Magnetic particle imaging: visualization of instruments for cardiovascular intervention
Abstract
PURPOSE: To evaluate the feasibility of different approaches of instrument visualization for cardiovascular interventions guided by using magnetic particle imaging (MPI). MATERIALS AND METHODS: Two balloon (percutaneous transluminal angioplasty) catheters were used. The balloon was filled either with diluted superparamagnetic iron oxide (SPIO) ferucarbotran (25 mmol of iron per liter) or with sodium chloride. Both catheters were inserted into a vessel phantom that was filled oppositional to the balloon content with sodium chloride or diluted SPIO (25 mmol of iron per liter). In addition, the administration of a 1.4-mL bolus of pure SPIO (500 mmol of iron per liter) followed by 5 mL of sodium chloride through a SPIO-labeled balloon catheter into the sodium chloride-filled vessel phantom was recorded. Images were recorded by using a preclinical MPI demonstrator. All images were acquired by using a field of view of 3.6 × 3.6 × 2.0 cm. RESULTS: By using MPI, both balloon catheters could be visualized with high temporal (21.54 msec per image) and sufficient spatial (≤ 3 mm) resolution without any motion artifacts. The movement through the field of view, the inflation and deflation of the balloon, and the application of the SPIO bolus were visualized at a rate of 46 three-dimensional data sets per second. CONCLUSION: Visualization of SPIO-labeled instruments for cardiovascular intervention at high temporal resolution as well as monitoring the application of a SPIO-based tracer by using labeled instruments is feasible. Further work is necessary to evaluate different labeling approaches for diagnostic catheters and guidewires and to demonstrate their navigation in the vascular system after administration of contrast material. SUPPLEMENTAL MATERIAL: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120424/-/DC1.
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MPI can visualize SPION-labeled catheters with good temporal and spatial resolution upon incorporation of ferucarbotran.
“Furthermore, MPI has been shown to be able to visualize SPION-labeled catheters, providing good temporal (upon balloon filling) and spatial resolution upon the incorporation of ferucarbotran [197].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [197]
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- Authors
- Haegele, J., Rahmer, J., Gleich, B., Borgert, J., Wojtczyk, H., Panagiotopoulos, N., Buzug, T. M., Barkhausen, J., & Vogt, F. M.
- Affiliations
- University Hospital Schleswig-Holstein (DE)
- Philips (Germany) (DE)
- University of Lübeck (DE)
- ORCID
- Venue
- Radiology
- Published
- 2012-12
- Volume
- 265
- Issue
- 3
- Pages
- 933-938
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2120361645
- Cited by
- 151
- References
- 14
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 9 · 2023: 5 · 2022: 11 · 2021: 11 · 2020: 13 · 2019: 14 · 2018: 15 · 2017: 13 · 2016: 10 · 2015: 6 · 2014: 8 · 2013: 11
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- magnetic particle imaging, cardiovascular interventions, percutaneous transluminal angioplasty, balloon catheter, superparamagnetic iron oxide nanoparticles, ferucarbotran, vessel phantom, temporal resolution, catheter navigation
- MeSH terms
- Contrast Media, Dextrans, Feasibility Studies, Humans, Image Enhancement, Magnetic Resonance Imaging, Polyvinyl Chloride, Sodium Chloride, Angioplasty, Balloon, Coronary, Artifacts, Phantoms, Imaging, Imaging, Three-Dimensional, Magnetite Nanoparticles
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