Three-dimensional real-time in vivo magnetic particle imaging
Open accessAbstract
Magnetic particle imaging (MPI) is a new tomographic imaging method potentially capable of rapid 3D dynamic imaging of magnetic tracer materials. Until now, only dynamic 2D phantom experiments with high tracer concentrations have been demonstrated. In this letter, first in vivo 3D real-time MPI scans are presented revealing details of a beating mouse heart using a clinically approved concentration of a commercially available MRI contrast agent. A temporal resolution of 21.5 ms is achieved at a 3D field of view of 20.4 x 12 x 16.8 mm(3) with a spatial resolution sufficient to resolve all heart chambers. With these abilities, MPI has taken a huge step toward medical application.
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Upon surface modification, superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging, magnetic particle imaging, targeted delivery of drugs, proteins, antibodies and nucleic acids, hyperthermia, biosensing, tissue repair, and separation of biomolecules.
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From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [12]
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Computerized transverse axial scanning (tomography): Part 1. Description of system
Hounsfield, G. N. (1973) · British Journal of Radiology · doi:10.1259/0007-1285-46-552-1016 · Cited by 3,930 · see citing works
Image Formation by Induced Local Interactions: Examples Employing Nuclear Magnetic Resonance
Lauterbur, P. C. (1973) · Nature · doi:10.1038/242190a0 · Cited by 3,621 · see citing works
Tomographic imaging using the nonlinear response of magnetic particles
Gleich, B., & Weizenecker, J. (2005) · Nature · doi:10.1038/nature03808 · Cited by 2,011 · see citing works
Self-citationComputerized transverse axial scanning (tomography): Part 2. Clinical application*
Ambrose, J. (1973) · British Journal of Radiology · doi:10.1259/0007-1285-46-552-1023 · Cited by 842 · see citing works
k‐t BLAST and k‐t SENSE: Dynamic MRI with high frame rate exploiting spatiotemporal correlations
Tsao, J., Boesiger, P., & Pruessmann, K. P. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10611 · Cited by 805 · see citing works
A Positron-Emission Transaxial Tomograph for Nuclear Imaging (PETT)
Ter‐Pogossian, M. M., Phelps, M. E., Hoffman, E. J., & Mullani, N. A. (1975) · Radiology · doi:10.1148/114.1.89 · Cited by 682 · see citing works
Clinical Imaging of the High-Risk or Vulnerable Atherosclerotic Plaque
Fayad, Z. A., & Fuster, V. (2001) · Circulation Research · doi:10.1161/hh1601.095596 · Cited by 519 · see citing works
Image Separation Radioisotope Scanning
Kuhl, D. E., & Edwards, R. Q. (1963) · Radiology · doi:10.1148/80.4.653 · Cited by 423 · see citing works
Principles of Magnetic Resonance Imaging
Liang, Z., & Lauterbur, P. C. (1999) · Institute of Electrical and Electronics Engineers eBooks · doi:10.1109/9780470545652 · Cited by 412 · see citing works
Effects of anesthetics on systemic hemodynamics in mice
Janssen, B. J., Celle, T. D., Debets, J., et al. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01192.2003 · Cited by 318 · see citing works
Wust, P., Gneveckow, U., Wust, P., Gneveckow, U., Johannsen, M., Böhmer, D., Henkel, T. O., Kahmann, F., Sehouli, J., FELIX, R., et al. (2006) · International Journal of Hyperthermia · doi:10.1080/02656730601106037 · Cited by 295 · see citing works
Highly constrained backprojection for time‐resolved MRI
Mistretta, C. A., Wieben, O. E., Velikina, J., et al. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20772 · Cited by 274 · see citing works
A simulation study on the resolution and sensitivity of magnetic particle imaging
Weizenecker, J., Borgert, J., & Gleich, B. (2007) · Physics in Medicine and Biology · doi:10.1088/0031-9155/52/21/001 · Cited by 267 · see citing works
Self-citationSchmitt, R. R., Froehner, S., Brunn, J., et al. (2005) · European Radiology · doi:10.1007/s00330-005-2707-z · Cited by 247 · see citing works
Prognostic value of troponin after elective percutaneous coronary intervention: A meta‐analysis
Nienhuis, M. B., Ottervanger, J. P., Bilo, H. J. G., et al. (2008) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.21345 · Cited by 176 · see citing works
Magnetic particle imaging using a field free line
Weizenecker, J., Gleich, B., & Borgert, J. (2008) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/41/10/105009 · Cited by 170 · see citing works
Self-citationLawaczeck, R., Bauer, H., Frenzel, T., Hasegawa, M., Ito, Y., Kito, K., Miwa, N., TSUTSUI, H., Vogler, H., & Weinmann, H. J. (1997) · Acta Radiologica · doi:10.1080/02841859709174391 · Cited by 148 · see citing works
Experimental results on fast 2D-encoded magnetic particle imaging
