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Cited by 160Traumatic Brain Injury ResearchAutomotive and Human Injury BiomechanicsTraumatic Brain Injury and Neurovascular Disturbances

A review of neuroimaging findings in repetitive brain trauma

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Koerte, Inga K., Lin, Alexander P., Willems, Anna, Muehlmann, Marc, Hufschmidt, Jakob, Coleman, Michael J., Green, Isobel, Liao, Huijun +8 more·2015·Brain Pathology
DOI 10.1111/bpa.12249PMC PMC5699448
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Abstract

Chronic traumatic encephalopathy ( CTE ) is a neurodegenerative disease confirmed at postmortem. Those at highest risk are professional athletes who participate in contact sports and military personnel who are exposed to repetitive blast events. All neuropathologically confirmed CTE cases, to date, have had a history of repetitive head impacts. This suggests that repetitive head impacts may be necessary for the initiation of the pathogenetic cascade that, in some cases, leads to CTE . Importantly, while all CTE appears to result from repetitive brain trauma, not all repetitive brain trauma results in CTE . Magnetic resonance imaging has great potential for understanding better the underlying mechanisms of repetitive brain trauma. In this review, we provide an overview of advanced imaging techniques currently used to investigate brain anomalies. We also provide an overview of neuroimaging findings in those exposed to repetitive head impacts in the acute/subacute and chronic phase of injury and in more neurodegenerative phases of injury, as well as in military personnel exposed to repetitive head impacts. Finally, we discuss future directions for research that will likely lead to a better understanding of the underlying mechanisms separating those who recover from repetitive brain trauma vs. those who go on to develop CTE .

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  • The corpus callosum white matter has been shown to be the most sensitive region to repetitive head trauma.

    “Interestingly, the corpus callosum white matter has been shown to be the most sensitive region to repetitive head trauma [497].”

    From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [497]

    In the Imaging Findings section (page unavailable), the review reports an association between head-impact exposure and diffusion measures in the corpus callosum. It also reports associations in several other brain regions and does not establish that callosal white matter is the most sensitive region. The same section notes that the corpus callosum may not be biochemically sensitive to these injuries in the acute phase. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Koerte, I. K., Lin, A. P., Willems, A., Muehlmann, M., Hufschmidt, J., Coleman, M. J., Green, I., Liao, H., Tate, D. F., Wilde, E. A., Pasternak, O., Bouix, S., Rathi, Y., Bigler, E. D., Stern, R. A., & Shenton, M. E.
Affiliations
  • Brigham and Women's Hospital (US)
  • Brooke Army Medical Center (US)
  • Michael E. DeBakey VA Medical Center (US)
  • Psychiatry Neuroimaging Laboratory Departments of Psychiatry and Radiology Brigham and Women's Hospital and Harvard Medical School Boston MA
  • Brigham Young University (US)
  • Boston University (US)
ORCID
Venue
Brain Pathology
Publisher
Wiley
Published
2015-04-23
Volume
25
Issue
3
Pages
318-349
ISSN
  • 1015-6305 (ISSN-L)
  • 1750-3639
DOI
10.1111/bpa.12249
PMC
PMC5699448
OpenAlex
W1483140595
Cited by
160
References
16
Citations by year
2026: 21 · 2025: 14 · 2024: 10 · 2023: 12 · 2022: 7 · 2021: 17 · 2020: 20 · 2019: 12 · 2018: 18 · 2017: 14 · 2016: 9 · 2015: 5 · 2014: 1
FWCI
1.99
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Brain Pathology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Espace ÉTS (ETS) (submittedVersion)
  • FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke (L30 NS063444, R56NS078337, R01NS078337, U01NS086659)
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
chronic traumatic encephalopathy, repetitive head impacts, neuroimaging, magnetic resonance imaging, military personnel, blast exposure, contact athletes, neurodegeneration, brain anomalies
MeSH terms
Brain, Brain Injuries, Chronic Disease, Humans, Image Processing, Computer-Assisted, Time Factors, Neuroimaging

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