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Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing
Open accessAbstract
Some patients with positive chest CT findings may present with negative results of real-time reverse-transcription polymerase chain reaction (RT-PCR) tests for coronavirus disease 2019 (COVID-19). In this study, the authors present chest CT findings from five patients with COVID-19 infection who had initial negative RT-PCR results. All five patients had typical imaging findings, including ground-glass opacity (five patients) and/or mixed ground-glass opacity and mixed consolidation (two patients). After isolation for presumed COVID-19 pneumonia, all patients were eventually confirmed to have COVID-19 infection by means of repeated swab tests. A combination of repeated swab tests and CT scanning may be helpful for individuals with a high clinical suspicion of COVID-19 infection but negative findings at RT-PCR screening.
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“There are currently a number of different ways to detect COVID-19, whereas computed tomography and X-rays remain the major surgical techniques [80–82].”
From A comprehensive survey on federated learning techniques for healthcare informatics (2023) · cites this paper as [81]
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Analysing most efficient deep learning model to detect COVID-19 from computer tomography images
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“Many cases where an initial test result was negative despite a strong suspicion of COVID-19 based on CT findings have shown a positive result on repeated testing, including the case the author reported (41,42).”
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“CT thorax suggested a small aortic root abscess between the left and right Valsalva sinuses but no lung parenchymal changes suggestive of COVID‐19.”
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“Now, reverse-transcription polymerase chain reaction (RT-PCR) is an acceptable procedure for diagnosing COVID-19; this test is performed manually to carry out viral nucleic acid examination by using nasopharyngeal and throat swabs [3].”
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The diagnostic performance of deep-learning-based CT severity score to identify COVID-19 pneumonia
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“26,27 According to Ji et al, there is a significant positive correlation between COVID-19 mortality and healthcare burden.”
BackgroundRecent Progresses in Electrochemical DNA Biosensors for SARS-CoV-2 Detection
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“Sensitivity of chest CT has been reported as high as 97% as compared to RT-PCR [4] and CT abnormalities could precede RT-PCR positivity [12] .”
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“In addition, according to Zou et al [24], viral load in our study was detected in nasopharyngeal swabs rather than in throat swabs like in the studies by Xie et al [21] and Ai et al [22].”
ResultSpontaneous Pneumomediastinum Associated with COVID-19 Pneumonia
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“Other atypical CT signs appear in the form of pseudonodular condensations, sometimes accompanied by an inverted halo sign [2, 3].”
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“However, the recently published literature reports a lack of proper diagnostic sensitivity of the test, which is unfavorable to control the infection in epidemic areas [5, 7, 9, 10].”
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Larici, A. R., Cicchetti, G., Marano, R., Bonomo, L., & Storto, M. L. (2021) · Chinese Journal of Academic Radiology · doi:10.1007/s42058-021-00068-0 · Cited by 16
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Progress in COVID research and developments during pandemic
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Deep learning framework for prediction of infection severity of COVID-19
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“Moreover, RT-PCR has been reported having a high false-negative rate and a low sensitivity (8, 9).”
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“For the peripheral regions of tissue, more than one lobe was found in the form of GGOs, or less nodules were found in each lobe [14,17].”
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Liu, X., Sun, Y., Song, H., Zhang, W., Liu, T., Chu, Z., Gu, X., Ma, Z., & Jin, W. (2024) · Talanta · doi:10.1016/j.talanta.2024.125994 · Cited by 17
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Recent Advancements in the Diagnosis, Prevention, and Prospective Drug Therapy of COVID-19
Ahsan, W., Alhazmi, H. A., Patel, K., Mangla, B., Bratty, M. A., Javed, S., Najmi, A., Sultan, M. H., Makeen, H. A., Khalid, A., et al. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00384 · Cited by 18
“Therefore, in these cases, a computerized tomography scan of the chest is suggested as a complementary tool (66, 67).”
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“At the moment, Remdesivir, Ribavirin (nucleoside analogues), Favipiravir, Griffithsin (inhibitor of SARS and MERS spike proteins) and Ritonavir/Lopinavir (protease enzyme inhibitors) [54], Abidol (Umifenovir) [55], Oseltamivir (neuraminidase inhibitors), EK1 peptide, and anti-inflammatory drugs are being employed to t…”
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The Relationship Between Chest Imaging Findings and the Viral Load of COVID-19
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“However, obtaining the viral load needs a long-term PCR test which has the potential of providing a false negative (18), therefore, investigating the relationships between these factors and the vial load may overcome the disadvantage.”
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Prosthetic aortic valve endocarditis complicated by COVID‐19 and hemorrhage
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Implementation of Preoperative Screening Protocols in Otolaryngology During the COVID‐19 Pandemic
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Metadata
- Authors
- Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., & Liu, J.
- Affiliations
- Central South University (CN)
- Corresponding author
- Liu, Jun
- Venue
- Radiology
- Published
- 2020-08
- Volume
- 296
- Issue
- 2
- Pages
- E41-E45
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- PMC
- PMC7233363
- OpenAlex
- W3006110666
- Cited by
- 1,960
- References
- 6
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 75 · 2023: 136 · 2022: 282 · 2021: 575 · 2020: 850
- FWCI
- 60.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Radiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › COVID-19 diagnosis using AI
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Keywords
- COVID-19 pandemic, COVID-19 pneumonia, chest CT findings, ground-glass opacities, delayed diagnosis
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Vaccines, COVID-19 Testing, Adult, Aged, False Negative Reactions, Female, Humans, Male, Middle Aged, Pneumonia, Viral, Radiographic Image Interpretation, Computer-Assisted, Tomography, X-Ray Computed, Reproducibility of Results, Coronavirus Infections, Clinical Laboratory Techniques, Reverse Transcriptase Polymerase Chain Reaction, Pandemics
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