The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Bicuspid Aortic Valve: Four-dimensional MR Evaluation of Ascending Aortic Systolic Flow Patterns
Abstract
PURPOSE: To use time-resolved three-dimensional phase-contrast magnetic resonance (MR) imaging, also called four-dimensional flow MR imaging, to evaluate systolic blood flow patterns in the ascending aorta that may predispose patients with a bicuspid aortic valve (BAV) to aneurysm. MATERIALS AND METHODS: The HIPAA-compliant protocol received institutional review board approval, and informed consent was obtained. Four-dimensional flow MR imaging was used to assess blood flow in the thoracic aorta of 53 individuals: 20 patients with a BAV, 25 patients with a tricuspid aortic valve (TAV), and eight healthy volunteers. The Fisher exact test was used to evaluate the significance of flow pattern differences. RESULTS: Nested helical flow was seen at peak systole in the ascending aorta of 15 of 20 patients with a BAV but in none of the healthy volunteers or patients with a TAV. This flow pattern was seen both in patients with a BAV with a dilated ascending aorta (n = 6) and in those with a normal ascending aorta (n = 9), was seen in the absence of aortic stenosis (n = 5), and was associated with eccentric systolic flow jets in all cases. Fusion of right and left leaflets gave rise to right-handed helical flow and right-anterior flow jets (n = 11), whereas right and noncoronary fusion gave rise to left-handed helical flow with left-posterior flow jets (n = 4). CONCLUSION: Four-dimensional flow MR imaging showed abnormal helical systolic flow in the ascending aorta of patients with a BAV, including those without aneurysm or aortic stenosis. Identification and characterization of eccentric flow jets in these patients may help identify those at risk for development of ascending aortic aneurysm.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Two-dimensional echocardiographic aortic root dimensions in normal children and adults
Roman, M. J., Devereux, R. B., Kramer-Fox, R., & O'Loughlin, J. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90430-x · Cited by 1,102
Clinical significance of the bicuspid aortic valve
Ward, C. (2000) · Heart · doi:10.1136/heart.83.1.81 · Cited by 803
Clinical and Pathophysiological Implications of a Bicuspid Aortic Valve
Fedak, P. W. M., Verma, S., David, T. E., Leask, R. L., Weisel, R. D., & Butany, J. (2002) · Circulation · doi:10.1161/01.cir.0000027905.26586.e8 · Cited by 800
Kilner, P. J., Yang, G. Z., Mohiaddin, R. H., Firmin, D. N., & Longmore, D. B. (1993) · Circulation · doi:10.1161/01.cir.88.5.2235 · Cited by 592
Niwa, K., Perloff, J. K., Bhuta, S. M., Laks, H., Drinkwater, D. C., Child, J. S., & Miner, P. D. (2001) · Circulation · doi:10.1161/01.cir.103.3.393 · Cited by 573
Concomitant gradient terms in phase contrast MR: Analysis and correction
Bernstein, M. A., Zhou, X. J., Polzin, J. A., King, K. F., Ganin, A., Pelc, N. J., & Glover, G. H. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390218 · Cited by 547
Aortic root dilatation in young men with normally functioning bicuspid aortic valves
Nistri, S., Sorbo, M. D., Marin, M., Palisi, M., Scognamiglio, R., & Thiene, G. (1999) · Heart · doi:10.1136/hrt.82.1.19 · Cited by 465
Schaefer, B. M., Lewin, M. B., Stout, K. K., Gill, E., Prueitt, A., Byers, P. H., & Otto, C. M. (2008) · Heart · doi:10.1136/hrt.2007.132092 · Cited by 442
Hahn, R. T., Roman, M. J., Mogtadek, A. H., & Devereux, R. B. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90479-7 · Cited by 406
Mechanisms Underlying Aortic Dilatation in Congenital Aortic Valve Malformation
Bonderman, D., Gharehbaghi-Schnell, E., Wollenek, G., Maurer, G., Baumgartner, H., & Lang, I. M. (1999) · Circulation · doi:10.1161/01.cir.99.16.2138 · Cited by 316
Cited by
Lindman, B. R., Clavel, M.-A., Mathieu, P., Iung, B., Lancellotti, P., Otto, C. M., & Pibarot, P. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.6 · Cited by 982
Markl, M., Frydrychowicz, A., Kozerke, S., Hope, M., & Wieben, O. (2012) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.23632 · Cited by 788
Self-citationAortic Dilatation in Patients with Bicuspid Aortic Valve
Verma, S., & Siu, S. C. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1207059 · Cited by 507
Bicuspid Aortic Valve Is Associated With Altered Wall Shear Stress in the Ascending Aorta
Barker, A. J., Markl, M., Bürk, J., Lorenz, R., Bock, J., Bauer, S., Schulz-Menger, J., & von Knobelsdorff-Brenkenhoff, F. (2012) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.112.973370 · Cited by 454
Borger, M. A., Fedak, P. W. M., Stephens, E. H., Gleason, T. G., Girdauskas, E., Ikonomidis, J. S., Khoynezhad, A., Siu, S. C., Verma, S., Hope, M. D., et al. (2018) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2018.02.115 · Cited by 287
Self-citation
Metadata
- Authors
- Hope, M. D., Hope, T. A., Meadows, A. K., Ordovas, K. G., Urbania, T. H., Alley, M. T., & Higgins, C. B.
- Venue
- Radiology
- Published
- 2010-04
- Volume
- 255
- Issue
- 1
- Pages
- 53-61
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2088342987
- Cited by
- 417
- References
- 23
- FWCI
- 25.83
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Bicuspid Aortic Valve: Four-dimensional MR Evaluation of Ascending Aortic Systolic Flow Patterns. https://app.cochat.ai/papers/10.1148/radiol.09091437
- The paper
- Hope, M. D., Hope, T. A., Meadows, A. K., Ordovas, K. G., Urbania, T. H., Alley, M. T., & Higgins, C. B. (2010). Bicuspid Aortic Valve: Four-dimensional MR Evaluation of Ascending Aortic Systolic Flow Patterns. Radiology. https://doi.org/10.1148/radiol.09091437
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
