A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging
Open accessAbstract
This paper aims to update the clinical researches using superparamagnetic iron oxide (SPIO) nanoparticles as magnetic resonance imaging (MRI) contrast agent published during the past five years. PubMed database was used for literature search, and the search terms were (SPIO OR superparamagnetic iron oxide OR Resovist OR Ferumoxytol OR Ferumoxtran-10) AND (MRI OR magnetic resonance imaging). The literature search results show clinical research on SPIO remains robust, particularly fuelled by the approval of ferumoxytol for intravenously administration. SPIOs have been tested on MR angiography, sentinel lymph node detection, lymph node metastasis evaluation; inflammation evaluation; blood volume measurement; as well as liver imaging. Two experimental SPIOs with unique potentials are also discussed in this review. A curcumin-conjugated SPIO can penetrate brain blood barrier (BBB) and bind to amyloid plaques in Alzheime's disease transgenic mice brain, and thereafter detectable by MRI. Another SPIO was fabricated with a core of Fe3O4 nanoparticle and a shell coating of concentrated hydrophilic polymer brushes and are almost not taken by peripheral macrophages as well as by mononuclear phagocytes and reticuloendothelial system (RES) due to the suppression of non-specific protein binding caused by their stealthy ''brush-afforded'' structure. This SPIO may offer potentials for the applications such as drug targeting and tissue or organ imaging other than liver and lymph nodes.
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Some approved SPION have later been withdrawn because of the availability of alternative diagnostic probes and protocols.
“However, some of the approved SPION have later on been withdrawn, because of the availability of alternative diagnostic probes and protocols [27].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [27]
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- Authors
- Wáng, Y. X. J., & Idée, J.-M.
- Affiliations
- Chinese University of Hong Kong (HK)
- Guerbet (France) (FR)
- Corresponding author
- Wáng, Yì Xiáng J.
- ORCID
- Wáng, Yì Xiáng J.
- Venue
- Quantitative Imaging in Medicine and Surgery
- Publisher
- AME Publishing Company
- Published
- 2017-02
- Volume
- 7
- Issue
- 1
- Pages
- 88-122
- ISSN
- 2223-4292 (ISSN-L)
- 2223-4306
- PMC
- PMC5337187
- OpenAlex
- W2593812550
- Cited by
- 247
- References
- 163
- Citations by year
- 2026: 11 · 2025: 24 · 2024: 22 · 2023: 20 · 2022: 27 · 2021: 39 · 2020: 27 · 2019: 38 · 2018: 29 · 2017: 9 · 2016: 1
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Quantitative Imaging in Medicine and Surgery (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
- Keywords
- superparamagnetic iron oxide nanoparticles, MRI contrast agents, ferumoxytol, magnetic resonance angiography, sentinel lymph node mapping, lymph node metastasis, inflammation imaging, blood volume measurement, liver imaging, targeted drug delivery
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