Cited by 531Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesLong-Term Effects of COVID-19

Mild Traumatic Brain Injury (mTBI) and chronic cognitive impairment: A scoping review

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McInnes, Kerry, Friesen, Christopher L., MacKenzie, Diane E., Westwood, David A., Boe, Shaun G.·2017·PLOS ONE

Abstract

Mild traumatic brain injury (mTBI), or concussion, is the most common type of traumatic brain injury. With mTBI comes symptoms that include headaches, fatigue, depression, anxiety and irritability, as well as impaired cognitive function. Symptom resolution is thought to occur within 3 months post-injury, with the exception of a small percentage of individuals who are said to experience persistent post-concussion syndrome. The number of individuals who experience persistent symptoms appears to be low despite clear evidence of longer-term pathophysiological changes resulting from mTBI. In light of the incongruency between these longer-term changes in brain pathology and the number of individuals with longer-term mTBI-related symptoms, particularly impaired cognitive function, we performed a scoping review of the literature that behaviourally assessed short- and long-term cognitive function in individuals with a single mTBI, with the goal of identifying the impact of a single concussion on cognitive function in the chronic stage post-injury. CINAHL, Embase, and Medline/Ovid were searched July 2015 for studies related to concussion and cognitive impairment. Data relating to the presence/absence of cognitive impairment were extracted from 45 studies meeting our inclusion criteria. Results indicate that, in contrast to the prevailing view that most symptoms of concussion are resolved within 3 months post-injury, approximately half of individuals with a single mTBI demonstrate long-term cognitive impairment. Study limitations notwithstanding, these findings highlight the need to carefully examine the long-term implications of a single mTBI.

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Authors
McInnes, K., Friesen, C. L., MacKenzie, D. E., Westwood, D. A., & Boe, S. G.
Affiliations
Dalhousie University (CA)
Corresponding author
Boe, Shaun G.
Venue
PLOS ONE
Published
2017-04-11
Volume
12
Issue
4
Pages
e0174847
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2606627358
Cited by
531
References
75
Citations by year
2026: 60 · 2025: 71 · 2024: 64 · 2023: 59 · 2022: 47 · 2021: 65 · 2020: 66 · 2019: 57 · 2018: 33 · 2017: 8
FWCI
5.95
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
Keywords
mild traumatic brain injury, concussion, post-concussion syndrome, long-term cognitive function, persistent post-concussion symptoms, symptom resolution, neuropathology
MeSH terms
Brain Concussion, Chronic Disease, Humans, Cognitive Dysfunction

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