Gleich, B., Weizenecker, J., & Borgert, J. (2008) · Physics in Medicine and Biology · doi:10.1088/0031-9155/53/6/n01 · Cited by 128 · see citing works
Self-citationWang, J., Reykowski, A., & Dickas, J. (1995) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.412657 · Cited by 110 · see citing works
Lymph node imaging: Basic principles
Luciani, A., Itti, E., Rahmouni, A., Meignan, M. A., & Clémеnt, O. (2006) · European Journal of Radiology · doi:10.1016/j.ejrad.2005.12.038 · Cited by 88 · see citing works
Vlaardingerbroek, M. T., & den Boer, J. A. (2003) · Springer eBooks · doi:10.1007/978-3-662-05252-5 · Cited by 68 · see citing works
電算機による横断軸性スキャニング(断層像) 第1部 装置に関する記述
Hounsfield, G. N. (1973) · British Journal of Radiology · Cited by 48 · see citing works
Borgert, J., Gleich, B., & Buzug, T. M. (2011) · Springer eBooks · doi:10.1007/978-3-540-74658-4_24 · Cited by 44 · see citing works
Self-citationOn Row Relaxation Methods for Large Constrained Least Squares Problems
Dax, A. (1993) · SIAM Journal on Scientific Computing · doi:10.1137/0914036 · Cited by 38 · see citing works
Measurements of Mouse Pulmonary Artery Biomechanics
Chesler, N. C., and, J. T.-F., & Millburne, K. M. (2004) · Journal of Biomechanical Engineering · doi:10.1115/1.1695578 · Cited by 37 · see citing works
Li, M., Kudo, H., Hu, J., et al. (2004) · IEEE Transactions on Nuclear Science · doi:10.1109/tns.2004.829789 · Cited by 29 · see citing works
A noninvasive multimodal technique to monitor brain tumor vascularization
Saxena, V., González-Gómez, I., & Laug, W. E. (2007) · Physics in Medicine and Biology · doi:10.1088/0031-9155/52/17/013 · Cited by 19 · see citing works
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Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
Magnetic particle imaging: current developments and future directions
Panagiotopoulos, N., Vogt, F., Barkhausen, J., Buzug, T. M., Duschka, R. L., Lüdtke-Buzug, K., Ahlborg, M., Bringout, G., Debbeler, C., Gräser, M., et al. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s70488 · Cited by 289 · see citing works
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Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Arami, H., Saritas, E. U., Croft, L. R., Konkle, J., Goodwill, P. W., Halkola, A., Rahmer, J., et al. (2015) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2014.2375065 · Cited by 222 · see citing works
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Khandhar, A. P., Ferguson, R. M., Arami, H., & Krishnan, K. M. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.087 · Cited by 152 · see citing works
Magnetic particle imaging: visualization of instruments for cardiovascular intervention
Haegele, J., Rahmer, J., Gleich, B., Borgert, J., Wojtczyk, H., Panagiotopoulos, N., Buzug, T. M., Barkhausen, J., & Vogt, F. M. (2012) · Radiology · doi:10.1148/radiol.12120424 · Cited by 151 · see citing works
Self-citationKratz, H., Taupitz, M., Ariza de Schellenberger, A., Kosch, O., Eberbeck, D., Wagner, S., Trahms, L., Hamm, B., & Schnorr, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190214 · Cited by 92 · see citing works
Design of superparamagnetic nanoparticles for magnetic particle imaging (MPI)
Du, Y., Lai, P., Leung, C., & Pong, P. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140918682 · Cited by 81 · see citing works
First <i>in vivo</i> traveling wave magnetic particle imaging of a beating mouse heart
Vogel, P., Rückert, M. A., Klauer, P., Kullmann, W. H., Jakob, P. M., & Behr, V. C. (2016) · Physics in Medicine & Biology · doi:10.1088/0031-9155/61/18/6620 · Cited by 60 · see citing works
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- Authors
- Weizenecker, J., Gleich, B., Rahmer, J., Dahnke, H., & Borgert, J.
- Affiliations
- Philips (Germany) (DE)
- Venue
- Physics in Medicine and Biology
- Publisher
- IOP Publishing
- Published
- 2009-02-10
- Volume
- 54
- Issue
- 5
- Pages
- L1-L10
- ISSN
- 0031-9155 (ISSN-L)
- 1361-6560
- OpenAlex
- W2151752675
- Cited by
- 651
- References
- 27
- Citations by year
- 2026: 27 · 2025: 40 · 2024: 39 · 2023: 24 · 2022: 36 · 2021: 38 · 2020: 36 · 2019: 37 · 2018: 46 · 2017: 58 · 2016: 41 · 2015: 53 · 2014: 26 · 2013: 47 · 2012: 47
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Physics in Medicine and Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (13N9079, FKZ 13N9079)
- Universitätsklinikum Hamburg-Eppendorf
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Keywords
- magnetic particle imaging, in vivo imaging, cardiac imaging, MRI contrast agents, magnetic tracers, temporal resolution, cardiac chambers
- MeSH terms
- Animals, Contrast Media, Female, Magnetic Resonance Imaging, Phantoms, Imaging, Imaging, Three-Dimensional, Mice
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