The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Mild Traumatic Brain Injury: Longitudinal Regional Brain Volume Changes
Open accessAbstract
PURPOSE: To investigate longitudinal changes in global and regional brain volume in patients 1 year after mild traumatic brain injury (MTBI) and to correlate such changes with clinical and neurocognitive metrics. MATERIALS AND METHODS: This institutional review board-approved study was HIPAA compliant. Twenty-eight patients with MTBI (with 19 followed up at 1 year) with posttraumatic symptoms after injury and 22 matched control subjects (with 12 followed up at 1 year) were enrolled. Automated segmentation of brain regions to compute regional gray matter (GM) and white matter (WM) volumes was performed by using three-dimensional T1-weighted 3.0-T magnetic resonance imaging, and results were correlated with clinical metrics. Pearson and Spearman rank correlation coefficients were computed between longitudinal brain volume and neurocognitive scores, as well as clinical metrics, over the course of the follow-up period. RESULTS: One year after MTBI, there was measurable global brain atrophy, larger than that in control subjects. The anterior cingulate WM bilaterally and the left cingulate gyrus isthmus WM, as well as the right precuneal GM, showed significant decreases in regional volume in patients with MTBI over the 1st year after injury (corrected P < .05); this was confirmed by means of cross-sectional comparison with data in control subjects (corrected P < .05). Left and right rostral anterior cingulum WM volume loss correlated with changes in neurocognitive measures of memory (r = 0.65, P = .005) and attention (r = 0.60, P = .01). At 1-year follow-up, WM volume in the left cingulate gyrus isthmus correlated with clinical scores of anxiety (Spearman rank correlation r = -0.68, P = .007) and postconcussive symptoms (Spearman rank correlation r = -0.65, P = .01). CONCLUSION: These observations demonstrate structural changes to the brain 1 year after injury after a single concussive episode. Regional brain atrophy is not exclusive to moderate and severe traumatic brain injury but may be seen after mild injury. In particular, the anterior part of the cingulum and the cingulate gyrus isthmus, as well as the precuneal GM, may be distinctively vulnerable 1 year after MTBI.
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Cites
An inventory for measuring clinical anxiety: Psychometric properties.
Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.56.6.893 · Cited by 14,407
Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., van der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00569-x · Cited by 8,610
SMITH, S., & NICHOLS, T. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.061 · Cited by 5,250
Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature
Destrieux, C., Fischl, B., Dale, A., & Halgren, E. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.010 · Cited by 2,956
Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury
McKee, A. C., Cantu, R. C., Nowinski, C. J., Hedley-Whyte, E. T., Gavett, B. E., Budson, A. E., Santini, V. E., Lee, H.-S., Kubilus, C. A., & Stern, R. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181a9d503 · Cited by 2,295
Incidence of mild and moderate brain injury in the United States, 1991
D. M. SOSIN, J. E. S. (1996) · Brain Injury · doi:10.1080/026990596124719 · Cited by 594
EPIDEMIOLOGIC ASPECTS OF BRAIN INJURY
Kraus, J. F., & McArthur, D. L. (1996) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70266-8 · Cited by 304
The regulation of cognitive control following rostral anterior cingulate cortex lesion in humans
di Pellegrino, G., Ciaramelli, E., & Làdavas, E. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.2.275 · Cited by 169
Cited by
Mild Traumatic Brain Injury (mTBI) and chronic cognitive impairment: A scoping review
McInnes, K., Friesen, C. L., MacKenzie, D. E., Westwood, D. A., & Boe, S. G. (2017) · PLOS ONE · doi:10.1371/journal.pone.0174847 · Cited by 531
Faden, A. I., & Loane, D. J. (2015) · Neurotherapeutics · doi:10.1007/s13311-014-0319-5 · Cited by 245
A review of neuroimaging findings in repetitive brain trauma
Koerte, I. K., Lin, A. P., Willems, A., Muehlmann, M., Hufschmidt, J., Coleman, M. J., Green, I., Liao, H., Tate, D. F., Wilde, E. A., et al. (2015) · Brain Pathology · doi:10.1111/bpa.12249 · Cited by 160
Chronic traumatic encephalopathy: Where are we and where are we going?
Mez, J., Stern, R. A., & McKee, A. C. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0407-7 · Cited by 120
LoBue, C., Munro, C., Schaffert, J., Didehbani, N., Hart, Batjer, H., & Cullum, C. M. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-190028 · Cited by 86
Metadata
- Authors
- Zhou, Y., Kierans, A., Kenul, D., Ge, Y., Rath, J., Reaume, J., Grossman, R. I., & Lui, Y. W.
- Venue
- Radiology
- Published
- 2013-06
- Volume
- 267
- Issue
- 3
- Pages
- 880-890
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2149108136
- Cited by
- 236
- References
- 8
- FWCI
- 16.65
- Type
- journal article
- Language
- en
- Open access
- green
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