Cited by 284Sperm and Testicular FunctionReproductive biology and impacts on aquatic speciesReproductive Biology and Fertility

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Mechanisms of Sperm Chemotaxis

Kaupp, U. Benjamin, Kashikar, Nachiket D., Weyand, Ingo·2008·Annual Review of Physiology

DOI 10.1146/annurev.physiol.70.113006.100654

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Abstract

Sperm are attracted by chemical factors that are released by the egg-a process called chemotaxis. Most of our knowledge on sperm chemotaxis originates from the study of marine invertebrates. In recent years, the main features of the chemotactic signaling pathway and the swimming behavior evoked by chemoattractants have been elucidated in sea urchins. In contrast, our understanding of mammalian sperm chemotaxis is still rudimentary and subject to an ongoing debate. In this review, we raise new questions and discuss current concepts of sperm chemotaxis. Finally, we highlight commonalities and differences of sensory signaling in sperm, photoreceptors, and olfactory neurons.

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Authors: Kaupp, U. B., Kashikar, N. D., & Weyand, I.
Affiliations: Forschungszentrum Jülich (DE)
ORCID: Kaupp, U. Benjamin
Kashikar, Nachiket D.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 2008-03-01
Volume: 70
Issue: 1
Pages: 93-117
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.physiol.70.113006.100654
OpenAlex: W2155214806
Cited by: 284
References: 144
Citations by year: 2026: 4 · 2025: 8 · 2024: 12 · 2023: 7 · 2022: 11 · 2021: 18 · 2020: 18 · 2019: 14 · 2018: 8 · 2017: 19 · 2016: 10 · 2015: 19 · 2014: 23 · 2013: 23 · 2012: 14
FWCI: 2.15
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
JuSER (Forschungszentrum Jülich) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: sperm chemotaxis, chemotactic signaling, chemoattractants, sea urchin sperm, mammalian sperm, sensory signaling, photoreceptors, olfactory sensory neurons
MeSH terms: Animals, Chemotaxis, Humans, Male, Sperm Motility, Spermatozoa, Signal Transduction

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Mechanisms of Sperm Chemotaxis

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