary and subject to an ongoing debate. In this review, we raise new questions and discuss current concepts of sperm chemotaxis. Finally, we highlight commonalities and differences of sensory signaling in sperm, photoreceptors, and olfactory neurons.

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BackgroundInfluential
Understanding the Cell’s Response to Chemical Signals: Utilisation of Microfluidic Technology in Studies of Cellular and Dictyostelium discoideum Chemotaxis
Muljadi, M., Fu, Y.-C., & Cheng, C. (2022) · Micromachines · doi:10.3390/mi13101737 · Cited by 14
“Coli [9,10], lymphocytes such as T cells [11], and eukaryotes such as sperm cells [12], among others.”
Background
Calcium Signaling in Sperm: Help from Prostasomes
Ren, D. (2011) · Science Signaling · doi:10.1126/scisignal.2002102 · Cited by 14
“A similar CaVdependent mechanism has also been widely believed to be responsible for the Ca entry into sperm elicited by various physiological stimuli, such as egg proteins, serum albumin, and progesterone (13, 14).”
Background
Regulation of the starfish sperm acrosome reaction by cGMP, pH, cAMP and Ca2+
Matsumoto, M., Kawase, O., Islam, M. S., Naruse, M., Watanabe, S.-N., Ishikawa, R., & Hoshi, M. (2008) · The International Journal of Developmental Biology · doi:10.1387/ijdb.072511mm · Cited by 14
“Resact is a chemoattractant for sperm and it evokes elevations of intracellular Ca2+ ([Ca2+]i) in the flagellum (Garbers & Kopf, 1989; Kaupp et al., 2008).”
Background
Egg-sperm interaction in sturgeon: role of ovarian fluid
Kholodnyy, V., Dzyuba, B., Gadêlha, H., Cosson, J., & Boryshpolets, S. (2020) · Fish Physiology and Biochemistry · doi:10.1007/s10695-020-00852-2 · Cited by 13
Implications of ram sperm rheotaxis analysed by microfluidics for fertility
Abdel‐Ghani, M. A., El-sherry, T. M., Mahmoud, G. B., & Nagano, M. (2020) · Reproduction in Domestic Animals · doi:10.1111/rda.13804 · Cited by 13
Multiplexed microfluidic screening of bacterial chemotaxis
Stehnach, M. R., Henshaw, R. J., Floge, S. A., & Guasto, J. (2023) · eLife · doi:10.7554/elife.85348 · Cited by 13
Dynamics of a microswimmer–microplatelet composite
Daddi‐Moussa‐Ider, A., Lisicki, M., Löwen, H., & Menzel, A. M. (2020) · Open Research Online - ORO (The Open University) · Cited by 13
β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility
Li, X., Yuan, C., Shi, J., Kang, H. W., Chen, Y. A., Duan, Y., Jin, J., Cheung, L. P., Li, T. C., Liu, Y., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100825 · Cited by 13
Multi-robot target entrapment using cooperative hierarchical gene regulatory network
Wu, M., Zhu, X., Ma, L., Bao, W., Fan, Z., & Jin, Y. (2023) · Swarm and Evolutionary Computation · doi:10.1016/j.swevo.2023.101310 · Cited by 13
Niflumic acid disrupts marine spermatozoan chemotaxis without impairing the spatiotemporal detection of chemoattractant gradients
Guerrero, A., Espinal, J., Wood, C. D., Rendón, J. M., Carneiro, J., Martínez‐Mekler, G., & Darszon, A. (2013) · Journal of Cell Science · doi:10.1242/jcs.121442 · Cited by 13
“from the female gamete or, more commonly, their investments (Kaupp et al., 2008; Darszon et al., 2011).”
Background
Modeling Chemotaxis of Microswimmers: From Individual to Collective Behavior
Liebchen, B., & Löwen, H. (2019) · WORLD SCIENTIFIC (EUROPE) eBooks · doi:10.1142/9781786347015_0020 · Cited by 13
“) apart from a delay (or memory) time t 0 which takes into account that a nite time is needed for sensing the chemical. Integrating or superimposing over the Green’s function of chemical diusion, Eq.(2), the chemotactic force F~(~r p;t), Eq. (18), is modelled as February 5, 2019 3:18 ws-rv9x6 Book Title Liebchen_Loewe…”
Background
Sperm Accumulation Induced by the Female Reproductive Fluid: Putative Evidence of Chemoattraction Using a New Tool
Devigili, A., Cattelan, S., & Gasparini, C. (2021) · Cells · doi:10.3390/cells10092472 · Cited by 12
Shaping the gradients driving phoretic micro-swimmers: influence of swimming speed, budget of carbonic acid and environment
Möller, N., Liebchen, B., & Palberg, T. (2021) · The European Physical Journal E · doi:10.1140/epje/s10189-021-00026-9 · Cited by 12
Sperm guidance to the egg finds calcium at the helm
Sugiyama, H., & Chandler, D. E. (2013) · PROTOPLASMA · doi:10.1007/s00709-013-0550-7 · Cited by 12
“In fact, it appears that sperm chemotaxis has arisen numerous times independently during the course of evolution based on the observation that the sperm chemoattractants given off by eggs or accessory cells are diverse, ranging from peptides and amino acids to lipids and steroids to carbohydrates and proteins (Eisenba…”
Analysis of sperm chemotaxis
Ramírez-Gómez, H. V., Tuval, I., Guerrero, A., & Darszon, A. (2019) · Methods in cell biology · doi:10.1016/bs.mcb.2018.12.002 · Cited by 12
The activation and cryopreservation of sablefish (Anoplopoma fimbria) sperm
Immerman, D. A., & Goetz, F. W. (2014) · Aquaculture · doi:10.1016/j.aquaculture.2014.04.010 · Cited by 11
Evolution of gamete attraction molecules: evidence for purifying selection in speract and its receptor, in the pantropical sea urchin Diadema
Jagadeeshan, S., Coppard, S. E., & Lessios, H. A. (2015) · Evolution & Development · doi:10.1111/ede.12108 · Cited by 11
“causing sperm to “turn” and “run” toward the source of the gradient (Kaupp et al. 2008; Guerrero et al. 2010).”
Sperm Chemotaxis as Revealed With Live and Synthetic Eggs
Himes, J. E., Riffell, J. A., Zimmer, C. A., & Zimmer, R. K. (2011) · Biological Bulletin · doi:10.1086/bblv220n1p1 · Cited by 11
Individual female differences in chemoattractant production change the scale of sea urchin gamete interactions
Hussain, Y. H., Sadı́lek, M., Salad, S., Zimmer, R. K., & Riffell, J. A. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.01.006 · Cited by 11
An in-vitro assay using human spermatozoa to detect toxicity of biologically active substances
Vollmer, T., Ljungberg, B., Jankowski, V., Jankowski, J., Glorieux, G., & Stegmayr, B. G. (2019) · Scientific Reports · doi:10.1038/s41598-019-50929-z · Cited by 12
Allurin, an Amphibian Sperm Chemoattractant Having Implications for Mammalian Sperm Physiology
Burnett, L. A., Washburn, C. A., Sugiyama, H., Xiang, X., Olson, J. H., Al-Anzi, B., Bieber, A. L., & Chandler, D. E. (2012) · International review of cytology · doi:10.1016/b978-0-12-394306-4.00007-1 · Cited by 11
Autonomous changes in the swimming direction of sperm in the gastropodStrombus luhuanus
Shiba, K., Shibata, D., & Inaba, K. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.095398 · Cited by 11
“However, a transient increase of the intracellular Ca2+ concentration induced by chemoattractants caused changes in flagellar asymmetry, resulting in chemotaxis toward the eggs (Kaupp et al., 2008; Shiba et al., 2008; Yoshida and Yoshida, 2011; Mizuno et al., 2012).”
Background
Advances in microfluidic technology for sperm screening and in vitro fertilization
Ma, J., Xie, Q., Zhang, Y., Xiao, Q., Liu, X., Qiao, C., & Tian, Y. (2024) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-023-05120-9 · Cited by 10
“Spermatozoa are attracted to cytokines released from the oocyte and are able to navigate within the short-range inward fertilization site through chemotaxis [57].”
Chemosensory and hyperoxia circuits in C. elegans males influence sperm navigational capacity
Hoang, H. D., & Miller, M. A. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2002047 · Cited by 9
Spermatozoa: A Historical Perspective.
Suárez, J. P., du Plessis, S. S., & Maya, W. D. C. (2018) · Europe PMC (PubMed Central) · doi:10.22074/ijfs.2018.5316 · Cited by 10
“A number of these molecules have been implicated in capacitation, hyperactivation, and eliciting the acrosome reaction (13).”
Background
The single flagellum of Leishmania has a fixed polarisation of its asymmetric beat
Wang, Z., Beneke, T., Gluenz, E., & Wheeler, R. J. (2020) · Journal of Cell Science · doi:10.1242/jcs.246637 · Cited by 10
Immunocytochemical Localization of Olfactory-signaling Molecules in Human and Rat Spermatozoa
Makeyeva, Y., Nicol, C., Ledger, W. J., & Ryugo, D. K. (2020) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155420939833 · Cited by 9
Sperm Transcripts Associated With Odorant Binding and Olfactory Transduction Pathways Are Altered in Breeding Bulls Producing Poor-Quality Semen
Karuthadurai, T., Das, D. N., Kumaresan, A., Sinha, M. K., Elango, K., Nag, P., King, J. P. E. S., Datta, T. K., Manimaran, A., Jeyakumar, S., et al. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.799386 · Cited by 9
“Oocyte releases chemicals to attract the capacitated sperm, but the sperm motility toward oocyte also depends on the thermal gradient and the chemicals released from the oviduct (96).”
Background
In Silico Determination of the Effect of Multi-Target Drugs on Calcium Dynamics Signaling Network Underlying Sea Urchin Spermatozoa Motility
Enríquez, J. E., Darszon, A., Guerrero, A., & Martínez‐Mekler, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104451 · Cited by 9
“This swimming pattern is common to a wide variety of organisms with external fertilization [3,4,8–16].”
Background
Peritoneal fluid modifies the response of human spermatozoa to follicular fluid
Caille, A. M., Berta, C. L., Cuasnicu, P. S., & Munuce, M. J. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2011.12.010 · Cited by 9
“Progesterone stimulates several sperm functions, including hyperactivation, chemotaxis towards the oocyte and physiological AR (Kaupp et al., 2008).”
Background
Sperm Migration and Hyaluronic Acid Binding: Implications for Male Fertility Evaluation
Marchlewska, K., Erkiert-Kusiak, M., Walczak-Jędrzejowska, R., & Słowikowska‐Hilczer, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189995 · Cited by 8
“…in humans is still under review [33], but several attractants One component of the medium used in the migration test is albumin; contact with this medium allows spermatozoa to swim out of the seminal plasma, indicating the presence of positive chemotaxis. are used in experimental studies [34].”
Method

Authors: Kaupp, U. B., Kashikar, N. D., & Weyand, I.
Affiliations: Forschungszentrum Jülich (DE)
ORCID: Kaupp, U. Benjamin
Kashikar, Nachiket D.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 2008-03-01
Volume: 70
Issue: 1
Pages: 93-117
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.physiol.70.113006.100654
OpenAlex: W2155214806
Cited by: 284
References: 144
Citations by year: 2026: 4 · 2025: 8 · 2024: 12 · 2023: 7 · 2022: 11 · 2021: 18 · 2020: 18 · 2019: 14 · 2018: 8 · 2017: 19 · 2016: 10 · 2015: 19 · 2014: 23 · 2013: 23 · 2012: 14
FWCI: 2.15
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
JuSER (Forschungszentrum Jülich) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: sperm chemotaxis, chemotactic signaling, chemoattractants, sea urchin sperm, mammalian sperm, sensory signaling, photoreceptors, olfactory sensory neurons
MeSH terms: Animals, Chemotaxis, Humans, Male, Sperm Motility, Spermatozoa, Signal Transduction

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Mechanisms of Sperm Chemotaxis

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